Understanding the broad influence of sex hormones and sex differences in the brain

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path

Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works

Physiology and neurobiology of stress and adaptation: central role of the brain

McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 4,981 · cited 1× · see citing works

Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592 · see citing works

STRESS AND HIPPOCAMPAL PLASTICITY

McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087 · see citing works

Dynamics of hippocampal neurogenesis in adult humans

Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841 · see citing works

Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons

Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., & Chattarji, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06810.2002 · Cited by 1,662 · see citing works

Atlas of estradiol‐concentrating cells in the central nervous system of the female rat

Pfaff, D. W., & Keiner, M. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901510204 · Cited by 1,494 · see citing works

Estrogen Actions in the Central Nervous System

McEwen, B. S., & Alves, S. E. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0365 · Cited by 1,483 · see citing works

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

Sorge, R. E., Mapplebeck, J. C. S., Rosen, S., Beggs, S., Taves, S., Alexander, J. K., Martin, L. J., Austin, J.-S., Sotocinal, S. G., Chen, D., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4053 · Cited by 1,442 · see citing works

Evidence for a morphological sex difference within the medial preoptic area of the rat brain

Gorski, R. A., Gordon, J. H., Shryne, J. E., & Southam, A. M. (1978) · Brain Research · doi:10.1016/0006-8993(78)90723-0 · Cited by 1,230 · see citing works

Sex differences in the structural connectome of the human brain

Ingalhalikar, M., Smith, A., Parker, D., Satterthwaite, T. D., Elliott, M. A., Ruparel, K., Hakonarson, H., Gur, R. E., Gur, R. C., & Verma, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316909110 · Cited by 1,223 · see citing works

Sex and internal secretions

Young, W. C., & Allen, E. (1961) · Williams & Wilkins eBooks · doi:10.5962/bhl.title.7323 · Cited by 1,171 · see citing works

Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons

Woolley, C., Gould, E., Frankfurt, M., & McEwen, B. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-12-04035.1990 · Cited by 1,107 · see citing works

The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course

McEwen, B. S., & Morrison, J. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.028 · Cited by 1,079 · see citing works

Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat

Woolley, C. S., & McEwen, B. S. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903360210 · Cited by 1,073 · see citing works

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

Mogil, J. S. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3360 · Cited by 1,065 · see citing works

A Role for Brain Stress Systems in Addiction

Koob, G. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.012 · Cited by 1,056 · see citing works

Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus

Cameron, H. A., & Gould, E. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90224-0 · Cited by 999 · see citing works

The hippocampus—what does it do?

Eichenbaum, H., Otto, T., & Cohen, N. J. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90724-i · Cited by 867 · see citing works

Repeated stress causes reversible impairments of spatial memory performance.

Luine, V., Villegas, M., Martinez, C., & McEwen, B. (1994) · Brain Research · doi:10.1016/0006-8993(94)91778-7 · Cited by 813 · see citing works

Organizational and activational effects of sex steroids on brain and behavior: A reanalysis

Arnold, A. P. (1985) · Hormones and Behavior · doi:10.1016/0018-506x(85)90042-x · Cited by 805 · see citing works

The Formation of Estrogens by Central Neuroendocrine Tissues

NAFTOLIN, F., RYAN, K. J., DAVIES, I. J., REDDY, V. V., FLORES, F., PETRO, Z., KUHN, M., WHITE, R. J., TAKAOKA, Y., & WOLIN, L. (1975) · Proceedings of the 1974 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571131-9.50012-8 · Cited by 793 · see citing works

Chemical and Anatomical Plasticity of Brain

Bennett, E. L., Diamond, M. C., Krech, D., & Rosenzweig, M. R. (1964) · Science · doi:10.1126/science.146.3644.610 · Cited by 767 · see citing works

Reframing sexual differentiation of the brain

McCarthy, M. M., & Arnold, A. P. (2011) · Nature Neuroscience · doi:10.1038/nn.2834 · Cited by 728 · see citing works

Sex Differences in the Brain: The Not So Inconvenient Truth

McCarthy, M. M., Arnold, A. P., Ball, G. F., Blaustein, J. D., & De Vries, G. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5372-11.2012 · Cited by 724 · see citing works

Selective Retention of Corticosterone by Limbic Structures in Rat Brain

McEwen, B. S., Weiss, J. M., & Schwartz, L. S. (1968) · Nature · doi:10.1038/220911a0 · Cited by 713 · see citing works

Estradiol Increases the Sensitivity of Hippocampal CA1 Pyramidal Cells to NMDA Receptor-Mediated Synaptic Input: Correlation with Dendritic Spine Density

Woolley, C., Weiland, N., McEwen, B., & Schwartzkroin, P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01848.1997 · Cited by 711 · see citing works

Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women

Sherwin, B. B. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90060-1 · Cited by 705 · see citing works

Sex beyond the genitalia: the human brain mosaic

Joel, D., Berman, Z., Tavor, I., Wexler, N., Gaber, O., Stein, Y., Shefi, N., Pool, J., Urchs, S., Margulies, D. S., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509654112 · Cited by 684 · see citing works

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

Toft, D. O., & Górski, J. (1966) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.55.6.1574 · Cited by 682 · see citing works

Nox family NADPH oxidases: Molecular mechanisms of activation.

Brandes, R., Weissmann, N., & Schröder, K. (2014) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2014.07.046 · Cited by 660 · see citing works

Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017α and P450 aromatase localized in neurons

Hojo, Y., Hattori, T.-A., Enami, T., Furukawa, A., Suzuki, K., Ishii, H.-T., Mukai, H., Morrison, J. H., Janssen, W. G. M., Kominami, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2630225100 · Cited by 644 · see citing works

Rapid actions of plasma membrane estrogen receptors

Kelly, M. J., & Levin, E. R. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00377-0 · Cited by 643 · see citing works

Estrogen Actions in the Central Nervous System

McEwen, B. S. (1999) · Endocrine Reviews · doi:10.1210/er.20.3.279 · Cited by 640 · see citing works

Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor

Mermelstein, P. G., Becker, J., & Surmeier, D. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00595.1996 · Cited by 633 · see citing works

Estrogens and Brain Function

Pfaff, D. W. (1980) · Springer eBooks · doi:10.1007/978-1-4613-8084-9 · Cited by 588 · see citing works

Hypothalamic Regulatory Hormones

Schally, A. V., Arimura, A., & Kastin, A. J. (1973) · Science · doi:10.1126/science.179.4071.341 · Cited by 575 · see citing works

Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress

Galea, L. A. M., McEwen, B. S., Tanapat, P., Deak, T., Spencer, R. L., & Dhabhar, F. S. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00233-9 · Cited by 540 · see citing works

Pattern of dendritic branching in occipital cortex of rats reared in complex environments

Greenough, W. T., & Volkmar, F. R. (1973) · Experimental Neurology · doi:10.1016/0014-4886(73)90090-3 · Cited by 536 · see citing works

Organization of the entorhinal—hippocampal system: A review of current anatomical data

Witter, M. P. (1993) · Hippocampus · doi:10.1002/hipo.1993.4500030707 · Cited by 534 · see citing works

Estradiol Increases Dendritic Spine Density by Reducing GABA Neurotransmission in Hippocampal Neurons

Murphy, D., Cole, N., Greenberger, V., & Segal, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02550.1998 · Cited by 506 · see citing works

Sex Differences and Opposite Effects of Stress on Dendritic Spine Density in the Male Versus Female Hippocampus

Shors, T. J., Chua, C., & Falduto, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06292.2001 · Cited by 496 · see citing works

Space in the brain: How the hippocampal formation supports spatial cognition

Hartley, T., Lever, C., Burgess, N., & O'Keefe, J. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0510 · Cited by 495 · see citing works

Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites

Milner, T. A., McEwen, B. S., Hayashi, S., Li, C. J., Reagan, L. P., & Alves, S. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010115)429:3 · Cited by 491 · see citing works

Hormones and Sexual Behavior

Feder, H. H. (1984) · Annual Review of Psychology · doi:10.1146/annurev.ps.35.020184.001121 · Cited by 474 · see citing works

Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse

Hara, Y., Waters, E. M., McEwen, B. S., & Morrison, J. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00036.2014 · Cited by 470 · see citing works

Peptides in the brain: the new endocrinology of the neuron.

