Regulation Mechanisms and Signaling Pathways of Autophagy

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914

Autophagy as a Regulated Pathway of Cellular Degradation

Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630

Induction of autophagy and inhibition of tumorigenesis by beclin 1

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082

Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury

Yan, M., Shu, S., Guo, C., Tang, C., & Dong, Z. (2018) · Annals of Medicine · doi:10.1080/07853890.2018.1489142 · Cited by 177

Silver nanoparticles synthesized from Adenium obesum leaf extract induced DNA damage, apoptosis and autophagy via generation of reactive oxygen species

Farah, M. A., Ali, M. A., Chen, S., Li, Y., Al-Hemaid, F. M. A., Abou-Tarboush, F. M., Al‐Anazi, K. M., & Lee, J. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.01.027 · Cited by 176

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

López‐Castejón, G., Luheshi, N., Compan, V., High, S., Whitehead, R. C., Flitsch, S. L., Kirov, A., Prudovsky, I. A., Swanton, E., & Brough, D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.422238 · Cited by 175

Targeting apoptotic and autophagic pathways for cancer therapeutics

Liu, J., Mou, L., Yu, J., Liu, B., & Bao, J. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.10.001 · Cited by 175

Virus-induced ER stress and the unfolded protein response

Zhang, L., & Wang, A. (2012) · Frontiers in Plant Science · doi:10.3389/fpls.2012.00293 · Cited by 175

Inhaled Pollutants: The Molecular Scene behind Respiratory and Systemic Diseases Associated with Ultrafine Particulate Matter

Traboulsi, H., Guerrina, N., Iu, M., Maysinger, D., Ariya, P. A., & Baglole, C. J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020243 · Cited by 175

The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion

Xia, Y., Liu, N., Xie, X., Bi, G., Ba, H., Li, L., Zhang, J., Deng, X., Yao, Y., Tang, Z., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1569916 · Cited by 177

Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling

Lorzadeh, S., Kohan, L., Ghavami, S., & Azarpira, N. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118926 · Cited by 175

Cardiovascular autophagy

Lavandero, S., Troncoso, R., Rothermel, B. A., Martinet, W., Sadoshima, J., & Hill, J. A. (2013) · Autophagy · doi:10.4161/auto.25969 · Cited by 174

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.11.004 · Cited by 173

Autophagy Is Rapidly Induced by Salt Stress and Is Required for Salt Tolerance in Arabidopsis

Luo, L., Zhang, P., Zhu, R., Fu, J., Su, J., Zheng, J., Wang, Z., Wang, D., & Gong, Q. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01459 · Cited by 173

Autophagy precedes apoptosis during the remodeling of silkworm larval midgut

Franzetti, E., Huang, Z.-J., Shi, Y.-X., Xie, K., Deng, X.-J., Li, J.-P., Li, Q.-R., Yang, W.-Y., Zeng, W.-N., Casartelli, M., et al. (2012) · Apoptosis · doi:10.1007/s10495-011-0675-0 · Cited by 172

Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction?

Peric, A., & Annaert, W. G. (2015) · Acta Neuropathologica · doi:10.1007/s00401-014-1379-7 · Cited by 172

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells

Vázquez, P., Arroba, A. I., Cecconi, F., de la Rosa, E. J., Boya, P., & De Pablo, F. (2012) · Autophagy · doi:10.4161/auto.8.2.18535 · Cited by 171

Autophagy as a mediator of chemotherapy-induced cell death in cancer

Notte, A., Leclère, L., & Michiels, C. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.015 · Cited by 171

Autophagy and endocrine resistance in breast cancer

Cook, K. L., Shajahan‐Haq, A. N., & Clarke, R. C. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.11.111 · Cited by 171

Autophagy in cellular growth control

Wang, R. C., & Levine, B. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.009 · Cited by 172

Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis

Portal‐Núñez, S., Esbrit, P., Alcaraz, M. J., & Largo, R. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.12.012 · Cited by 170

p53-Mediated Molecular Control of Autophagy in Tumor Cells

Mrakovcic, M., & Fröhlich, L. F. (2018) · Biomolecules · doi:10.3390/biom8020014 · Cited by 170

FIP200 is required for maintenance and differentiation of postnatal neural stem cells

Wang, C., Liang, C.-C., Bian, Z. C., Zhu, Y., & Guan, J.-L. (2013) · Nature Neuroscience · doi:10.1038/nn.3365 · Cited by 169

Autophagy Dysregulation in Amyotrophic Lateral Sclerosis

Chen, S., Zhang, X., Song, L., & Le, W. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00546.x · Cited by 170

Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1

Toledo, M., Batista‐González, A., Merheb, E., Aoun, M. L., Tarabra, E., Feng, D., Sarparanta, J., Merlo, P., Botrè, F., Schwartz, G. J., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.023 · Cited by 169

Autophagy in protists

Duszenko, M., Ginger, M. L., Brennand, A., Gualdrón‐López, M., Colombo, M. I., Coombs, G. H., Coppens, I., Jayabalasingham, B., Langsley, G., de Castro, S. L., et al. (2011) · Autophagy · doi:10.4161/auto.7.2.13310 · Cited by 168

Autophagy in tumor suppression and cancer therapy

Kung, C.-P., Budina, A., Balaburski, G. M., Bergenstock, M., & Murphy, M. E. (2011) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v21.i1.50 · Cited by 168

Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder—murine Pompe disease

Raben, N., Schreiner, C. N., Baum, R., Takikita, S., Xu, S., Xie, T., Myerowitz, R., Komatsu, M., van der Meulen, J. H., Nagaraju, K., et al. (2010) · Autophagy · doi:10.4161/auto.6.8.13378 · Cited by 168

Resistance to endocrine therapy in breast cancer: molecular mechanisms and future goals

Szostakowska-Rodzoś, M., Trębińska-Stryjewska, A., Grzybowska, E. A., & Fabisiewicz, A. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-5023-4 · Cited by 168

microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells

Comincini, S., Allavena, G., Palumbo, S., Morini, M., Durando, F., Angeletti, F., Pirtoli, L., & Miracco, C. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.24597 · Cited by 167

Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG

Li, X., He, L., Che, K. H., Funderburk, S. F., Pan, L., Pan, N., Zhang, M., Yue, Z., & Zhao, Y. (2012) · Nature Communications · doi:10.1038/ncomms1648 · Cited by 167

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Hernández‐Tiedra, S., Fabriàs, G., Dávila, D., Salanueva, Í. J., Casas, J., Montes, L. R., Antón, Z., García-Taboada, E., Salazar‐Roa, M., Lorente, M., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1213927 · Cited by 168

Defective Autophagy and Mitophagy in Aging and Alzheimer’s Disease

Tran, M., & Reddy, P. H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.612757 · Cited by 167

Insufficient Autophagy Contributes to Mitochondrial Dysfunction, Organ Failure, and Adverse Outcome in an Animal Model of Critical Illness*

Gunst, J., Derese, I., Aertgeerts, A., Ververs, E.-J., Wauters, A., den Berghe, G. V., & Vanhorebeek, I. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182676657 · Cited by 166

Induction of Autophagy by Palmitic Acid via Protein Kinase C-mediated Signaling Pathway Independent of mTOR (Mammalian Target of Rapamycin)

Tan, S. H., Shui, G., Zhou, J., Li, J. J., Bay, B., Wenk, M. R., & Shen, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.294157 · Cited by 165

Mitochondrial Roles and Cytoprotection in Chronic Liver Injury

Esposti, D. D., Hamelin, J., Bosselut, N., Saffroy, R., Sebagh, M., Pommier, A., Martel, C., & Lemoine, A. (2012) · Biochemistry Research International · doi:10.1155/2012/387626 · Cited by 165

