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Tumor Necrosis Factor, Other Cytokines and Disease

Tracey, Kevin J., Cerami, Anthony·1993·Annual Review of Cell Biology

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INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1 7 CYTOKINES AND EFFECTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1 8 Cell Sources and Stimuli . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1 8 Biosynthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 320 Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321 REGULA TORS AND EFFECTORS OF CYTOKINE EFFECTS . . . . . . . . . . . . 322 Factors that Enhance Effects of TNF . . . . . . . . . . . . . . . . . . . . . . . . . . . 322 Factors that Suppress Effects of TNF . . . . . . . . . . . . . . . . . . . . . . . . . . . 323 Secondary Mediators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325 Locations of Production in Tissues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 326 Development of Tolerance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327 CYTOKINES AND DISEASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329 Shock and Tissue Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329 Cachexia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 330 Insulin Resistance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 332 Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 332 Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 332 HlV Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 333 Adult Respiratory Distress Syndrome and Reperfusion Injury . . . . . . . . . . . . . 333 Diseases of Central Nervous System . . . . . . . . . . . . . . . . . . . . . . . . . . . . 334 FUTURE OF CYTOKINES IN THE BIOLOGY OF DISEASE . . . . . . . . . . . . . 335

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Authors: Tracey, K. J., & Cerami, A.
Venue: Annual Review of Cell Biology
Publisher: Annual Reviews
Published: 1993-11
Volume: 9
Issue: 1
Pages: 317-343
ISSN: 0743-4634 (ISSN-L)
DOI: 10.1146/annurev.cb.09.110193.001533
OpenAlex: W2129889907
Cited by: 783
References: 1
FWCI: 12.49
Type: journal article
Language: en
Open access: closed

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Tumor Necrosis Factor, Other Cytokines and Disease

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