Cited by 2,265Circadian rhythm and melatoninSleep and Work-Related FatigueNonlinear Dynamics and Pattern Formation

The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.

Central and Peripheral Circadian Clocks in Mammals

Open access

Mohawk, Jennifer A., Green, Carla B., Takahashi, Joseph S.·2012·Annual Review of Neuroscience

DOI 10.1146/annurev-neuro-060909-153128PMC PMC3710582

Open this paper in CoChat — free account

Abstract

The circadian system of mammals is composed of a hierarchy of oscillators that function at the cellular, tissue, and systems levels. A common molecular mechanism underlies the cell-autonomous circadian oscillator throughout the body, yet this clock system is adapted to different functional contexts. In the central suprachiasmatic nucleus (SCN) of the hypothalamus, a coupled population of neuronal circadian oscillators acts as a master pacemaker for the organism to drive rhythms in activity and rest, feeding, body temperature, and hormones. Coupling within the SCN network confers robustness to the SCN pacemaker, which in turn provides stability to the overall temporal architecture of the organism. Throughout the majority of the cells in the body, cell-autonomous circadian clocks are intimately enmeshed within metabolic pathways. Thus, an emerging view for the adaptive significance of circadian clocks is their fundamental role in orchestrating metabolism.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev-neuro-060909-153128

Cites

113 of 113 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Self-citation
The mammalian circadian timing system: organization and coordination of central and peripheral clocks
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Self-citation
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310
Self-citation
The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · cited 1×
“PGC-1α is critical for adaptive responses to nutritional and metabolic state, particularly following fasting (reviewed in Lin et al. 2005).”
Background
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
Self-citation

Show all 113 references

Research works printed but not linked: 3

Kaneko M, 1980, Am. J. Physiol., 239, R309
Mahoney CE, 2010, Am. J. Physiol., 299, R751
Richter C, 1922, Comp. Psychol. Monogr., 1, 1

