THE SYNAPTIC VESICLE CYCLE

Short-Term Synaptic Plasticity

Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068

SNAP receptors implicated in vesicle targeting and fusion

Söllner, T. H., Whiteheart, S. W., Brunner, M., Erdjument‐Bromage, H., Geromanos, S. J., Tempst, P., & Rothman, J. E. (1993) · Nature · doi:10.1038/362318a0 · Cited by 3,239

EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION

Heuser, J. E., & Reese, T. S. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.57.2.315 · Cited by 2,147

The synaptic vesicle cycle: a cascade of protein–protein interactions

Südhof, T. C. (1995) · Nature · doi:10.1038/375645a0 · Cited by 1,991

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C. (1994) · Cell · doi:10.1016/0092-8674(94)90556-8 · Cited by 1,483

Synaptic assembly of the brain in the absence of neurotransmitter secretion.

Verhage, M., Maia, A., Plomp, J., Brussaard, A., Heeroma, J., Vermeer, H., Toonen, R., Hammer, R., van den Berg, T. K., Missler, M., et al. (2000) · Science · doi:10.1126/science.287.5454.864 · Cited by 1,387

Membrane Fusion

Jahn, R., Lang, T., & Südhof, T. C. (2003) · Cell · doi:10.1016/s0092-8674(03)00112-0 · Cited by 1,364

Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones

Bennett, M. K., Calakos, N., & Scheller, R. H. (1992) · Science · doi:10.1126/science.1321498 · Cited by 1,263

SNARE-mediated membrane fusion

Chen, Y. A., & Scheller, R. H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052017 · Cited by 1,133

Definition of the readily releasable pool of vesicles at hippocampal synapses.

Rosenmund, C., & Stevens, C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80146-4 · Cited by 1,084

Intellectual disability and autism spectrum disorders: Causal genes and molecular mechanisms

Srivastava, A. K., & Schwartz, C. E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.015 · Cited by 273

Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

Lotharius, J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.20.2395 · Cited by 273

Astrocytes: Orchestrating synaptic plasticity?

Pittà, M. D., Brunel, N., & Volterra, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.001 · Cited by 272

Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications

Lett, T. A. P., Wallace, T., Chowdhury, N. I., Tiwari, A. K., Kennedy, J. L., & Müller, D. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.109 · Cited by 269

Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography

Fernández-Busnadiego, R., Zuber, B., Maurer, U. E., Cyrklaff, M., Baumeister, W., & Lučić, V. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200908082 · Cited by 267

Mimicking Neurotransmitter Release in Chemical Synapses via Hysteresis Engineering in MoS2 Transistors

Arnold, A. J., Razavieh, A., Nasr, J. R., Schulman, D. S., Eichfeld, C. M., & Das, S. (2017) · ACS Nano · doi:10.1021/acsnano.7b00113 · Cited by 265

Physiology and Pathology of Calcium Signaling in the Brain

Kawamoto, E. M., Vivar, C., & Camandola, S. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00061 · Cited by 264

The Synaptic Vesicle Protein CSPα Prevents Presynaptic Degeneration

Fernández‐Chacón, R., Wölfel, M., Nishimune, H., Tabares, L., Schmitz, F., Castellano-Muñoz, M., Rosenmund, C., Montesinos, M. L., Sanes, J. R., Schneggenburger, R., et al. (2004) · Neuron · doi:10.1016/s0896-6273(04)00190-4 · Cited by 264

Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release

Rizo, J., Chen, X., & Araç, D. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.04.006 · Cited by 262

Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1α

Chevaleyre, V., Heifets, B. D., Kaeser, P. S., Südhof, T. C., & Castillo, P. E. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.020 · Cited by 261

The Drosophila Larva as a Model for Studying Chemosensation and Chemosensory Learning: A Review

Gerber, B., & Stocker, R. F. (2006) · Chemical Senses · doi:10.1093/chemse/bjl030 · Cited by 260

