Vertebrate Endoderm Development and Organ Formation

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568

Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells

D’Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O., Agulnick, A. D., Smart, N. G., Moorman, M. A., KROON, E. J., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,913

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843

Efficient differentiation of human embryonic stem cells to definitive endoderm

D'Amour, K. A., Agulnick, A. D., Eliazer, S., Kelly, O. G., Kroon, E., & Baetge, E. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1163 · Cited by 1,730

Retinoic Acid Synthesis and Signaling during Early Organogenesis

Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098

Development of definitive endoderm from embryonic stem cells in culture

Kubo, A., Shinozaki, K., Shannon, J. M., Kouskoff, V., Kennedy, M., Woo, S. L. C., Fehling, H. J., & Keller, G. M. (2004) · Development · doi:10.1242/dev.01044 · Cited by 830

Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors

Jung, J., Zheng, M., Goldfarb, M., & Zaret, K. S. (1999) · Science · doi:10.1126/science.284.5422.1998 · Cited by 721

Depletion of definitive gut endoderm in Sox17 -null mutant mice

Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704

Origin and organization of the zebrafish fate map

Kimmel, C. B., Warga, R. M., & Schilling, T. F. (1990) · Development · doi:10.1242/dev.108.4.581 · Cited by 698

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

Ciruna, B. G., & Rossant, J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00017-x · Cited by 695

Chromatin Architecture of the Pitx2 Locus Requires CTCF- and Pitx2-Dependent Asymmetry that Mirrors Embryonic Gut Laterality

Welsh, I. C., Kwak, H., Chen, F. L., Werner, M., Shopland, L. S., Danko, C. G., Lis, J. T., Zhang, M., Martin, J. F., & Kurpios, N. A. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.075 · Cited by 46

Repulsive cues combined with physical barriers and cell–cell adhesion determine progenitor cell positioning during organogenesis

Paksa, A., Bandemer, J., Höckendorf, B., Razin, N., Tarbashevich, K., Minina, S., Meyen, D., Biundo, A., Leidel, S. A., Peyriéras, N., et al. (2016) · Nature Communications · doi:10.1038/ncomms11288 · Cited by 45

Trapping cell spheroids and organoids using digital acoustofluidics

Cai, H., Wu, Z., Ao, Z., Nunez, A., Chen, B., Jiang, L., Bondesson, M., & Guo, F. (2020) · Biofabrication · doi:10.1088/1758-5090/ab9582 · Cited by 51

Notch signaling in the division of germ layers in bilaterian embryos

Favarolo, M. B., & López, S. L. (2018) · Mechanisms of Development · doi:10.1016/j.mod.2018.06.005 · Cited by 44

Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling

Kim, H. J., Kim, G., Chi, K. Y., Kim, H., Jang, Y. J., Jo, S., Lee, J., Lee, Y., Woo, D., Han, C., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03235-5 · Cited by 45

Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis

Dempsey, P. J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.07.011 · Cited by 46

Wnt signaling: implications in endoderm development and pancreas organogenesis

Scheibner, K., Bakhti, M., Bastidas-Ponce, A., & Lickert, H. (2019) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.07.002 · Cited by 44

Large intestine embryogenesis: Molecular pathways and related disorders (Review)

Kostouros, A., Koliarakis, I., Natsis, K. S., Spandidos, D. A., Tsatsakis, A. M., & Tsiaoussis, J. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4583 · Cited by 44

Molecular Embryology of the Foregut

Faure, S., & Barbara, P. D. S. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182105a1a · Cited by 44

An integrated transcriptomic cell atlas of human endoderm-derived organoids

Xu, Q., Halle, L., Hediyeh-zadeh, S., Kuijs, M., Riedweg, R., Kilik, U., Recaldin, T., Yu, Q., Rall, I., Frum, T., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02182-6 · Cited by 49

A gene regulatory program controlling early Xenopus mesendoderm formation: Network conservation and motifs

Charney, R. M., Paraiso, K. D., Blitz, I. L., & Cho, K. W. Y. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.03.003 · Cited by 44

Recapitulating and Deciphering Human Pancreas Development From Human Pluripotent Stem Cells in a Dish

Petersen, M. B. K., Gonçalves, C. A., Kim, Y. H., & Grapin‐Botton, A. (2018) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.02.009 · Cited by 48

Different thresholds of Wnt-Frizzled 7 signaling coordinate proliferation, morphogenesis and fate of endoderm progenitor cells

Zhang, Z., Rankin, S. A., & Zorn, A. M. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.02.024 · Cited by 42

Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules

Kearns, N. A., Genga, R. M. J., Ziller, M. J., Kapinas, K., Peters, H., Brehm, M. A., Meissner, A., & Maehr, R. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.06.007 · Cited by 41

Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems

Kishimoto, K., Iwasawa, K., Sorel, A., Ferran-Heredia, C., Han, L., Morimoto, M., Wells, J. M., Takebe, T., & Zorn, A. M. (2022) · Nature Protocols · doi:10.1038/s41596-022-00733-3 · Cited by 41

Treatment of Human Embryonic Stem Cells with Different Combinations of Priming and Inducing Factors Toward Definitive Endoderm

Tahamtani, Y., Azarnia, M., Farrokhi, A., Sharifi‐Zarchi, A., Aghdami, N., & Baharvand, H. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0453 · Cited by 41

FGF signaling is required for anterior but not posterior specification of the murine liver bud

Wang, J., Rhee, S., Palaria, A., & Tremblay, K. D. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24215 · Cited by 40

hPSC-derived organoids: models of human development and disease

Frum, T., & Spence, J. R. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01969-w · Cited by 43

Human Pluripotent Stem Cell-Derived Alveolar Organoid with Macrophages

Seo, H.-R., Han, H., Lee, Y., Noh, Y., Cho, S.-J., & Kim, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169211 · Cited by 39

A dynamic regulatory network explains ParaHox gene control of gut patterning in the sea urchin

Annunziata, R., & Arnone, M. I. (2014) · Development · doi:10.1242/dev.105775 · Cited by 39

The Canonical Wnt Pathway as a Key Regulator in Liver Development, Differentiation and Homeostatic Renewal

Wild, S. L., Elghajiji, A., Rodriguez, C. G., Weston, S. D., Burke, Z. D., & Tosh, D. (2020) · Genes · doi:10.3390/genes11101163 · Cited by 40

Recent Advancements in Regenerative Approaches for Thymus Rejuvenation

Sharma, H., & Moroni, L. (2021) · Advanced Science · doi:10.1002/advs.202100543 · Cited by 41

Regulation of endoderm formation and left-right asymmetry by miR-92 during early zebrafish development

Li, N., Wei, C., Olena, A. F., & Patton, J. G. (2011) · Development · doi:10.1242/dev.056697 · Cited by 39

Synthetic organizer cells guide development via spatial and biochemical instructions

Yamada, T., Trentesaux, C., Brunger, J. M., Xiao, Y., Stevens, A. J., Martyn, I., Kašpárek, P., Shroff, N. P., Aguilar, A., Bruneau, B. G., et al. (2024) · Cell · doi:10.1016/j.cell.2024.11.017 · Cited by 39

GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation

Yang, J., Lu, P., Li, M., Yan, C., Zhang, T., & Jiang, W. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.07.014 · Cited by 38

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche

Willnow, D., Benary, U., Margineanu, A., Vignola, M. L., Konrath, F., Pongrac, I. M., Karimaddini, Z., Vigilante, A., Wolf, J., & Spagnoli, F. M. (2021) · Nature · doi:10.1038/s41586-021-03844-1 · Cited by 39

Cross-species single-cell transcriptomic analysis reveals divergence of cell composition and functions in mammalian ileum epithelium

Li, H., Wang, X., Wang, Y., Zhang, M., Fan, H. D., Wang, H., Cui, A., Zhao, J., Ji, W., & Chen, Y. (2022) · Cell Regeneration · doi:10.1186/s13619-022-00118-7 · Cited by 38

Gene Regulatory Networks Governing Lung Specification

Rankin, S. A., & Zorn, A. M. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24810 · Cited by 41

Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer

Francis, R., Guo, H., Streutker, C., Ahmed, M., Yung, T. M., Dirks, P. B., He, H. H., & Kim, T.-H. (2019) · Science Advances · doi:10.1126/sciadv.aax8898 · Cited by 37

Role of thymus in health and disease

Gulla, S., Reddy, M. C., Reddy, V. C., Chitta, S., Bhanoori, M., & Lomada, D. (2022) · International Reviews of Immunology · doi:10.1080/08830185.2022.2064461 · Cited by 39

Hormonal Control of Stem Cell Systems

Gancz, D., & Gilboa, L. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122331 · Cited by 37

Wnt/β-Catenin Signaling in Liver Pathobiology

Carson, M. D., & Nejak‐Bowen, K. N. (2024) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-111523-023535 · Cited by 36

Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells

MATSUNO, K., Mae, S.-I., Okada, C., Nakamura, M., Watanabe, A., Toyoda, T., Uchida, E., & Osafune, K. (2016) · Differentiation · doi:10.1016/j.diff.2016.04.002 · Cited by 36

Agenesis of the dorsal pancreas: systematic review of a clinical challenge

Cienfuegos, J. A., Rotellar, F., Salguero, J., Benito, A., Solórzano, J. L., & Sangro, B. (2016) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2016.4474/2016 · Cited by 36

A high-content small molecule screen identifies novel inducers of definitive endoderm

Korostylev, A., Mahaddalkar, P. U., Keminer, O., Hadian, K., Schorpp, K., Gribbon, P. M., & Lickert, H. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.009 · Cited by 36

Differentiation of Definitive Endoderm from Mouse Embryonic Stem Cells

Kim, P. T. W., & Ong, C. J. (2012) · Results and problems in cell differentiation · doi:10.1007/978-3-642-30406-4_17 · Cited by 36

Liver development and cancer formation in zebrafish

Lu, J., Hsia, Y., Tu, H., Hsiao, Y., Yang, W., Wang, H., & Yuh, C. (2011) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20205 · Cited by 37

PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix

Villegas, S. N., Rothová, M., Barrios-Llerena, M. E., Pulina, M. V., Hadjantonakis, A., Bihan, T. L., Astrof, S., & Brickman, J. M. (2013) · eLife · doi:10.7554/elife.00806 · Cited by 36

Comprehensive timeline of mesodermal development in the quail small intestine

Thomason, R. T., Bader, D. M., & Winters, N. I. (2012) · Developmental Dynamics · doi:10.1002/dvdy.23855 · Cited by 36

Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm developmentPreprint

Banerjee, K. K., Saxena, M., Kumar, N., Chen, L., Cavazza, A., Toke, N. H., O’Neill, N. K., Madha, S., Jadhav, U., Verzi, M. P., et al. (2018) · Genes & Development · doi:10.1101/gad.318832.118 · Cited by 36

Reversing Epithelial Polarity in Pluripotent Stem Cell-Derived Intestinal Organoids

Kakni, P., López‐Iglesias, C., Truckenmüller, R. K., Habibović, P., & Giselbrecht, S. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.879024 · Cited by 35

Single-cell analysis reveals lineage segregation in early post-implantation mouse embryos

Wen, J., Zeng, Y., Fang, Z., Gu, J., Ge, L., Tang, F., Qu, Z., Hu, J., Cui, Y., Zhang, K., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.780585 · Cited by 37

Role and effective therapeutic target of gut microbiota in NAFLD/NASH (Review)

Liu, Q., Liu, S., Chen, L., Zhao, Z., Du, S.-X., Dong, Q., Xin, Y., & Xuan, S. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7781 · Cited by 37

Differentiation of pluripotent stem cells for regenerative medicine

Li, K., Kong, Y., Zhang, M., Xie, F., Liu, P., & Xu, S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.01.182 · Cited by 34

A comparative study of endoderm differentiation in humans and chimpanzees

Blake, L. E., Thomas, S. M., Blischak, J., Hsiao, C. J., Chavarria, C. I., Myrthil, M., Gilad, Y., & Pavlovic, B. J. (2018) · Genome biology · doi:10.1186/s13059-018-1490-5 · Cited by 34

The developmental toxicity of PM2.5 on the early stages of fetal lung with human lung bud tip progenitor organoids

Wang, R., Kang, N., Zhang, W., Chen, B., Xu, S., & Wu, L. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121764 · Cited by 34

Self-renewal of the gastric epithelium from stem and progenitor cells

Hoffmann, W. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s402 · Cited by 34

Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies

Kishimoto, K., & Morimoto, M. (2021) · Development · doi:10.1242/dev.198192 · Cited by 33

Wnt signaling in stem cells during development and cell lineage specification

Chidiac, R., & Angers, S. (2023) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2023.01.005 · Cited by 34

From bench to bedside: an interdisciplinary journey through the gut-lung axis with insights into lung cancer and immunotherapy

Dóra, D., Szőcs, E., Soós, Á., Halasy, V., Somodi, C., Mihucz, A., Rostás, M., Mógor, F., Lohinai, Z., & Nagy, N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1434804 · Cited by 33

Formation of the digestive tract in Ciona intestinalis includes two distinct morphogenic processes between its anterior and posterior parts

Nakazawa, K., Yamazawa, T., Moriyama, Y., Ogura, Y., Kawai, N., Sasakura, Y., & Saiga, H. (2013) · Developmental Dynamics · doi:10.1002/dvdy.24009 · Cited by 33

Generating Intestinal Tissue from Stem Cells: Potential for Research and Therapy

Howell, J. C., & Wells, J. M. (2011) · Regenerative Medicine · doi:10.2217/rme.11.90 · Cited by 33

A Fate Map of the Murine Pancreas Buds Reveals a Multipotent Ventral Foregut Organ Progenitor

Angelo, J. R., Guerrero-Zayas, M.-I., & Tremblay, K. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040707 · Cited by 33

Theoretical tool bridging cell polarities with development of robust morphologies

Nissen, S. B., Rønhild, S., Trusina, A., & Sneppen, K. (2018) · eLife · doi:10.7554/elife.38407 · Cited by 37

Gastrointestinal organoids: a next-generation tool for modeling human development

Singh, A., Poling, H. M., Spence, J. R., Wells, J. M., & Helmrath, M. A. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00199.2020 · Cited by 33

Role of Jagged1-Notch pathway in thyroid development

Marelli, F., & Persani, L. (2018) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0715-x · Cited by 32

Single-Cell Chromatin Accessibility Analysis Reveals the Epigenetic Basis and Signature Transcription Factors for the Molecular Subtypes of Colorectal Cancers

Liu, Z., Hu, Y., Xie, H., Chen, K., Wen, L., Fu, W., Zhou, X., & Tang, F. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1445 · Cited by 32

Conserved regulatory state expression controlled by divergent developmental gene regulatory networks in echinoids

Erkenbrack, E. M., Davidson, E. H., & Peter, I. S. (2018) · Development · doi:10.1242/dev.167288 · Cited by 32

Long noncoding RNA ANCR inhibits the differentiation of mesenchymal stem cells toward definitive endoderm by facilitating the association of PTBP1 with ID2

Li, J., Yang, Y., Fan, J., Xu, H., Fan, L., Li, H., & Zhao, R. C. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1738-3 · Cited by 32

Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference

Libby, A. R. G., Joy, D. A., So, P.-L., Mandegar, M. A., Muncie, J. M., Mendoza-Camacho, F. N., Weaver, V. M., Conklin, B. R., & McDevitt, T. C. (2018) · eLife · doi:10.7554/elife.36045 · Cited by 32

Single-cell patterning and axis characterization in the murine and human definitive endoderm

Li, L., Wang, X., Xu, Z., Wang, Y., Ye, F., Yang, L., Qiu, W., Li, Y., Yu, X., Gu, J., et al. (2020) · Cell Research · doi:10.1038/s41422-020-00426-0 · Cited by 33

Derivation of Endodermal Progenitors From Pluripotent Stem Cells

Ikonomou, L., & Kotton, D. N. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24771 · Cited by 34

Loss of Sonic Hedgehog Leads to Alterations in Intestinal Secretory Cell Maturation and Autophagy

Sansfaçon, J. G., Allaire, J. M., Jones, C. M., Boudreau, F., & Perreault, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098751 · Cited by 36

Patterning and shaping the endoderm in vivo and in culture

Kraus, M. R.-C., & Grapin‐Botton, A. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.05.002 · Cited by 32

Tissue engineering 2.0: guiding self-organization during pluripotent stem cell differentiation

Woodford, C. M., & Zandstra, P. W. (2012) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.03.003 · Cited by 34

The global gene expression profile of the secondary transition during pancreatic development

Willmann, S. J., Mueller, N. S., Engert, S., Sterr, M., Burtscher, I., Raducanu, A., Irmler, M., Beckers, J., Sass, S., Theis, F. J., et al. (2015) · Mechanisms of Development · doi:10.1016/j.mod.2015.11.004 · Cited by 32

From Definitive Endoderm to Gut—a Process of Growth and Maturation

Guiu, J., & Jensen, K. B. (2015) · Stem Cells and Development · doi:10.1089/scd.2015.0017 · Cited by 32

Scaffold-free 3D culturing enhance pluripotency, immunomodulatory factors, and differentiation potential of Wharton’s jelly-mesenchymal stem cells

Thakur, G., Bok, E., Kim, S.-B., Jo, C.-H., Oh, S.-J., Baek, J., Park, J. E., Kang, Y., Lee, S., Kumar, R., et al. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151245 · Cited by 31

