Structure, Regulation and Function of NF-kappaB

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 4,979

Phosphorylation meets ubiquitination: the control of NF-κB activity

Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766

Ischemic Cell Death in Brain Neurons

Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043

CELLULAR RESPONSES TO INTERFERON-γ

Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890

NF-κB, the first quarter-century: remarkable progress and outstanding questions

Hayden, M. S., & Ghosh, S. (2012) · Genes & Development · doi:10.1101/gad.183434.111 · Cited by 1,693

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

Brown, K., Gerstberger, S., Carlson, L., Franzoso, G., & Siebenlist, U. (1995) · Science · doi:10.1126/science.7878466 · Cited by 1,434

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

Thanos, D., & Maniatis, T. (1995) · Cell · doi:10.1016/0092-8674(95)90136-1 · Cited by 1,014

Requirement for NF-κB in osteoclast and B-cell development

Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F., & Siebenlist, U. (1997) · Genes & Development · doi:10.1101/gad.11.24.3482 · Cited by 996

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

Belvin, M. P., & Anderson, K. V. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.393 · Cited by 836

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways

McKay, L. I., & Cidlowski, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0375 · Cited by 805

Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B

Wahl, C., Liptay, S., Adler, G., & Schmid, R. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci992 · Cited by 742

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

Didonato, J., Mercurio, F., Rosette, C., Wu-Li, J., Suyang, H., Ghosh, S., & Karin, M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1295 · Cited by 707

Transcriptional Cross Talk between NF-κB and p53

Webster, G. A., & Perkins, N. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3485 · Cited by 598

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

Salminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.09.002 · Cited by 581

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

Sizemore, N., Leung, S., & Stark, G. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4798 · Cited by 557

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

Perona, R., Montaner, S., Saniger, L., Sánchez-Pérez, I., Bravo, R., & Lacal, J. C. (1997) · Genes & Development · doi:10.1101/gad.11.4.463 · Cited by 519

Zinc deficiency, DNA damage and cancer risk

Ho, E. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.07.005 · Cited by 518

Increased NF-Κb Signalling Up-Regulates BACE1 Expression and its Therapeutic Potential in Alzheimer's Disease

Chen, C.-H., Zhou, W., Liu, S., Deng, Y., Cai, F., Tone, M., Tone, Y., Tong, Y., & Song, W. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000149 · Cited by 433

Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients

Rao, J. S., Harry, G. J., Rapoport, S. I., & Kim, H. W. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.47 · Cited by 432

Angiotensin II Induces Interleukin-6 Transcription in Vascular Smooth Muscle Cells Through Pleiotropic Activation of Nuclear Factor-κB Transcription Factors

Han, Y., Runge, M. S., & Brasier, A. R. (1999) · Circulation Research · doi:10.1161/01.res.84.6.695 · Cited by 377

Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease

Edwards, M. R., Bartlett, N. W., Clarke, D., Birrell, M., Belvisi, M., & Johnston, S. L. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.09.003 · Cited by 375

Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction

Schwandner, R., Yamaguchi, K., & Cao, Z. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.7.1233 · Cited by 349

An ancient system of host defense

Medzhitov, R., & Janeway, C. A. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80024-1 · Cited by 327

Zinc: Mechanisms of Host Defense1,

Prasad, A. S. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.5.1345 · Cited by 314

A Role of Poly (ADP-Ribose) Polymerase in NF- B Transcriptional Activation

Hassa, P. O., & Hottiger, M. O. (1999) · Biological Chemistry · doi:10.1515/bc.1999.118 · Cited by 296

Modulation of leukocyte–endothelial interactions by reactive metabolites of oxygen and nitrogen: relevance to ischemic heart disease

Grisham, M. B., Granger, D. N., & Lefer, D. J. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00094-x · Cited by 293

Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation.

Zhu, Z., Tang, W., Ray, A., Wu, Y., Einarsson, O., Landry, M. L., Gwaltney, J., & Elias, J. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118431 · Cited by 282

Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of IκBα in NF-κB activation by an oxidative stress

Schoonbroodt, S., Ferreira, V., Best-Belpomme, M., Boelaert, J. R., Legrand-Poels, S., Korner, M., & Piette, J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.8.4292 · Cited by 263

Role of transcription factors in mediating post-ischemic cerebral inflammation and brain damage

YI, J., PARK, S., KAPADIA, R., & VEMUGANTI, R. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.019 · Cited by 206

Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients

Bao, B., Prasad, A. S., Beck, F. W. J., Snell, D., Suneja, A., Sarkar, F. H., Doshi, N., Fitzgerald, J. T., & Swerdlow, P. (2008) · Translational Research · doi:10.1016/j.trsl.2008.06.001 · Cited by 187

Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-κB site

Azimi, N., Brown, K., Bamford, R. N., Tagaya, Y., Siebenlist, U., & Waldmann, T. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2452 · Cited by 181

Central role of transcription factor NF‐IL6 for cytokine and iron‐mediated regulation of murine inducible nitric oxide synthase expression

Dlaska, M., & Weiss, G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.10.6171 · Cited by 176

Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis

Campbell, I. K., Gerondakis, S., O’Donnell, K., & Wicks, I. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8298 · Cited by 168

NF-κB p50 and p52 Expression Is Not Required for RANK-Expressing Osteoclast Progenitor Formation but Is Essential for RANK- and Cytokine-Mediated Osteoclastogenesis

