Cited by 2,265Circadian rhythm and melatoninSleep and Work-Related FatigueNonlinear Dynamics and Pattern Formation

The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.

Central and Peripheral Circadian Clocks in Mammals

Open access

Mohawk, Jennifer A., Green, Carla B., Takahashi, Joseph S.·2012·Annual Review of Neuroscience

DOI 10.1146/annurev-neuro-060909-153128PMC PMC3710582

Open this paper in CoChat — free account

Abstract

The circadian system of mammals is composed of a hierarchy of oscillators that function at the cellular, tissue, and systems levels. A common molecular mechanism underlies the cell-autonomous circadian oscillator throughout the body, yet this clock system is adapted to different functional contexts. In the central suprachiasmatic nucleus (SCN) of the hypothalamus, a coupled population of neuronal circadian oscillators acts as a master pacemaker for the organism to drive rhythms in activity and rest, feeding, body temperature, and hormones. Coupling within the SCN network confers robustness to the SCN pacemaker, which in turn provides stability to the overall temporal architecture of the organism. Throughout the majority of the cells in the body, cell-autonomous circadian clocks are intimately enmeshed within metabolic pathways. Thus, an emerging view for the adaptive significance of circadian clocks is their fundamental role in orchestrating metabolism.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev-neuro-060909-153128

Cites

113 of 113 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Self-citation
The mammalian circadian timing system: organization and coordination of central and peripheral clocks
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Self-citation
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310
Self-citation
The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · cited 1×
“PGC-1α is critical for adaptive responses to nutritional and metabolic state, particularly following fasting (reviewed in Lin et al. 2005).”
Background
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
Self-citation

Show all 113 references

Research works printed but not linked: 3

Kaneko M, 1980, Am. J. Physiol., 239, R309
Mahoney CE, 2010, Am. J. Physiol., 299, R751
Richter C, 1922, Comp. Psychol. Monogr., 1, 1

