Cited by 815Developmental Biology and Gene RegulationPluripotent Stem Cells ResearchRenal and related cancers

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Vertebrate Endoderm Development and Organ Formation

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Zorn, Aaron M., Wells, James M.·2009·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev.cellbio.042308.113344PMC PMC2861293

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Abstract

The endoderm germ layer contributes to the respiratory and gastrointestinal tracts and to all of their associated organs. Over the past decade, studies in vertebrate model organisms, including frog, fish, chick, and mouse, have greatly enhanced our understanding of the molecular basis of endoderm organ development. We review this progress with a focus on early stages of endoderm organogenesis including endoderm formation, gut tube morphogenesis and patterning, and organ specification. Lastly, we discuss how developmental mechanisms that regulate endoderm organogenesis are used to direct differentiation of embryonic stem cells into specific adult cell types, which function to alleviate disease symptoms in animal models.

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Wnt/β-Catenin Signaling in Development and Disease
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Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
D’Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O., Agulnick, A. D., Smart, N. G., Moorman, M. A., KROON, E. J., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,913
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Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843
Efficient differentiation of human embryonic stem cells to definitive endoderm
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Retinoic Acid Synthesis and Signaling during Early Organogenesis
Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098
Development of definitive endoderm from embryonic stem cells in culture
Kubo, A., Shinozaki, K., Shannon, J. M., Kouskoff, V., Kennedy, M., Woo, S. L. C., Fehling, H. J., & Keller, G. M. (2004) · Development · doi:10.1242/dev.01044 · Cited by 830
Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors
Jung, J., Zheng, M., Goldfarb, M., & Zaret, K. S. (1999) · Science · doi:10.1126/science.284.5422.1998 · Cited by 721
Depletion of definitive gut endoderm in Sox17 -null mutant mice
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Origin and organization of the zebrafish fate map
Kimmel, C. B., Warga, R. M., & Schilling, T. F. (1990) · Development · doi:10.1242/dev.108.4.581 · Cited by 698
FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak
Ciruna, B. G., & Rossant, J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00017-x · Cited by 695

Show all 180 references

Research works printed but not linked: 1

Fukuda-Taira S, 1981, J. Embryol. Exp. Morph., 63, 111

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Authors: Zorn, A. M., & Wells, J. M.
Affiliations: Cincinnati Children's Hospital Medical Center (US)
ORCID: Zorn, Aaron M.
Wells, James M.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2009-11-01
Volume: 25
Issue: 1
Pages: 221-251
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.042308.113344
PMC: PMC2861293
OpenAlex: W2137175341
Cited by: 812
References: 180
Citations by year: 2026: 35 · 2025: 51 · 2024: 49 · 2023: 45 · 2022: 64 · 2021: 64 · 2020: 56 · 2019: 57 · 2018: 58 · 2017: 52 · 2016: 52 · 2015: 39 · 2014: 41 · 2013: 49 · 2012: 46
FWCI: 2.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Child Health Research Foundation
National Institute of General Medical Sciences (R01GM072915)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080823, R01DK070858, R01DK092456)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Health Sciences › Medicine › Oncology › Renal and related cancers
Keywords: endoderm development, organogenesis, organ specifications, respiratory tract development, gastrointestinal tract development, embryonic stem cell differentiation, vertebrate model organisms
MeSH terms: Animals, Endoderm, Humans, Vertebrates, Organogenesis

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Vertebrate Endoderm Development and Organ Formation

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