Xing, L., Bushnell, T. P., Carlson, L., Tai, Z., Tondravi, M., Siebenlist, U., Young, F., & Boyce, B. F. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.7.1200 · Cited by 165

HTLV Tax: A Fascinating Multifunctional Co-Regulator of Viral and Cellular Pathways

Currer, R., Van Duyne, R., Jaworski, E., Guendel, I., Sampey, G., Das, R., Narayanan, A., & Kashanchi, F. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00406 · Cited by 156

Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis

Kannian, P., & Green, P. L. (2010) · Viruses · doi:10.3390/v2092037 · Cited by 139

Age-related changes in the regulation of transcription factor NF-κB in rat brain

Korhonen, P., Helenius, M., & Salminen, A. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00190-0 · Cited by 138

DNA damage drives accelerated bone aging via an NF- κ B–dependent mechanism

Chen, Q., Liu, K., Robinson, A. R., Clauson, C. L., Blair, H. C., Robbins, P. D., Niedernhofer, L. J., & Ouyang, H. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1851 · Cited by 135

Methamphetamine potentiates HIV-1 Tat protein-mediated activation of redox-sensitive pathways in discrete regions of the brain

Flora, G., Lee, Y. W., Nath, A., Hennig, B., Maragos, W., & Toborek, M. (2003) · Experimental Neurology · doi:10.1006/exnr.2002.8048 · Cited by 99

Human T-lymphotropic virus type I tax activates I-κB kinase by inhibiting I-κB kinase-associated serine/threonine protein phosphatase 2A

Fu, D.-X., Kuo, Y.-L., Liu, B.-Y., Jeang, K.-T., & Giam, C.-Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210631200 · Cited by 95

Zinc activates NF-κB in HUT-78 cells

Prasad, A. S., Bao, B., Beck, F. W. J., & Sarkar, F. H. (2001) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2001.118108 · Cited by 94

Toll-like receptor family members in skin fibroblasts are functional and have a higher expression compared to skin keratinocytes

YAO, C., OH, J.-H., LEE, D. H., BAE, J.-S., JIN, C. L., PARK, C.-H., & CHUNG, J. H. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2146 · Cited by 90

Metformin inhibits nuclear factor κB activation and decreases serum high-sensitivity C-reactive protein level in experimental atherogenesis of rabbits

Li, S.-N., Wang, X., Zeng, Q.-T., Feng, Y.-B., Cheng, X., Mao, X.-B., Wang, T.-H., & Deng, H.-P. (2009) · Heart and Vessels · doi:10.1007/s00380-008-1137-7 · Cited by 88

Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model

St. Louis, D. C., Woodcock, J. B., Fransozo, G., Blair, P. J., Carlson, L. M., Murillo, M., Wells, M. R., Williams, A. J., Smoot, D. S., Kaushal, S., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3237 · Cited by 87

Selective Inhibition of NF-kB Activation and TNF-α Production in Macrophages by Red Blood Cell-Mediated Delivery of Dexamethasone

Crinelli, R., Antonelli, A., Bianchi, M., Gentilini, L., Scaramucci, S., & Magnani, M. (2000) · Blood Cells, Molecules, and Diseases · doi:10.1006/bcmd.2000.0298 · Cited by 84

Nuclear factor‐κB regulates seizure threshold and gene transcription following convulsant stimulation

Lubin, F. D., Ren, Y., Xu, X., & Anderson, A. E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04863.x · Cited by 75

NF-κB, inducible nitric oxide synthase and apoptosis by Helicobacter pylori infection

Lim, J. W., Kim, H., & Kim, K. H. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00592-5 · Cited by 74

Phorbol esters induce differentiation of human CD34+ hemopoietic progenitors to dendritic cells: Evidence for protein kinase C-mediated signaling

Davis, T. A., Saini, A. A., Blair, P. J., Levine, B. L., Craighead, N., Harlan, D. M., June, C. H., & Lee, K. P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.8.3689 · Cited by 70

Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-κB activation

Prasad, A. S., Bao, B., Beck, F. W. J., & Sarkar, F. H. (2002) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2002.127908 · Cited by 65

UVB-induced association of tumor necrosis factor (TNF) receptor 1/TNF receptor-associated factor-2 mediates activation of Rel proteins

Tobin, D., van Hogerlinden, M., & Toftgård, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.565 · Cited by 55

Mitochondrial-Derived Oxidants and Quartz Activation of Chemokine Gene Expression

Driscoll, K. E., Howard, B. W., Carter, J. M., Janssen, Y. M. W., Mossman, B. T., & Isfort, R. J. (2001) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4615-0667-6_74 · Cited by 41

Supplementation of N-Acetylcysteine Normalizes Lipopolysaccharide-Induced Nuclear Factor κB Activation and Proinflammatory Cytokine Production During Early Rehabilitation of Protein Malnourished Mice

Li, J., Quan, N., & Bray, T. M. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.11.3286 · Cited by 37

p38 mitogen-activated protein kinase-induced nuclear factor kappa-light-chain-enhancer of activated B cell activity is required for neuroprotection in retinal ischemia/reperfusion injury.

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Molecular modeling of the oxidized form of nuclear factor-κB suggests a mechanism for redox regulation of DNA binding and transcriptional activation

Chandrasekaran, V., & Taylor, E. W. (2008) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2007.05.007 · Cited by 11