State of the Science: An Update on Renal Cell Carcinoma

Jonasch, E. W., Futreal, P. A., Davis, I. J., Bailey, S. T., Kim, W. Y., Brugarolas, J., Giaccia, A. J., Kurban, G., Pause, A., Frydman, J., et al. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0117 · Cited by 166

The emerging role of acetylation in the regulation of autophagy

Bánréti, Á., Sass, M., & Graba, Y. (2013) · Autophagy · doi:10.4161/auto.23908 · Cited by 164

Targeting Histone Deacetylases for Cancer Therapy: From Molecular Mechanisms to Clinical Implications

Li, Z., & Zhu, W. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.9067 · Cited by 164

Glucose-Regulated Protein 78 Controls Cross-talk between Apoptosis and Autophagy to Determine Antiestrogen Responsiveness

Cook, K. L., Shajahan‐Haq, A. N., Wärri, A. M., Lu, J., Hilakivi-Clarke, L. A., & Clarke, R. C. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0269 · Cited by 164

ATG8 Expansion: A Driver of Selective Autophagy Diversification?

Kellner, R., la Concepción, J. C. D., Maqbool, A., Kamoun, S., & Dagdas, Y. (2016) · Trends in Plant Science · doi:10.1016/j.tplants.2016.11.015 · Cited by 163

The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer

Shafei, A., Ramzy, M. M., Hegazy, A. I., Husseny, A. K., EL-hadary, U. G., Taha, M. M., & Mosa, A. A. (2018) · Gene · doi:10.1016/j.gene.2018.01.016 · Cited by 163

TMEM41B is a novel regulator of autophagy and lipid mobilization

Moretti, F., Bergman, P., Dodgson, S. E., Marcellin, D., Claerr, I., Goodwin, J. M., DeJesus, R., Kang, Z., Antczak, C., Begue, D., et al. (2018) · EMBO Reports · doi:10.15252/embr.201845889 · Cited by 166

Autophagy in bone: Self-eating to stay in balance

Pierrefite‐Carle, V., Santucci‐Darmanin, S., Breuil, V., Camuzard, O., & Carle, G. F. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.08.004 · Cited by 161

Inflammatory pathways in the early steps of colorectal cancer development

Mariani, F. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i29.9716 · Cited by 161

Redox Control of the Survival of Healthy and Diseased Cells

Zhang, Y., Du, Y., Le, W., Wang, K., Kieffer, N., & Zhang, J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3685 · Cited by 161

Autophagy: More Than a Nonselective Pathway

Reggiori, F., Komatsu, M., Finley, K. D., & Simonsen, A. (2012) · International Journal of Cell Biology · doi:10.1155/2012/219625 · Cited by 161

The Life and Death of a Plant Cell

Kabbage, M., Kessens, R., Bartholomay, L. C., & Williams, B. (2017) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-043015-111655 · Cited by 161

Molecular basis of mycobacterial survival in macrophages

Awuh, J. A., & Flo, T. H. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2422-8 · Cited by 160

Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids

Khan, A. Q., Rashid, K., AlAmodi, A. A., Agha, M. V., Akhtar, S., Hakeem, I., Raza, S. S., & Shahab Uddin, M. S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112142 · Cited by 164

MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9

Yang, J., Chen, D., He, Y., Meléndez, A., Feng, Z., Hong, Q., Bai, X., Li, Q., Cai, G., Wang, J., et al. (2011) · AGE · doi:10.1007/s11357-011-9324-3 · Cited by 161

Dengue Virus and Autophagy

Heaton, N. S., & Randall, G. C. (2011) · Viruses · doi:10.3390/v3081332 · Cited by 160

Mitochondrial alternative oxidase‐dependent autophagy involved in ethylene‐mediated drought tolerance in Solanum lycopersicum

