The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Vertebrate Endoderm Development and Organ Formation
Open accessAbstract
The endoderm germ layer contributes to the respiratory and gastrointestinal tracts and to all of their associated organs. Over the past decade, studies in vertebrate model organisms, including frog, fish, chick, and mouse, have greatly enhanced our understanding of the molecular basis of endoderm organ development. We review this progress with a focus on early stages of endoderm organogenesis including endoderm formation, gut tube morphogenesis and patterning, and organ specification. Lastly, we discuss how developmental mechanisms that regulate endoderm organogenesis are used to direct differentiation of embryonic stem cells into specific adult cell types, which function to alleviate disease symptoms in animal models.
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“The gut endoderm is the precursor of the respiratory and digestive tracts, and their associated organs1,2 (Fig. 1).”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [1]
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“TF expression was exceptionally accurate in predicting AP pseudo-space order (Extended Data Fig. 9c, Correlation: 0.97), indicating that transcriptional regulation, presumably in response to signals from neighboring mesenchyme1, plays a key role in gut tube patterning.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [1]
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Cites
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Self-citationMet regulates endoderm migration in zebrafishPreprint
Tu, P. S., Ruiz-Corral, A. M., Woo, S., & Materna, S. C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.01.722050
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Regional organization of nutrient absorption across the small intestine
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SMAD6 is required for normal foregut development in humans and frogs
Pagan, V., Rankin, S. A., Edwards, N. A., Thorner, K., Xie, S., Chung, W. K., Shen, Y., Zorn, A. M., & Wells, J. M. (2026) · Development · doi:10.1242/dev.205236
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3D MERFISH reveals cell-type diversity generated by mRNA partitioning in spiralian embryogenesisPreprint
Wang, Y., Patil, T., Neal, S., Jenie, I., Ignatoff, E., Bintu, B., & Lyons, D. C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.05.756875
Meena, N. K., & Sabharwal, P. (2026) · Journal of Ayurveda and Integrated Medical Sciences · doi:10.21760/jaims.11.9.46
Development and Pathology of the Mammalian Pylorus.
Prakash, A. (2013) · Deep Blue (University of Michigan)
Metadata
- Authors
- Zorn, A. M., & Wells, J. M.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2009-11-01
- Volume
- 25
- Issue
- 1
- Pages
- 221-251
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- PMC
- PMC2861293
- OpenAlex
- W2137175341
- Cited by
- 812
- References
- 180
- Citations by year
- 2026: 35 · 2025: 51 · 2024: 49 · 2023: 45 · 2022: 64 · 2021: 64 · 2020: 56 · 2019: 57 · 2018: 58 · 2017: 52 · 2016: 52 · 2015: 39 · 2014: 41 · 2013: 49 · 2012: 46
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Child Health Research Foundation
- National Institute of General Medical Sciences (R01GM072915)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080823, R01DK070858, R01DK092456)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Keywords
- endoderm development, organogenesis, organ specifications, respiratory tract development, gastrointestinal tract development, embryonic stem cell differentiation, vertebrate model organisms
- MeSH terms
- Animals, Endoderm, Humans, Vertebrates, Organogenesis
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