The sequence of events that underlie quantal transmission at central glutamatergic synapses

Lisman, J. E., Raghavachari, S., & Tsien, R. W. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2191 · Cited by 260

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon

Altrock, W. D., tom Dieck, S., Sokolov, M., Meyer, A. C., Sigler, A., Brakebusch, C., Fässler, R., Richter, K., Boeckers, T. M., Potschka, H., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00088-6 · Cited by 258

Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids

Araç, D., Chen, X., Khant, H. A., Ubach, J., Ludtke, S. J., Kikkawa, M., Johnson, A. E., Chiu, W., Südhof, T. C., & Rizo, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1056 · Cited by 256

Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule

Hirano, T., Murakami, M., Fukada, T., Nishida, K., Yamasaki, S., & Suzuki, T. (2008) · Advances in immunology · doi:10.1016/s0065-2776(08)00003-5 · Cited by 256

Which way to go? Cytoskeletal organization and polarized transport in neurons

Kapitein, L. C., & Hoogenraad, C. C. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.015 · Cited by 256

Rab GTPases and Membrane Trafficking in Neurodegeneration

Kiral, F. R., Kohrs, F. E., Jin, E. J., & Hiesinger, P. R. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.010 · Cited by 249

Mechanisms of SNARE proteins in membrane fusion

Jahn, R., Cafiso, D. C., & Tamm, L. K. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00668-x · Cited by 248

Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis

Newton, A. J., Kirchhausen, T. L., & Murthy, V. N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606212103 · Cited by 245

Bringing Dynamic Molecular Machines into Focus by Methyl-TROSY NMR

Rosenzweig, R., & Kay, L. E. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035829 · Cited by 243

The calyx of Held

Schneggenburger, R., & Forsythe, I. D. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0272-7 · Cited by 241

Synaptic transmission at retinal ribbon synapses

Heidelberger, R., Thoreson, W. B., & Witkovsky, P. (2005) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2005.04.002 · Cited by 239

Neurotrophin-Mediated Rapid Signaling in the Central Nervous System: Mechanisms and Functions

Blum, R., & Konnerth, A. (2005) · Physiology · doi:10.1152/physiol.00042.2004 · Cited by 239

Molecular Circuitry of Endocytosis at Nerve Terminals

Dittman, J., & Ryan, T. A. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113302 · Cited by 238

Enteroendocrine cells express functional Toll-like receptors

Bogunovic, M., Davé, S. H., Tilstra, J. S., Chang, D. T. W., Harpaz, N., Xiong, H., Mayer, L. F., & Plevy, S. E. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00249.2006 · Cited by 236

Membrane Lipids in Presynaptic Function and Disease

Lauwers, E., Goodchild, R. E., & Verstreken, P. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.033 · Cited by 236

Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: Therapeutic implications for migraine and other pains

Burstein, R., Zhang, X., Levy, D., Aoki, K. R., & Brin, M. F. (2014) · Cephalalgia · doi:10.1177/0333102414527648 · Cited by 233

LTP Requires a Unique Postsynaptic SNARE Fusion Machinery

Jurado, S., Goswami, D., Zhang, Y., Molina, A. J. M., Südhof, T. C., & Malenka, R. C. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.029 · Cited by 232

Glucose transporter 4: cycling, compartments and controversies

Dugani, S. B., & Klip, A. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400584 · Cited by 232

Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome

Aligianis, I. A., Johnson, C. A., Gissen, P., Chen, D., Hampshire, D. J., Hoffmann, K., Maina, E. N., Morgan, N. V., Tee, L. J., Morton, J. E. V., et al. (2005) · Nature Genetics · doi:10.1038/ng1517 · Cited by 231

Distinct domains of complexin I differentially regulate neurotransmitter release

Xue, M., Reim, K., Chen, X., Chao, H., Deng, H., Rizo, J., Brose, N., & Rosenmund, C. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1292 · Cited by 229

Cell biological steps and checkpoints in accessing NK cell cytotoxicity

Mace, E. M., Dongre, P., Hsu, H., Sinha, P., James, A. M., Mann, S. S., Forbes, L. R., Watkin, L. B., & Orange, J. S. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2013.96 · Cited by 227

Genome-wide Dissection of MicroRNA Functions and Cotargeting Networks Using Gene Set Signatures

Tsang, J. S., Ebert, M. S., & van Oudenaarden, A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.007 · Cited by 226

Bassoon speeds vesicle reloading at a central excitatory synapse

Hallermann, S., Fejtova, A., Schmidt, H., Weyhersmüller, A., Silver, R. A., Gundelfinger, E. D., & Eilers, J. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.026 · Cited by 223

Multiple intermediates in SNARE-induced membrane fusion

Yoon, T., Okumuş, B., Zhang, F., Shin, Y.-K., & Ha, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606032103 · Cited by 223

The endocytic network in plants

Šamaj, J., Read, N. D., Volkmann, D., Menzel, D., & Baluška, F. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.06.006 · Cited by 222

Unsolved Mysteries in Membrane Traffic

Pfeffer, S. R. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.061705.130002 · Cited by 222

Arabidopsis Synaptotagmin 1 Is Required for the Maintenance of Plasma Membrane Integrity and Cell Viability

Schapire, A. L., Voigt, B., Jásik, J., Rosado, A., López-Cobollo, R., Menzel, D., Salinas, J., Mancuso, S., Valpuesta, V., Baluška, F., et al. (2008) · The Plant Cell · doi:10.1105/tpc.108.063859 · Cited by 220

SYD-2 Liprin-α organizes presynaptic active zone formation through ELKS

Dai, Y., Taru, H., Deken, S. L., Grill, B., Ackley, B., Nonet, M. L., & Jin, Y. (2006) · Nature Neuroscience · doi:10.1038/nn1808 · Cited by 218

Constitutive sharing of recycling synaptic vesicles between presynaptic boutons

Darcy, K., Staras, K., Collinson, L., & Goda, Y. (2006) · Nature Neuroscience · doi:10.1038/nn1640 · Cited by 217

Airway mucus: The good, the bad, the sticky

Evans, C. M., & Koo, J. S. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.11.001 · Cited by 216

Wnt-7a Modulates the Synaptic Vesicle Cycle and Synaptic Transmission in Hippocampal Neurons

Cerpa, W. F., Godoy, J. A., Alfaro, I. E., Farías, G. G., Metcalfe, M., Fuentealba, R. A., Bonansco, C., & Inestrosa, N. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705943200 · Cited by 214

Differential Expression of Synaptic Proteins in the Frontal and Temporal Cortex of Elderly Subjects With Mild Cognitive Impairment

Counts, S., Nadeem, M., Lad, S. P., Wuu, J., & Mufson, E. J. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-200606000-00007 · Cited by 212

Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease

Guo, L., Tian, J., & Du, H. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160702 · Cited by 211

Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis

Ohara-Imaizumi, M., Fujiwara, T., Nakamichi, Y., Okamura, T., Akimoto, Y., Kawai, J., Matsushima, S., Kawakami, H., Watanabe, T., Akagawa, K., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608132 · Cited by 211

Mechanism of neurotransmitter release coming into focus

Rizo, J. (2018) · Protein Science · doi:10.1002/pro.3445 · Cited by 210

Membrane Curvature in Synaptic Vesicle Fusion and Beyond

McMahon, H. T., Kozlov, M. M., & Martens, S. (2010) · Cell · doi:10.1016/j.cell.2010.02.017 · Cited by 210

Wnt Signaling Positions Neuromuscular Connectivity by Inhibiting Synapse Formation in C. elegans

Klassen, M. P., & Shen, K. (2007) · Cell · doi:10.1016/j.cell.2007.06.046 · Cited by 210

What is rate-limiting during sustained synaptic activity: vesicle supply or the availability of release sites

Neher, E. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00144 · Cited by 209

The TRPM7 Ion Channel Functions in Cholinergic Synaptic Vesicles and Affects Transmitter Release

Krapivinsky, G. B., Mochida, S., Krapivinsky, L., Cibulsky, S. M., & Clapham, D. E. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.033 · Cited by 209

Understanding Synapses: Past, Present, and Future

Südhof, T. C., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.011 · Cited by 207

The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions

Simon, D. J., Madison, J. M., Conery, A. L., Thompson-Peer, K. L., Soskis, M. J., Ruvkun, G., Kaplan, J. M., & Kim, J. K. (2008) · Cell · doi:10.1016/j.cell.2008.04.035 · Cited by 206

SCRAPPER-Dependent Ubiquitination of Active Zone Protein RIM1 Regulates Synaptic Vesicle Release

Yao, I., Takagi, H., Ageta, H., Kahyo, T., Sato, S., Hatanaka, K., Fukuda, Y., Chiba, T., Morone, N., Yuasa, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.06.052 · Cited by 204

Synaptic Vesicles Interchange Their Membrane Proteins with a Large Surface Reservoir during Recycling

Fernández-Alfonso, T., Kwan, R., & Ryan, T. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.008 · Cited by 202

SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions

Antonucci, F., Corradini, I., Fossati, G., Tomasoni, R., Menna, E., & Matteoli, M. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00007 · Cited by 202

CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation–transcription coupling

Wheeler, D. G., Barrett, C. F., Groth, R. D., Safa, P., & Tsien, R. W. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200805048 · Cited by 201

Transmission, Development, and Plasticity of Synapses

Harris, K. P., & Littleton, J. T. (2015) · Genetics · doi:10.1534/genetics.115.176529 · Cited by 201

The axonal cytoskeleton: from organization to function

Kevenaar, J. T., & Hoogenraad, C. C. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00044 · Cited by 200

Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function

Maycox, P. R., Kelly, F., Taylor, A. R., Bates, S., Reid, J. L., Logendra, R., Barnes, M. R., Larminie, C. G. C., Jones, N. A., Lennon, M. G., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.18 · Cited by 200

Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis

Rießland, M., Kaczmarek, A., Schneider, S. M., Swoboda, K. J., Löhr, H., Bradler, C., Grysko, V., Dimitriadi, M., Hosseinibarkooie, S., Torres‐Benito, L., et al. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.01.005 · Cited by 200

A Shift from a Pivotal to Supporting Role for the Growth-Associated Protein (GAP-43) in the Coordination of Axonal Structural and Functional Plasticity

Holahan, M. R. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00266 · Cited by 200

Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity

Schlüter, O. M., Basu, J., Südhof, T. C., & Rosenmund, C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3553-05.2006 · Cited by 199

A Mutation in SNAP29, Coding for a SNARE Protein Involved in Intracellular Trafficking, Causes a Novel Neurocutaneous Syndrome Characterized by Cerebral Dysgenesis, Neuropathy, Ichthyosis, and Palmoplantar Keratoderma

Sprecher, E., Ishida‐Yamamoto, A., Mizrachi-Koren, M., Rapaport, D., Goldsher, D., Indelman, M., Topaz, O., Chefetz, I., Keren, H., O’Brien, T. J., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/432556 · Cited by 196

The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)

Südhof, T. C. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201406359 · Cited by 196

Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis

Mukherjee, K., Yang, X., Gerber, S. H., Kwon, H.-B., Ho, A., Castillo, P. E., Liu, X., & Südhof, T. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002307107 · Cited by 195

A review of ketamine in affective disorders: Current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action

Naughton, M., Clarke, G. A., O’Leary, O. F., Cryan, J. F., & Dinan, T. G. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.11.014 · Cited by 195

Regulation of Membrane Fusion in Synaptic Excitation-Secretion Coupling: Speed and Accuracy Matter

