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Cited by 47

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RNA Binding Proteins and the Pathogenesis of Frontotemporal Lobar Degeneration

Hofmann, Jeffrey W., Seeley, William W., Huang, Eric J.·2019·Annual Review of Pathology: Mechanisms of Disease
DOI 10.1146/annurev-pathmechdis-012418-012955PMC PMC6731550
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Abstract

Frontotemporal dementia is a group of early onset dementia syndromes linked to underlying frontotemporal lobar degeneration (FTLD) pathology that can be classified based on the formation of abnormal protein aggregates involving tau and two RNA binding proteins, TDP-43 and FUS. Although elucidation of the mechanisms leading to FTLD pathology is in progress, recent advances in genetics and neuropathology indicate that a majority of FTLD cases with proteinopathy involving RNA binding proteins show highly congruent genotype–phenotype correlations. Specifically, recent studies have uncovered the unique properties of the low-complexity domains in RNA binding proteins that can facilitate liquid–liquid phase separation in the formation of membraneless organelles. Furthermore, there is compelling evidence that mutations in FTLD genes lead to dysfunction in diverse cellular pathways that converge on the endolysosomal pathway, autophagy, and neuroinflammation. Together, these results provide key mechanistic insights into the pathogenesis and potential therapeutic targets of FTLD.

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Research works printed but not linked: 119

  1. Miller BL, 2013, Frontotemporal Dementia
  2. 10.1212/WNL.58.11.1615 · DOI
  3. Pick A, 1892, Prag. Med. Wochenschr., 17, 165
  4. 10.1159/000219215 · DOI
  5. 10.1007/BF02866241 · DOI
  6. 10.1093/brain/awr179 · DOI · Paper page
  7. 10.1212/WNL.0b013e31821103e6 · DOI · Paper page
  8. 10.1002/ana.10570 · DOI
  9. 10.1136/jnnp.60.6.615 · DOI
  10. 10.1101/cshperspect.a023622 · DOI
  11. 10.1016/j.neuron.2009.03.024 · DOI · Paper page
  12. 10.1016/j.neuron.2011.12.040 · DOI · Paper page
  13. 10.1016/j.neuron.2012.03.004 · DOI · Paper page
  14. 10.1136/jnnp-2012-304644 · DOI · Paper page
  15. 10.1212/NXI.0000000000000301 · DOI · Paper page
  16. 10.1371/journal.pmed.1002487 · DOI
  17. 10.1038/nrn.2017.36 · DOI
  18. 10.1007/s00401-011-0845-8 · DOI
  19. 10.1002/ana.20873 · DOI · Paper page
  20. 10.1093/jnen/nlw034 · DOI
  21. 10.1007/s00401-013-1171-0 · DOI
  22. 10.1016/j.bbrc.2006.10.093 · DOI · Paper page
  23. 10.1126/science.1134108 · DOI · Paper page
  24. 10.1038/nature05017 · DOI · Paper page
  25. 10.1016/j.neuron.2011.09.011 · DOI · Paper page
  26. 10.1016/j.neuron.2011.09.010 · DOI · Paper page
  27. 10.1186/s40478-017-0493-x · DOI
  28. 10.1016/j.neuron.2017.07.025 · DOI
  29. Koriath CA, 2017, Alzheimer's Dement, 6, 75, 10.1016/j.dadm.2016.10.003 · DOI
  30. 10.1007/s00401-007-0224-7 · DOI
  31. 10.1126/science.1166066 · DOI
  32. 10.1126/science.1165942 · DOI
  33. 10.1101/cshperspect.a024299 · DOI
  34. 10.1016/j.brainres.2016.03.036 · DOI
  35. 10.1111/j.1750-3639.2010.00413.x · DOI
  36. 10.1111/jnc.13622 · DOI · Paper page
  37. 10.1038/nn.2778 · DOI · Paper page
  38. 10.1038/s41593-017-0047-3 · DOI
  39. 10.1146/annurev-biochem-061516-044700 · DOI
  40. 10.1038/nchembio.95 · DOI
  41. 10.1016/j.cell.2012.04.016 · DOI
  42. 10.1016/j.cell.2013.10.033 · DOI
  43. 10.1101/gad.204602.112 · DOI
  44. 10.1016/j.celrep.2013.11.017 · DOI
  45. 10.1038/nature10879 · DOI
  46. 10.1016/j.cell.2015.09.015 · DOI · Paper page
  47. 10.1016/j.cell.2015.07.047 · DOI · Paper page
  48. 10.1016/j.molcel.2015.09.006 · DOI · Paper page
  49. 10.1016/j.molcel.2015.08.018 · DOI
  50. 10.1016/j.cell.2009.02.044 · DOI
  51. 10.1016/j.cell.2017.08.048 · DOI
  52. 10.1523/JNEUROSCI.0172-14.2014 · DOI · Paper page
  53. 10.15252/embj.201696394 · DOI
  54. 10.1016/j.cell.2016.04.047 · DOI
  55. 10.1016/j.cell.2016.11.054 · DOI
  56. 10.1126/science.aaf4382 · DOI
  57. 10.1016/j.tcb.2016.05.004 · DOI
  58. 10.1016/j.neuron.2004.07.022 · DOI
  59. 10.1038/srep00529 · DOI
  60. 10.1016/j.chembiol.2013.02.013 · DOI
  61. 10.1016/j.neuron.2015.10.030 · DOI · Paper page
  62. 10.1038/nature11922 · DOI
  63. Todd PK, 2010, Ann. Neurol., 67, 291, 10.1002/ana.21948 · DOI
  64. 10.1016/j.neuron.2013.10.015 · DOI · Paper page
  65. 10.1016/j.neuron.2015.11.018 · DOI
  66. 10.1016/j.neuron.2016.04.005 · DOI
  67. 10.1073/pnas.1318835110 · DOI
  68. Reddy K, 2013, J. Biol. Chem, 288, 9860
  69. 10.1016/j.neuron.2013.02.004 · DOI
  70. 10.1126/science.1232927 · DOI
  71. 10.1126/science.aaa9344 · DOI
  72. 10.1093/brain/aww250 · DOI
  73. 10.1126/science.1254917 · DOI
  74. 10.1016/j.cell.2016.10.002 · DOI
  75. 10.1016/j.cell.2016.10.003 · DOI
  76. 10.1093/hmg/ddu279 · DOI
  77. 10.1007/s00401-015-1401-8 · DOI
  78. 10.1093/bioinformatics/bts725 · DOI · Paper page
  79. 10.1091/mbc.e16-01-0003 · DOI
  80. 10.1186/s40478-016-0324-5 · DOI · Paper page
  81. 10.1007/s00401-007-0223-8 · DOI
  82. 10.1016/j.neuron.2010.09.034 · DOI · Paper page
  83. 10.1523/JNEUROSCI.5757-10.2011 · DOI
  84. 10.1523/JNEUROSCI.4808-14.2015 · DOI
  85. 10.1083/jcb.201502029 · DOI
  86. Kishimoto Y, 1992, J. Lipid Res., 33, 1255, 10.1016/S0022-2275(20)40540-1 · DOI
  87. 10.1007/BF03380135 · DOI
  88. 10.1016/j.brainres.2014.08.022 · DOI
  89. 10.1007/s11910-013-0366-z · DOI
  90. 10.1016/j.neurobiolaging.2016.02.019 · DOI · Paper page
  91. 10.1016/j.ajhg.2012.04.021 · DOI · Paper page
  92. Gotzl JK, 2014, Acta Neuropathol, 127, 845
  93. 10.2353/ajpath.2010.090915 · DOI
  94. 10.1172/JCI63113 · DOI
  95. 10.1016/j.neuron.2017.06.026 · DOI
  96. 10.1523/JNEUROSCI.6103-11.2013 · DOI
  97. 10.1016/j.celrep.2017.08.056 · DOI
  98. 10.1038/nm.3232 · DOI · Paper page
  99. 10.1212/01.wnl.0000176987.47875.28 · DOI
  100. 10.1001/archneurol.2009.72 · DOI
  101. 10.1038/ng1884 · DOI · Paper page
  102. 10.1016/j.neurobiolaging.2009.10.011 · DOI
  103. 10.1073/pnas.1722344115 · DOI
  104. 10.1016/j.tcb.2016.11.007 · DOI
  105. 10.1016/j.cell.2012.03.017 · DOI · Paper page
  106. 10.1126/science.1204592 · DOI · Paper page
  107. 10.1073/pnas.1100650108 · DOI
  108. 10.1084/jem.20160999 · DOI · Paper page
  109. 10.1007/s00401-017-1668-z · DOI
  110. 10.1146/annurev-neuro-061010-113810 · DOI · Paper page
  111. 10.1016/j.cell.2007.10.036 · DOI · Paper page
  112. 10.1083/jcb.201706157 · DOI
  113. 10.4161/auto.36098 · DOI
  114. 10.1016/j.bbapap.2013.03.020 · DOI
  115. 10.1007/s00401-014-1367-y · DOI
  116. 10.1212/WNL.0b013e31826e25df · DOI · Paper page
  117. 10.1016/j.cell.2013.05.037 · DOI · Paper page
  118. 10.1038/cdd.2014.103 · DOI
  119. 10.1371/journal.pbio.2002183 · DOI · Paper page

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Metadata

Authors
Hofmann, J. W., Seeley, W. W., & Huang, E. J.
Venue
Annual Review of Pathology: Mechanisms of Disease
Publisher
Annual Reviews
Published
2019-01-24
Volume
14
Issue
1
Pages
469-495
ISSN
  • 1553-4006
  • 1553-4014
DOI
10.1146/annurev-pathmechdis-012418-012955
PMC
PMC6731550
Cited by
47
References
37
Language
en

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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