Guillemin, R. (1978) · Science · doi:10.1126/science.212832 · Cited by 455 · see citing works

Hypertension Caused by Angiotensin II Infusion Involves Increased Superoxide Production in the Central Nervous System

Zimmerman, M. C., Lazartigues, E. D., Sharma, R. V., & Davisson, R. L. (2004) · Circulation Research · doi:10.1161/01.res.0000135483.12297.e4 · Cited by 440 · see citing works

Gonadal Hormones Affect Spine Synaptic Density in the CA1 Hippocampal Subfield of Male Rats

Léránth, C., Petneházy, Ö., & MacLusky, N. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01588.2003 · Cited by 407 · see citing works

Gonadal Hormones Induce Dendritic Growth in the Adult Avian Brain

DeVoogd, T. J., & Nottebohm, F. (1981) · Science · doi:10.1126/science.7280692 · Cited by 386 · see citing works

Multidimensional assessment of empathic abilities: Neural correlates and gender differences

Derntl, B., Finkelmeyer, A., Eickhoff, S., Kellermann, T., Falkenberg, D. I., Schneider, F., & Habel, U. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.10.006 · Cited by 377 · see citing works

Stress facilitates classical conditioning in males, but impairs classical conditioning in females through activational effects of ovarian hormones

Wood, G. E., & Shors, T. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4066 · Cited by 359 · see citing works

Ultrastructural localization of estrogen receptor β immunoreactivity in the rat hippocampal formation

Milner, T. A., Ayoola, K., Drake, C. T., Herrick, S. P., Tabori, N. E., McEwen, B. S., Mitra, S. W., & Alves, S. E. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20724 · Cited by 358 · see citing works

Characteristics of membrane progestin receptor alpha (mPRα) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions

Thomas, P. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.01.001 · Cited by 352 · see citing works

Women have greater density of neurons in posterior temporal cortex

Witelson, S. F., Glezer, I., & Kigar, D. L. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03418.1995 · Cited by 344 · see citing works

The Vitamin D Receptor Is Present in Caveolae-Enriched Plasma Membranes and Binds 1α,25(OH)2-Vitamin D3in Vivo and in Vitro

Huhtakangas, J. A., Olivera, C. J., Bishop, J. E., Zanello, L. P., & Norman, A. W. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0116 · Cited by 337 · see citing works

Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females

Almey, A., Milner, T. A., & Brake, W. G. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.010 · Cited by 315 · see citing works

Rat brain binds adrenal steroid hormone: Radioautography of hippocampus with corticosterone

Gerlach, J. L., & McEwen, B. S. (1972) · Science · doi:10.1126/science.175.4026.1133 · Cited by 306 · see citing works

Biological Basis of Sex Differences in the Propensity to Self-administer Cocaine

Hu, M., Crombag, H. S., Robinson, T. E., & Becker, J. B. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300301 · Cited by 303 · see citing works

Estrogen effects on the brain: Actions beyond the hypothalamus via novel mechanisms.

McEwen, B. S., Akama, K. T., Spencer-Segal, J. L., Milner, T. A., & Waters, E. M. (2012) · Behavioral Neuroscience · doi:10.1037/a0026708 · Cited by 302 · see citing works

Estradiol-Concentrating Neurons: Topography in the Hypothalamus by Dry-Mount Autoradiography

Stumpf, W. E. (1968) · Science · doi:10.1126/science.162.3857.1001 · Cited by 298 · see citing works

Estradiol selectively regulates agonist binding sites on the N-methyl-D- aspartate receptor complex in the CA1 region of the hippocampus

Weiland, N. G. (1992) · Endocrinology · doi:10.1210/endo.131.2.1353442 · Cited by 297 · see citing works

Distribution and hormonal regulation of androgen receptor (AR) and AR messenger ribonucleic acid in the rat hippocampus

Kerr, J. E., Allore, R., Beck, S. G., & Handa, R. J. (1995) · Endocrinology · doi:10.1210/endo.136.8.7628354 · Cited by 296 · see citing works

Hormones and Sexual Behavior

Young, W. C., Goy, R. W., & Phoenix, C. H. (1964) · Science · doi:10.1126/science.143.3603.212 · Cited by 295 · see citing works

Chronic stress effects on memory: sex differences in performance and monoaminergic activity

Bowman, R. E., Beck, K. D., & Luine, V. N. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00022-3 · Cited by 290 · see citing works

Estradiol Acutely Suppresses Inhibition in the Hippocampus through a Sex-Specific Endocannabinoid and mGluR-Dependent Mechanism

Huang, G. Z., & Woolley, C. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.035 · Cited by 288 · see citing works

Comparing levels of cocaine cue reactivity in male and female outpatients

Robbins, S. J., Ehrman, R. N., Childress, A. R., & O’Brien, C. P. (1999) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00135-5 · Cited by 285 · see citing works

The validity of the Hamilton and Montgomery-�sberg depression rating scales as screening and diagnostic tools for depression in Parkinson's disease

Leentjens, A. F. G., Verhey, F. R. J., Lousberg, R. L., Spitsbergen, H., & Wilmink, F. W. (2000) · International Journal of Geriatric Psychiatry · doi:10.1002/1099-1166(200007)15:7 · Cited by 280 · see citing works

Sex difference and estrous cycle variations in amphetamine-elicited rotational behavior

Becker, J. B., Robinson, T. E., & Lorenz, K. A. (1982) · European Journal of Pharmacology · doi:10.1016/0014-2999(82)90178-9 · Cited by 268 · see citing works

Estrogen Is Essential for Maintaining Nigrostriatal Dopamine Neurons in Primates: Implications for Parkinson's Disease and Memory

Léránth, C., Roth, R. H., Elsworth, J. D., Naftolin, F. N., Horváth, T. L., & Redmond, D. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08604.2000 · Cited by 267 · see citing works

Autoradiographic Localization of Radioactivity in Rat Brain after Injection of Tritiated Sex Hormones

Pfaff, D. W. (1968) · Science · doi:10.1126/science.161.3848.1355 · Cited by 265 · see citing works

Cytoskeletal changes underlie estrogen’s acute effects on synaptic transmission and plasticity.

Kramár, E. A., Chen, L. Y., Brandon, N. J., Rex, C. S., Liu, F., Gall, C. M., & Lynch, G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3059-09.2009 · Cited by 264 · see citing works

Acetylcholine Mediates the Estrogen-Induced Increase in NMDA Receptor Binding in CA1 of the Hippocampus and the Associated Improvement in Working Memory

Daniel, J. M., & Dohanich, G. P. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06949.2001 · Cited by 263 · see citing works

Sex differences in the development of angiotensin II-induced hypertension in conscious mice.

Xue, B., Pamidimukkala, J., & Hay, M. (2005) · American Journal of Physiology. Heart and Circulatory Physiology · doi:10.1152/ajpheart.00969.2004 · Cited by 259 · see citing works

Her versus his migraine: multiple sex differences in brain function and structure

Maleki, N., Linnman, C., Brawn, J., Burstein, R., Becerra, L. R., & Borsook, D. (2012) · Brain · doi:10.1093/brain/aws175 · Cited by 255 · see citing works

NMDA Receptor Activation Increases Free Radical Production through Nitric Oxide and NOX2

Girouard, H., Wang, G., Gallo, E. F., Anrather, J., Zhou, P., Pickel, V. M., & Iadecola, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0133-09.2009 · Cited by 254 · see citing works

Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies

Castner, S. A., Li, X., & Becker, J. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)91225-h · Cited by 253 · see citing works

Progestin receptor levels in rat hypothalamic and limbic nuclei

Parsons, B., Rainbow, T. C., MacLusky, N. J., & McEwen, B. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-10-01446.1982 · Cited by 250 · see citing works

Restraint stress reversibly enhances spatial memory performance

Luine, V. N., Martinez, C., Villegas, M., Magariños, A. M., & McEwen, B. S. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02016-0 · Cited by 249 · see citing works

Gonadal Steroids Modify Dendritic Spine Density in Ventromedial Hypothalamic Neurons: A Golgi Study in the Adult Rat

Frankfurt, M., Gould, E., Woolley, C. S., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000125387 · Cited by 239 · see citing works

Effects of estrogen on the basal ganglia

Hartesveldt, C. V., & Joyce, J. N. (1986) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(86)90029-1 · Cited by 238 · see citing works

Electrical Activity During the Estrous Cycle of the Rat: Cyclic Changes in Limbic Structures

Terasawa, E., & Timiras, P. S. (1968) · Endocrinology · doi:10.1210/endo-83-2-207 · Cited by 227 · see citing works

Postmenopausal Estrogen Use Affects Risk for Parkinson Disease

Currie, L. J., Harrison, M. B., Trugman, J. M., Bennett, J. P., & Wooten, G. F. (2004) · Archives of Neurology · doi:10.1001/archneur.61.6.886 · Cited by 226 · see citing works

Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus

Pawlak, R., Rao, B. S. S., Melchor, J. P., Chattarji, S., McEwen, B., & Strickland, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509232102 · Cited by 223 · see citing works

Sex differences in the rapid and acute effects of estrogen on striatal D2 dopamine receptor binding

Bazzett, T. J., & Becker, J. B. (1994) · Brain Research · doi:10.1016/0006-8993(94)91229-7 · Cited by 222 · see citing works

Diencephalic placement of estradiol and sexual receptivity in the female rat

Lisk, R. D. (1962) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1962.203.3.493 · Cited by 220 · see citing works

Aromatase Cytochrome P450 and Extragonadal Estrogen Play a Role in Ischemic Neuroprotection

McCullough, L. D., Blizzard, K. K., Simpson, E. R., Öz, O. K., & Hurn, P. D. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08701.2003 · Cited by 214 · see citing works