Wojcik, S. M., & Brose, N. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.013 · Cited by 194

Conditional Expression of Parkinson's Disease-Related Mutant -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1

Lin, X. Z., Parisiadou, L., Sgobio, C., Liu, G., Yu, J. H., Sun, L., Shim, H., Gu, X., Luo, J., Long, C., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1731-12.2012 · Cited by 192

Quantitative Comparison of Glutamatergic and GABAergic Synaptic Vesicles Unveils Selectivity for Few Proteins Including MAL2, a Novel Synaptic Vesicle Protein

Grønborg, M., Pavlos, N. J., Brunk, I., Chua, J. J. E., Münster‐Wandowski, A., Riedel, D., Ahnert‐Hilger, G., Urlaub, H., & Jahn, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4074-09.2010 · Cited by 192

Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons

Eastwood, S. L., & Harrison, P. J. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.05.010 · Cited by 190

Sorting Out Astrocyte Physiology from Pharmacology

Fiacco, T. A., Agulhon, C., & McCarthy, K. D. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145602 · Cited by 190

Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size

Toonen, R. F. G., Wierda, K. D. B., Sons, M. S., de Wit, H., Cornelisse, L. N., Brussaard, A. B., Plomp, J. J., & Verhage, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608507103 · Cited by 189

Adult Neurogenesis and Psychiatric DisordersPreprint

Kang, E., Wen, Z., Song, H., Christian, K. M., & Ming, G. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019026 · Cited by 189

Acrylamide axonopathy revisited

LoPachin, R. M., Balaban, C. D., & Ross, J. F. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(02)00072-8 · Cited by 188

The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology of Alzheimer’s Disease

Rudy, C. C., Hunsberger, H. C., Weitzner, D. S., & Reed, M. N. (2015) · Aging and Disease · doi:10.14336/ad.2014.0423 · Cited by 187

Metal ions as modulators of protein conformation and misfolding in neurodegeneration

Leal, S. S., Botelho, H. M., & Gomes, C. M. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.04.004 · Cited by 187

E-Syts, a family of membranous Ca 2+ -sensor proteins with multiple C 2 domains

Min, S., Chang, W.-P., & Südhof, T. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611725104 · Cited by 187

Recent advances in quantitative colocalization analysis: Focus on neuroscience

Zinchuk, V. S., & Grossenbacher‐Zinchuk, O. (2009) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2009.03.001 · Cited by 186

Molecular Mechanisms of Presynaptic Differentiation

Jin, Y., & Garner, C. C. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123417 · Cited by 186

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

Roosen, D. A., & Cookson, M. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0140-1 · Cited by 186

Presynaptic LTP and LTD of Excitatory and Inhibitory SynapsesPreprint

Castillo, P. E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005728 · Cited by 186

Optogenetic Inhibition of Synaptic Release with Chromophore-Assisted Light Inactivation (CALI)

Lin, J. Y., Sann, S. B., Zhou, K., Nabavi, S., Proulx, C. D., Malinow, R., Jin, Y., & Tsien, R. Y. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.022 · Cited by 184

Cell biology of the NCL proteins: What they do and don't do

Cárcel‐Trullols, J., Kovács, A., & Pearce, D. A. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.04.027 · Cited by 183

Self-organized criticality occurs in non-conservative neuronal networks during ‘up’ states

Millman, D. J., Mihalaş, Ş., Kirkwood, A., & Niebur, E. (2010) · Nature Physics · doi:10.1038/nphys1757 · Cited by 181

Crucial Role of Drosophila Neurexin in Proper Active Zone Apposition to Postsynaptic Densities, Synaptic Growth, and Synaptic Transmission

Li, J., Ashley, J., Budnik, V., & Bhat, M. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.002 · Cited by 180

Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids

Stein, A., Radhakrishnan, A., Riedel, D., Fasshauer, D., & Jahn, R. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1305 · Cited by 180

Vesicle Endocytosis Requires Dynamin-Dependent GTP Hydrolysis at a Fast CNS Synapse

Yamashita, T., Hige, T., & Takahashi, T. (2005) · Science · doi:10.1126/science.1103631 · Cited by 179

Lipid regulation of the synaptic vesicle cycle

Rohrbough, J. C., & Broadie, K. S. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1608 · Cited by 179

Single‐Cell Microelectrochemistry

Schulte, A., & Schuhmann, W. W. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604851 · Cited by 178

Molecular architecture of the neuromuscular junction

Hughes, B. W., Kusner, L. L., & Kaminski, H. J. (2005) · Muscle & Nerve · doi:10.1002/mus.20440 · Cited by 178

SV2 Renders Primed Synaptic Vesicles Competent for Ca2+-Induced Exocytosis

Chang, W.-P., & Südhof, T. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4521-08.2009 · Cited by 176

Synaptotagmin I and II are present in distinct subsets of central synapses

Fox, M. A., & Sanes, J. R. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21381 · Cited by 176

Identification of TMEM230 mutations in familial Parkinson's disease

Deng, H., Shi, Y., Yang, Y., Ahmeti, K., Miller, N., Huang, C., Cheng, L., Zhai, H., Deng, S., Nuytemans, K., et al. (2016) · Nature Genetics · doi:10.1038/ng.3589 · Cited by 174

GPCR mediated regulation of synaptic transmission

Betke, K. M., Wells, C. A., & Hamm, H. E. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.009 · Cited by 172

Frequency-Dependent Kinetics and Prevalence of Kiss-and-Run and Reuse at Hippocampal Synapses Studied with Novel Quenching Methods

Harata, N. C., Choi, S., Pyle, J. L., Aravanis, A. M., & Tsien, R. W. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.018 · Cited by 172

Accessory Proteins Stabilize the Acceptor Complex for Synaptobrevin, the 1:1 Syntaxin/SNAP-25 Complex

Weninger, K., Bowen, M. E., Choi, U. B., Chu, S., & Brünger, A. T. (2008) · Structure · doi:10.1016/j.str.2007.12.010 · Cited by 172

Calcium wave signaling in cancer cells

Parkash, J., & Asotra, K. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.09.013 · Cited by 171

Autophagy in the presynaptic compartment in health and disease

Vijayan, V., & Verstreken, P. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201611113 · Cited by 170

Regulation of Synaptic Transmission by RAB-3 and RAB-27 inCaenorhabditis elegans

Mahoney, T. R., Liu, Q., Itoh, T., Luo, S., Hadwiger, G., Vincent, R., Wang, Z., Fukuda, M., & Nonet, M. L. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-12-1170 · Cited by 170

α‐Synuclein and Polyunsaturated Fatty Acids Promote Clathrin‐Mediated Endocytosis and Synaptic Vesicle Recycling

Ben Gedalya, T., Loeb, V., Israeli, E., Altschuler, Y., Selkoe, D. J., & Sharon, R. (2009) · Traffic · doi:10.1111/j.1600-0854.2008.00853.x · Cited by 169

Snares and Munc18 in synaptic vesicle fusion

Rizo, J., & Südhof, T. C. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn898 · Cited by 539

Molecular machines governing exocytosis of synaptic vesicles

Jahn, R., & Fasshauer, D. (2012) · Nature · doi:10.1038/nature11320 · Cited by 1,004

The molecular machinery of synaptic vesicle exocytosis

Li, L., & Chin, L. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2240-7 · Cited by 129

Mechanism of neurotransmitter release coming into focus

Rizo, J. (2018) · Protein Science · doi:10.1002/pro.3445 · Cited by 210

3. Molecular analysis of neurotransmitter release

Schiavo, G., & Stenbeck, G. (2017) · Princeton University Press eBooks · doi:10.2307/j.ctv3hh4x0.8