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Cited by 2,399

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Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

Trinchieri, Giorgio·1995·Annual Review of Immunology
DOI 10.1146/annurev.iy.13.040195.001343
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Abstract

Interleukin-12 (IL-12) is a heterodimeric cytokine produced mostly by phagocytic cells in response to bacteria, bacterial products, and intracellular parasites, and to some degree by B lymphocytes. IL-12 induces cytokine production, primarily of IFN-γ, from NK and T cells, acts as a growth factor for activated NK and T cells, enhances the cytotoxic activity of NK cells, and favors cytotoxic T lymphocyte generation. In vivo IL-12 acts primarily at three stages during the innate resistance/adaptive immune response to infection: 1. Early in the infection, IL-12 is produced and induces production from NK and T cells of IFN-γ , which contributes to phagocytic cell activation and inflammation; 2. IL-12 and IL-12- induced IFN-γ favor Thl cell differentiation by priming CD4+ T cells for high IFN-γ production; and 3. IL-12 contributes to optimal IFN-γ production and to proliferation of differentiated Th l cells in response to antigen. The early preference expressed in the immune response depends on the balance between IL-12, which favors Thl responses, and IL-4, which favors Th2 responses. Thus,IL-12 represents a functional bridge between the early nonspecific innate resistance and the subsequent antigen-specific adaptive immunity.

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Metadata

Authors
Trinchieri, G.
Venue
Annual Review of Immunology
Publisher
Annual Reviews
Published
1995-04
Volume
13
Issue
1
Pages
251-276
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
DOI
10.1146/annurev.iy.13.040195.001343
OpenAlex
W2108473659
Cited by
2,399
References
0
FWCI
66.94
Type
journal article
Language
en
Open access
closed

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