Autoradiographic localization of estradiol-binding neurons in the rat hippocampal formation and entorhinal cortex

Loy, R., Gerlach, J. L., & McEwen, B. S. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90028-4 · Cited by 210 · see citing works

Hippocampal formation: Shedding light on the influence of sex and stress on the brain

McEwen, B. S., & Milner, T. A. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.02.006 · Cited by 206 · see citing works

Androgens Increase Spine Synapse Density in the CA1 Hippocampal Subfield of Ovariectomized Female Rats

Léránth, C., Hajszán, T., & MacLusky, N. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4516-03.2004 · Cited by 206 · see citing works

Caveolin Proteins Are Essential for Distinct Effects of Membrane Estrogen Receptors in Neurons

Boulware, M. I., Kordasiewicz, H. B., & Mermelstein, P. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1647-07.2007 · Cited by 204 · see citing works

Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats

Eiland, L. R., Ramroop, J. R., Hill, M. N., Manley, J., & McEwen, B. S. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.04.015 · Cited by 203 · see citing works

Stress and relapse to drug seeking in rats: studies on the generality of the effect

Shalev, U., Highfield, D. A., Yap, J. J., & Shaham, Y. (2000) · Psychopharmacology · doi:10.1007/s002130000441 · Cited by 198 · see citing works

Spine Loss and Regrowth in Hippocampus following Deafferentation

Parnavelas, J. G., LYNCH, G. S., Brecha, N. C., Cotman, C. W., & Globus, A. (1974) · Nature · doi:10.1038/248071a0 · Cited by 198 · see citing works

Estrogen Stimulates Postsynaptic Density-95 Rapid Protein Synthesis via the Akt/Protein Kinase B Pathway

Akama, K. T., & McEwen, B. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02333.2003 · Cited by 197 · see citing works

Receptors Reconsidered: A 20-Year Perspective

Jensen, E. V., Greene, G. L., Closs, L. E., DeSombre, E. R., & Nadji, M. (1982) · Elsevier eBooks · doi:10.1016/b978-0-12-571138-8.50006-8 · Cited by 194 · see citing works

Estrogen Promotes Stress Sensitivity in a Prefrontal Cortex-Amygdala Pathway

Shansky, R. M., Hamo, C., Hof, P. R., Lou, W., McEwen, B. S., & Morrison, J. H. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq003 · Cited by 191 · see citing works

Neuronal stem cells in the brain of adult vertebrates

Álvarez-Buylla, A., & Lois, C. (1995) · Stem Cells · doi:10.1002/stem.5530130307 · Cited by 190 · see citing works

Estrogen receptors in dendrites and axon terminals in the guinea pig hypothalamus

Blaustein, J. D., Lehman, M. N., Turcotte, J. C., & Greene, G. L. (1992) · Endocrinology · doi:10.1210/endo.131.1.1612006 · Cited by 186 · see citing works

Ultrastructural evidence that androgen receptors are located at extranuclear sites in the rat hippocampal formation

Tabori, N. E., Stewart, L. S., Znamensky, V., Romeo, R. D., Alves, S. E., McEwen, B. S., & Milner, T. A. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.048 · Cited by 184 · see citing works

Estradiol Acutely Potentiates Hippocampal Excitatory Synaptic Transmission through a Presynaptic Mechanism

Smejkalová, T., & Woolley, C. S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4161-10.2010 · Cited by 183 · see citing works

Estrogen administration increases neuronal responses to excitatory amino acids as a long-term effect

Smith, S. S. (1989) · Brain Research · doi:10.1016/0006-8993(89)91691-0 · Cited by 183 · see citing works

Why Are Some Neurons Replaced in Adult Brain?

Nottebohm, F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00624.2002 · Cited by 180 · see citing works

ŒSTROGENS AND EXTRAPYRAMIDAL SYSTEM

Bédard, P. J., Langelier, P., & Villeneuve, A. (1977) · The Lancet · doi:10.1016/s0140-6736(77)90429-9 · Cited by 179 · see citing works

NADPH Oxidase Contributes to Angiotensin II Signaling in the Nucleus Tractus Solitarius

Wang, G., Anrather, J., Huang, J., Speth, R. C., Pickel, V. M., & Iadecola, C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1176-04.2004 · Cited by 176 · see citing works

Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortex

Hao, J., Rapp, P. R., Janssen, W. G. M., Lou, W. Y. W., Lasley, B. L., Hof, P. R., & Morrison, J. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704757104 · Cited by 176 · see citing works

Chronic Stress and Neural Function: Accounting for Sex and Age

Luine, V. N., Beck, K. D., Bowman, R. E., Frankfurt, M., & MacLusky, N. J. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01594.x · Cited by 173 · see citing works

Neuronal proliferation in the 9-month-old rodent ? Radioautographic study of granule cells in the hippocampus

Kaplan, M., & Bell, D. H. (1983) · Experimental Brain Research · doi:10.1007/bf00237141 · Cited by 172 · see citing works

SELECTIVE RETENTION OF OESTRADIOL BY CELL NUCLEI IN SPECIFIC BRAIN REGIONS OF THE OVARIECTOMIZED RAT1

Zigmond, R. E., & McEwen, B. S. (1970) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1970.tb02242.x · Cited by 172 · see citing works

Effects of sex and the estrous cycle on regulation of intravenously self-administered cocaine in rats

Lynch, W. J., Arizzi, M. N., & Carroll, M. E. (2000) · Psychopharmacology · doi:10.1007/s002130000488 · Cited by 172 · see citing works

Localized Behavioral Effects of Tritiated Estradiol Implants in the Ventromedial Hypothalamus of Female Rats*

Davis, P. G., McEwen, B. S., & Pfaff, D. W. (1979) · Endocrinology · doi:10.1210/endo-104-4-898 · Cited by 172 · see citing works

Paraventricular nucleus, stress response, and cardiovascular disease

Benarroch, E. E. (2005) · Clinical Autonomic Research · doi:10.1007/s10286-005-0290-7 · Cited by 170 · see citing works

Mitochondria as Therapeutic Targets of Estrogen Action in the Central Nervous System

Nilsen, J., & Brinton, R. D. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337193 · Cited by 166 · see citing works

The ever‐changing brain: Cellular and molecular mechanisms for the effects of stressful experiences

McEwen, B. S. (2012) · Developmental Neurobiology · doi:10.1002/dneu.20968 · Cited by 165 · see citing works

Neuronal birth and death

Gould, E., & McEwen, B. S. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90138-o · Cited by 164 · see citing works

Minireview: Sex Chromosomes and Brain Sexual Differentiation

Arnold, A. P., Xu, J., Grisham, W., Chen, X., Kim, Y., & Itoh, Y. (2003) · Endocrinology · doi:10.1210/en.2003-1491 · Cited by 164 · see citing works

Recent progress in hormone research

Talamantes, F. J. (1980) · General and Comparative Endocrinology · doi:10.1016/0016-6480(80)90112-4 · Cited by 162 · see citing works

Sex-Specific Neuroanatomical Correlates of Fear Expression in Prefrontal-Amygdala Circuits

Gruene, T. M., Roberts, E., Thomas, V., Ronzio, A., & Shansky, R. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.014 · Cited by 160 · see citing works

Estrogen Levels Regulate the Subcellular Distribution of Phosphorylated Akt in Hippocampal CA1 Dendrites

Znamensky, V., Akama, K. T., McEwen, B. S., & Milner, T. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02340.2003 · Cited by 158 · see citing works

GENDER DIFFERENCES IN COCAINE CRAVING AMONG NON-TREATMENT-SEEKING INDIVIDUALS WITH COCAINE DEPENDENCE

Elman, I., Karlsgodt, K. H., & Gastfriend, D. R. (2001) · The American Journal of Drug and Alcohol Abuse · doi:10.1081/ada-100103705 · Cited by 158 · see citing works

Stress and Disease: Is Being Female a Predisposing Factor?

Becker, J. B., Monteggia, L. M., Perrot-Sinal, T. S., Romeo, R. D., Taylor, J. R., Yehuda, R., & Bale, T. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3565-07.2007 · Cited by 158 · see citing works

Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis

Okamoto, M., Hojo, Y., Inoue, K., Matsui, T., Kawato, S., McEwen, B. S., & Soya, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210023109 · Cited by 157 · see citing works

Patterns in the human brain mosaic discriminate males from females

Chekroud, A. M., Ward, E. J., Rosenberg, M. D., & Holmes, A. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523888113 · Cited by 148 · see citing works

Characterization of an Animal Model of Postmenopausal Hypertension in Spontaneously Hypertensive Rats

Fortepiani, L. A., Zhang, H., Racusen, L. C., Roberts, L. J., & Reckelhoff, J. F. (2003) · Hypertension · doi:10.1161/01.hyp.0000046924.94886.ef · Cited by 147 · see citing works

Steroid hormone target sites in the brain: The differential distribution of estrogen, progestin, androgen and glucocorticosteroid

Stumpf, W. E., & Sar, M. (1976) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(76)90050-9 · Cited by 142 · see citing works

Electrical stimulation of the hypothalamus and the mechanism of neural control of the adenohypophysis

Harris, G. W. (1948) · The Journal of Physiology · doi:10.1113/jphysiol.1948.sp004286 · Cited by 141 · see citing works

Neuroendocrine involvement in aging: Evidence from studies of reproductive aging and caloric restriction

Nelson, J. F., Karelus, K., Bergman, M. D., & Felicio, L. S. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00072-m · Cited by 139 · see citing works

Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

Bliss, T. V. P., & Lømo, T. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010273 · Cited by 135 · see citing works

Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction

Chartoff, E. H., & Mavrikaki, M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00466 · Cited by 134 · see citing works

Posttraining intrahippocampal estradiol injections enhance spatial memory in male rats: Interaction with cholinergic systems.

Packard, M. G., Kohlmaier, J. R., & Alexander, G. M. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.3.626 · Cited by 133 · see citing works

Androgen cell signaling pathways involved in neuroprotective actions

Pike, C. J., Nguyen, T. V., Ramsden, M., Yao, M., Murphy, M. P., & Rosario, E. R. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.11.006 · Cited by 132 · see citing works

Opioid systems in the dentate gyrus

Drake, C. T., Chavkin, C., & Milner, T. A. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63015-5 · Cited by 130 · see citing works

Neuropeptide Y in the dentate gyrus

Sperk, G., Hamilton, T. J., & Colmers, W. F. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63017-9 · Cited by 129 · see citing works

Sex differences in angiotensin II- and aldosterone-induced hypertension: the central protective effects of estrogen

Xue, B., Johnson, A. K., & Hay, M. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00222.2013 · Cited by 129 · see citing works

Accelerated Ovarian Failure: A novel, chemically induced animal model of menopause

Kempen, T. A. V., Milner, T. A., & Waters, E. M. (2011) · Brain Research · doi:10.1016/j.brainres.2010.12.064 · Cited by 123 · see citing works

Posttraining intrahippocampal estradiol injections enhance spatial memory in male rats: Interaction with cholinergic systems.

Packard, M. G., Kohlmaier, J. R., & Alexander, G. M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.3.626 · Cited by 118 · see citing works

Central Regulation of the Endocrine System

Fuxé, K., Hökfelt, T. G. M., & Luft, R. (1979) · Springer eBooks · doi:10.1007/978-1-4684-3396-8 · Cited by 117 · see citing works

Estrogen Receptors Are Found in Glia and at Extranuclear Neuronal Sites in the Dorsal Striatum of Female Rats: Evidence for Cholinergic But Not Dopaminergic Colocalization

Almey, A., Filardo, E. J., Milner, T. A., & Brake, W. G. (2012) · Endocrinology · doi:10.1210/en.2012-1458 · Cited by 116 · see citing works

Sex Differences in Hippocampal Estradiol-Induced N-Methyl-D-Aspartic Acid Binding and Ultrastructural Localization of Estrogen Receptor-Alpha

Romeo, R. D., McCarthy, J. B., Wang, A. C., Milner, T. A., & McEwen, B. S. (2005) · Neuroendocrinology · doi:10.1159/000089557 · Cited by 115 · see citing works

Ultrastructural localization of neuropeptide Y‐like immunoreactivity in the rat hippocampal formation

Milner, T. A., & Veznedaroglu, E. (1992) · Hippocampus · doi:10.1002/hipo.450020204 · Cited by 114 · see citing works

Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action

Wehling, M., Christ, M., & Theisen, K. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.5.e974 · Cited by 114 · see citing works

A Role for the Basal Forebrain Cholinergic System in Estrogen-Induced Disinhibition of Hippocampal Pyramidal Cells

Rudick, C. N., Gibbs, R. B., & Woolley, C. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04479.2003 · Cited by 112 · see citing works

Gonadal Hormones Modulate the Dendritic Spine Densities of Primary Cortical Pyramidal Neurons in Adult Female Rat

Chen, J., Yan, Y.-T., Wang, T., Chen, L.-J., Wang, Y.-J., & Tseng, G. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp048 · Cited by 110 · see citing works

Subcellular relationships between cholinergic terminals and estrogen receptor‐α in the dorsal hippocampus

Towart, L. A., Alves, S. E., Znamensky, V., Hayashi, S., McEwen, B. S., & Milner, T. A. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10753 · Cited by 109 · see citing works

Nox2, Ca 2+ , and Protein Kinase C Play a Role in Angiotensin II-Induced Free Radical Production in Nucleus Tractus Solitarius

Wang, G., Anrather, J., Glass, M. J., Tarsitano, M., Zhou, P., Frys, K. A., Pickel, V. M., & Iadecola, C. (2006) · Hypertension · doi:10.1161/01.hyp.0000236647.55200.07 · Cited by 109 · see citing works

Clinically relevant basic science studies of gender differences and sex hormone effects.

Bs, M., Se, A., Bulloch, K., & Ng, W. (1998) · PubMed · Cited by 102 · see citing works

Pre‐ and postsynaptic plasticity underlying augmented glutamatergic inputs to hypothalamic presympathetic neurons in spontaneously hypertensive rats

Li, D., Yang, Q., Pan, H., & Pan, H. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.149732 · Cited by 100 · see citing works

Steroids, sex and the cerebellar cortex: implications for human disease

Dean, S. L., & McCarthy, M. M. (2008) · The Cerebellum · doi:10.1007/s12311-008-0003-6 · Cited by 99 · see citing works

The neuroanatomy of sexual dimorphism in opioid analgesia

Averitt, D. L., & Murphy, A. Z. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.04.004 · Cited by 97 · see citing works

Environment complexity stimulates visual cortex neurogenesis: death of a dogma and a research career

Kaplan, M. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01967-6 · Cited by 95 · see citing works

The cerebellum as a target for estrogen action

Hedges, V., Ebner, T., Meisel, R., & Mermelstein, P. (2012) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2012.08.005 · Cited by 94 · see citing works

Estrogen and the aging brain: an elixir for the weary cortical network

Dumitriu, D., Rapp, P. R., McEwen, B. S., & Morrison, J. H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05529.x · Cited by 92 · see citing works

Medial prefrontal cortical estradiol rapidly alters memory system bias in female rats: ultrastructural analysis reveals membrane-associated estrogen receptors as potential mediators

Almey, A., Cannell, E., Bertram, K., Filardo, E., Milner, T. A., & Brake, W. G. (2014) · Endocrinology · doi:10.1210/en.2014-1463 · Cited by 91 · see citing works

Estrogen-induction of dendritic spines in ventromedial hypothalamus and hippocampus: effects of neonatal aromatase blockade and adult GDX

Lewis, C., McEwen, B. S., & Frankfurt, M. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(95)00052-f · Cited by 90 · see citing works

Membrane-Initiated Estradiol Signaling Induces Spinogenesis Required for Female Sexual Receptivity

Christensen, A., Dewing, P., & Micevych, P. E. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3030-11.2011 · Cited by 89 · see citing works

Opioid-mediated facilitation of long-term potentiation at the lateral perforant path-dentate granule cell synapse.

Xie, C. W., & Lewis, D. V. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22950-0 · Cited by 88 · see citing works

Estrogen and Ovariectomy Regulate mRNA and Protein of Glutamic Acid Decarboxylases and Cation-Chloride Cotransporters in the Adult Rat Hippocampus

Nakamura, N. H., Rosell, D. R., Akama, K. T., & McEwen, B. S. (2004) · Neuroendocrinology · doi:10.1159/000083657 · Cited by 87 · see citing works

Morphine and Heroin Differentially Modulate In Vivo Hippocampal LTP in Opiate-Dependent Rat

Bao, G., Kang, L., Li, H., Li, Y., Pu, L., Xia, P., Ma, L., & Pei, G. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301308 · Cited by 85 · see citing works

Estradiol Facilitates the Release of Neuropeptide Y to Suppress Hippocampus-Dependent Seizures

Ledoux, V. A., Smejkalová, T., May, R. M., Cooke, B. M., & Woolley, C. S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4688-08.2009 · Cited by 85 · see citing works

Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2

Bruchas, M. R., Xu, M., & Chavkin, C. (2008) · Neuroreport · doi:10.1097/wnr.0b013e32830dd655 · Cited by 83 · see citing works

Sex-Biased Stress Signaling: The Corticotropin-Releasing Factor Receptor as a Model

Valentino, R. J., Bangasser, D. A., & Bockstaele, E. J. V. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.083550 · Cited by 83 · see citing works

A “window of opportunity:” the reduction of coronary heart disease and total mortality with menopausal therapies is age- and time-dependent

Hodis, H. N., & Mack, W. J. (2011) · Brain Research · doi:10.1016/j.brainres.2010.10.076 · Cited by 83 · see citing works

Cells in regions of rhesus monkey brain and pituitary retain radioactive estradiol, corticosterone and cortisol differentially