Sorted by citations

Items 301–400 of 1,001

Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness
Forsyth, C. B., Voigt, R. M., & Keshavarzian, A. (2014) · Redox Biology · doi:10.1016/j.redox.2014.10.002 · Cited by 76
Circadian clock: a regulator of the immunity in cancer
Zhang, Z., Zeng, P., Gao, W., Zhou, Q., Feng, T., & Tian, X. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00721-2 · Cited by 80
SRC-2 Is an Essential Coactivator for Orchestrating Metabolism and Circadian Rhythm
Stashi, E., Lanz, R. B., Mao, J., Michailidis, G. C., Zhu, B., Kettner, N. M., Putluri, N., Reineke, E. L., Reineke, L. C., Dasgupta, S., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.027 · Cited by 74
Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease
Kocerha, J., Dwivedi, Y., & Brennand, K. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.30 · Cited by 76
Resynchronization of circadian oscillators and the east-west asymmetry of jet-lag
Lu, Z., Klein-Cardeña, K., Lee, S., Antonsen, T. M., Girvan, M., & Ott, E. (2016) · Chaos: An Interdisciplinary Journal of Nonlinear Science · doi:10.1063/1.4954275 · Cited by 75
Pulmonary group 2 innate lymphoid cells: surprises and challenges
Starkey, M. R., McKenzie, A. N. J., Belz, G. T., & Hansbro, P. M. (2019) · Mucosal Immunology · doi:10.1038/s41385-018-0130-4 · Cited by 77
Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body
Evans, J. A., Suen, T.-C., Callif, B. L., Mitchell, A. S., Castañón‐Cervantes, O., Baker, K. M., Kloehn, I., Baba, K., Teubner, B. J. W., Ehlen, J. C., et al. (2015) · BMC Biology · doi:10.1186/s12915-015-0157-x · Cited by 75
Heterogeneity of the Peripheral Circadian Systems in Drosophila melanogaster: A Review
Ito, C., & Tomioka, K. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00008 · Cited by 75
Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization
Fonken, L. K., Kitt, M. M., Gaudet, A. D., Barrientos, R. M., Watkins, L. R., & Maier, S. F. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.019 · Cited by 77
Circadian Rhythm Disruption and Sepsis in Severe Trauma Patients
Coiffard, B., Diallo, A. B., Culver, A., Mezouar, S., Hammad, E., Vigne, C., Nicolino-Brunet, C., Dignat‐George, F., Baumstarck, K., Boucékine, M., et al. (2018) · Shock · doi:10.1097/shk.0000000000001241 · Cited by 76
Circadian Neurobiology and the Physiologic Regulation of Sleep and Wakefulness
Schwartz, W. J., & Klerman, E. B. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.03.001 · Cited by 84
Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length
Gao, P., Yoo, S. H., Lee, K. J., Rosensweig, C., Takahashi, J. S., Chen, B. P., & Green, C. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.509604 · Cited by 73
Self-citation
Collective timekeeping among cells of the master circadian clock
Evans, J. A. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0054 · Cited by 77
Neuron-specific knockouts indicate the importance of network communication to Drosophila rhythmicity
Schlichting, M., Díaz, M. M., Xin, J., & Rosbash, M. (2019) · eLife · doi:10.7554/elife.48301 · Cited by 74
Circadian Clock Regulates Inflammation and the Development of Neurodegeneration
Wang, X., & Li, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.696554 · Cited by 78
The Neurobiology of Circadian Rhythms
Sollars, P. J., & Pickard, G. E. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.003 · Cited by 82
Long-term in vivo recording of circadian rhythms in brains of freely moving mice
Mei, L., Fan, Y., Lv, X., Welsh, D. K., Zhan, C., & Zhang, E. E. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717735115 · Cited by 73
Biological rhythms in the deep-sea hydrothermal mussel Bathymodiolus azoricus
Mat, A. M., Sarrazin, J., Markov, G. V., Apremont, V., Dubreuil, C., Eché, C., Fabioux, C., Klopp, C., Sarradin, P., Tanguy, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17284-4 · Cited by 70
Endocrine disrupting chemicals: effects on pituitary, thyroid and adrenal glands
Egalini, F., Marinelli, L., Rossi, M., Motta, G., Prencipe, N., Giaccherino, R. R., Pagano, L., Grottoli, S., & Giordano, R. (2022) · Endocrine · doi:10.1007/s12020-022-03076-x · Cited by 73
Rod electrical coupling is controlled by a circadian clock and dopamine in mouse retina
Jin, N., Chuang, A. Z., Masson, P. J., & Ribelayga, C. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.284919 · Cited by 73
The role of circadian clock genes in tumors
Li, H.-X. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s203144 · Cited by 80
REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis
Griffin, P., Sheehan, P. W., Dimitry, J. M., Guo, C., Kanan, M. F., Lee, J., Zhang, J., & Musiek, E. S. (2020) · eLife · doi:10.7554/elife.58765 · Cited by 73
Meal timing and its role in obesity and associated diseases
Peters, B., Vahlhaus, J., & Pivovarova-Ramich, O. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1359772 · Cited by 72
Circadian rhythms, alcohol and gut interactions
Forsyth, C. B., Voigt, R. M., Burgess, H. J., Swanson, G. R., & Keshavarzian, A. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.07.021 · Cited by 73
Clock gene Per2 as a controller of liver carcinogenesis
Mteyrek, A., Filipski, E., Guettier, C., Okyar, A., & Lévi, F. (2016) · Oncotarget · doi:10.18632/oncotarget.11037 · Cited by 73
Family resources and stress associated with having a mentally retarded child.
Minnes, P. (1988) · PubMed · Cited by 72
Circadian dysfunction may be a key component of the non-motor symptoms of Parkinson's disease: Insights from a transgenic mouse model
Willison, L. D., Kudo, T., Loh, D. H., Kuljis, D. A., & Colwell, C. S. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.01.014 · Cited by 73
A Kiss to drive rhythms in reproduction
Simonneaux, V. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14287 · Cited by 70
Physiologically Relevant Changes in Serotonin Resolved by Fast Microdialysis
Yang, H., Thompson, A. B., McIntosh, B. J., Altieri, S. C., & Andrews, A. M. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400072f · Cited by 73
Molecular Architecture of the Circadian Clock in Mammals
Takahashi, J. S. (2016) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-27069-2_2 · Cited by 74
Self-citation
Therapeutic applications of circadian rhythms for the cardiovascular system
Tsimakouridze, E. V., Alibhai, F. J., & Martino, T. A. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00077 · Cited by 72
Circadian molecular clock disruption in chronic pulmonary diseases
Giri, A., Wang, Q., Rahman, I., & Sundar, I. K. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.04.002 · Cited by 70
Brain-muscle communication prevents muscle aging by maintaining daily physiology
Kumar, A., Vaca-Dempere, M., Mortimer, T., Deryagin, O., Smith, J. G., Petrus, P., Koronowski, K. B., Greco, C. M., Segalés, J., Andrés, E., et al. (2024) · Science · doi:10.1126/science.adj8533 · Cited by 72
Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation
Niu, Y., Heddes, M., Altaha, B., Birkner, M., Kleigrewe, K., Meng, C., Haller, D., & Kießling, S. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01189-z · Cited by 73
Post-transcriptional control of the mammalian circadian clock: implications for health and disease
Preußner, M., & Heyd, F. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1820-y · Cited by 69
TIMELESS mutation alters phase responsiveness and causes advanced sleep phase
Kurien, P. A., Hsu, P.-K., de Leon, J. G., Wu, D., McMahon, T., Shi, G., Xu, Y., Lipzen, A., Pennacchio, L. A., Jones, C. R., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1819110116 · Cited by 70
Exercise timing and circadian rhythms
Wolff, C. A., & Esser, K. A. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.04.020 · Cited by 69
Immunometabolism around the Clock
Carroll, R. G., Timmons, G. A., Cervantes‐Silva, M. P., Kennedy, O. D., & Curtis, A. M. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.013 · Cited by 72
Th17 Differentiation and Their Pro-inflammation Function
Song, X., Gao, H., & Qian, Y. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-9487-9_5 · Cited by 70
Circadian disruption and biomarkers of tumor progression in breast cancer patients awaiting surgery
Cash, E. D., Sephton, S. E., Chagpar, A. B., Spiegel, D., Rebholz, W. N., Zimmaro, L. A., Tillie, J. M., & Dhabhar, F. S. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.017 · Cited by 70
Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) Are Necessary for Light Entrainment of Peripheral Clocks
Kofuji, P., Mure, L. S., Massman, L., Purrier, N., Panda, S., & Engeland, W. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168651 · Cited by 69
Mathematical modeling of circadian rhythms
Asgari-Targhi, A., & Klerman, E. B. (2018) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1439 · Cited by 73
Immunoregulatory Sensory Circuits in Group 3 Innate Lymphoid Cell (ILC3) Function and Tissue Homeostasis
Domingues, R. G., & Hepworth, M. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00116 · Cited by 73
Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity
Aguilar‐López, B. A., Moreno‐Altamirano, M. M. B., Dockrell, H. M., Duchen, M. R., & Sánchez‐García, F. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00051 · Cited by 73
A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease
Peng, X., Fan, R., Xie, L., Shi, X., Dong, K., Zhang, S., Tao, J., Xu, W., Ma, D., Chen, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010504 · Cited by 70
An Expanding Role for Nonvisual Opsins in Extraocular Light Sensing Physiology
Andrabi, M., Upton, B. A., Lang, R. A., & Vemaraju, S. (2023) · Annual Review of Vision Science · doi:10.1146/annurev-vision-100820-094018 · Cited by 69
Brighter nights and darker days predict higher mortality risk: A prospective analysis of personal light exposure in >88,000 individuals
Windred, D. P., Burns, A. C., Lane, J. M., Olivier, P. L., Rutter, M. K., Saxena, R., Phillips, A. J. K., & Cain, S. W. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2405924121 · Cited by 68
Clock genes, pancreatic function, and diabetes
Vieira, E. C., Burris, T. P., & Quesada, I. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.10.007 · Cited by 72
Circadian CLOCK Mediates Activation of Transforming Growth Factor-β Signaling and Renal Fibrosis through Cyclooxygenase 2
Chen, W.-D., Yeh, J., Peng, M., Shie, S., Lin, S., Yang, C., Chen, T., Hung, K., Wang, C., Hsieh, C., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.08.003 · Cited by 69
Mammalian Circadian Period, But Not Phase and Amplitude, Is Robust Against Redox and Metabolic Perturbations
Putker, M., Crosby, P., Feeney, K. A., Hoyle, N. P., Costa, A. S. H., Gaude, E., Frezza, C., & O'Neill, J. S. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6911 · Cited by 69
Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety
Satyanarayanan, S. K., Chien, Y.-C., Chang, J. P., Huang, S., Guu, T., Su, H., & Su, K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.03.003 · Cited by 68
Effect of acute total sleep deprivation on plasma melatonin, cortisol and metabolite rhythms in females
Honma, A., Revell, V. L., Gunn, P. J., Davies, S. K., Middleton, B., Raynaud, F. I., & Skene, D. J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14411 · Cited by 75
An inventory of crosstalk between ubiquitination and other post-translational modifications in orchestrating cellular processes
Barbour, H., Nkwe, N. S., Estavoyer, B., Messmer, C., Gushul-Leclaire, M., Villot, R., Uriarte, M., Boulay, K., Hlayhel, S., Farhat, B., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106276 · Cited by 70
Time-fixed feeding prevents obesity induced by chronic advances of light/dark cycles in mouse models of jet-lag/shift work
Oike, H., Sakurai, M., Ippoushi, K., & Kobori, M. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.059 · Cited by 67
Tracking circadian rhythms of bone mineral deposition in murine calvarial organ cultures
McElderry, J.-D. P., Zhao, G., Khmaladze, A. T., Wilson, C. G. M., Franceschi, R. T., & Morris, M. D. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1924 · Cited by 68
Chrononutrition—When We Eat Is of the Essence in Tackling Obesity
Ahluwalia, M. K. (2022) · Nutrients · doi:10.3390/nu14235080 · Cited by 76
Influence of mental stress and environmental toxins on circadian clocks: Implications for redox regulation of the heart and cardioprotection
Li, H., Kilgallen, A. B., Münzel, T. F., Wolf, E., Lecour, S., Schulz, R., Daiber, A., & Laake, L. W. V. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14949 · Cited by 67
Circadian Coordination of Antimicrobial Responses
Tognini, P., Thaiss, C. A., Elinav, E., & Sassone‐Corsi, P. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.007 · Cited by 65
HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape
Qu, M., Qu, H., Jia, Z., & Kay, S. A. (2021) · Nature Communications · doi:10.1038/s41467-021-26567-3 · Cited by 65
Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period
Takasu, N. N., Nakamura, T. J., Tokuda, I. T., Todo, T., Block, G. D., & Nakamura, W. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.049 · Cited by 65
Circadian regulation of epithelial functions in the intestine
Pácha, J., & Sumová, A. (2013) · Acta Physiologica · doi:10.1111/apha.12090 · Cited by 67
Disrupted Reproduction, Estrous Cycle, and Circadian Rhythms in Female Mice Deficient in Vasoactive Intestinal Peptide
Loh, D. H., Kuljis, D. A., Azuma, L., Wu, Y., Truong, D. A., Wang, H. B., & Colwell, C. S. (2014) · Journal of Biological Rhythms · doi:10.1177/0748730414549767 · Cited by 67
Diurnal Variation of Hormonal and Lipid Biomarkers in a Molecular Epidemiology-Like Setting
van Kerkhof, L. W. M., Dycke, K. C. G. V., Jansen, E. H. J. M., Beekhof, P., van Oostrom, C. T. M., Ruskovska, T., Velickova, N., Kamcev, N., Pennings, J. L. A., STEEG, H. V., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135652 · Cited by 66
The Circadian System Contributes to Apnea Lengthening across the Night in Obstructive Sleep Apnea
Butler, M. P., Smales, C., Wu, H., Hussain, M. V., Mohamed, Y. A., Morimoto, M., & Shea, S. A. (2015) · SLEEP · doi:10.5665/sleep.5166 · Cited by 65
Long Non-Coding RNA Profiling in a Non-Alcoholic Fatty Liver Disease Rodent Model: New Insight into Pathogenesis
Chen, Y., Huang, H., Xu, C., Yu, C., & Li, Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010021 · Cited by 66
Artificial light-at-night – a novel lifestyle risk factor for metabolic disorder and cancer morbidity
Zubidat, A. E., & Haim, A. (2017) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2016-0116 · Cited by 68
Circadian rhythms and environmental disturbances – underexplored interactions
Prokkola, J. M., & Nikinmaa, M. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.179267 · Cited by 72
RETRACTED: Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis‐Like Changes in Knee Joint
Kc, R., Li, X., Voigt, R. M., Ellman, M. B., Summa, K. C., Vitaterna, M. H., Keshavarizian, A., Turek, F. W., Meng, Q., Stein, G. S., et al. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.24946 · Cited by 64
Retracted
Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons
Li, S., He, Q., Wang, H., Tang, X., Ho, K. W., Gao, X., Zhang, Q., Shen, Y., Cheung, A. S. T., Wong, F., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.09.019 · Cited by 63
The effect of white light on normal and malignant murine melanocytes: A link between opsins, clock genes, and melanogenesis
de Assis, L. V. M., Moraes, M. N., Cruz‐Machado, S. D. S., & Castrucci, A. M. D. L. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.03.001 · Cited by 62
A Review of Sleep and Its Disorders in Patients with Parkinson's Disease in Relation to Various Brain Structures
French, I. T., & Muthusamy, K. A. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00114 · Cited by 69
Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock
Park, J., Zhu, H., O’Sullivan, S. J., Ogunnaike, B. A., Weaver, D. R., Schwaber, J. S., & Vadigepalli, R. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00481 · Cited by 65
Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation
Chaudhari, A. B., Gupta, R., Patel, S. A., Velingkaar, N., & Kondratov, R. V. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-08-0624 · Cited by 65
Circadian rhythm of the Leydig cells endocrine function is attenuated during aging
Baburski, A. Z., Sokanovic, S. J., Bjelic, M. M., Pletikosic, S. M. R., Andrić, S. A., & Kostic, T. S. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.11.002 · Cited by 62
Cellular mechanisms and integrative timing of neuroendocrine control of GnRH secretion by kisspeptin
Beltramo, M., Dardente, H., Cayla, X., & Caraty, A. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.10.015 · Cited by 65
Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain
Kervezee, L., Hartman, R., van den Berg, D., Shimizu, S., Yamamoto, Y., Meijer, J. H., & de Lange, E. C. M. (2014) · The AAPS Journal · doi:10.1208/s12248-014-9625-4 · Cited by 63
Epigenetic Regulation of Biological Rhythms: An Evolutionary Ancient Molecular Timer
Stevenson, T. J. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.11.003 · Cited by 66
Circadian rhythms and substance use disorders: A bidirectional relationship
Tamura, E. K., Silva, K. S. O., Ferreira-Moraes, F. A., Marinho, E. A. V., & Guerrero‐Vargas, N. N. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173105 · Cited by 67
The Hepatic Circadian Clock Modulates Xenobiotic Metabolism in Mice
DeBruyne, J. P., Weaver, D. R., & Dallmann, R. (2014) · Journal of Biological Rhythms · doi:10.1177/0748730414544740 · Cited by 62
Feeding during the resting phase causes profound changes in physiology and desynchronization between liver and muscle rhythms of rats
Opperhuizen, A., Wang, D., Foppen, E., Jansen, R., Surovtseva, O. V., de Vries, J., Fliers, E., & Kalsbeek, A. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13377 · Cited by 64
Remote reprogramming of hepatic circadian transcriptome by breast cancer
Hojo, H., Enya, S., Arai, M., Suzuki, Y., Nojiri, T., Kangawa, K., Koyama, S., & Kawaoka, S. (2017) · Oncotarget · doi:10.18632/oncotarget.16699 · Cited by 61
The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1
Biancolin, A. D., Martchenko, A., Mitova, E., Gurges, P., Michalchyshyn, E., Chalmers, J. A., Doria, A., Mychaleckyj, J. C., Adriaenssens, A. E., Reimann, F. M., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.11.004 · Cited by 62
Effects of vitamin D on mood and sleep in the healthy population: Interpretations from the serotonergic pathway
Huiberts, L., & Smolders, K. C. H. J. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101379 · Cited by 67
Circadian Rhythms and the Gastrointestinal Tract: Relationship to Metabolism and Gut Hormones
Martchenko, A., Martchenko, S. E., Biancolin, A. D., & Brubaker, P. L. (2020) · Endocrinology · doi:10.1210/endocr/bqaa167 · Cited by 61
Brain Mechanisms of COVID-19-Sleep Disorders
Semyachkina-Glushkovskaya, O. V., Mamedova, A., Telnova, V., Klimova, M., Saranceva, E. I., Ageev, V., Yu, T., Zhu, D. Y., Penzel, T., & Kurths, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136917 · Cited by 63
Major roles of the circadian clock in cancer
Huang, C. L., Zhang, C., Cao, Y., Li, J., & Bi, F. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2022.0474 · Cited by 64
Circadian Clock–Coupled Lung Cellular and Molecular Functions in Chronic Airway Diseases
Sundar, I. K., Yao, H., Sellix, M. T., & Rahman, I. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0476tr · Cited by 61
Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson’s disease male Wistar rat model and effect of melatonin administration
Mattam, U., & Jagota, A. (2014) · Biogerontology · doi:10.1007/s10522-014-9541-0 · Cited by 62
Neurobiological Functions of the Period Circadian Clock 2 Gene, Per2
Kim, M., de la Peña, J. B., Cheong, J. H., & Kim, H. J. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.131 · Cited by 67
Glucagon and/or IGF-1 Production Regulates Resetting of the Liver Circadian Clock in Response to a Protein or Amino Acid-only Diet
Ikeda, Y., Kamagata, M., Hirao, M., Yasuda, S., Iwami, S., Sasaki, H., Tsubosaka, M., Hattori, Y., Todoh, A., Tamura, K., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.01.012 · Cited by 61
Circadian regulation of adipose function
Shostak, A., Husse, J., & Oster, H. (2013) · Adipocyte · doi:10.4161/adip.26007 · Cited by 63
Chemical chronobiology: Toward drugs manipulating time
Wallach, T. E., & Kramer, A. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.04.059 · Cited by 61
Physiological links between circadian rhythms, metabolism and nutrition
Johnston, J. D. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.078295 · Cited by 59
Excitatory and inhibitory synaptic dysfunction in mania: an emerging hypothesis from animal model studies
Lee, Y., Zhang, Y., Kim, S., & Han, K. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0028-y · Cited by 60
Circadian Rhythms in Cardiovascular Metabolism
Lal, H., Verma, S. K., Wang, Y., Xie, M., & Young, M. E. (2024) · Circulation Research · doi:10.1161/circresaha.123.323520 · Cited by 67
Differential role of melatonin in restoration of age-induced alterations in daily rhythms of expression of various clock genes in suprachiasmatic nucleus of male Wistar rats
Mattam, U., & Jagota, A. (2014) · Biogerontology · doi:10.1007/s10522-014-9495-2 · Cited by 60
An ecdysone-responsive nuclear receptor regulates circadian rhythms in Drosophila
Kumar, S., Chen, D., Jang, C. J., Nall, A., Zheng, X., & Sehgal, A. (2014) · Nature Communications · doi:10.1038/ncomms6697 · Cited by 59
Circadian clock and steroidogenic-related gene expression profiles in mouse Leydig cells following dexamethasone stimulation
Chen, H., Gao, L., Xiong, Y., Yang, D., Li, C., Wang, A., & Jin, Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.149 · Cited by 59
The Effect of Circadian and Sleep Disruptions on Obesity Risk
Noh, J. H. (2018) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2018.27.2.78 · Cited by 63
Sex differences in circadian endocrine rhythms: Clinical implications
Nicolaides, N. C., & Chrousos, G. P. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14692 · Cited by 60

Authors: Mohawk, J. A., Green, C. B., & Takahashi, J. S.
Affiliations: Department of Neuroscience,
Howard Hughes Medical Institute (US)
Corresponding author: Takahashi, Joseph S.
ORCID: Mohawk, Jennifer A.
Green, Carla B.
Takahashi, Joseph S.
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2012-07-21
Volume: 35
Issue: 1
Pages: 445-462
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev-neuro-060909-153128
PMC: PMC3710582
OpenAlex: W2164824098
Cited by: 2,265
References: 113
Citations by year: 2026: 149 · 2025: 194 · 2024: 189 · 2023: 182 · 2022: 197 · 2021: 202 · 2020: 201 · 2019: 150 · 2018: 161 · 2017: 144 · 2016: 154 · 2015: 129 · 2014: 108 · 2013: 89 · 2012: 11
FWCI: 12.16
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (5p50mh074924-05)
National Institute of Mental Health (P50 MH-074924, R01MH078024)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Nonlinear Dynamics and Pattern Formation
Keywords: circadian clock, suprachiasmatic nucleus, central pacemaker, peripheral circadian oscillators, cell-autonomous clock, metabolic rhythms, metabolism, feeding rhythm, body temperature rhythm, hormonal rhythms
MeSH terms: Animals, Circadian Rhythm, Feeding Behavior, Mammals, Methamphetamine, Models, Biological, Neural Pathways, Neurons, Suprachiasmatic Nucleus, Signal Transduction, Circadian Clocks

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Central and Peripheral Circadian Clocks in Mammals

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks