Regulation Mechanisms and Signaling Pathways of Autophagy

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914

Autophagy as a Regulated Pathway of Cellular Degradation

Klionsky, D. J., & Emr, S. D. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,630

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025

Autophagy: from phenomenology to molecular understanding in less than a decade

Klionsky, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2245 · Cited by 1,977

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911

Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01453-06 · Cited by 1,832

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798

Autophagy: molecular machinery for self-eating

Yorimitsu, T., & Klionsky, D. J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401765 · Cited by 1,566

Selective degradation of mitochondria by mitophagy

Kim, I., Rodriguez-Enriquez, S., & Lemasters, J. J. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.034 · Cited by 1,558

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00568-3 · Cited by 1,555

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,510

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T., & Thompson, C. B. (2005) · Cell · doi:10.1016/j.cell.2004.11.046 · Cited by 1,487

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384

Regulation of TORC1 by Rag GTPases in nutrient response

Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., & Guan, K.-L. (2008) · Nature Cell Biology · doi:10.1038/ncb1753 · Cited by 1,349

Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

Sanjuan, M. A., Dillon, C. P., Tait, S. W. G., Moshiach, S., Dorsey, F., Connell, S., Komatsu, M., Tanaka, K., Cleveland, J. L., Withoff, S., et al. (2007) · Nature · doi:10.1038/nature06421 · Cited by 1,347

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

Wei, Y., Pattingre, S., Sinha, S., Bassik, M., & Levine, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.001 · Cited by 1,329

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

Noda, T., & Ohsumi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.3963 · Cited by 1,303

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.

Pandey, U. B., Nie, Z., Batlevi, Y., McCray, B. A., Ritson, G. P., Nedelsky, N. B., Schwartz, S. L., DiProspero, N. A., Knight, M. A., Schuldiner, O., et al. (2007) · Nature · doi:10.1038/nature05853 · Cited by 1,234

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R. J., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F. P., & Hawkins, P. T. (1997) · Science · doi:10.1126/science.277.5325.567 · Cited by 1,216

Essential role for Nix in autophagic maturation of erythroid cells

Sandoval, H., Thiagarajan, P., Dasgupta, S. K., Schumacher, A., Prchal, J. T., Chen, M., & Wang, J. (2008) · Nature · doi:10.1038/nature07006 · Cited by 1,185

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

Itakura, E., Kishi, C., Inoue, K., & Mizushima, N. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-01-0080 · Cited by 1,176

Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex

Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.6.1507 · Cited by 1,145

The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy

Hanada, T., Noda, N. N., Satomi, Y., Ichimura, Y., Fujioka, Y., Takao, T., Inagaki, F., & Ohsumi, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700195200 · Cited by 1,123 · cited 1×

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

Fujita, N., Itoh, T., Omori, H., Fukuda, M., Noda, T., & Yoshimori, T. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1257 · Cited by 1,123

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

Tanida, I., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2005) · Autophagy · doi:10.4161/auto.1.2.1697 · Cited by 1,108

Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2

Høyer-Hansen, M., Bastholm, L., Szyniarowski, P., Campanella, M., Szabadkai, G., Farkas, T., Bianchi, K., Fehrenbacher, N., Elling, F., Rizzuto, R., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.009 · Cited by 1,072

The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

Suzuki, K., Kirisako, T., Kamada, Y., Mizushima, N., Noda, T., & Ohsumi, Y. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.5971 · Cited by 1,060

Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response

Bernales, S., McDonald, K. L., & Walter, P. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040423 · Cited by 1,047

The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

Kirisako, T., Ichimura, Y., Okada, H., Kabeya, Y., Mizushima, N., Yoshimori, T., Ohsumi, M., Takao, T., Noda, T., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.263 · Cited by 1,024

Rheb Binds and Regulates the mTOR Kinase

Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K., & Avruch, J. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.053 · Cited by 1,005

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting in Saccharomyces cerevisiae

Kihara, A., Noda, T., Ishihara, N., & Ohsumi, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.3.519 · Cited by 1,004

NIX is required for programmed mitochondrial clearance during reticulocyte maturation