Gerlach, J. L., McEwen, B. S., Pfaff, D. W., Moskovitz, S., Ferin, M., Carmel, P. W., & Zimmerman, E. A. (1976) · Brain Research · doi:10.1016/0006-8993(76)90463-7 · Cited by 81 · see citing works

GABAergic neurons in the rat hippocampal formation: ultrastructure and synaptic relationships with catecholaminergic terminals

Milner, T. A., & Bacon, C. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-10-03410.1989 · Cited by 80 · see citing works

Ultrastructural localization of extranuclear progestin receptors in the rat hippocampal formation

Waters, E. M., Torres-Reverón, A., McEwen, B. S., & Milner, T. A. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21826 · Cited by 77 · see citing works

Extranuclear estrogen receptor beta immunoreactivity is on doublecortin-containing cells in the adult and neonatal rat dentate gyrus

Herrick, S. P., Waters, E. M., Drake, C. T., McEwen, B. S., & Milner, T. A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.084 · Cited by 77 · see citing works

Multivariate revisit to “sex beyond the genitalia”

Rosenblatt, J. D. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523961113 · Cited by 77 · see citing works

Sex steroids and the dentate gyrus

Hajszán, T., Milner, T. A., & Leranth, C. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63023-4 · Cited by 73 · see citing works

Mu opioid receptors are associated with the induction of hippocampal mossy fiber long-term potentiation.

Derrick, B. E., Rodriguez, S. B., Lieberman, D. N., & Martinez, J. L. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10407-2 · Cited by 73 · see citing works

Hormonal Activation of the Striatum and the Nucleus Accumbens Modulates Paced Mating Behavior in the Female Rat

Li, X., & Becker, J. B. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1412 · Cited by 70 · see citing works

Signaling pathways mediating the neuroprotective effects of sex steroids and SERMs in Parkinson’s disease

Bourque, M., Dluzen, D. E., & Paolo, T. D. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.02.003 · Cited by 69 · see citing works

Opioid Receptor-Dependent Sex Differences in Synaptic Plasticity in the Hippocampal Mossy Fiber Pathway of the Adult Rat

Harte‐Hargrove, L. C., Varga-Wesson, A., Duffy, Á., Milner, T. A., & Scharfman, H. E. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0820-14.2015 · Cited by 63 · see citing works

Stress differentially alters mu opioid receptor density and trafficking in parvalbumin‐containing interneurons in the female and male rat hippocampus

Milner, T. A., Burstein, S. R., Marrone, G. F., Khalid, S., Gonzalez, A. D., Williams, T. J., Schierberl, K. C., Torres-Reverón, A., Gonzales, K. L., McEwen, B. S., et al. (2013) · Synapse · doi:10.1002/syn.21683 · Cited by 60 · see citing works

Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors

MacLusky, N. J., Hajszán, T., Johansen, J. A., Jordan, C. L., & Leranth, C. (2006) · Endocrinology · doi:10.1210/en.2005-0673 · Cited by 60 · see citing works

Association of 3H Corticosterone-1,2 with Macromolecules extracted from Brain Cell Nuclei

McEwen, B. S., & Plapinger, L. (1970) · Nature · doi:10.1038/226263a0 · Cited by 59 · see citing works

A trip down memory lane about sex differences in the brain

Shors, T. J. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0124 · Cited by 59 · see citing works

Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons

Wang, G., Coleman, C. G., Chan, J., Faraco, G., Marques-Lopes, J., Milner, T. A., Guruju, M. R., Anrather, J., Davisson, R. L., Iadecola, C., et al. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00367.2012 · Cited by 58 · see citing works

Nuclear and Extranuclear Estrogen Binding Sites in the Rat Forebrain and Autonomic Medullary Areas

Milner, T. A., Lubbers, L. S., Alves, S. E., & McEwen, B. S. (2008) · Endocrinology · doi:10.1210/en.2008-0307 · Cited by 57 · see citing works

Estrogen increases axodendritic synapses in the VMN of rats after ovariectomy

Frankfurt, M., & McEwen, B. S. (1991) · Neuroreport · doi:10.1097/00001756-199107000-00006 · Cited by 55 · see citing works

LIM kinase mediates estrogen action on the actin depolymerization factor Cofilin

Yuen, G. S., McEwen, B. S., & Akama, K. T. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.067 · Cited by 54 · see citing works

Ultrastructural heterogeneity of enkephalin‐containing terminals in the rat hippocampal formation

Commons, K. G., & Milner, T. A. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903580303 · Cited by 53 · see citing works

Joel et al.'s method systematically fails to detect large, consistent sex differences

Giudice, M. D., Lippa, R. A., Puts, D. A., Bailey, D. H., Bailey, J. M., & Schmitt, D. P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525534113 · Cited by 53 · see citing works

Changes in interneuronal phenotypes regulated by estradiol in the adult rat hippocampus: A potential role for neuropeptide Y

Nakamura, N. H., & McEwen, B. S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.056 · Cited by 51 · see citing works

Ovarian steroids alter mu opioid receptor trafficking in hippocampal parvalbumin GABAergic interneurons

Torres-Reverón, A., Williams, T. J., Chapleau, J. D., Waters, E. M., McEwen, B. S., Drake, C. T., & Milner, T. A. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.06.001 · Cited by 49 · see citing works

Implications of CA3 NMDA and opiate receptors for spatial pattern completion in rats

Kesner, R. P., & Warthen, D. K. (2009) · Hippocampus · doi:10.1002/hipo.20676 · Cited by 46 · see citing works

Dihydrotestosterone Increases Hippocampal N-Methyl-d-Aspartate Binding But Does Not Affect Choline Acetyltransferase Cell Number in the Forebrain or Choline Transporter Levels in the CA1 Region of Adult Male Rats

Romeo, R. D., Staub, D. R., Jasnow, A. M., Karatsoreos, I. N., Thornton, J. E., & McEwen, B. S. (2005) · Endocrinology · doi:10.1210/en.2004-0886 · Cited by 46 · see citing works

Hormonal regulation of delta opioid receptor immunoreactivity in interneurons and pyramidal cells in the rat hippocampus

Williams, T. J., Torres-Reverón, A., Chapleau, J. D., & Milner, T. A. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.01.002 · Cited by 46 · see citing works

Characterization of Neural Estrogen Signaling and Neurotrophic Changes in the Accelerated Ovarian Failure Mouse Model of Menopause

Kempen, T. A. V., Gorecka, J., Gonzalez, A. D., Soeda, F., Milner, T. A., & Waters, E. M. (2014) · Endocrinology · doi:10.1210/en.2014-1190 · Cited by 46 · see citing works

NMDA Receptor Plasticity in the Hypothalamic Paraventricular Nucleus Contributes to the Elevated Blood Pressure Produced by Angiotensin II

Glass, M. J., Wang, G., Coleman, C. G., Chan, J., Ogorodnik, E., Kempen, T. A. V., Milner, T. A., Butler, S. D., Young, C. N., Davisson, R. L., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2301-14.2015 · Cited by 45 · see citing works

Yes! Sex Matters: Sex, the Brain and Blood Pressure

Hay, M., Xue, B., & Johnson, A. K. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0458-4 · Cited by 45 · see citing works

Membrane Trafficking of NADPH Oxidase p47phoxin Paraventricular Hypothalamic Neurons Parallels Local Free Radical Production in Angiotensin II Slow-Pressor Hypertension

Coleman, C. G., Wang, G., Faraco, G., Marques-Lopes, J., Waters, E. M., Milner, T. A., Iadecola, C., & Pickel, V. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3061-12.2013 · Cited by 43 · see citing works

Hippocampal dynorphin immunoreactivity increases in response to gonadal steroids and is positioned for direct modulation by ovarian steroid receptors

Torres-Reverón, A., Khalid, S., Williams, T. J., Waters, E. M., Jacome, L. F., Luine, V. N., Drake, C. T., McEwen, B. S., & Milner, T. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.023 · Cited by 42 · see citing works

Slow‐pressor angiotensin II hypertension and concomitant dendritic NMDA receptor trafficking in estrogen receptor β–containing neurons of the mouse hypothalamic paraventricular nucleus are sex and age dependent

Marques-Lopes, J., Kempen, T. A. V., Waters, E. M., Pickel, V. M., Iadecola, C., & Milner, T. A. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23569 · Cited by 40 · see citing works

Reproductive aging, menopause, and health outcomes

Pinkerton, J. V., & Stovall, D. W. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05526.x · Cited by 37 · see citing works

Hippocampal mossy fiber leu-enkephalin immunoreactivity in female rats is significantly altered following both acute and chronic stress

Pierce, J. P., Kelter, D. T., McEwen, B. S., Waters, E. M., & Milner, T. A. (2013) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2013.10.004 · Cited by 36 · see citing works

Sex and Age Result in Differential Regulation of the Renal Thiazide-Sensitive NaCl Cotransporter and the Epithelial Sodium Channel in Angiotensin II-Infused Mice