Sorted by citations

Items 901–1,000 of 1,001

Expression of antimicrobial peptide genes oscillates along day/night rhythm protecting mice skin from bacteria
Bilska, B., Zegar, A., Slominski, A. T., Kleszczyński, K., Cichy, J., & Pyza, E. (2020) · Experimental Dermatology · doi:10.1111/exd.14229 · Cited by 23
Low-dose spironolactone in the treatment of female hirsutism.
Ylöstalo, P., Heikkinen, J., Kauppila, A., Pakarinen, A., & Järvinen, P. A. (1987) · PubMed · Cited by 23
Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies
Godos, J., Currenti, W., Ferri, R., Lanza, G., Caraci, F., Frias-Toral, E., Guglielmetti, M., Ferraris, C., Lipari, V., Carvajal Altamiranda, S., et al. (2025) · Nutrients · doi:10.3390/nu17030529 · Cited by 22
On the basis of sex and sleep: the influence of the estrous cycle and sex on sleep-wake behavior
Swift, K. M., Gary, N. C., & Urbanczyk, P. J. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1426189 · Cited by 32
Oscillator networks with tissue-specific circadian clocks in plants
Inoue, K., Araki, T., & Endo, M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.002 · Cited by 22
Chronobiological regulation of psychosocial and physiological outcomes in multiple sclerosis
Somma, E. D., Jain, R. W., Poon, K. W. C., Tresidder, K. A., Segal, J. P., & Ghasemlou, N. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.011 · Cited by 21
The Role of Clock Genes in Fibrinolysis Regulation: Circadian Disturbance and Its Effect on Fibrinolytic Activity
Carmona, P., Méndez, N., Ili, C., & Brebi, P. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00129 · Cited by 24
Advances in DNA Repair—Emerging Players in the Arena of Eukaryotic DNA Repair
Kciuk, M., Bukowski, K., Marciniak, B., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113934 · Cited by 23
Progress in modelling of brain dynamics during anaesthesia and the role of sleep-wake circuitry
Nguyen, G., & Postnova, S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114388 · Cited by 21
Hourly activity patterns and behaviour-based management of feedlot steers with and without a cattle brush
Meneses, X. C. A., Park, R. M., Ridge, E. E., & Daigle, C. L. (2021) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2021.105241 · Cited by 22
RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart
Wang, Y., Anderson, C., Dobrzynski, H., Hart, G., D’Souza, A., & Boyett, M. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-82202-7 · Cited by 22
The circadian oscillator analysed at the single‐transcript level
Phillips, N. E., Hugues, A., Yeung, J., Durandau, E., Nicolas, D., & Naef, F. (2021) · Molecular Systems Biology · doi:10.15252/msb.202010135 · Cited by 19
Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/β-catenin pathway
Vallée, A., Lecarpentier, Y., & Vallée, J.-N. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01086-1 · Cited by 23
Systematic review: Acute thermal effects of artificial light in the daytime
Wang, N., Wang, J., & Feng, Y. (2022) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2022.112601 · Cited by 25
Hair Follicles as a Critical Model for Monitoring the Circadian Clock
Liu, L., Li, M.-H., & Zheng, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032407 · Cited by 23
Neuroprotective effects of melatonin in neurodegenerative and autoimmune central nervous system diseases
Shin, J.-W. (2023) · encephalitis · doi:10.47936/encephalitis.2022.00094 · Cited by 23
Properties of Life
Rosslenbroich, B. (2023) · The MIT Press eBooks · doi:10.7551/mitpress/14739.001.0001 · Cited by 25
Higher central circadian temperature amplitude is associated with greater metabolite rhythmicity in humans
Windred, D. P., Anderson, C., Jeppe, K. J., Ftouni, S., Grant, L. K., Nijagal, B., Rajaratnam, S. M. W., McConville, M. J., Tull, D., Lockley, S. W., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-67297-y · Cited by 21
Circadian actigraphic rest–activity rhythms following surgery for endometrial cancer: A prospective, longitudinal study
Rumble, M. E., Rose, S. L., White, K. H., Moore, A. H., Gehrman, P., Benca, R. M., & Costanzo, E. S. (2015) · Gynecologic Oncology · doi:10.1016/j.ygyno.2015.04.001 · Cited by 22
Non-24-Hour Sleep-Wake Disorder Revisited – A Case Study
Garbazza, C., Bromundt, V., Eckert, A., Brunner, D. P., Meier, F., Hackethal, S., & Cajochen, C. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00017 · Cited by 23
Circadian clock as possible protective mechanism to pollution induced keratinocytes damage
Benedusi, M., Frigato, E., Beltramello, M., Bertolucci, C., & Valacchi, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.017 · Cited by 22
Aging, melatonin biosynthesis, and circadian clockworks in the gastrointestinal system of the laboratory mouse
Paulose, J. K., Cassone, C. V., & Cassone, V. M. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00095.2018 · Cited by 22
