Cited by 2,265Circadian rhythm and melatoninSleep and Work-Related FatigueNonlinear Dynamics and Pattern Formation

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Central and Peripheral Circadian Clocks in Mammals

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Mohawk, Jennifer A., Green, Carla B., Takahashi, Joseph S.·2012·Annual Review of Neuroscience

DOI 10.1146/annurev-neuro-060909-153128PMC PMC3710582

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Abstract

The circadian system of mammals is composed of a hierarchy of oscillators that function at the cellular, tissue, and systems levels. A common molecular mechanism underlies the cell-autonomous circadian oscillator throughout the body, yet this clock system is adapted to different functional contexts. In the central suprachiasmatic nucleus (SCN) of the hypothalamus, a coupled population of neuronal circadian oscillators acts as a master pacemaker for the organism to drive rhythms in activity and rest, feeding, body temperature, and hormones. Coupling within the SCN network confers robustness to the SCN pacemaker, which in turn provides stability to the overall temporal architecture of the organism. Throughout the majority of the cells in the body, cell-autonomous circadian clocks are intimately enmeshed within metabolic pathways. Thus, an emerging view for the adaptive significance of circadian clocks is their fundamental role in orchestrating metabolism.

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Authors: Mohawk, J. A., Green, C. B., & Takahashi, J. S.
Affiliations: Department of Neuroscience,
Howard Hughes Medical Institute (US)
Corresponding author: Takahashi, Joseph S.
ORCID: Mohawk, Jennifer A.
Green, Carla B.
Takahashi, Joseph S.
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2012-07-21
Volume: 35
Issue: 1
Pages: 445-462
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev-neuro-060909-153128
PMC: PMC3710582
OpenAlex: W2164824098
Cited by: 2,265
References: 113
Citations by year: 2026: 149 · 2025: 194 · 2024: 189 · 2023: 182 · 2022: 197 · 2021: 202 · 2020: 201 · 2019: 150 · 2018: 161 · 2017: 144 · 2016: 154 · 2015: 129 · 2014: 108 · 2013: 89 · 2012: 11
FWCI: 12.16
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (5p50mh074924-05)
National Institute of Mental Health (P50 MH-074924, R01MH078024)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
Keywords: circadian clock, suprachiasmatic nucleus, central pacemaker, peripheral circadian oscillators, cell-autonomous clock, metabolic rhythms, metabolism, feeding rhythm, body temperature rhythm, hormonal rhythms
MeSH terms: Animals, Circadian Rhythm, Feeding Behavior, Mammals, Methamphetamine, Models, Biological, Neural Pathways, Neurons, Suprachiasmatic Nucleus, Signal Transduction, Circadian Clocks

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Central and Peripheral Circadian Clocks in Mammals

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