Zhu, T., Zou, L., Li, Y., Yao, X., Xu, F., Deng, X., Zhang, D., & Lin, H. (2018) · Plant Biotechnology Journal · doi:10.1111/pbi.12939 · Cited by 160

MCL‐1 is a stress sensor that regulates autophagy in a developmentally regulated manner

Germain, M., Nguyen, A. P., Le Grand, J. N., Arbour, N., Vanderluit, J. L., Park, D. S., Opferman, J. T., & Slack, R. S. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.327 · Cited by 159

Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus

Pierdominici, M., Vomero, M., Barbati, C., Colasanti, T., Maselli, A., Vacirca, D., Giovannetti, A., Malorni, W., & Ortona, E. (2012) · The FASEB Journal · doi:10.1096/fj.11-194175 · Cited by 160

Autophagy, Microbial Sensing, Endoplasmic Reticulum Stress, and Epithelial Function in Inflammatory Bowel Disease

Kaser, A., & Blumberg, R. S. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.048 · Cited by 158

Inhibition of LRRK2 kinase activity stimulates macroautophagy

Manzoni, C., Mamais, A., Dihanich, S., Abeti, R., Soutar, M. P. M., Plun‐Favreau, H., Giunti, P., Tooze, S. A., Bandopadhyay, R., & Lewis, P. A. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.07.020 · Cited by 158

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

Martinez‐Outschoorn, U., Whitaker‐Menezes, D., Pavlides, S., Chiavarina, B., Bonuccelli, G., Trimmer, C., Tsirigos, A., Migneco, G., Witkiewicz, A. K., Balliet, R. M., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.21.13817 · Cited by 158

Mitophagy receptor FUNDC1 is regulated by PGC-1α/NRF1 to fine tune mitochondrial homeostasis

Liu, L., Li, Y., Wang, J., Zhang, D., Wu, H., Li, W., Wei, H., Ta, N., Fan, Y., Liu, Y., et al. (2021) · EMBO Reports · doi:10.15252/embr.202050629 · Cited by 159

Glucocorticoid dose determines osteocyte cell fate

Jia, J., Yao, W., Guan, M., Dai, W., Shahnazari, M., Kar, R., Bonewald, L., Jiang, J. X., & Lane, N. E. (2011) · The FASEB Journal · doi:10.1096/fj.11-182519 · Cited by 157

Massively Parallel RNA Sequencing Identifies a Complex Immune Gene Repertoire in the lophotrochozoan Mytilus edulis

Philipp, E. E. R., Kraemer, L., Melzner, F., Poustka, A. J., Thieme, S., Findeisen, U., Schreiber, S., & Rosenstiel, P. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033091 · Cited by 157

Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes

Silva, T., Reis, J., Teixeira, J., & Borges, F. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.03.008 · Cited by 158

RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation

He, X., Zhu, Y., Zhang, Y., Geng, Y., Gong, J., Geng, J., Zhang, P., Zhang, X., Liu, N., Peng, Y., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100978 · Cited by 157

Autophagy as a target for cancer therapy: new developments

Nawrocki, S. T., Carew, & Kelly, K. (2012) · Cancer Management and Research · doi:10.2147/cmar.s26133 · Cited by 156

Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer

Bhat, T. A., Chaudhary, A. K., Kumar, S., O’Malley, J., Inigo, J. R., Kumar, R., Yadav, N., & Chandra, D. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.12.002 · Cited by 157

Mitochondria and autophagy: Critical interplay between the two homeostats

Okamoto, K., & Kondo‐Okamoto, N. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.001 · Cited by 155

The intersecting roles of endoplasmic reticulum stress, ubiquitin–proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease

Cybulsky, A. V. (2012) · Kidney International · doi:10.1038/ki.2012.390 · Cited by 154

The elimination of accumulated and aggregated proteins: A role for aggrephagy in neurodegeneration

Yamamoto, A., & Simonsen, A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.08.015 · Cited by 155

Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence

Sachdeva, K., Do, D. C., Zhang, Y., Hu, X., Chen, J., & Gao, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02787 · Cited by 154

p62/SQSTM1 at the interface of aging, autophagy, and disease

Bitto, A., Lerner, C. A., Nacarelli, T., Crowe, E. P., Torres, C. A., & Sell, C. (2014) · AGE · doi:10.1007/s11357-014-9626-3 · Cited by 154

Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model

Park, H.-Y. L., Kim, J. H., & Park, C. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.26 · Cited by 153

Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice

Moresi, V., Carrer, M., Grueter, C. E., Rifki, O. F., Shelton, J. M., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121159109 · Cited by 152

Targeting Autophagy Addiction in Cancer

Mancias, J. D., & Kimmelman, A. C. (2011) · Oncotarget · doi:10.18632/oncotarget.384 · Cited by 152

Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis

Prause, J. U., Goswami, A., Katona, I., Roos, A., Schnizler, M. K., Bushuven, E., Dreier, A., Buchkremer, S., Johann, S., Beyer, C., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt008 · Cited by 152

Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells

Melzer, C., von der Ohe, J., Lehnert, H., Ungefroren, H., & Hass, R. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0595-x · Cited by 152

Molecular mechanism and physiological role of pexophagy

Manjithaya, R. R., Nazarko, T. Y., Farré, J., & Subramani, S. E. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.019 · Cited by 150

Targeting autophagy in neurodegenerative diseases

Vidal, R. L., Matus, S., Bargsted, L., & Hetz, C. A. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.09.002 · Cited by 149

TRAF Family Proteins Regulate Autophagy Dynamics by Modulating AUTOPHAGY PROTEIN6 Stability in Arabidopsis

Qi, H., Xia, F., Xie, L., Yu, L., Chen, Q., Zhuang, X., Wang, Q., Li, F., Jiang, L., Xie, Q., et al. (2017) · The Plant Cell · doi:10.1105/tpc.17.00056 · Cited by 149

Autophagy in stem cell aging

Revuelta, M., & Matheu, A. (2017) · Aging Cell · doi:10.1111/acel.12655 · Cited by 149

20-hydroxyecdysone upregulatesAtggenes to induce autophagy in the Bombyx fat body

Tian, L., Ma, L., Guo, E., Deng, X., Ma, S., Xia, Q., Cao, Y., & Li, S. (2013) · Autophagy · doi:10.4161/auto.24731 · Cited by 148

Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism

Dubland, J. A., & Francis, G. A. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00003 · Cited by 148

Anti-aging pharmacology: Promises and pitfalls

Vaiserman, A. M., Lushchak, O. V., & Koliada, A. K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.004 · Cited by 148

Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy

Peraro, L., Zou, Z., Makwana, K. M., Cummings, A. E., Ball, H. L., Yu, H., Lin, Y., Levine, B., & Kritzer, J. A. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b01698 · Cited by 148

Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy

van Stee, M. F., de Graaf, A. A., & Groen, A. K. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0738-4 · Cited by 148

Oxidative stress-induced apoptosis and autophagy: Balancing the contrary forces in spermatogenesis

Sharma, P., Kaushal, N., Saleth, L. R., Ghavami, S., Dhingra, S., & Kaur, P. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166742 · Cited by 148

Regenerative decline of stem cells in sarcopenia

Sousa-Victor, P., & Muñoz-Cánoves, P. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.02.002 · Cited by 147

Autophagosome formation in mammalian cells

Burman, C., & Ktistakis, N. T. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0222-z · Cited by 147

HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinoma

Pan, B., Chen, D., Huang, J., Wang, R., Feng, B. C., Song, H., & Chen, L. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-165 · Cited by 147

β-Hydroxybutyrate: A signaling metabolite in starvation response?