Effect of pinealectomy on the circadian clock of the chick retina under different monochromatic lights
Bian, J., Wang, Z., Dong, Y., Cao, J., & Chen, Y. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1566740 · Cited by 22
Role of the microbiota in circadian rhythms of the host
Schmalle, V., & Lorentz, A. (2020) · Chronobiology International · doi:10.1080/07420528.2020.1726374 · Cited by 25
Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS
Kula-Eversole, E., Lee, D. H., Samba, I., Yildirim, E., Levine, D. C., Hong, H., Lear, B. C., Bass, J. T., Rosbash, M., & Allada, R. (2020) · Current Biology · doi:10.1016/j.cub.2020.10.013 · Cited by 22
Circadian regulation of transporter expression and implications for drug disposition
Pácha, J., Balounová, K., & Soták, M. (2020) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1868438 · Cited by 22
Circadian disruption of core body temperature in trauma patients: a single-center retrospective observational study
Culver, A., Coiffard, B., Antonini, F., Duclos, G., Hammad, E., Vigne, C., Mege, J.-L., Baumstarck, K., Boucekine, M., Zieleskiewicz, L., et al. (2020) · Journal of Intensive Care · doi:10.1186/s40560-019-0425-x · Cited by 21
Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological health
Kim, E., Yoo, S. H., & Chen, Z. (2022) · F1000Research · doi:10.12688/f1000research.126364.1 · Cited by 24
Circadian Disruption across Lifespan Impairs Glucose Homeostasis and Insulin Sensitivity in Adult Mice
Her, T. K., Li, J., Lin, H., Liu, D., Root, K. M., Regal, J. F., Alejandro, E. U., & Cao, R. (2024) · Metabolites · doi:10.3390/metabo14020126 · Cited by 21
Dual orexin receptor antagonists as promising therapeutics for Alzheimer’s disease
Ragsdale, S. M., Radovich, J. M., Coiduras, I. I., McCall, W. V., Grant, S. C., Lee, C. S., & Wilber, A. A. (2025) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00025-5 · Cited by 20
Biochemical mechanism of the mammalian circadian clock
Liu, Y., & Sancar, A. (2025) · FEBS Letters · doi:10.1002/1873-3468.70150 · Cited by 33
The Tibetan medicine Zuotai influences clock gene expression in the liver of mice
Li, H., Li, W.-K., Lu, Y., Wei, L., & Liu, J. (2016) · PeerJ · doi:10.7717/peerj.1632 · Cited by 21
Phosphorylation Regulating the Ratio of Intracellular CRY1 Protein Determines the Circadian Period
Liu, N., & Zhang, E. E. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00159 · Cited by 20
Circadian control of mitochondrial dynamics and functions
Ezagouri, S., & Asher, G. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.05.008 · Cited by 22
Meta‐analysis of melatonin levels in cluster headache—Review of clinical implications
Liampas, I., Siokas, V., Brotis, A. G., Aloizou, A., Mentis, A. A., Vikelis, M., & Dardiotis, E. (2020) · Acta Neurologica Scandinavica · doi:10.1111/ane.13317 · Cited by 21
Circadian Rhythms, Sleep, Immunity, and Fragility in the Elderly: The Model of the Susceptibility to Infections
Garbarino, S., Lanteri, P., Sannita, W. G., Bragazzi, N. L., & Scoditti, E. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.558417 · Cited by 23
Molecular resolution of a behavioral paradox: sleep and arousal are regulated by distinct acetylcholine receptors in different neuronal types in Drosophila
Dai, X., Zhou, E., Yang, W., Mao, R., Zhang, W., & Rao, Y. (2021) · SLEEP · doi:10.1093/sleep/zsab017 · Cited by 22
Tea combats circadian rhythm disorder syndrome via the gut-liver-brain axis: potential mechanisms speculated
Hu, S., Luo, L., & Zeng, L. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2040945 · Cited by 21
The Circadian Clocks, Oscillations of Pain-Related Mediators, and Pain
Chu, Y., He, H., Liu, Q., Jia, S., Fan, W., & Huang, F. P. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01205-8 · Cited by 22
Effects of light pollution on photoperiod-driven seasonality
Liu, J. A., Meléndez‐Fernández, O. H., Bumgarner, J. R., & Nelson, R. J. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105150 · Cited by 21
Clock-linked genes underlie seasonal migratory timing in a diurnal raptor
Bossu, C. M., Heath, J. A., Kaltenecker, G. S., Helm, B., & Ruegg, K. (2022) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2021.2507 · Cited by 21
The Circadian Regulation of Nutrient Metabolism in Diet-Induced Obesity and Metabolic Disease
Woodie, L. N., Oral, K. T., Krusen, B. M., & Lazar, M. A. (2022) · Nutrients · doi:10.3390/nu14153136 · Cited by 24
[Retracted] Role of Glial Cell‐Derived Oxidative Stress in Blood‐Brain Barrier Damage after Acute Ischemic Stroke
Hu, X., Wang, Y., Du, W., Liang, L., Wang, W., & Jin, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7762078 · Cited by 21
Retracted
Circadian clock gene Clock-Bmal1 regulates cellular senescence in Chronic obstructive pulmonary disease