Translating Developmental Principles to Generate Human Gastric Organoids

Eicher, A. K., Berns, H. M., & Wells, J. M. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.12.014 · Cited by 34

Gut–lung axis: role of the gut microbiota in non-small cell lung cancer immunotherapy

Zhang, H., & Xu, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1257515 · Cited by 31

Traffic jam in the primitive streak: The role of defective mesoderm migration in birth defects

Herion, N. J., Salbaum, J. M., & Kappen, C. (2014) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.23283 · Cited by 30

Transorganogenesis and transdifferentiation in C. elegans are dependent on differentiated cell identity

Riddle, M. R., Spickard, E. A., Jevince, A. R., Nguyen, K. C. Q., Hall, D. H., Joshi, P. M., & Rothman, J. H. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.09.020 · Cited by 30

Radial WNT5A-Guided Post-mitotic Filopodial Pathfinding Is Critical for Midgut Tube Elongation

Wang, S., Cebrián, C., Schnell, S. D., & Gumucio, D. L. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.011 · Cited by 30

Self-organization of organoids from endoderm-derived cells

Lewis, A. C., Keshara, R., Kim, Y. H., & Grapin‐Botton, A. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-02010-w · Cited by 33

Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development

Sinha, T., Lin, L., Li, D., Davis, J. A., Evans, S. Μ., Wynshaw-Boris, A. J., & Wang, J. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.11.005 · Cited by 30

Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos

Pfister, S., Jones, V. J., Power, M., Truisi, G. L., Khoo, P., Steiner, K. A., Kanai‐Azuma, M., Kanai, Y., Tam, P., & Loebel, D. A. F. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.103158sp · Cited by 30

β-Cell specific transcription factors in the context of diabetes mellitus and β-cell regeneration

Balakrishnan, S., Dhavamani, S., & Prahalathan, C. (2020) · Mechanisms of Development · doi:10.1016/j.mod.2020.103634 · Cited by 30

Recent advances in tissue stem cells

Fu, X., He, Q., Tao, Y., Wang, M., Wang, W., Wang, Y., Yu, Q. C., Zhang, F., Zhang, X., Chen, Y., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-2007-8 · Cited by 30

Intestinal cellular heterogeneity and disease development revealed by single-cell technology

Wang, Y., Song, W., Yu, S., Liu, Y., & Chen, Y. (2022) · Cell Regeneration · doi:10.1186/s13619-022-00127-6 · Cited by 29

Nodal signaling establishes a competency window for stochastic cell fate switching

Economou, A. D., Guglielmi, L., East, P., & Hill, C. S. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.11.008 · Cited by 29

Generation of Lung Epithelium from Pluripotent Stem Cells

Wong, A. P., & Rossant, J. (2013) · Current Pathobiology Reports · doi:10.1007/s40139-013-0016-9 · Cited by 28

Compartmentalized expression patterns of pancreatic- and gastric-related genes in the alimentary canal of the ascidian Ciona intestinalis: evolutionary insights into the functional regionality of the gastrointestinal tract in Olfactores

Nakayama, S., & Ogasawara, M. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2627-7 · Cited by 28

Molecular patterning during the development of Phoronopsis harmeri reveals similarities to rhynchonelliform brachiopods

Andrikou, C., Passamaneck, Y. J., Lowe, C. J., Martindale, M. Q., & Hejnol, A. (2019) · EvoDevo · doi:10.1186/s13227-019-0146-1 · Cited by 28

The Organizer and Its Signaling in Embryonic Development

Kumar, V., Park, S., Lee, U., & Kim, J. (2021) · Journal of Developmental Biology · doi:10.3390/jdb9040047 · Cited by 28

Challenges to, and prospects for, reverse engineering the gastrointestinal tract using organoids

Kakni, P., Truckenmüller, R. K., Habibović, P., & Giselbrecht, S. (2022) · Trends in biotechnology · doi:10.1016/j.tibtech.2022.01.006 · Cited by 28

Collagen Type I Improves the Differentiation of Human Embryonic Stem Cells towards Definitive Endoderm

Rasmussen, C. H., Petersen, D. R., Moeller, J. B., Hansson, M. D., & Dufva, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145389 · Cited by 28

Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation

Allaire, J. M., Roy, S. A. B., Ouellet, C., Lemieux, É., Jones, C. M., Paquet, M., Boudreau, F., & Perreault, N. (2016) · International Journal of Cancer · doi:10.1002/ijc.30001 · Cited by 28

Clinical Guidelines of the Russian Society for the Study of the Liver, Russian Gastroenterological Association, Russian Society for the Prevention of Non-Communicable Diseases, Russian Association of Endocrinologists, Russian Scientific Medical Society of Therapists, National Society of Preventive Cardiology, Russian Association of Gerontologists and Geriatricians on Non-Alcoholic Fatty Liver Disease

Ivashkin, V. T., Drapkina, O. M., Maevskaya, M. V., Raikhelson, K. L., Okovityi, S. V., Жаркова, М. С., Grechishnikova, V. R., Abdulganieva, D. I., Alekseenko, S. A., Ardatskaya, M. D., et al. (2025) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2025-35-1-94-152 · Cited by 29

The promise of human organoids in the digestive system

Funata, M., Nio, Y., Erion, D. M., Thompson, W. L., & Takebe, T. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00661-3 · Cited by 28

Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates

Tóth, A., Steinmeyer, S. H., Kannan, P. S., Gray, J. K., Jackson, C. M., Mukherjee, S., Demmert, M., Sheak, J. R., Benson, D., Kitzmiller, J. A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abl8574 · Cited by 29

Sfrp5 Modulates Both Wnt and BMP Signaling and Regulates Gastrointestinal Organogensis in the Zebrafish, Danio rerio

Stuckenholz, C., Lu, L., Thakur, P. C., Choi, T. Y., Shin, D., & Bahary, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062470 · Cited by 27

Analysis of alternative signaling pathways of endoderm induction of human embryonic stem cells identifies context specific differences

Mathew, S., Jaramillo, M., Zhang, X., Zhang, L. A., Soto–Gutiérrez, A., & Banerjee, I. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-154 · Cited by 27

Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development

Olayanju, A., Jones, L. G., Greco, K. V., Goldring, C. E., & Ansari, T. (2018) · Journal of Applied Toxicology · doi:10.1002/jat.3641 · Cited by 28

Human β‐defensin‐2 suppresses key features of asthma in murine models of allergic airways disease

Pinkerton, J., Kim, R., Koeninger, L., Armbruster, N. S., Hansbro, N. G., Brown, A. C., Jayaraman, R., Shen, S., Malek, N. P., Cooper, M. A., et al. (2020) · Clinical & Experimental Allergy · doi:10.1111/cea.13766 · Cited by 27

Prolonged FGF signaling is necessary for lung and liver induction in Xenopus

Shifley, E. T., Kenny, A. P., Rankin, S. A., & Zorn, A. M. (2012) · BMC Developmental Biology · doi:10.1186/1471-213x-12-27 · Cited by 26

A Simple and economical route to generate functional hepatocyte‐like cells from hESCs and their application in evaluating alcohol induced liver damage

Pal, R., Mamidi, M. K., Das, A. K., Gupta, P. K., & Bhonde, R. R. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23391 · Cited by 26

The Parahox gene Pdx1 is required to maintain positional identity in the adult foregut

Holland, A. M., Garcia, S., Naselli, G., MacDonald, R. J., & Harrison, L. C. (2013) · The International Journal of Developmental Biology · doi:10.1387/ijdb.120048ah · Cited by 26

Pancreatic Progenitors and Organoids as a Prerequisite to Model Pancreatic Diseases and Cancer

Hohwieler, M., Müller, M., Frappart, P., & Heller, S. (2019) · Stem Cells International · doi:10.1155/2019/9301382 · Cited by 27

Rapid and robust directed differentiation of mouse epiblast stem cells into definitive endoderm and forebrain organoids

Medina-Cano, D., Corrigan, E. K., Glenn, R. A., Islam, M. T., Lin, Y., Kim, J., Cho, H., & Vierbuchen, T. (2022) · Development · doi:10.1242/dev.200561 · Cited by 26

Vertebrate endoderm development

Weatherbee, B. A. T., Rankin, S. A., & Zorn, A. M. (2026) · Development · doi:10.1242/dev.205164

Endoderm development: from patterning to organogenesis

Grapin‐Botton, A., & Melton, D. A. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01957-5 · Cited by 279

Understanding endoderm development: More than just a series of tubes

Murtaugh, L. C., & Wells, J. M. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22587 · Cited by 1

At new heights – endodermal lineages in development and disease

Ober, E. A., & Grapin‐Botton, A. (2015) · Development · doi:10.1242/dev.121095 · Cited by 2

Blackwell Publishing, Ltd.Review Endoderm development in vertebrates: fate mapping, induction and regional specification

Fukuda, K., & Kikuchi, Y. (2015)