The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Central and Peripheral Circadian Clocks in Mammals
Open accessAbstract
The circadian system of mammals is composed of a hierarchy of oscillators that function at the cellular, tissue, and systems levels. A common molecular mechanism underlies the cell-autonomous circadian oscillator throughout the body, yet this clock system is adapted to different functional contexts. In the central suprachiasmatic nucleus (SCN) of the hypothalamus, a coupled population of neuronal circadian oscillators acts as a master pacemaker for the organism to drive rhythms in activity and rest, feeding, body temperature, and hormones. Coupling within the SCN network confers robustness to the SCN pacemaker, which in turn provides stability to the overall temporal architecture of the organism. Throughout the majority of the cells in the body, cell-autonomous circadian clocks are intimately enmeshed within metabolic pathways. Thus, an emerging view for the adaptive significance of circadian clocks is their fundamental role in orchestrating metabolism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Experimental administration of glucocorticoid synchronizes the peripheral clocks located in liver, muscle, and adipose tissue which are the major storage sites for glycogen, protein, and fat, respectively, as well as other metabolically relevant organs such as pancreas and gut [60–63].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [63]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Resetting of the peripheral clock occurs through well-defined molecular mechanisms that involve direct interaction of glucocorticoids, glucocorticoid response elements and the regulatory regions of core clock genes Bmal1, Cry1, Per1 and Per2 [63, 64].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [63]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Self-citationDibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Self-citationCoordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310
Self-citationPreitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · cited 1×
“PGC-1α is critical for adaptive responses to nutritional and metabolic state, particularly following fasting (reviewed in Lin et al. 2005).”
BackgroundA Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
Self-citation
Research works printed but not linked: 3
- Kaneko M, 1980, Am. J. Physiol., 239, R309
- Mahoney CE, 2010, Am. J. Physiol., 299, R751
- Richter C, 1922, Comp. Psychol. Monogr., 1, 1
Cited by
Sorted by citations
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,786
Self-citationTranskingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449
Circadian physiology of metabolism
Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092
Generation of circadian rhythms in the suprachiasmatic nucleus
Hastings, M. H., Maywood, E. S., & Brancaccio, M. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0026-z · Cited by 1,065
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013
Mechanisms linking circadian clocks, sleep, and neurodegeneration
Musiek, E. S., & Holtzman, D. M. (2016) · Science · doi:10.1126/science.aah4968 · Cited by 878
Chronotype and Social Jetlag: A (Self-) Critical Review
Roenneberg, T., Pilz, L. K., Zerbini, G., & Winnebeck, E. C. (2019) · Biology · doi:10.3390/biology8030054 · Cited by 803
Circadian regulation of glucose, lipid, and energy metabolism in humans
Poggiogalle, E., Jamshed, H., & Peterson, C. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.017 · Cited by 743
Effects of light on human circadian rhythms, sleep and mood
Blume, C., Garbazza, C., & Spitschan, M. (2019) · Somnologie · doi:10.1007/s11818-019-00215-x · Cited by 695
Circadian misalignment increases cardiovascular disease risk factors in humans
Morris, C. J., Purvis, T. E., Hu, K., & Scheer, F. A. J. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516953113 · Cited by 691
The aging clock: circadian rhythms and later life
Hood, S., & Amir, S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90328 · Cited by 645
REV-ERB and ROR nuclear receptors as drug targets
Kojetin, D. J., & Burris, T. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4100 · Cited by 595
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 547
Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease
Musiek, E. S., Xiong, D. D., & Holtzman, D. M. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.121 · Cited by 529
Effect of sleep deprivation on the human metabolome
Davies, S. K., Ang, J. E., Revell, V. L., Holmes, B., Mann, A., Robertson, F. P., Cui, N., Middleton, B., Ackermann, K., Kayser, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402663111 · Cited by 527
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70317 · Cited by 524
Morris, C. J., Yang, J. N., Garcia, J. I., Myers, S., Bozzi, I., Wang, W., Buxton, O. M., Shea, S. A., & Scheer, F. A. J. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418955112 · Cited by 523
Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis
Kettner, N. M., Voicu, H., Finegold, M. J., Coarfa, C., Sreekumar, A., Putluri, N., Katchy, C. A., Lee, C., Moore, D. D., & Fu, L. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.007 · Cited by 508
“The molecular clock also targets clock-controlled genes (CCGs) to couple diverse functions of peripheral organs with daily physical activity (Mohawk et al., 2012).”
BackgroundCircadian rhythm as a therapeutic target
Ruan, W., Yuan, X., & Eltzschig, H. K. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00109-w · Cited by 518
Circadian clock genes and the transcriptional architecture of the clock mechanism
Cox, K. H., & Takahashi, J. S. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0153 · Cited by 514
Self-citationLymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses
Druzd, D., Matveeva, O., Ince, L. M., Harrison, U., He, W., Schmal, C., Herzel, H., Tsang, A. H. K., Kawakami, N., Leliavski, A., et al. (2017) · Immunity · doi:10.1016/j.immuni.2016.12.011 · Cited by 487
The Effects of Light at Night on Circadian Clocks and Metabolism
Fonken, L. K., & Nelson, R. J. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1051 · Cited by 494
Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease
Musiek, E. S., Bhimasani, M., Zangrilli, M. A., Morris, J. C., Holtzman, D. M., & Ju, Y.-E. S. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.4719 · Cited by 465
T H 17 Cell Differentiation Is Regulated by the Circadian Clock
Yu, X., Rollins, D., Ruhn, K. A., Stubblefield, J. J., Green, C. B., Kashiwada, M., Rothman, P. B., Takahashi, J. S., & Hooper, L. V. (2013) · Science · doi:10.1126/science.1243884 · Cited by 451
Self-citationRole of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443
Peek, C. B., Levine, D. C., Cedernaes, J., Taguchi, A., Kobayashi, Y., Tsai, S. J., Bonar, N. A., McNulty, M., Ramsey, K. M., & Bass, J. T. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.010 · Cited by 413
Mistimed sleep disrupts circadian regulation of the human transcriptome
Archer, S. N., Laing, E. E., Möller-Levet, C. S., van der Veen, D. R., Bucca, G., Lazar, A. S., Santhi, N., Slak, A., Kabiljo, R., von Schantz, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316335111 · Cited by 386
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 402
Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer
Bishehsari, F., Voigt, R. M., & Keshavarzian, A. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00427-4 · Cited by 384
'The clocks that time us'—circadian rhythms in neurodegenerative disorders
Videnović, A., Lázár, A. S., Barker, R. A., & Overeem, S. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.206 · Cited by 381
Circadian System and Glucose Metabolism: Implications for Physiology and Disease
Qian, J., & Scheer, F. A. J. L. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.005 · Cited by 370
Medicine in the Fourth Dimension
Cederroth, C. R., Albrecht, U., Bass, J. T., Brown, S. A., Dyhrfjeld‐Johnsen, J., Gachon, F., Green, C. B., Hastings, M. H., Helfrich‐Förster, C., Hogenesch, J. B., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.019 · Cited by 374
Self-citationImpact of circadian disruption on glucose metabolism: implications for type 2 diabetes
Mason, I. C., Qian, J., Adler, G. K., & Scheer, F. A. J. L. (2020) · Diabetologia · doi:10.1007/s00125-019-05059-6 · Cited by 359
REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis
Wang, S., Lin, Y., Yuan, X., Li, F., Guo, L., & Wu, B. (2018) · Nature Communications · doi:10.1038/s41467-018-06568-5 · Cited by 363
Sex differences in circadian timing systems: implications for disease
Bailey, M., & Silver, R. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.003 · Cited by 348
Circadian rhythms and disorders of the timing of sleep
Meyer, N., Harvey, A. G., Lockley, S. W., & Dijk, D.-J. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00877-7 · Cited by 346
Time-restricted eating for the prevention and management of metabolic diseases
Manoogian, E. N. C., Chow, L. S., Taub, P. R., Laferrère, B., & Panda, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab027 · Cited by 344
Yoo, S. H., Mohawk, J. A., Siepka, S. M., Shan, Y., Huh, S. K., Hong, H., Kornblum, I., Kumar, V., Koike, N., Xu, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.055 · Cited by 346
Self-citationMauvoisin, D., Wang, J., Jouffe, C., Martin, E., Atger, F., Waridel, P., Quadroni, M., Gachon, F., & Naef, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314066111 · Cited by 329
Man, K., Loudon, A., & Chawla, A. (2016) · Science · doi:10.1126/science.aah4966 · Cited by 341
Dim Light at Night Disrupts Molecular Circadian Rhythms and Increases Body Weight
Fonken, L. K., Aubrecht, T. G., Meléndez‐Fernández, O. H., Weil, Z. M., & Nelson, R. J. (2013) · Journal of Biological Rhythms · doi:10.1177/0748730413493862 · Cited by 333
Multiple Functions and Regulation of Mammalian Peroxiredoxins
Rhee, S. G., & Kil, I. S. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014431 · Cited by 325
Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy
Dallmann, R., Okyar, A., & Lévi, F. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.03.004 · Cited by 298
cis-Regulatory Requirements for Tissue-Specific Programs of the Circadian Clock
Meireles-Filho, A. C. A., Bardet, A. F., Yáñez-Cuna, J. O., Stampfel, G., & Stark, A. (2013) · Current Biology · doi:10.1016/j.cub.2013.11.017 · Cited by 296
Schmidt, M. H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.001 · Cited by 291
Health Consequences of Circadian Disruption in Humans and Animal Models
Evans, J. A., & Davidson, A. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00010-5 · Cited by 291
Tissue-specific clocks in Arabidopsis show asymmetric coupling
Endo, M., Shimizu, H., Nohales, M. A., Araki, T., & Kay, S. A. (2014) · Nature · doi:10.1038/nature13919 · Cited by 286
Sulli, G., Manoogian, E. N. C., Taub, P. R., & Panda, S. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.07.003 · Cited by 293
Microglia inflammatory responses are controlled by an intrinsic circadian clock
Fonken, L. K., Frank, M. G., Kitt, M. M., Barrientos, R. M., Watkins, L. R., & Maier, S. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.009 · Cited by 291
Seasonal Regulation of Reproduction in Mammals
Hazlerigg, D. G., & Simonneaux, V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00034-x · Cited by 288
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
Eban-Rothschild, A., Appelbaum, L., & de Lecea, L. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.294 · Cited by 282
Circadian rhythm and the gut microbiome
Voigt, R. M., Forsyth, C. B., Green, S. J., Engen, P. A., & Keshavarzian, A. (2016) · International Review of Neurobiology · doi:10.1016/bs.irn.2016.07.002 · Cited by 274
Circadian clock protein Rev-erbα regulates neuroinflammation
Griffin, P., Dimitry, J. M., Sheehan, P. W., Lananna, B. V., Guo, C., Robinette, M. L., Hayes, M. E., Cedeño, M. R., Nadarajah, C. J., Ezerskiy, L. A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812405116 · Cited by 263
Regulation and Role of Transcription Factors in Osteogenesis
Chan, W. C. W., Tan, Z., To, M. K.-T., & Chan, D. T.-M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115445 · Cited by 276
Circadian dysfunction induces leptin resistance in mice
Kettner, N. M., Mayo, S. A., Hua, J., Lee, C., Moore, D. D., & Fu, L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.005 · Cited by 260
Feeding Rhythms and the Circadian Regulation of Metabolism
Pickel, L., & Sung, H. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00039 · Cited by 282
Circadian rhythms in neurodegenerative disorders
Nassan, M. M., & Videnović, A. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00577-7 · Cited by 266
A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux
Zhang, S., Yue, Z., Arnold, D. M., Artiushin, G., & Sehgal, A. (2018) · Cell · doi:10.1016/j.cell.2018.02.017 · Cited by 254
CLOCK:BMAL1 is a pioneer-like transcription factorPreprint
Menet, J. S., Pescatore, S., & Rosbash, M. (2014) · Genes & Development · doi:10.1101/gad.228536.113 · Cited by 268
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251
Interconnection between circadian clocks and thyroid function
Ikegami, K., Refetoff, S., Van Cauter, E., & Yoshimura, T. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0237-z · Cited by 251
New Insights Into the Circadian Rhythm and Its Related Diseases
Xie, Y., Tang, Q., Chen, G., Xie, M., Yu, S., Zhao, J., & Chen, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00682 · Cited by 250
Importance of circadian timing for aging and longevity
Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2021) · Nature Communications · doi:10.1038/s41467-021-22922-6 · Cited by 258
Self-citationChronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health
Almoosawi, S., Vingeliene, S., Gachon, F., Voortman, T., Palla, L., Johnston, J. D., Van Dam, R. M., Darimont, C., & Karagounis, L. G. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy070 · Cited by 247
Ruben, M. D., Smith, D. F., FitzGerald, G. A., & Hogenesch, J. B. (2019) · Science · doi:10.1126/science.aax7621 · Cited by 249
Genetics of circadian rhythms and sleep in human health and disease
Lane, J. M., Qian, J., Mignot, E., Redline, S., Scheer, F. A. J. L., & Saxena, R. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-022-00519-z · Cited by 236
Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals
Kumar Jha, P., Challet, E., & Kalsbeek, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.024 · Cited by 235
Honma, S. (2018) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-0597-5 · Cited by 242
Molecular components of the circadian clock in mammals
Takahashi, J. S. (2015) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12514 · Cited by 230
Self-citationThyroid Hormone and Seasonal Rhythmicity
Dardente, H., Hazlerigg, D. G., & Ebling, F. J. P. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00019 · Cited by 226
The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock
Brooks, J. F., Behrendt, C. L., Ruhn, K. A., Lee, S., Raj, P., Takahashi, J. S., & Hooper, L. V. (2021) · Cell · doi:10.1016/j.cell.2021.07.001 · Cited by 226
Self-citationLoss of circadian clock gene expression is associated with tumor progression in breast cancer
Cadenas, C., van de Sandt, L., Edlund, K., Lohr, M., Hellwig, B., Marchan, R., Schmidt, M., Rahnenführer, J., Oster, H., & Hengstler, J. G. (2014) · Cell Cycle · doi:10.4161/15384101.2014.954454 · Cited by 231
Cracking the O-GlcNAc code in metabolism
Ruan, H., Singh, J. P., Li, M., Wu, J., & Yang, X. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.02.002 · Cited by 224
The Plant Circadian Clock: From a Simple Timekeeper to a Complex Developmental ManagerPreprint
Sánchez, S. E., & Kay, S. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027748 · Cited by 225
Social Jetlag and Related Risks for Human Health: A Timely Review
Caliandro, R., Streng, A. A., van Kerkhof, L. W. M., van der Horst, G. T. J., & Chaves, I. (2021) · Nutrients · doi:10.3390/nu13124543 · Cited by 231
Aiello, I., Fedele, M. L. M., Román, F. R., Marpegán, L., Caldart, C. S., Chiesa, J. J., Golombek, D. A., Finkielstein, C. V., & Paladino, N. (2020) · Science Advances · doi:10.1126/sciadv.aaz4530 · Cited by 222
Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity
van Moorsel, D., Hansen, J., Havekes, B., Scheer, F. A. J. L., Jörgensen, J. A., Hoeks, J., Schrauwen-Hinderling, V. B., Duez, H., Lefebvre, P., Schaper, N. C., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.012 · Cited by 218
Moreno, C. R. D. C., Marqueze, E. C., Sargent, C., Wright, K. P., Ferguson, S. A., & Tucker, P. (2019) · Industrial Health · doi:10.2486/indhealth.sw-1 · Cited by 246
O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination
Li, M., Ruan, H., Hughes, M. E., Lee, J.-S., Singh, J. P., Jones, S. P., Nitabach, M. N., & Yang, X. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.015 · Cited by 225
Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold
Zhu, X., Bührer, C., & Wellmann, S. M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2253-7 · Cited by 228
The circadian timing system in clinical oncology
Innominato, P. F., Roche, V., Palesh, O. G., Ulusakarya, A., Spiegel, D., & Lévi, F. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.916990 · Cited by 214
Coogan, A. N., & McGowan, N. M. (2017) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-016-0214-5 · Cited by 208
Dissipative structures in biological systems: bistability, oscillations, spatial patterns and waves
Goldbeter, A. (2018) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2017.0376 · Cited by 210
Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms
Black, N., D’Souza, A., Wang, Y., Piggins, H. D., Dobrzynski, H., Morris, G. M., & Boyett, M. R. (2018) · Heart Rhythm · doi:10.1016/j.hrthm.2018.08.026 · Cited by 212
Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions
Ayyar, V. S., & Sukumaran, S. (2021) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-021-09751-2 · Cited by 228
Circadian Oscillators: Around the Transcription–Translation Feedback Loop and on to Output
Hurley, J., Loros, J., & Dunlap, J. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.07.009 · Cited by 206
Regulation of amyloid-β dynamics and pathology by the circadian clock
Kress, G. J., Liao, F., Dimitry, J. M., Cedeño, M. R., FitzGerald, G. A., Holtzman, D. M., & Musiek, E. S. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172347 · Cited by 214
mTOR signaling regulates central and peripheral circadian clock function
Ramanathan, C., Kathale, N. D., Liu, D., Lee, C., Freeman, D. A., Hogenesch, J. B., Cao, R., & Liu, A. C. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007369 · Cited by 209
Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet
Tognini, P., Murakami, M., Liu, Y., Eckel‐Mahan, K. L., Newman, J. C., Verdin, E. M., Baldi, P., & Sassone‐Corsi, P. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.015 · Cited by 207
Depner, C. M., Melanson, E. L., Eckel, R. H., Snell-Bergeon, J. K., Perreault, L., Bergman, B. C., Higgins, J. A., Guerin, M. K., Stothard, E. R., Morton, S. J., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.01.069 · Cited by 203
Zeb, F., Wu, X., Chen, L., Fatima, S., Haq, I.-U., Chen, A., Majeed, F., Feng, Q., & Li, M. (2020) · British Journal of Nutrition · doi:10.1017/s0007114519003428 · Cited by 202
Lananna, B. V., McKee, C. A., King, M. W., Del-Aguila, J. L., Dimitry, J. M., Farias, F. H. G., Nadarajah, C. J., Xiong, D. D., Guo, C., Cammack, A. J., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax3519 · Cited by 201
Regulation of the Blood–Brain Barrier by Circadian Rhythms and Sleep
Cuddapah, V. A., Zhang, S., & Sehgal, A. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.05.001 · Cited by 208
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation
Pariollaud, M., Gibbs, J. E., Hopwood, T. W., Brown, S. L., Begley, N., Vonslow, R. M., Poolman, T. M., Guo, B., Saer, B., Jones, D. H., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93910 · Cited by 201
Extensive Oscillatory Gene Expression during C. elegans Larval Development
Hendriks, G., Gaidatzis, D., Aeschimann, F., & Großhans, H. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.013 · Cited by 193
The Association between Chronotype and Dietary Pattern among Adults: A Scoping Review
Mazri, F. H., Manaf, Z. A., Shahar, S., & Mat Ludin, A. F. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17010068 · Cited by 198
Hwang, J., Sundar, I. K., Yao, H., Sellix, M. T., & Rahman, I. (2013) · The FASEB Journal · doi:10.1096/fj.13-232629 · Cited by 197
A sleep-inducing gene, nemuri , links sleep and immune function in Drosophila
Toda, H., Williams, J. A., Gulledge, M., & Sehgal, A. (2019) · Science · doi:10.1126/science.aat1650 · Cited by 191
Schroeder, A., & Colwell, C. S. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.09.002 · Cited by 201
Metadata
- Authors
- Mohawk, J. A., Green, C. B., & Takahashi, J. S.
- Affiliations
- Department of Neuroscience,
- Howard Hughes Medical Institute (US)
- Corresponding author
- Takahashi, Joseph S.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2012-07-21
- Volume
- 35
- Issue
- 1
- Pages
- 445-462
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- PMC
- PMC3710582
- OpenAlex
- W2164824098
- Cited by
- 2,265
- References
- 113
- Citations by year
- 2026: 149 · 2025: 194 · 2024: 189 · 2023: 182 · 2022: 197 · 2021: 202 · 2020: 201 · 2019: 150 · 2018: 161 · 2017: 144 · 2016: 154 · 2015: 129 · 2014: 108 · 2013: 89 · 2012: 11
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5p50mh074924-05)
- National Institute of Mental Health (P50 MH-074924, R01MH078024)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
- Keywords
- circadian clock, suprachiasmatic nucleus, central pacemaker, peripheral circadian oscillators, cell-autonomous clock, metabolic rhythms, metabolism, feeding rhythm, body temperature rhythm, hormonal rhythms
- MeSH terms
- Animals, Circadian Rhythm, Feeding Behavior, Mammals, Methamphetamine, Models, Biological, Neural Pathways, Neurons, Suprachiasmatic Nucleus, Signal Transduction, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