Li, L., Zhang, M., Zhao, C., Cheng, Y., Liu, C., & Shi, M. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-02237-y · Cited by 22
The relationship between sleep and salivary and serum inflammatory biomarkers in adolescents
Alqaderi, H. E., Abdullah, A., Finkelman, M., Abu‐Farha, M., Devarajan, S., Abubaker, J. A., Ramesh, N., Tavares, M. A., Al‐Mulla, F., & Bin‐Hasan, S. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1175483 · Cited by 22
The association of dietary approaches to stop hypertension (DASH) and Mediterranean diet with mental health, sleep quality and chronotype in women with overweight and obesity: a cross-sectional study
Shiraseb, F., Mirzababaei, A., Daneshzad, E., Khosravinia, D., Clark, C. C. T., & Mirzaei, K. (2023) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-023-01581-0 · Cited by 24
Circadian Rhythms and Sleep Disorders Associated to Major Depressive Disorder: Pathophysiology and Therapeutic Opportunities
Manosso, L. M., Duarte, L. A., Martinello, N. S., de Mathia, G. B., & Réus, G. Z. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273254093231020052002 · Cited by 25
Maternal Olfactory Cues Synchronize the Circadian System of Artificially Raised Newborn Rabbits
Montúfar‐Chaveznava, R., Trejo-Muñoz, L., Hernández-Campos, O., Navarrete, E., & Caldelas, I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074048 · Cited by 21
Circadian Tick‐Talking Across the Neuroendocrine System and Suprachiasmatic Nuclei Circuits: The Enigmatic Communication Between the Molecular and Electrical Membrane Clocks
Belle, M. D. C. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12279 · Cited by 23
Circadian redox rhythms in the regulation of neuronal excitability
Bothwell, M. Y., & Gillette, M. U. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.025 · Cited by 23
Frontline Science: Rev-Erbα links blue light with enhanced bacterial clearance and improved survival in murine Klebsiella pneumoniae pneumonia
Griepentrog, J. E., Zhang, X., Lewis, A., Gianfrate, G., Labiner, H. E., Zou, B., Xiong, Z., Lee, J. S., & Rosengart, M. R. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.4hi0519-155r · Cited by 20
A Role for the Biological Clock in Liver Cancer
Mazzoccoli, G., Miele, L., Marrone, G., Mazza, T., Vinciguerra, M., & Grieco, A. (2019) · Cancers · doi:10.3390/cancers11111778 · Cited by 22
High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems
Xie, J., Wang, D., Ling, S., Yang, G., Yang, Y., & Chen, W. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01271 · Cited by 20
New insights on the role of the retina in diagnostic and therapeutic strategies in major depressive disorder
Cosker, E., Schwan, R., Angioï-Duprez, K., Laprévote, V., & Schwitzer, T. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.006 · Cited by 21
Nobiletin: Targeting the Circadian Network to Promote Bioenergetics and Healthy Aging
Mileykovskaya, E., Yoo, S., Dowhan, W., & Chen, Z. (2020) · Biochemistry (Moscow) · doi:10.1134/s000629792012007x · Cited by 22
Circadian miR-449c-5p regulates uterine Ca2+ transport during eggshell calcification in chickens
Cui, Z., Zhang, Z., Amevor, F. K., Du, X., Li, L., Tian, Y., Kang, X., Shu, G., Zhu, Q. C., Wang, Y., et al. (2021) · BMC Genomics · doi:10.1186/s12864-021-08074-3 · Cited by 21
Interaction of pituitary hormones and expression of clock genes modulated by bone morphogenetic protein-4 and melatonin
Tsukamoto-Yamauchi, N., Terasaka, T., Iwasaki, Y., & Otsuka, F. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.100 · Cited by 21
Hypoxic Conditions Modulate Chondrogenesis through the Circadian Clock: The Role of Hypoxia-Inducible Factor-1α
Juhász, K. Z., Hajdú, T., Kovács, P., Vágó, J., Matta, C., & Takács, R. (2024) · Cells · doi:10.3390/cells13060512 · Cited by 20
Deep analysis of wild Vitis flower transcriptome reveals unexplored genome regions associated with sex specification
Ramos, M. J. N., Coito, J. L., Fino, J., Cunha, J., Silva, H., de Almeida, P. G., Costa, M. M. R., Amâncio, S., Paulo, O. S., & Rocheta, M. (2016) · Plant Molecular Biology · doi:10.1007/s11103-016-0553-9 · Cited by 20
Circadian expression of Fabp7 mRNA is disrupted in Bmal1 KO mice
Gerstner, J. R., & Paschos, G. K. (2020) · Molecular Brain · doi:10.1186/s13041-020-00568-7 · Cited by 20
Circa-SCOPE: high-throughput live single-cell imaging method for analysis of circadian clock resetting
Manella, G., Aizik, D., Aviram, R., Golik, M., & Asher, G. (2021) · Nature Communications · doi:10.1038/s41467-021-26210-1 · Cited by 20
The biology of time: dynamic responses of cell types to developmental, circadian and environmental cues
Swift, J., Greenham, K., Ecker, J. R., Coruzzi, G. M., & McClung, C. R. (2021) · The Plant Journal · doi:10.1111/tpj.15589 · Cited by 22
High-Fat Nutritional Challenge Reshapes Circadian Signatures in Murine Extraorbital Lacrimal Glands