Schweers, R. L., Zhang, J., Randall, M. S., Loyd, M. R., Li, W., Dorsey, F. C., Kundu, M., Opferman, J. T., Cleveland, J. L., Miller, J. L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708818104 · Cited by 979

Role for Rab7 in maturation of late autophagic vacuoles

Jäger, S., Bucci, C., Tanida, I., Ueno, T., Kominami, E., Säftig, P., & Eskelinen, E. (2004) · Journal of Cell Science · doi:10.1242/jcs.01370 · Cited by 970

Endoplasmic Reticulum Stress Triggers Autophagy

Yorimitsu, T., Nair, U., Yang, Z., & Klionsky, D. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607007200 · Cited by 968

The molecular machinery of autophagy: unanswered questions

Klionsky, D. J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01620 · Cited by 960

ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

Kouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., Ogawa, S., Kaufman, R. J., Kominami, E., & Momoi, T. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401984 · Cited by 934

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

Tanaka, Y., Guhde, G., Suter, A., Eskelinen, E.-L., Hartmann, D., Lüllmann-Rauch, R., Janssen, P. M. L., Blanz, J., von Figura, K., & Saftig, P. (2000) · Nature · doi:10.1038/35022595 · Cited by 925

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A., & Pan, D. (2003) · Nature Cell Biology · doi:10.1038/ncb999 · Cited by 924

Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

Singh, S. B., Davis, A. S., Taylor, G. A., & Deretic, V. (2006) · Science · doi:10.1126/science.1129577 · Cited by 915

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

Hara, T., Takamura, A., Kishi, C., Iemura, S.-I., Natsume, T., Guan, J.-L., & Mizushima, N. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712064 · Cited by 904

The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

Liang, J., Shao, S. H., Xu, Z.-X., Hennessy, B. T., Ding, Z., Larrea, M. D., Kondo, S., Dumont, D. J., Gutterman, J. U., Walker, C. L., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1537 · Cited by 886

Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T., & Ohsumi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.435 · Cited by 881 · cited 1×

Toll-like Receptor 4 Is a Sensor for Autophagy Associated with Innate Immunity

Xu, Y., Jagannath, C., Liu, X.-D., Sharafkhaneh, A., Kolodziejska, K. E., & Eissa, N. T. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.022 · Cited by 880

Direct Induction of Autophagy by Atg1 Inhibits Cell Growth and Induces Apoptotic Cell Death

Scott, R. C., Juhász, G., & Neufeld, T. P. (2007) · Current Biology · doi:10.1016/j.cub.2006.10.053 · Cited by 871

HSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein

Orvedahl, A., Alexander, D., Tallóczy, Z., Sun, Q., Wei, Y., Zhang, W., Burns, D., Leib, D. A., & Levine, B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2006.12.001 · Cited by 857

The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy

Geng, J., & Klionsky, D. J. (2008) · EMBO Reports · doi:10.1038/embor.2008.163 · Cited by 825

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

Young, A. R. J., Chan, E. Y. W., Hu, X. W., Köchl, R., Crawshaw, S. G., High, S., Hailey, D. W., Lippincott-Schwartz, J., & Tooze, S. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03172 · Cited by 815

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

Mizushima, N., Kuma, A., Kobayashi, Y., Yamamoto, A., Matsubae, M., Takao, T., Natsume, T., Ohsumi, Y., & Yoshimori, T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00381 · Cited by 791

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

Nobukuni, T., Joaquin, M., Roccio, M., Dann, S. G., Kim, S. Y., Gulati, P., Byfield, M. P., Backer, J., Natt, F., Bos, J. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506925102 · Cited by 775

Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway

Tallóczy, Z., Jiang, W., Virgin, H. W., Leib, D. A., Scheuner, D., Kaufman, R. J., Eskelinen, E., & Levine, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012485299 · Cited by 757

Atg8 Controls Phagophore Expansion during Autophagosome Formation

Xie, Z., Nair, U., & Klionsky, D. J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1292 · Cited by 753

Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast

Natarajan, K., Meyer, M. R., Jackson, B. M., Slade, D., Roberts, C., Hinnebusch, A. G., & Marton, M. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4347-4368.2001 · Cited by 749

Toll‐like receptors control autophagy

Delgado, M. A., Elmaoued, R. A., Davis, A. S., Kyei, G., & Deretic, V. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.31 · Cited by 744

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

Kraft, C., Deplazes, A., Sohrmann, M., & Peter, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1723 · Cited by 733

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.

Iwata, A., Riley, B. E., Johnston, J. A., & Kopito, R. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508786200 · Cited by 719

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

Ding, W.-X., Ni, H.-M., Gao, W., Yoshimori, T., Stolz, D. B., Ron, D., & Yin, X.-M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070188 · Cited by 708

Hierarchy of Atg proteins in pre‐autophagosomal structure organization

Suzuki, K., Kubota, Y., Sekito, T., & Ohsumi, Y. (2007) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01050.x · Cited by 691

Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells

Chen, Y., McMillan‐Ward, E., Kong, J., Israels, S. J., & Gibson, S. B. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402233 · Cited by 687

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

Filimonenko, M., Stuffers, S., Raiborg, C., Yamamoto, A., Malerød, L., Fisher, E. M. C., Isaacs, A., Brech, A., Stenmark, H., & Simonsen, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702115 · Cited by 626

Apoptotic and autophagic cell death induced by histone deacetylase inhibitors

Shao, Y., Gao, Z., Marks, P. A., & Jiang, X. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408345102 · Cited by 611

DAP‐kinase‐mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl‐XL and induction of autophagy

Zalckvar, E., Berissi, H., Mizrachy, L., Idelchuk, Y., Koren, I., Eisenstein, M., Sabanay, H., Pinkas‐Kramarski, R., & Kimchi, A. (2009) · The EMBO Reports · doi:10.1038/embor.2008.246 · Cited by 592

The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

Arico, S., Petiot, A., Bauvy, C., Dubbelhuis, P. F., Meijer, A. J., Codogno, P., & Ogier‐Denis, É. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100319200 · Cited by 591

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

Kim, P. K., Hailey, D. W., Mullen, R. T., & Lippincott‐Schwartz, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810611105 · Cited by 556

hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase

Byfield, M. P., Murray, J. T., & Backer, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507201200 · Cited by 540

How Saccharomyces Responds to Nutrients

Zaman, S., Lippman, S. I., Zhao, X., & Broach, J. R. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130206 · Cited by 540

Differential Effects of Endoplasmic Reticulum Stress-induced Autophagy on Cell Survival

Ding, W., Ni, H., Gao, W., Hou, Y., Melan, M. A., Chen, X., Stolz, D. B., Shao, Z.-M., & Yin, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609267200 · Cited by 494

The Itinerary of Autophagosomes: From Peripheral Formation to Kiss‐and‐Run Fusion with Lysosomes

Jahreiss, L., Menzies, F. M., & Rubinsztein, D. C. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00701.x · Cited by 490

Induction of Autophagy Promotes Fusion of Multivesicular Bodies with Autophagic Vacuoles in K562 Cells

Fader, C. M., Sánchez‐Martínez, D., Furlán, M., & Colombo, M. I. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00677.x · Cited by 490

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl–mediated drug resistance

Carew, J. S., Nawrocki, S. T., Kahue, C. N., Zhang, H., Yang, C., Chung, L., Houghton, J. A., Huang, P., Giles, F. J., & Cleveland, J. L. (2007) · Blood · doi:10.1182/blood-2006-10-050260 · Cited by 487

The Atg1-Atg13 Complex Regulates Atg9 and Atg23 Retrieval Transport from the Pre-Autophagosomal Structure

Reggiori, F., Tucker, K. A., Stromhaug, P. E., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00402-7 · Cited by 476

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

Mercer, C. A., Kaliappan, A., & Dennis, P. B. (2009) · Autophagy · doi:10.4161/auto.5.5.8249 · Cited by 475

Apg16p is required for the function of the Apg12p–Apg5p conjugate in the yeast autophagy pathway

Mizushima, N., Noda, T., & Ohsumi, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.14.3888 · Cited by 461

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

Sun, Q., Fan, W., Chen, K., Ding, X., Chen, S., & Zhong, Q. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810452105 · Cited by 460

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

Li, J., Ni, M., Lee, B., Barrón, E., Hinton, D. R., & Lee, A. S. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.81 · Cited by 459

Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

Chen, Z.-H., Kim, H. P., Sciurba, F. C., Lee, S.-J., Feghali-Bostwick, C., Stolz, D. B., Dhir, R., Landreneau, R. J., Schuchert, M. J., Yousem, S. A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003316 · Cited by 459

Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes

Köchl, R., Hu, X. W., Chan, E. Y. W., & Tooze, S. A. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00368.x · Cited by 458

Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

Chen, Y., McMillan‐Ward, E., Kong, J., Israels, S. J., & Gibson, S. B. (2007) · Journal of Cell Science · doi:10.1242/jcs.011163 · Cited by 444

Structural basis of target recognition by Atg8/LC3 during selective autophagy

Noda, N. N., Kumeta, H., Nakatogawa, H., Satoo, K., Adachi, W., Ishii, J., Fujioka, Y., Ohsumi, Y., & Inagaki, F. (2008) · Genes to Cells · doi:10.1111/j.1365-2443.2008.01238.x · Cited by 437

Histone Deacetylase Inhibitors

Marks, P. A., Richon, V. M., Miller, T., & Kelly, W. K. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)91004-4 · Cited by 432

An Atg1/Atg13 Complex with Multiple Roles in TOR-mediated Autophagy Regulation

Chang, Y.-Y., & Neufeld, T. P. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1250 · Cited by 430

Dynein mutations impair autophagic clearance of aggregate-prone proteins

Ravikumar, B., Acevedo-Arozena, A., Imarisio, S., Berger, Z., Vacher, C., O'Kane, C. J., Brown, S. D. M., & Rubinsztein, D. C. (2005) · Nature Genetics · doi:10.1038/ng1591 · Cited by 416

Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism

Chan, E. Y. W., Longatti, A., McKnight, N. C., & Tooze, S. A. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01082-08 · Cited by 411

The Unfolding Tale of the Unfolded Protein Response

Ma, Y., & Hendershot, L. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00623-7 · Cited by 404

Autophagic control of listeria through intracellular innate immune recognition in drosophila

Yano, T., Mita, S., Ohmori, H., Oshima, Y., Fujimoto, Y., Ueda, R., Takada, H., Goldman, W. E., Fukase, K., Silverman, N. S., et al. (2008) · Nature Immunology · doi:10.1038/ni.1634 · Cited by 401

MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

Shi, C.-S., & Kehrl, J. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804478200 · Cited by 395

Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response†

Sir, D., Chen, W., Choi, J., Wakita, T., Yen, T. S. B., & Ou, J. J. (2008) · Hepatology · doi:10.1002/hep.22464 · Cited by 378

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

Nezis, I. P., Simonsen, A., Sagona, A. P., Finley, K., Gaumer, S., Contamine, D., Rusten, T. E., Stenmark, H., & Brech, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711108 · Cited by 370

BNIP3 Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy

Tracy, K., Dibling, B. C., Spike, B. T., Knabb, J. R., Schumacker, P., & Macleod, K. F. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02246-06 · Cited by 369

Autophagosome Requires Specific Early Sec Proteins for Its Formation and NSF/SNARE for Vacuolar Fusion

Ishihara, N., Hamasaki, M., Yokota, S., Suzuki, K., Kamada, Y., Kihara, A., Yoshimori, T., Noda, T., & Ohsumi, Y. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.11.3690 · Cited by 368

Mechanism of Cargo Selection in the Cytoplasm to Vacuole Targeting Pathway

Shintani, T., Huang, W.-P., Stromhaug, P. E., & Klionsky, D. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00373-8 · Cited by 362

Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3

Azad, M. B., Chen, Y., Henson, E. S., Cizeau, J., McMillan‐Ward, E., Israels, S. J., & Gibson, S. B. (2008) · Autophagy · doi:10.4161/auto.5278 · Cited by 355

ESCRTs and Fab1 Regulate Distinct Steps of Autophagy

Rusten, T. E., Vaccari, T., Lindmo, K., Rodahl, L. M., Nezis, I. P., Sem-Jacobsen, C., Wendler, F., Vincent, J., Brech, A., Bilder, D. H., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.09.032 · Cited by 355

The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function

Obara, K., Sekito, T., Niimi, K., & Ohsumi, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803180200 · Cited by 350

Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency

Long, X., Ortiz-Vega, S., Lin, Y., & Avruch, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500169200 · Cited by 349

Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II)

Fujita, E., Kouroku, Y., Isoai, A., Kumagai, H., Misutani, A., Matsuda, C., Hayashi, Y. K., & Momoi, T. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm002 · Cited by 342

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L

Papandreou, I., Lim, A. L., Laderoute, K., & Denko, N. C. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.84 · Cited by 334

PKR-Dependent Xenophagic Degradation of Herpes Simplex Virus Type 1

Tallóczy, Z., Virgin, IV, & Levine, B. (2006) · Autophagy · doi:10.4161/auto.2176 · Cited by 334

PpAtg30 Tags Peroxisomes for Turnover by Selective Autophagy

Farré, J.-C., Manjithaya, R., Mathewson, R. D., & Subramani, S. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.011 · Cited by 331

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila

Juhász, G., Hill, J. H., Yan, Y., Sass, M., Baehrecke, E. H., Backer, J., & Neufeld, T. P. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712051 · Cited by 321

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in DrosophilaPreprint

Reiling, J. H., & Hafen, E. (2004) · Genes & Development · doi:10.1101/gad.322704 · Cited by 306

Atg17 Functions in Cooperation with Atg1 and Atg13 in Yeast Autophagy

Kabeya, Y., Kamada, Y., Baba, M., Takikawa, H., Sasaki, M., & Ohsumi, Y. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0669 · Cited by 304

Antagonistic Controls of Autophagy and Glycogen Accumulation by Snf1p, the Yeast Homolog of AMP-Activated Protein Kinase, and the Cyclin-Dependent Kinase Pho85p

Wang, Z., Wilson, W. A., Fujino, M., & Roach, P. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5742-5752.2001 · Cited by 300

Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation

Kawamata, T., Kamada, Y., Kabeya, Y., Sekito, T., & Ohsumi, Y. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1048 · Cited by 294

Atg22 Recycles Amino Acids to Link the Degradative and Recycling Functions of Autophagy

Yang, Z., Huang, J., Geng, J., Nair, U., & Klionsky, D. J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-06-0479 · Cited by 293

Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast

Priault, M., Salin, B., Schaëffer, J., Vallette, F. M., di Rago, J.-P., & Martinou, J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401697 · Cited by 292

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

Pattingre, S., Bauvy, C., Carpentier, S., Levade, T., Levine, B., & Codogno, P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805920200 · Cited by 290

Microtubules Support Production of Starvation-induced Autophagosomes but Not Their Targeting and Fusion with Lysosomes

Fass, E., Shvets, E., Degani, I., Hirschberg, K., & Elazar, Z. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607031200 · Cited by 286

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation

Itoh, T., Fujita, N., Kanno, E., Yamamoto, A., Yoshimori, T., & Fukuda, M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1231 · Cited by 283

Amino Acids Interfere with the ERK1/2-dependent Control of Macroautophagy by Controlling the Activation of Raf-1 in Human Colon Cancer HT-29 Cells

Pattingre, S., Bauvy, C., & Codogno, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210998200 · Cited by 279

Regulation of Autophagy by the p300 Acetyltransferase

Lee, I. H., & Finkel, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807135200 · Cited by 277

How to Live Long and Prosper: Autophagy, Mitochondria, and Aging

Yen, W.-L., & Klionsky, D. J. (2008) · Physiology · doi:10.1152/physiol.00013.2008 · Cited by 271

Cvt19 Is a Receptor for the Cytoplasm-to-Vacuole Targeting Pathway

Scott, S. V., Guan, J., Hutchins, M. U., Kim, J., & Klionsky, D. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00263-5 · Cited by 269

Atg9 Cycles Between Mitochondria and the Pre-Autophagosomal Structure in Yeasts

Reggiori, F., Shintani, T., Chong, H., Nair, U., & Klionsky, D. J. (2005) · Autophagy · doi:10.4161/auto.1.2.1840 · Cited by 266

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death

Gözüaçık, D., Bialik, S., Raveh, T., Mitou, G., Shohat-Ophir, G., Sabanay, H., Mizushima, N., Yoshimori, T., & Kimchi, A. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.121 · Cited by 266