Rojas‐Morales, P., Tapia, E., & Pedraza‐Chaverrí, J. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.04.005 · Cited by 147

Cellular senescence and autophagy in the pathogenesis of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF)

Kuwano, K., Araya, J., Hara, H., Minagawa, S., Takasaka, N., Ito, S., Kobayashi, K., & Nakayama, K. (2016) · Respiratory Investigation · doi:10.1016/j.resinv.2016.03.010 · Cited by 150

Autophagy in Stem Cell Maintenance and Differentiation

Vessoni, A. T., Muotri, A. R., & Okamoto, O. K. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0526 · Cited by 146

Roles of c-FLIP in Apoptosis, Necroptosis, and Autophagy

Safa, A. R. (2013) · Journal of Carcinogenesis & Mutagenesis · doi:10.4172/2157-2518.s6-003 · Cited by 146

Autophagic homeostasis is required for the pluripotency of cancer stem cells

Sharif, T., Martell, E., Dai, C., Kennedy, B. E., Murphy, P., Clements, D. R., Kim, Y., Lee, P. W. K., & Gujar, S. A. (2016) · Autophagy · doi:10.1080/15548627.2016.1260808 · Cited by 146

TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation

Anand, P., Tait, S. W. G., Lamkanfi, M., Amer, A. O., Núñez, G., Pagès, G., Pouysségur, J., McGargill, M. A., Green, D. R., & Kanneganti, T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.310599 · Cited by 145

LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis

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Mitochondrial Involvement in Cisplatin Resistance

Cocetta, V., Ragazzi, E., & Montopoli, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143384 · Cited by 145

Macroautophagy in CNS health and disease

Griffey, C. J., & Yamamoto, A. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00588-3 · Cited by 147

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

Yamamoto, S., Kuramoto, K., Wang, N., Situ, X., Priyadarshini, M., Zhang, W., Cordoba-Chacon, J., Layden, B. T., & He, C. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.032 · Cited by 144

Decorin as a multivalent therapeutic agent against cancer

Neill, T., Schaefer, L., & Iozzo, R. V. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.016 · Cited by 144

Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine A-induced cell death

Ciechomska, I. A., Gabrusiewicz, K. R., Szczepankiewicz, A. A., & Kaminska, B. (2012) · Oncogene · doi:10.1038/onc.2012.174 · Cited by 144

Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death

Wang, K., Zhang, C., Bao, J., Jia, X., Liang, Y., Wang, X., Chen, M., Su, H., Li, P., Wan, J., et al. (2016) · Scientific Reports · doi:10.1038/srep26064 · Cited by 144

Binding of the pathogen receptor HSP90AA1 to avibirnavirus VP2 induces autophagy by inactivating the AKT-MTOR pathway

Hu, B., Zhang, Y., Lu, J. Q., Wu, H., Fan, C., Sun, Y., Ye, C., Liao, M., & Zhou, J. (2015) · Autophagy · doi:10.1080/15548627.2015.1017184 · Cited by 143

ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis

Xiong, Y., Yepuri, G., Forbiteh, M., Yu, Y., Montani, J., Yang, Z., & Ming, X. (2014) · Autophagy · doi:10.4161/15548627.2014.981789 · Cited by 143

Molecular mechanism and regulation of autophagy1

Yang, Y., Liang, Z., Gu, Z., & Qin, Z. (2005) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2005.00235.x · Cited by 224

Autophagy Regulation and Integration with Cell Signaling

Hamacher‐Brady, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4410 · Cited by 46

Autophagy signal transduction by ATG proteins: from hierarchies to networks

Wesselborg, S., & Stork, B. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2034-8 · Cited by 241

Autophagy in disease: a double-edged sword with therapeutic potential

Martinet, W., Agostinis, P., Vanhoecke, B., Dewaele, M., & de Meyer, G. R. Y. (2009) · Clinical Science · doi:10.1042/cs20080508 · Cited by 186

Other Molecular Mechanisms Regulating Autophagy

Zhang, N., & Zhao, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-0602-4_13 · Cited by 18