Zou, S., Jiao, X., Liu, J., Qi, D., Pei, X., Lu, D., Huang, S., & Li, Z. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.5.23 · Cited by 21
Chronobiology Meets Quantum Biology: A New Paradigm Overlooking the Horizon?
Mazzoccoli, G. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.892582 · Cited by 23
Redox Homeostasis in Ocular Tissues: Circadian Regulation of Glutathione in the Lens?
Lim, J. C.-H., Suzuki‐Kerr, H., Nguyen, T. X., Lim, C. J. J., & Poulsen, R. C. (2022) · Antioxidants · doi:10.3390/antiox11081516 · Cited by 21
Deficiency of the Circadian Clock Gene Rev-Erbα Induces Mood Disorders and Dysregulation of the Serotonergic System in Mice
Otsuka, T., Le, H. T., Thein, Z. L., Ihara, H., Sato, F., Nakao, T., & Kohsaka, A. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113960 · Cited by 21
Planetary sleep medicine: Studying sleep at the individual, population, and planetary level
Bragazzi, N. L., Garbarino, S., Puce, L., Trompetto, C., Marinelli, L., Currà, A., Jahrami, H., Trabelsi, K., Garcia, B. R. M., Asgary, A., et al. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1005100 · Cited by 21
Disturbed rhythmicity of intestinal hydrogen peroxide alters gut microbial oscillations in BMAL1-deficient monkeys
Yang, Y., Yu, P., Lu, Y., Gao, C., & Sun, Q. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112183 · Cited by 21
Molecular and Cellular Neurobiology of Circadian and Circannual Rhythms in Migraine: A Narrative Review
Imai, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210092 · Cited by 20
FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function
Gerstner, J. R., Flores, C. C., Lefton, M., Rogers, B., & Davis, C. J. (2023) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2023.1212213 · Cited by 23
Role of the circadian nuclear receptor REV-ERBα in dorsal raphe serotonin synthesis in mood regulation
Park, I., Choi, M., Kim, J., Jang, S., Kim, D., Kim, J., Choe, Y., Geum, D., Yu, S.-W., Choi, J., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06647-y · Cited by 20
Real-Time Recording of Circadian Per1 and Per2 Expression in the Suprachiasmatic Nucleus of Freely Moving Rats
Yamaguchi, Y., Okada, K., Mizuno, T., Ota, T., Yamada, H., Doi, M., Kobayashi, M., Tei, H., Shigeyoshi, Y., & Okamura, H. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415621412 · Cited by 20
A systems theoretic approach to analysis and control of mammalian circadian dynamics
Abel, J. H., & Doyle, F. J. (2016) · Process Safety and Environmental Protection · doi:10.1016/j.cherd.2016.09.033 · Cited by 21
Heat shock antagonizes UVA-induced responses in murine melanocytes and melanoma cells: an unexpected interaction
de Assis, L. V. M., Moraes, M. N., & Castrucci, A. M. D. L. (2017) · Photochemical & Photobiological Sciences · doi:10.1039/c6pp00330c · Cited by 20
Repeated manganese administration produced abnormal expression of circadian clock genes in the hypothalamus and liver of rats
Li, H., Fan, X., Luo, Y., Song, S., Liu, J., & Fan, Q. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.05.007 · Cited by 20
A time to fight: Circadian control of aggression and associated autonomic support
Todd, W. D., & Machado, N. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.12.008 · Cited by 22
The molecular clock protein Bmal1 regulates cell differentiation in mouse embryonic stem cells
Gallardo, A., Molina, A., Asenjo, H. G., Martorell‐Marugán, J., Montes, R., Ramos–Mejía, V., Sánchez–Pozo, A., Carmona‐Sáez, P., López-Onieva, L., & Landeira, D. (2020) · Life Science Alliance · doi:10.26508/lsa.201900535 · Cited by 19
Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease
Uddin, M. S., Sumsuzzman, D. M., Jeandet, P., Behl, T., Rauf, A., Amran, M. S., & Ashraf, G. M. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03325-x · Cited by 23
The role of the cardiomyocyte circadian clocks in ion channel regulation and cardiac electrophysiology
Schroder, E. A., Ono, M., Johnson, S. R., Rozmus, E. R., Burgess, D. E., Esser, K. A., & Delisle, B. P. (2022) · The Journal of Physiology · doi:10.1113/jp282402 · Cited by 22
Clocks within the Master Gland
Lin, X., Blum, I. D., & Storch, K.-F. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415580881 · Cited by 20
Daily rhythms of glycerophospholipid synthesis in fibroblast cultures involve differential enzyme contributions
Acosta-Rodríguez, V. A., Márquez, S., Salvador, G. A., Pasquaré, S. J., Gorné, L. D., Garbarino‐Pico, E., Giusto, N. M., & Guido, M. E. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m034264 · Cited by 19
Local receptors as novel regulators for peripheral clock expression
Wu, C., Sui, G., Archer, S. N., Sassone‐Corsi, P., AITKEN, K. J., Bägli, D., & Chen, Y. (2014) · The FASEB Journal · doi:10.1096/fj.13-243295 · Cited by 20