Activation of the RAS/Cyclic AMP Pathway Suppresses a TOR Deficiency in Yeast

Schmelzle, T., Beck, T. W., Martin, D. E., & Hall, M. N. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.338-351.2004 · Cited by 261

PARP-1 is involved in autophagy induced by DNA damage

Muñoz‐Gámez, J. A., Rodríguez-Vargas, J. M., Quiles, R., Aguilar‐Quesada, R., Martín‐Oliva, D., de MURCIA, G., Murcia, J. M., Almendros-Ruiz, A., de Almodóvar, J. M. R., & Oliver, F. J. (2009) · Autophagy · doi:10.4161/auto.5.1.7272 · Cited by 253

The Atg1 Kinase Complex Is Involved in the Regulation of Protein Recruitment to Initiate Sequestering Vesicle Formation for Nonspecific Autophagy in Saccharomyces cerevisiae

Cheong, H., Nair, U., Geng, J., & Klionsky, D. J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-08-0826 · Cited by 245

SEPA-1 Mediates the Specific Recognition and Degradation of P Granule Components by Autophagy in C. elegans

Zhang, Y., Yan, L., Zhou, Z., Yang, P., Tian, E., Zhang, K., Zhao, Y., Li, Z., Song, B., Han, J., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.022 · Cited by 239

Atg21 Is a Phosphoinositide Binding Protein Required for Efficient Lipidation and Localization of Atg8 during Uptake of Aminopeptidase I by Selective Autophagy

STRØMHAUG, P. E., Reggiori, F., Guan, J., Wang, C.-W., & Klionsky, D. J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-02-0147 · Cited by 238

Protein Kinase A and Sch9 Cooperatively Regulate Induction of Autophagy inSaccharomyces cerevisiae

Yorimitsu, T., Zaman, S., Broach, J. R., & Klionsky, D. J. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0485 · Cited by 237

An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase

Budovskaya, Y. V., Stephan, J. S., Deminoff, S. J., & Herman, P. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501046102 · Cited by 236

Pexophagy: The Selective Autophagy of Peroxisomes

Dunn, Jr., Cregg, J. M., Kiel, J. A. K. W., Klei, I. J. V. D., Oku, M., Sakai, Y., Sibirny, A. A., Stasyk, O. V., & Veenhuis, M. (2005) · Autophagy · doi:10.4161/auto.1.2.1737 · Cited by 222

Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast

He, C., Song, H., Yorimitsu, T., Monastyrska, I., Yen, W.-L., Legakis, J. E., & Klionsky, D. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200606084 · Cited by 219

Aut5/Cvt17p, a Putative Lipase Essential for Disintegration of Autophagic Bodies inside the Vacuole

Epple, U. D., Suriapranata, I., Eskelinen, E., & Thumm, M. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.20.5942-5955.2001 · Cited by 218

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

Vasseur, S., Afzal, S., Tardivel‐Lacombe, J., Park, D. S., Iovanna, J., & Mak, T. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812745106 · Cited by 217

Degradation of Lipid Vesicles in the Yeast Vacuole Requires Function of Cvt17, a Putative Lipase

Teter, S. A., Eggerton, K. P., Scott, S. V., Kim, J., Fischer, A. M., & Klionsky, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000739200 · Cited by 216

The Ras/cAMP-dependent Protein Kinase Signaling Pathway Regulates an Early Step of the Autophagy Process in Saccharomyces cerevisiae

Budovskaya, Y. V., Stephan, J. S., Reggiori, F., Klionsky, D. J., & Herman, P. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400272200 · Cited by 215

Midbody ring disposal by autophagy is a post-abscission event of cytokinesis

Pohl, C., & Jentsch, S. (2008) · Nature Cell Biology · doi:10.1038/ncb1813 · Cited by 204

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

Ramírez‐Valle, F., Braunstein, S. E., Zavadil, J., Formenti, S. C., & Schneider, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710215 · Cited by 198

Coenzyme Q deficiency triggers mitochondria degradation by mitophagy

Rodríguez-Hernández, Á., Cordero, M. D., Salviati, L., Artuch, R., Pineda, M., Briones, P., Izquierdo, L. G., Cotán, D., Navas, P., & Sánchez-Alcázar, J. A. (2009) · Autophagy · doi:10.4161/auto.5.1.7174 · Cited by 197

Cooperative Binding of the Cytoplasm to Vacuole Targeting Pathway Proteins, Cvt13 and Cvt20, to Phosphatidylinositol 3-Phosphate at the Pre-autophagosomal Structure Is Required for Selective Autophagy

Nice, D. C., Sato, T. K., STRØMHAUG, P. E., Emr, S. D., & Klionsky, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204736200 · Cited by 191

Atg27 Is Required for Autophagy-dependent Cycling of Atg9

Yen, W.-L., Legakis, J. E., Nair, U., & Klionsky, D. J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0612 · Cited by 190

Atg17 Regulates the Magnitude of the Autophagic Response

Cheong, H., Yorimitsu, T., Reggiori, F., Legakis, J. E., Wang, C.-W., & Klionsky, D. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0894 · Cited by 187

Protein Kinase Cθ Is Required for Autophagy in Response to Stress in the Endoplasmic Reticulum

Sakaki, K., Wu, J., & Kaufman, R. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710209200 · Cited by 185

Autophagy: A Forty-Year Search for a Missing Membrane Source

Juhász, G., & Neufeld, T. P. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040036 · Cited by 168

Ras is involved in the negative control of autophagy through the class I PI3-kinase

Furuta, S., Hidaka, E., Ogata, A., Yokota, S., & Kamata, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207539 · Cited by 163

The Actin Cytoskeleton Is Required for Selective Types of Autophagy, but Not Nonspecific Autophagy, in the Yeast Saccharomyces cerevisiae

Reggiori, F., Monastyrska, I., Shintani, T., & Klionsky, D. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0629 · Cited by 155

How Shall I Eat Thee?

Klionsky, D. J., Cuervo, A. M., Dunn, W. A., Levine, B., van der Klei, I. J., & Seglen, P. O. (2007) · Autophagy · doi:10.4161/auto.4377 · Cited by 149

Elongation Factor-2 Kinase Regulates Autophagy in Human Glioblastoma Cells

Wu, H., Yang, J., Jin, S., Zhang, H., & Hait, W. N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1554 · Cited by 146

ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase

Lee, S. B., Kim, S., Lee, J., Park, J., Lee, G., Kim, Y., Kim, J., & Chung, J. (2007) · EMBO Reports · doi:10.1038/sj.embor.7400917 · Cited by 140

Host Cell Autophagy Is Induced by Toxoplasma gondii and Contributes to Parasite Growth

Wang, Y., Weiss, L. M., & Orlofsky, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807890200 · Cited by 136

A Cycling Protein Complex Required for Selective Autophagy

Legakis, J. E., Yen, W.-L., & Klionsky, D. J. (2007) · Autophagy · doi:10.4161/auto.4129 · Cited by 129

Early Stages of the Secretory Pathway, but Not Endosomes, Are Required for Cvt Vesicle and Autophagosome Assembly inSaccharomyces cerevisiae

Reggiori, F., Wang, C.-W., Nair, U., Shintani, T., Abeliovich, H., & Klionsky, D. J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-07-0479 · Cited by 128

Self-Interaction Is Critical for Atg9 Transport and Function at the Phagophore Assembly Site during Autophagy

He, C., Baba, M., Cao, Y., & Klionsky, D. J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0544 · Cited by 127

Cytoplasm to vacuole trafficking of aminopeptidase I requires a t‐SNARE–Sec1p complex composed of Tlg2p and Vps45p

Abeliovich, H., Darsow, T., & Emr, S. D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.6005 · Cited by 126

Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body

Juhász, G., Puskás, L. G., Komonyi, O., Érdi, B., Maróy, P., Neufeld, T. P., & Sass, M. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402123 · Cited by 121

Arp2 Links Autophagic Machinery with the Actin Cytoskeleton

Monastyrska, I., He, C., Geng, J., Hoppe, A. D., Li, Z., & Klionsky, D. J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0892 · Cited by 118

Vps51 Is Part of the Yeast Vps Fifty-three Tethering Complex Essential for Retrograde Traffic from the Early Endosome and Cvt Vesicle Completion

Reggiori, F., Wang, C.-W., STRØMHAUG, P. E., Shintani, T., & Klionsky, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210436200 · Cited by 108

SAHA induces caspase‐independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway

Hrzenjak, A., Kremser, M., Strohmeier, B., Moinfar, F., Zatloukal, K., & Denk, H. (2008) · The Journal of Pathology · doi:10.1002/path.2434 · Cited by 103

Rapamycin-induced Translational Derepression of GCN4 mRNA Involves a Novel Mechanism for Activation of the eIF2α Kinase GCN2

Kubota, H., Obata, T., Ota, K., Sasaki, T., & Ito, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300133200 · Cited by 103

Trs85 (Gsg1), a Component of the TRAPP Complexes, Is Required for the Organization of the Preautophagosomal Structure during Selective Autophagy via the Cvt Pathway

Meiling-Wesse, K., Epple, U. D., Krick, R., Barth, H., Appelles, A., Voss, C., Eskelinen, E., & Thumm, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501701200 · Cited by 99

Inhibition of histone deacetylase1 induces autophagy

Oh, M., Choi, I.-K., & Kwon, H. J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.019 · Cited by 97

Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy

Yorimitsu, T., He, C., Wang, K., & Klionsky, D. J. (2009) · Autophagy · doi:10.4161/auto.5.5.8091 · Cited by 95

Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation

Watanabe, M., Adachi, S., Matsubara, H., Imai, T., Yui, Y., Mizushima, Y., Hiraumi, Y., Watanabe, K., Kamitsuji, Y., Toyokuni, S., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.23897 · Cited by 72

Early Secretory Pathway Gene TRS85 is Required for Selective Macroautophagy of Peroxisomes in Yarrowia lipolytica

Nazarko, T. Y., Huang, J., Nicaud, J.-M., Klionsky, D. J., & Sibirny, A. A. (2005) · Autophagy · doi:10.4161/auto.1.1.1512 · Cited by 63

Atg19 Mediates a Dual Interaction Cargo Sorting Mechanism in Selective Autophagy

Chang, C.-Y., & Huang, W. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0683 · Cited by 60

Novel Roles for Protein Kinase C;-dependent Signaling Pathways in Acute Hypoxic Stress-induced Autophagy

Chen, J.-L., Lin, H. H., Kim, K., Lin, A., Forman, H. J., & Ann, D. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804239200 · Cited by 52

Autophagy induced by suberoylanilide hydroxamic acid in Hela S3 cells involves inhibition of protein kinase B and up-regulation of Beclin 1

Cao, Q., Yu, C., Xue, R., Hsueh, W., Pan, P., Chen, Z., Wang, S., McNutt, M. A., & Gu, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.07.020 · Cited by 38

EXPRESSION OF CONCERN: Antitumor effects of a novel sulfur‐containing hydroxamate histone deacetylase inhibitor H40

Long, J., Zhao, J., Yan, Z., Liu, Z., & Wang, N. (2008) · International Journal of Cancer · doi:10.1002/ijc.24074 · Cited by 32

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

Autophagy: Renovation of Cells and Tissues

Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615

Reactive Oxygen Species in Inflammation and Tissue Injury

Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897

Methods in Mammalian Autophagy Research

Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497

mTOR: from growth signal integration to cancer, diabetes and ageing

Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941

Molecular mechanism and regulation of autophagy1

Yang, Y., Liang, Z., Gu, Z., & Qin, Z. (2005) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2005.00235.x · Cited by 224

Autophagy Regulation and Integration with Cell Signaling

Hamacher‐Brady, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4410 · Cited by 46

Autophagy signal transduction by ATG proteins: from hierarchies to networks

Wesselborg, S., & Stork, B. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2034-8 · Cited by 241

Autophagy in disease: a double-edged sword with therapeutic potential

Martinet, W., Agostinis, P., Vanhoecke, B., Dewaele, M., & de Meyer, G. R. Y. (2009) · Clinical Science · doi:10.1042/cs20080508 · Cited by 186

Other Molecular Mechanisms Regulating Autophagy

Zhang, N., & Zhao, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-0602-4_13 · Cited by 18