Tiwari, S., Li, L., Riazi, S., Halagappa, V. K. M., & ECELBARGER, C. A. (2009) · American Journal of Nephrology · doi:10.1159/000252776 · Cited by 35 · see citing works

Ovarian steroids modulate leu-enkephalin levels and target leu-enkephalinergic profiles in the female hippocampal mossy fiber pathway

Torres-Reverón, A., Khalid, S., Williams, T. J., Waters, E. M., Drake, C. T., McEwen, B. S., & Milner, T. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.058 · Cited by 33 · see citing works

Female protection from slow‐pressor effects of angiotensin II involves prevention of ROS production independent of NMDA receptor trafficking in hypothalamic neurons expressing angiotensin 1A receptors

Marques-Lopes, J., Lynch, M., Kempen, T. A. V., Waters, E. M., Wang, G., Iadecola, C., Pickel, V. M., & Milner, T. A. (2015) · Synapse · doi:10.1002/syn.21800 · Cited by 32 · see citing works

Redistribution of NMDA Receptors in Estrogen-Receptor-β-Containing Paraventricular Hypothalamic Neurons following Slow-Pressor Angiotensin II Hypertension in Female Mice with Accelerated Ovarian Failure

Marques-Lopes, J., Tesfaye, E., Israilov, S., Kempen, T. A. V., Wang, G., Glass, M. J., Pickel, V. M., Iadecola, C., Waters, E. M., & Milner, T. A. (2016) · Neuroendocrinology · doi:10.1159/000446073 · Cited by 29 · see citing works

On the mis-presentation and misinterpretation of gender-related data: The case of Ingalhalikar’s human connectome study

Joel, D., & Tarrasch, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323319111 · Cited by 28 · see citing works

More than a feeling: A unified view of stress measurement for population science

Epel, E. S., Crosswell, A. D., Mayer, S. E., Prather, A. A., Slavich, G. M., Puterman, E., & Mendes, W. B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.03.001 · Cited by 1,077 · see citing works

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments

Duman, R. S., Sanacora, G., & Krystal, J. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.013 · Cited by 1,026 · see citing works

Sex Differences in the Adult Human Brain: Evidence from 5216 UK Biobank Participants

Ritchie, S. J., Cox, S. R., Shen, X., Lombardo, M. V., Reus, L. M., Alloza, C., Harris, M. A., Alderson, H. L., Hunter, S., Neilson, E., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy109 · Cited by 855 · see citing works

Treatment resistant depression: A multi-scale, systems biology approach

Akil, H., Gordon, J. A., Hen, R., Javitch, J. A., Mayberg, H. S., McEwen, B. S., Meaney, M. J., & Nestler, E. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.019 · Cited by 443 · see citing works

Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair

Zárate, S., Stevnsner, T., & Gredilla, R. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00430 · Cited by 286 · see citing works

Sex differences and the neurobiology of affective disorders

Rubinow, D. R., & Schmidt, P. J. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0148-z · Cited by 274 · see citing works

Sex in the brain: hormones and sex differences

Marrocco, J., & McEwen, B. S. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.4/jmarrocco · Cited by 235 · see citing works

Sex and gender differences in schizophrenic psychoses—a critical review

Riecher‐Rössler, A., Butler, S., & Kulkarni, J. (2018) · Archives of Women s Mental Health · doi:10.1007/s00737-018-0847-9 · Cited by 229 · see citing works

Neuroanatomy and function of human sexual behavior: A neglected or unknown issue?

Calabrò, R. S., Cacciola, A., Bruschetta, D., Milardi, D., Quattrini, F., Sciarrone, F., Rosa, G. L., Bramanti, P., & Anastasi, G. (2019) · Brain and Behavior · doi:10.1002/brb3.1389 · Cited by 208 · see citing works

Sex: A Significant Risk Factor for Neurodevelopmental and Neurodegenerative Disorders

Pinares-Garcia, P., Stratikopoulos, M., Zagato, A., Loke, H., & Lee, J. (2018) · Brain Sciences · doi:10.3390/brainsci8080154 · Cited by 200 · see citing works

You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan

Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200 · see citing works

The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders

Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00540-x · Cited by 197 · see citing works

Women and Suicidal Behavior

Canetto, S. S., & Chen, J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108561716.042 · Cited by 194 · see citing works

Steroid Transport, Local Synthesis, and Signaling within the Brain: Roles in Neurogenesis, Neuroprotection, and Sexual Behaviors

Diotel, N., Charlier, T. D., d’Hellencourt, C. L., Couret, D., Trudeau, V. L., Cano‐Nicolau, J., Meilhac, O., Kah, O., & Pellegrini, E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00084 · Cited by 189 · see citing works

Sex differences in neural stress responses and correlation with subjective stress and stress regulation

Goldfarb, E. V., Seo, D., & Sinha, R. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100177 · Cited by 155 · see citing works

Problems and Progress regarding Sex Bias and Omission in Neuroscience Research

Will, T., Proaño, S. B., Thomas, A. M., Kunz, L. M., Thompson, K. C., Ginnari, L. A., Jones, C. H., Lucas, S.-C., Reavis, E. M., Dorris, D. M., et al. (2017) · eNeuro · doi:10.1523/eneuro.0278-17.2017 · Cited by 154 · see citing works

Zebrafish Models of Neurodevelopmental Disorders: Limitations and Benefits of Current Tools and Techniques

Vaz, R., Hofmeister, W., & Lindstrand, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061296 · Cited by 143 · see citing works

Beyond the binary: Rethinking sex and the brain

Joel, D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.018 · Cited by 140 · see citing works

Sex bias and omission in neuroscience research is influenced by research model and journal, but not reported NIH funding

Mamlouk, G. M., Dorris, D. M., Barrett, L. R., & Meitzen, J. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100835 · Cited by 131 · see citing works

Redefining neuroendocrinology: Epigenetics of brain-body communication over the life course

McEwen, B. S. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.11.001 · Cited by 129 · see citing works

Sex and gender differences in pain: past, present, and future

Keogh, E. (2022) · Pain · doi:10.1097/j.pain.0000000000002738 · Cited by 133 · see citing works

Supporting sexuality and improving sexual function in transgender persons

Holmberg, M., Arver, S., & Dhejne, C. (2018) · Nature Reviews Urology · doi:10.1038/s41585-018-0108-8 · Cited by 126 · see citing works

The neuroscience of sadness: A multidisciplinary synthesis and collaborative review

Arias-López, J. A., Williams, C., Raghvani, R., Aghajani, M., Báez, S., Belzung, C., Booij, L., Busatto, G. F., Chiarella, J., Fu, C. H. Y., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.006 · Cited by 132 · see citing works

Sex Differences in Animal Models of Traumatic Brain Injury

Rubin, T. G., & Lipton, M. L. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519844020 · Cited by 117 · see citing works

Schizophrenia and Sex Hormones: What Is the Link?

Brzezinski‐Sinai, N. A., & Brzezinski, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00693 · Cited by 116 · see citing works

Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders

Ullah, M. F., Ahmad, A., Bhat, S. H., Abuduhier, F. M., Barreto, G. E., & Ashraf, G. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.003 · Cited by 113 · see citing works

Ovarian hormones: a long overlooked but critical contributor to cognitive brain structures and function

Beltz, A., & Moser, J. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14255 · Cited by 98 · see citing works

Endocrine-disrupting chemicals and child health

Ghassabian, A., Vandenberg, L., Kannan, K., & Trasande, L. (2022) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-021921-093352 · Cited by 112 · see citing works

Association of chronic diseases with depression, anxiety and stress in Chinese general population: The CHCN-BTH cohort study

Liu, X., Cao, H., Zhu, H., Zhang, H., Niu, K., Tang, N., Cui, Z. Q., Pan, L., Yao, C., Gao, Q., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.01.040 · Cited by 109 · see citing works

Estrogen receptor α drives pro-resilient transcription in mouse models of depression

Lorsch, Z. S., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Parise, E. M., Salery, M., Cahill, M. E., Hodes, G. E., Pfau, M. L., Kronman, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03567-4 · Cited by 104 · see citing works

Estrogens in schizophrenia: progress, current challenges and opportunities

Brand, B. A., de Boer, J. N., & Sommer, I. E. (2021) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000699 · Cited by 103 · see citing works

Psychobiological risk factors for suicidal thoughts and behaviors in adolescence: a consideration of the role of puberty

Ho, T. C., Gifuni, A. J., & Gotlib, I. H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01171-5 · Cited by 100 · see citing works

Sex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD

Lawrence, K. E., Hernandez, L. M., Bowman, H. C., Padgaonkar, N. T., Fuster, E., Jack, A., Aylward, E., Gaab, N., Horn, J. D. V., Bernier, R., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa105 · Cited by 93 · see citing works

Depressive symptoms and their association with social determinants and chronic diseases in middle-aged and elderly Chinese people