Entrainment of mouse peripheral circadian clocks to <24 h feeding/fasting cycles under 24 h light/dark conditions
Hamaguchi, Y., Tahara, Y., Kuroda, H., Haraguchi, A., & Shibata, S. (2015) · Scientific Reports · doi:10.1038/srep14207 · Cited by 20
Postnatal Ontogeny of the Circadian Expression of the Adrenal Clock Genes and Corticosterone Rhythm in Male Rats
Roa, S. L. R., Martínez, E. Z., Martins, C. S., Antonini, S. R. R., de Castro, M., & Moreira, A. C. (2017) · Endocrinology · doi:10.1210/en.2016-1782 · Cited by 20
Circadian rhythm disruption-mediated downregulation of Bmal1 exacerbates DSS-induced colitis by impairing intestinal barrier
Zhang, Z., Li, W., Han, X., Tian, D., Yan, W., Liu, M., & Li, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1402395 · Cited by 20
The multifaceted impact of circadian disruption on cancer risk: a systematic review of insights and economic implications
Clemente‐Suárez, V. J., Navarro-Jiménez, E., Benítez-Agudelo, J. C., Beltrán-Velasco, A. I., Belinchón-deMiguel, P., Ramos‐Campo, D. J., Villanueva-Tobaldo, C. V., Martín-Rodríguez, A., & Tornero-Aguilera, J. F. (2025) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2025.04.005 · Cited by 25
Adolescent Dietary Habit-induced Obstetric and Gynecologic Disease (ADHOGD) as a New Hypothesis—Possible Involvement of Clock System
Fujiwara, T., Ono, M., Mieda, M., Yoshikawa, H., Nakata, R., Daikoku, T., Sekizuka‐Kagami, N., Maida, Y., Ando, H., & Fujiwara, H. (2020) · Nutrients · doi:10.3390/nu12051294 · Cited by 19
Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration
Tan, X., Cao, F., Tang, F., Lu, C., Qiao-yan, Y., Feng, S., Yang, Z., Chen, S., He, X., Jiang, H., et al. (2021) · Journal of Immunology Research · doi:10.1155/2021/9995869 · Cited by 19
Molecular mechanisms of circadian rhythm and its influence on the pharmacokinetics of drugs
Vasdev, N., Rajpoot, K., & Tekade, R. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814425-1.00002-4 · Cited by 19
Potential Effect of the Circadian Clock on Erectile Dysfunction
Li, T., Bai, Y., Jiang, Y., Jiang, K., Tian, Y., Wang, Z., Ban, Y., Liang, X., Luo, G., & Sun, F. (2022) · Aging and Disease · doi:10.14336/ad.2021.0728 · Cited by 20
Caffeine Therapy for Apnea of Prematurity: Role of the Circadian CLOCK Gene Polymorphism
Guo, H., Long, J., Hu, Y., Liu, Y., He, X., Li, L., Xia, Y., Ding, X., Chen, F., Xu, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.724145 · Cited by 20
Wheel-Running Facilitates Phase Advances in Locomotor and Peripheral Circadian Rhythm in Social Jet Lag Model Mice
Oneda, S., Cao, S., Haraguchi, A., Sasaki, H., & Shibata, S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.821199 · Cited by 21
Circadian Disruption Primes Myofibroblasts for Accelerated Activation as a Mechanism Underpinning Fibrotic Progression in Non-Alcoholic Fatty Liver Disease
Jokl, E. J., Llewellyn, J., Simpson, K., Adegboye, O., Pritchett, J. P., Zeef, L. A. H., Donaldson, I. J., Athwal, V. S., Purssell, H., Street, O., et al. (2023) · Cells · doi:10.3390/cells12121582 · Cited by 19
NMDA and PACAP Receptor Signaling Interact to Mediate Retinal-Induced SCN Cellular Rhythmicity in the Absence of Light
Webb, I. C., Coolen, L. M., & Lehman, M. N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076365 · Cited by 19
Differential responses of circadian P er2 rhythms in cultured slices of discrete brain areas from rats showing internal desynchronisation by methamphetamine
Natsubori, A., Honma, K., & Honma, S. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12265 · Cited by 19
Chronobiomics: The Biological Clock as a New Principle in Host–Microbial Interactions
Thaiss, C. A., Levy, M., & Elinav, E. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005113 · Cited by 19
Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain
Morabito, M. V., Ravussin, Y., Mueller, B. R., Skowronski, A. A., Watanabe, K., Foo, K. S., Lee, S. X., Lehmann, A., Hjorth, S., Zeltser, L. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0168226 · Cited by 19
Inhibition of expression of the circadian clock gene Period causes metabolic abnormalities including repression of glycometabolism in Bombyx mori cells
Tao, H., Li, X., Qiu, J., Cui, W., Sima, Y., & Xu, S. (2017) · Scientific Reports · doi:10.1038/srep46258 · Cited by 19
Prepartal Energy Intake Alters Blood Polymorphonuclear Leukocyte Transcriptome During the Peripartal Period in Holstein Cows
Agrawal, A., Khan, M. J., Graugnard, D. E., Vailati-Riboni, M., Rodriguez‐Zas, S. L., Osorio, J. S., & Loor, J. J. (2017) · Bioinformatics and Biology Insights · doi:10.1177/1177932217704667 · Cited by 19
Circadian rhythm bifurcation induces flexible phase resetting by reducing circadian amplitude
Noguchi, T., Harrison, E. M., Sun, J., May, D., Ng, A., Welsh, D. K., & Gorman, M. R. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14086 · Cited by 19

