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Aminoacyl-tRNA Synthesis and Translational Quality Control

Ling, Jiqiang, Reynolds, Noah, Ibba, Michael·2009·Annual Review of Microbiology
DOI 10.1146/annurev.micro.091208.073210
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Abstract

Translating the 4-letter code of RNA into the 22-letter alphabet of proteins is a central feature of cellular life. The fidelity with which mRNA is translated during protein synthesis is determined by two factors: the availability of aminoacyl-tRNAs composed of cognate amino acid:tRNA pairs and the accurate selection of aminoacyl-tRNAs on the ribosome. The role of aminoacyl-tRNA synthetases in translation is to define the genetic code by accurately pairing cognate tRNAs with their corresponding amino acids. Synthetases achieve the amino acid substrate specificity necessary to keep errors in translation to an acceptable level in two ways: preferential binding of the cognate amino acid and selective editing of near-cognate amino acids. Editing significantly decreases the frequency of errors and is important for translational quality control, and many details of the various editing mechanisms and their effect on different cellular systems are now starting to emerge.

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Metadata

Authors
Ling, J., Reynolds, N., & Ibba, M.
Venue
Annual Review of Microbiology
Publisher
Annual Reviews
Published
2009-10-01
Volume
63
Issue
1
Pages
61-78
ISSN
  • 0066-4227 (ISSN-L)
  • 1545-3251
DOI
10.1146/annurev.micro.091208.073210
OpenAlex
W2147488317
Cited by
370
References
3
FWCI
1.44
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Aminoacyl-tRNA Synthesis and Translational Quality Control. https://app.cochat.ai/papers/10.1146/annurev.micro.091208.073210
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Ling, J., Reynolds, N., & Ibba, M. (2009). Aminoacyl-tRNA Synthesis and Translational Quality Control. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.091208.073210

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