Liu, Q., Cai, H., Yang, L. H., Xiang, Y.-B., Yang, G., Li, H., Gao, Y.-T., Zheng, W., Susser, E., & Shu, X. (2018) · Scientific Reports · doi:10.1038/s41598-018-22175-2 · Cited by 87 · see citing works

Estrogens and SERMS as adjunctive treatments for schizophrenia

Kulkarni, J., Butler, S., & Riecher‐Rössler, A. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.03.002 · Cited by 88 · see citing works

Sex differences in the blood–brain barrier: Implications for mental health

Dion‐Albert, L., Binder, L. B., Daigle, B., Hong-Minh, A., Lebel, M., & Ménard, C. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100989 · Cited by 89 · see citing works

A systematic review of psychosocial functioning changes after gender-affirming hormone therapy among transgender people

Doyle, D. M., Lewis, T. O. G., & Barreto, M. (2023) · Nature Human Behaviour · doi:10.1038/s41562-023-01605-w · Cited by 95 · see citing works

Sex Differences in the Development of the Rodent Corticolimbic System

Premachandran, H., Zhao, M., & Arruda-Carvalho, M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.583477 · Cited by 89 · see citing works

Protective effects of estrogen against cardiovascular disease mediated via oxidative stress in the brain

Lagranha, C. J., Silva, T. L. A., Silva, S. C. A., Braz, G. R. F., da Silva, A. I., Fernandes, M. P., & Sellitti, D. F. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.11.043 · Cited by 88 · see citing works

Sex differences in behavior and neuropharmacology of zebrafish

Genário, R., de Abreu, M. S., Giacomini, A. C. V. V., Demin, K. A., & Kalueff, A. V. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14438 · Cited by 83 · see citing works

Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER–ERK–NF-κB signaling pathway

Yu, Z., Su, G., Zhang, L., Liu, G., Zhou, Y., Fang, S., Zhang, Q., Wang, T., Huang, C., Huang, Z., et al. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00573-7 · Cited by 80 · see citing works

Sex differences in pain along the neuraxis

Presto, P., Mazzitelli, M., Junell, R., Griffin, Z., & Neugebauer, V. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109030 · Cited by 79 · see citing works

On the role of sex steroids in biological functions by classical and non-classical pathways. An update

Pillerová, M., Borbélyová, V., Hodosy, J., RILJAK, V., Renczés, E., Frick, K. M., & Tóthová, Ľ. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100926 · Cited by 78 · see citing works

Neuroimaging premenstrual dysphoric disorder: A systematic and critical review

Dubol, M., Epperson, C. N., Lanzenberger, R. R., Poromaa, I. S., & Comasco, E. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100838 · Cited by 77 · see citing works

Sex/gender differences in cognitive abilities

Kheloui, S., Jacmin-Park, S., Larocque, O., Kerr, P., Rossi, M., Cartier, L., & Juster, R.-P. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105333 · Cited by 78 · see citing works

The Impact of Traumatic Brain Injury on Later Life: Effects on Normal Aging and Neurodegenerative Diseases

Griesbach, G. S., Masel, B. E., Helvie, R. E., & Ashley, M. J. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5103 · Cited by 77 · see citing works

Enhancing precision in human neuroscience

Nebe, S., Reutter, M., Baker, D. H., Bölte, J., Domes, G., Gamer, M., Gärtner, A., Gießing, C., Gurr, C., Hilger, K., et al. (2023) · eLife · doi:10.7554/elife.85980 · Cited by 75 · see citing works

Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain

Dedek, A., Xu, J., Lorenzo, L.-É., Godin, A. G., Kandegedara, C. M., Glavina, G., Landrigan, J., Lombroso, P. J., Koninck, Y. D., Tsai, E. C., et al. (2021) · Brain · doi:10.1093/brain/awab408 · Cited by 74 · see citing works

Sex differences in pain responses

Sorge, R. E., & Strath, L. J. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.05.006 · Cited by 73 · see citing works

Adolescent maturation of the prefrontal cortex: Role of stress and sex in shaping adult risk for compromise

Shaw, G. A., Dupree, J. L., & Neigh, G. N. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12626 · Cited by 74 · see citing works

A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice

Marrocco, J., Petty, G. H., Ríos, M. B., Gray, J. D., Kogan, J. F., Waters, E. M., Schmidt, E. F., Lee, F. S., & McEwen, B. S. (2017) · Nature Communications · doi:10.1038/s41467-017-01014-4 · Cited by 69 · see citing works

Various Aspects of Sex and Gender Bias in Biomedical Research

Plevková, J., Brozmanová, M., Harsányiová, J., Sterusky, M., Honetschlager, J., & Buday, T. (2021) · Physiological Research · doi:10.33549/physiolres.934593 · Cited by 73 · see citing works

Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disease

Jett, S., Schelbaum, E., Jang, G., Yepez, C. B., Dyke, J., Pahlajani, S., Brinton, R. D., & Mosconi, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.948219 · Cited by 63 · see citing works

Network-specific sex differentiation of intrinsic brain function in males with autism

Floris, D. L., Lai, M., Nath, T., Milham, M. P., & Martino, A. D. (2018) · Molecular Autism · doi:10.1186/s13229-018-0192-x · Cited by 61 · see citing works

The Complex Relationships between Sex and the Brain

Joel, D., Garcı́a-Falgueras, A., & Swaab, D. F. (2019) · The Neuroscientist · doi:10.1177/1073858419867298 · Cited by 66 · see citing works

Hormones of the hypothalamic-pituitary-gonadal (HPG) axis in male depressive disorders – A systematic review and meta-analysis

Fischer, S., Ehlert, U., & Castro, R. T. A. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100792 · Cited by 66 · see citing works

Human menstrual cycle variation in subcortical functional brain connectivity: a multimodal analysis approach

Hidalgo‐Lopez, E., Mueller, K., Harris, T., Aichhorn, M., Sacher, J., & Pletzer, B. A. (2020) · Brain Structure and Function · doi:10.1007/s00429-019-02019-z · Cited by 68 · see citing works

Where Sex Meets Gender: How Sex and Gender Come Together to Cause Sex Differences in Mental Illness

Christiansen, D. M., McCarthy, M. M., & Seeman, M. V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.856436 · Cited by 65 · see citing works

Estrous Cycle Mediates Midbrain Neuron Excitability Altering Social Behavior upon Stress

Shanley, M. R., Miura, Y., Guevara, C. A., Onoichenco, A., Kore, R., Ustundag, E., Darwish, R., Renzoni, L., Sanchez, A. M. S., Blicker, E., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1504-22.2022 · Cited by 63 · see citing works

Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery

Konings, G. F. J., Brentjens, L. S., Delvoux, B., Linnanen, T., Cornel, K. M. C., Koskimies, P., Bongers, M. Y., Kruitwagen, R. F. P. M., Xanthoulea, S., & Romano, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00940 · Cited by 65 · see citing works

Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice

Giannetto, M. J., Xia, M., Stæger, F. F., Metcalfe, T., Vinitsky, H. S., Dang, J. A. M. L., Xavier, A. L. R., Kress, B. T., Nedergaard, M., & Hablitz, L. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-72621-3 · Cited by 61 · see citing works

Sex steroids and neurogenesis

Heberden, C. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.05.019 · Cited by 62 · see citing works

Ovarian hormones, sleep and cognition across the adult female lifespan: An integrated perspective

Gervais, N. J., Mong, J. A., & Agnès Lacreuse, A. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.08.002 · Cited by 57 · see citing works

Sex Differences in Medium Spiny Neuron Excitability and Glutamatergic Synaptic Input: Heterogeneity Across Striatal Regions and Evidence for Estradiol-Dependent Sexual Differentiation

Cao, J., Willett, J. A., Dorris, D. M., & Meitzen, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00173 · Cited by 57 · see citing works

Extrinsic neuromodulation in the rodent olfactory bulb

Brunert, D., & Rothermel, M. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03365-9 · Cited by 53 · see citing works

Sex Differences in Rat Intervertebral Disc Structure and Function Following Annular Puncture Injury

Mosley, G. E., Hoy, R. C., Nasser, P. R., Kaseta, T., Lai, A., Evashwick‐Rogler, T. W., Lee, M., & Iatridis, J. C. (2019) · Spine · doi:10.1097/brs.0000000000003055 · Cited by 54 · see citing works

The gender context of pain

Keogh, E. (2020) · Health Psychology Review · doi:10.1080/17437199.2020.1813602 · Cited by 54 · see citing works

Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor

Abi‐Ghanem, C., Degerny, C., Hussain, R., Lière, P., Pianos, A., Tourpin, S., Habert, R., Macklin, W. B., Schumacher, M., & Ghoumari, A. M. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007049 · Cited by 52 · see citing works

Spectral dynamic causal modelling in healthy women reveals brain connectivity changes along the menstrual cycle

Hidalgo‐Lopez, E., Zeidman, P., Harris, T., Razi, A., & Pletzer, B. A. (2021) · Communications Biology · doi:10.1038/s42003-021-02447-w · Cited by 51 · see citing works

Exploring sex differences: insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology

Lafta, M. S., Mwinyi, J., Affatato, O., Rukh, G., Dang, J., Andersson, G., & Schiöth, H. B. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1340108 · Cited by 62 · see citing works

Androgens modulate chronic intermittent hypoxia effects on brain and behavior

Snyder, B., Duong, P., Trieu, J., & Cunningham, R. L. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.09.005 · Cited by 48 · see citing works

Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease

Ruszkiewicz, J. A., Miranda‐Vizuete, A., Tinkov, A. A., Геннадиевна, С. М., Skalny, A. V., Tsatsakis, A. M., & Aschner, M. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1241-9 · Cited by 47 · see citing works

Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice

Zhao, Y., Li, H., Zhang, Y., Zhao, J., Liu, Z., Xing, F., Liu, M., Feng, Z., Li, W., & Zhang, J. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.08.003 · Cited by 47 · see citing works

The effect of APOE genotype on Alzheimer's disease risk is influenced by sex and docosahexaenoic acid status

Pontifex, M. G., Vauzour, D., & Minihane, A. M. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.05.017 · Cited by 46 · see citing works

Women's reproductive mental health: currently available evidence and future directions for research, clinical practice and health policy

Howard, L. M., Wilson, C. A., Reilly, T. J., Moss, K. M., Mishra, G. D., Coupland‐Smith, E., Riecher‐Rössler, A., Seedat, S., Smith, S. M., Steinberg, J. R., et al. (2025) · World Psychiatry · doi:10.1002/wps.21305 · Cited by 56 · see citing works

Female psychopharmacology matters! Towards a sex-specific psychopharmacology

Bolea-Alamanac, B. M., Bailey, S., Lovick, T. A., Scheele, D., & Valentino, R. J. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117747578 · Cited by 44 · see citing works

Contribution of AMPA Receptor-Mediated LTD in LA/BLA-CeA Pathway to Comorbid Aversive and Depressive Symptoms in Neuropathic Pain

Jiang, H., Liu, J., Xi, K., Liu, L., Kong, L.-Y., Cai, J., Cai, S.-Q., Han, X.-Y., Song, J., Yang, X., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2678-20.2021 · Cited by 43 · see citing works

The Effects of Chronic Stress on Migraine Relevant Phenotypes in Male Mice

Kaufmann, D., & Brennan, K. C. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00294 · Cited by 42 · see citing works

The Modulating Role of Sex and Anabolic-Androgenic Steroid Hormones in Cannabinoid Sensitivity

Struik, D., Sanna, F., & Fattore, L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00249 · Cited by 42 · see citing works

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Marongiu, R. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00242 · Cited by 44 · see citing works

Resilience, pain, and the brain: Relationships differ by sociodemographics

Tanner, J. J., Johnson, A. J., Terry, E. L., Cardoso, J. S., GARVAN, C. W., Staud, R. M., DEUTSCH, G., Deshpande, H., Lai, S., Addison, A., et al. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24790 · Cited by 42 · see citing works

High-amplitude network co-fluctuations linked to variation in hormone concentrations over the menstrual cycle

Greenwell, S. A., Faskowitz, J., Pritschet, L., Santander, T., Jacobs, E. G., & Betzel, R. F. (2023) · Network Neuroscience · doi:10.1162/netn_a_00307 · Cited by 43 · see citing works

Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function

Poley, M., Chen, G., Sharf‐Pauker, N., Avital, A., Kaduri, M., Sela, M., Mora‐Raimundo, P., Koren, L., Arber, S., Egorov, E., et al. (2022) · Advanced NanoBiomed Research · doi:10.1002/anbr.202200089 · Cited by 41 · see citing works

Sex-Specific Associations Between Chemotherapy, Chronic Conditions, and Neurocognitive Impairment in Acute Lymphoblastic Leukemia Survivors: A Report From the Childhood Cancer Survivor Study

van der Plas, E. A. A., Qiu, W., Nieman, B. J., Yasui, Y., Liu, Q., Dixon, S. B., Kadan‐Lottick, N. S., Weldon, C. B., Weil, B. R., Jacola, L. M., et al. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa136 · Cited by 41 · see citing works

The association between single and multiple chronic conditions and depression among older population in India: A comparative study between men and women

Meher, T., Muhammad, T., & Gharge, S. (2021) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5639 · Cited by 41 · see citing works

Contribution of stress and sex hormones to memory encoding

Merz, C. J. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.05.002 · Cited by 39 · see citing works

Sex Hormones, Sleep, and Memory: Interrelationships Across the Adult Female Lifespan

Harrington, Y. A., Parisi, J. M., Duan, D., Rojo‐Wissar, D. M., Holingue, C., & Spira, A. P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.800278 · Cited by 38 · see citing works

Sex-specific Effects of Endocrine-disrupting Chemicals on Brain Monoamines and Cognitive Behavior

Hilz, E. N., & Gore, A. C. (2022) · Endocrinology · doi:10.1210/endocr/bqac128 · Cited by 38 · see citing works

Changes in neurocognitive function and central nervous system structure in childhood acute lymphoblastic leukaemia survivors after treatment: a meta‐analysis

Zhou, C., Zhuang, Y., Lin, X., Michelson, A. D., & Zhang, A. (2019) · British Journal of Haematology · doi:10.1111/bjh.16279 · Cited by 37 · see citing works

Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease

Carreras, I., Aytan, N., Mellott, T. J., Choi, J., Lehar, M., Crabtree, L., Leite‐Morris, K. A., Jenkins, B. G., Blusztajn, J. K., & Dedeoglu, A. (2017) · Brain Research · doi:10.1016/j.brainres.2017.12.030 · Cited by 36 · see citing works

Modulation of CA2 neuronal activity increases behavioral responses to fear conditioning in female mice

Alexander, G. M., Riddick, N. V., McCann, K. E., Lustberg, D. J., Moy, S. S., & Dudek, S. M. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107044 · Cited by 33 · see citing works

Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain

Distler, U., Schumann, S., Kesseler, H.-G., Pielot, R., Smalla, K., Sielaff, M., Schmeißer, M. J., & Tenzer, S. (2020) · Cells · doi:10.3390/cells9020313 · Cited by 35 · see citing works

Life negative events and depressive symptoms: the China longitudinal ageing social survey

Wang, Z., Yang, H., Zheng, P., Liu, B., Guo, Z., Geng, S., & Hong, S. (2020) · BMC Public Health · doi:10.1186/s12889-020-09119-0 · Cited by 37 · see citing works

Molecular and Structural Evolution of Cytochrome P450 Aromatase

Nardo, G. D., Zhang, C., Marcelli, A. G., & Gilardi, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020631 · Cited by 36 · see citing works

Sex-specific alterations of cortical morphometry in treatment-naïve patients with major depressive disorder

Hu, X., Zhang, L., Liang, K., Cao, L., Liu, J., Li, H., Gao, Y., Hu, X., Hu, Y., Kuang, W., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01252-7 · Cited by 36 · see citing works

Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventions

Pallier, P. N., Ferrara, M., Romagnolo, F., Ferretti, M. T., Soreq, H., & Cerase, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102353 · Cited by 35 · see citing works

Brain-derived neurotrophic factor (BDNF) in perinatal depression: Side show or pivotal factor?

Singh, S., Fereshetyan, K., Shorter, S. A., Paliokha, R., Dremencov, E., Yenkoyan, K. B., & Ovsepian, S. V. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103467 · Cited by 36 · see citing works

The Human Brain Is Best Described as Being on a Female/Male Continuum: Evidence from a Neuroimaging Connectivity Study

Zhang, Y., Luo, Q., Huang, C., Lo, C. Z., Langley, C., Desrivières, S., Quinlan, E. B., Banaschewski, T., Millenet, S., Bokde, A. L. W., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa408 · Cited by 36 · see citing works

Sex differences in type and occurrence of adverse reactions to opioid analgesics: a retrospective cohort study

Lopes, G. S., Bielinski, S. J., Moyer, A. M., Jacobson, D. J., Wang, L., Jiang, R., Larson, N. B., Miller, V. M., Zhu, Y., Cavanaugh, D. C., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-044157 · Cited by 35 · see citing works

Comparison of kainate-induced seizures, cognitive impairment and hippocampal damage in male and female mice

Li, F., & Liu, L. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116621 · Cited by 33 · see citing works

Sex in the brain: hormones and sex differences

Marrocco, J., & McEwen, B. S. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.4/jmarrocco · Cited by 235 · see citing works

Sex Hormone Control of Neurophysiology and Behavior

Sun, S. D., & Tollkühn, J. (2026) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102124-031128 · Cited by 4 · see citing works

Role of female gonadal hormones in the CNS: Clinical and experimental aspects

Maggi, A. C., & Pérez, J. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90525-9 · Cited by 165 · see citing works

Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods

Barth, C., Villringer, A., & Sacher, J. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00037 · Cited by 731 · see citing works

Sex Differences in Brain Function

McCarthy, M. (2010) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0022344 · Cited by 3 · see citing works