Authors: Mohawk, J. A., Green, C. B., & Takahashi, J. S.
Affiliations: Department of Neuroscience,
Howard Hughes Medical Institute (US)
Corresponding author: Takahashi, Joseph S.
ORCID: Mohawk, Jennifer A.
Green, Carla B.
Takahashi, Joseph S.
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2012-07-21
Volume: 35
Issue: 1
Pages: 445-462
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev-neuro-060909-153128
PMC: PMC3710582
OpenAlex: W2164824098
Cited by: 2,265
References: 113
Citations by year: 2026: 149 · 2025: 194 · 2024: 189 · 2023: 182 · 2022: 197 · 2021: 202 · 2020: 201 · 2019: 150 · 2018: 161 · 2017: 144 · 2016: 154 · 2015: 129 · 2014: 108 · 2013: 89 · 2012: 11
FWCI: 12.16
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (5p50mh074924-05)
National Institute of Mental Health (P50 MH-074924, R01MH078024)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
Keywords: circadian clock, suprachiasmatic nucleus, central pacemaker, peripheral circadian oscillators, cell-autonomous clock, metabolic rhythms, metabolism, feeding rhythm, body temperature rhythm, hormonal rhythms
MeSH terms: Animals, Circadian Rhythm, Feeding Behavior, Mammals, Methamphetamine, Models, Biological, Neural Pathways, Neurons, Suprachiasmatic Nucleus, Signal Transduction, Circadian Clocks

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Central and Peripheral Circadian Clocks in Mammals

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks