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Central and Peripheral Circadian Clocks in Mammals
Open accessAbstract
The circadian system of mammals is composed of a hierarchy of oscillators that function at the cellular, tissue, and systems levels. A common molecular mechanism underlies the cell-autonomous circadian oscillator throughout the body, yet this clock system is adapted to different functional contexts. In the central suprachiasmatic nucleus (SCN) of the hypothalamus, a coupled population of neuronal circadian oscillators acts as a master pacemaker for the organism to drive rhythms in activity and rest, feeding, body temperature, and hormones. Coupling within the SCN network confers robustness to the SCN pacemaker, which in turn provides stability to the overall temporal architecture of the organism. Throughout the majority of the cells in the body, cell-autonomous circadian clocks are intimately enmeshed within metabolic pathways. Thus, an emerging view for the adaptive significance of circadian clocks is their fundamental role in orchestrating metabolism.
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“Experimental administration of glucocorticoid synchronizes the peripheral clocks located in liver, muscle, and adipose tissue which are the major storage sites for glycogen, protein, and fat, respectively, as well as other metabolically relevant organs such as pancreas and gut [60–63].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [63]
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“Resetting of the peripheral clock occurs through well-defined molecular mechanisms that involve direct interaction of glucocorticoids, glucocorticoid response elements and the regulatory regions of core clock genes Bmal1, Cry1, Per1 and Per2 [63, 64].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [63]
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Metadata
- Authors
- Mohawk, J. A., Green, C. B., & Takahashi, J. S.
- Affiliations
- Department of Neuroscience,
- Howard Hughes Medical Institute (US)
- Corresponding author
- Takahashi, Joseph S.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2012-07-21
- Volume
- 35
- Issue
- 1
- Pages
- 445-462
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- PMC
- PMC3710582
- OpenAlex
- W2164824098
- Cited by
- 2,265
- References
- 113
- Citations by year
- 2026: 149 · 2025: 194 · 2024: 189 · 2023: 182 · 2022: 197 · 2021: 202 · 2020: 201 · 2019: 150 · 2018: 161 · 2017: 144 · 2016: 154 · 2015: 129 · 2014: 108 · 2013: 89 · 2012: 11
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5p50mh074924-05)
- National Institute of Mental Health (P50 MH-074924, R01MH078024)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
- Keywords
- circadian clock, suprachiasmatic nucleus, central pacemaker, peripheral circadian oscillators, cell-autonomous clock, metabolic rhythms, metabolism, feeding rhythm, body temperature rhythm, hormonal rhythms
- MeSH terms
- Animals, Circadian Rhythm, Feeding Behavior, Mammals, Methamphetamine, Models, Biological, Neural Pathways, Neurons, Suprachiasmatic Nucleus, Signal Transduction, Circadian Clocks
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