Cited by 315Gut microbiota and healthGastrointestinal motility and disordersInfant Nutrition and Health

Role of colonic short-chain fatty acid transport in diarrhea

Binder, Henry J.·2010·Annual Review of Physiology

Abstract

Short-chain fatty acids (SCFA) are the major anion in stool and are synthesized from nonabsorbed carbohydrate by the colonic microbiota. Nonabsorbed carbohydrate are not absorbed in the colon and induce an osmotically mediated diarrhea; in contrast, SCFA are absorbed by colonic epithelial cells and stimulate Na-dependent fluid absorption via a cyclic AMP–independent process involving apical membrane Na-H, SCFA-HCO 3, and Cl-SCFA exchanges. SCFA production represents an adaptive process to conserve calories, fluid, and electrolytes. Inhibition of SCFA synthesis by antibiotics and administration of PEG, a substance that is not metabolized by colonic microbiota, both result in diarrhea. In contrast, increased production of SCFA as a result of providing starch that is relatively resistant to amylase digestion [so-called resistant starch (RS)] to oral rehydration solution (RS-ORS) improves the efficacy of ORS and represents an important approach to improve the effectiveness of ORS in the treatment of acute diarrhea in children under five years of age.

Integrity signals

Registry

Crossref · 10.1146/annurev-physiol-021909-135817

Cites

96 of 96 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • SGLT-1 is expressed primarily in the small intestine with highest density in the jejunum, followed by the duodenum and then the ileum.

    “SGLT-1 is expressed primarily in the small intestine with highest density in the jejunum followed by the duodenum and then ileum (39,40).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Binder, H. J.
Affiliations
Yale University (US)
Corresponding author
Binder, Henry J.
Venue
Annual Review of Physiology
Published
2010-03-17
Volume
72
Issue
1
Pages
297-313
ISSN
  • 0066-4278 (ISSN-L)
  • 1545-1585
OpenAlex
W2166520529
Cited by
315
References
96
Citations by year
2026: 14 · 2025: 22 · 2024: 28 · 2023: 22 · 2022: 27 · 2021: 29 · 2020: 19 · 2019: 27 · 2018: 23 · 2017: 17 · 2016: 20 · 2015: 13 · 2014: 11 · 2013: 19 · 2012: 11
FWCI
1.20
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords
short-chain fatty acids, osmotic diarrhea, colonic microbiota, resistant starch, oral rehydration solution, acute diarrhea in children, antibiotics, polyethylene glycol
MeSH terms
Cyclic AMP, Animals, Biological Transport, Active, Colon, Diarrhea, Fatty Acids, Volatile, Fluid Therapy, Humans, Intestinal Absorption, Osmotic Pressure, Sodium, Sodium-Hydrogen Exchangers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review