THE SYNAPTIC VESICLE CYCLE

Short-Term Synaptic Plasticity

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SNAP receptors implicated in vesicle targeting and fusion

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EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION

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The synaptic vesicle cycle: a cascade of protein–protein interactions

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Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

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Synaptic assembly of the brain in the absence of neurotransmitter secretion.

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Membrane Fusion

Jahn, R., Lang, T., & Südhof, T. C. (2003) · Cell · doi:10.1016/s0092-8674(03)00112-0 · Cited by 1,364

Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones

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SNARE-mediated membrane fusion

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Definition of the readily releasable pool of vesicles at hippocampal synapses.

Rosenmund, C., & Stevens, C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80146-4 · Cited by 1,084

Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation [published erratum appears in J Neurosci 1992 Aug;12(8):following table of contents]

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Synaptotagmin I functions as a calcium regulator of release probability

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Identification and characterization of the vesicular GABA transporter

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Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons

Takamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2000) · Nature · doi:10.1038/35025070 · Cited by 862

Contrasting properties of two forms of long-term potentiation in the hippocampus

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TURNOVER OF TRANSMITTER AND SYNAPTIC VESICLES AT THE FROG NEUROMUSCULAR JUNCTION

Ceccarelli, B., Hurlbut, W. P., & Mauro, A. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.57.2.499 · Cited by 837

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

Perin, M. S., Fried, V. A., Mignery, G. A., Jahn, R., & Südhof, T. C. (1990) · Nature · doi:10.1038/345260a0 · Cited by 819

Intracellular calcium dependence of transmitter release rates at a fast central synapse

Schneggenburger, R., & Neher, E. (2000) · Nature · doi:10.1038/35022702 · Cited by 793

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

Augustin, I., Rosenmund, C., Südhof, T. C., & Brose, N. (1999) · Nature · doi:10.1038/22768 · Cited by 787

A conformational switch in syntaxin during exocytosis: role of munc18

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Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin

Hata, Y., Slaughter, C., & Südhof, T. (1993) · Nature · doi:10.1038/366347a0 · Cited by 751

Essential functions of synapsins I and II in synaptic vesicle regulation

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The release of neural transmitter substances

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Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells.

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Beyond parallel fiber LTD: the diversity of synaptic and non-synaptic plasticity in the cerebellum

Hansel, C., Linden, D. J., & D'Angelo, E. (2001) · Nature Neuroscience · doi:10.1038/87419 · Cited by 694

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

Wang, Y., Okamoto, M., Schmitz, F., Hofmann, K., & Südhof, T. C. (1997) · Nature · doi:10.1038/41580 · Cited by 684

SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice

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A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons

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Calcium influx and transmitter release in a fast CNS synapse

Borst, J. G. G., & Sakmann, B. J. (1996) · Nature · doi:10.1038/383431a0 · Cited by 632

Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP

Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A., & Nicoll, R. A. (1994) · Science · doi:10.1126/science.7916482 · Cited by 618

Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

Li, C., Ullrich, B., Zhang, J. Z., Anderson, R. G. W., Brose, N., & Südhof, T. C. (1995) · Nature · doi:10.1038/375594a0 · Cited by 599

A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter

Liu, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90425-c · Cited by 589

RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone

Schoch, S., Castillo, P. E., Jo, T., Mukherjee, K., Geppert, M., Wang, Y., Schmitz, F., Malenka, R. C., & Südhof, T. C. (2002) · Nature · doi:10.1038/415321a · Cited by 579

The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate

Fremeau, R. T., Burman, J. L., Qureshi, T., Tran, C. H., Proctor, J. M., Johnson, J., Zhang, H., Sulzer, D. L., Copenhagen, D. R., Storm‐Mathisen, J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222546799 · Cited by 568

Presynaptic Specificity of Endocannabinoid Signaling in the Hippocampus

Wilson, R. I., Kunos, G., & Nicoll, R. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00372-5 · Cited by 543

Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis

Washbourne, P., Thompson, P. M., Carta, M., da Costa, E. T., Mathews, J. R., López‐Bendito, G., Molnár, Z., Bêcher, M. W., Valenzuela, C. F., Partridge, L. D., et al. (2001) · Nature Neuroscience · doi:10.1038/nn783 · Cited by 535

Synapsins: Mosaics of Shared and Individual Domains in a Family of Synaptic Vesicle Phosphoproteins

Südhof, T. C., Czernik, A. J., Kao, H., Takei, K., Johnston, P. A., Horiuchi, A., Kanazir, S., Wagner, M. A., Perin, M. S., Camilli, P. V. D., et al. (1989) · Science · doi:10.1126/science.2506642 · Cited by 533

Distinct pools of synaptic vesicles in neurotransmitter release

Pieribone, V. A., Shupliakov, O., Brodin, L., Hilfiker, S., Czernik, A. J., & Greengard, P. (1995) · Nature · doi:10.1038/375493a0 · Cited by 532

Two components of transmitter release at a central synapse.

Goda, Y., & Stevens, C. F. (1994) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.91.26.12942 · Cited by 529

Accessory factors in clathrin-dependent synaptic vesicle endocytosis

Slepnev, V. I., & Camilli, P. V. D. (2000) · Nature reviews. Neuroscience · doi:10.1038/35044540 · Cited by 517

Morphological correlates of functionally defined synaptic vesicle populations

Schikorski, T., & Stevens, C. F. (2001) · Nature Neuroscience · doi:10.1038/86042 · Cited by 516

Calcium Sensitivity of Glutamate Release in a Calyx-Type Terminal

Bollmann, J. H., Sakmann, B. J., & Borst, J. G. G. (2000) · Science · doi:10.1126/science.289.5481.953 · Cited by 510

Synaptotagmins: Why So Many?*

Südhof, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100052200 · Cited by 503

Complexins: Cytosolic proteins that regulate SNAP receptor function

McMahon, H. T., Missler, M., Li, C., & Südhof, T. C. (1995) · Cell · doi:10.1016/0092-8674(95)90239-2 · Cited by 500

Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release

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Expression cloning of a reserpine-sensitive vesicular monoamine transporter.

Erickson, J. D., Eiden, L. E., & Hoffman, B. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10993 · Cited by 492

cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase

Huang, Y.-Y., Li, X.-C., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90401-4 · Cited by 490

Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals

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The role of Rab3A in neurotransmitter release

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Three-Dimensional Structure of the Complexin/SNARE Complex

Chen, X., Tomchick, D. R., Kovrigin, E., Araç, D., Machius, M., Südhof, T. C., & Rizo, J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00583-4 · Cited by 455

Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.

Edelmann, L., Hanson, P. I., Chapman, E. R., & Jahn, R. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb06995.x · Cited by 453

Three modes of synaptic vesicular recycling revealed by single-vesicle imaging

Gandhi, S., & Stevens, C. F. (2003) · Nature · doi:10.1038/nature01677 · Cited by 452

Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices.

Bekkers, J. M., Richerson, G. B., & Stevens, C. F. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5359 · Cited by 452

Cyclic AMP Mediates a Presynaptic Form of LTP at Cerebellar Parallel Fiber Synapses

Salin, P. A., Malenka, R. C., & Nicoll, R. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80099-9 · Cited by 443

Timing of neurotransmission at fast synapses in the mammalian brain

Sabatini, B. L., & Regehr, W. G. (1996) · Nature · doi:10.1038/384170a0 · Cited by 442

Differential expression of synaptic vesicle protein 2 (SV2) isoforms

Bajjalieh, S., Frantz, G., Weimann, J., McConnell, S., & Scheller, R. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05223.1994 · Cited by 440

Currents through the fusion pore that forms during exocytosis of a secretory vesicle

Breckenridge, L. J., & Almers, W. (1987) · Nature · doi:10.1038/328814a0 · Cited by 432

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

von Mollard, G. F., Südhof, T. C., & Jahn, R. (1991) · Nature · doi:10.1038/349079a0 · Cited by 431

Pre‐ and postsynaptic whole‐cell recordings in the medial nucleus of the trapezoid body of the rat.

Borst, J. G. G., Helmchen, F., & Sakmann, B. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp021095 · Cited by 427

Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming

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The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

Geppert, M., Goda, Y., Stevens, C., & Südhof, T. (1997) · Nature · doi:10.1038/42954 · Cited by 422

Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release

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Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)

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Mammalian Homologues of Caenorhabditis elegans unc-13 Gene Define Novel Family of C2-domain Proteins

Brose, N., Hofmann, K., Hata, Y., & Südhof, T. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.42.25273 · Cited by 412

Molecular Cloning and Functional Identification of Mouse Vesicular Glutamate Transporter 3 and Its Expression in Subsets of Novel Excitatory Neurons

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Rabphilin-3A, a Putative Target Protein for smg p25A/rab3A p25 Small GTP-Binding Protein Related to Synaptotagmin

Shirataki, H., Kaibuchi, K., Sakoda, T., Kishida, S., Yamaguchi, T., Wada, K., Miyazaki, M., & Takai, Y. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2061-2068.1993 · Cited by 402

Munc18-1 Promotes Large Dense-Core Vesicle Docking

Voets, T., Toonen, R. F., Brian, E. C., de Wit, H., Moser, T., Rettig, J., Südhof, T. C., Neher, E., & Verhage, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00391-9 · Cited by 396

Three-Dimensional Structure of the Synaptotagmin 1 C2B-Domain

Fernández, I., Araç, D., Ubach, J., Gerber, S. H., Shin, O., Gao, Y., Anderson, R. G. W., Südhof, T. C., & Rizo, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00548-7 · Cited by 391

Optimizing Synaptic Architecture and Efficiency for High-Frequency Transmission

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RIM1α is required for presynaptic long-term potentiation

Castillo, P. E., Schoch, S., Schmitz, F., Südhof, T. C., & Malenka, R. C. (2002) · Nature · doi:10.1038/415327a · Cited by 389

Short-term plasticity at the calyx of held

von Gersdorff, H., & Borst, J. G. G. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn705 · Cited by 388

The architecture of active zone material at the frog's neuromuscular junction

Harlow, M. L., Ress, D., Stoschek, A., Marshall, R. M., & McMahan, U. J. (2001) · Nature · doi:10.1038/35054000 · Cited by 388

Rabenosyn-5, a Novel Rab5 Effector, Is Complexed with Hvps45 and Recruited to Endosomes through a Fyve Finger Domain

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The Caenorhabditis elegans unc-17 Gene: a Putative Vesicular Acetylcholine Transporter

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SV2A and SV2B Function as Redundant Ca2+ Regulators in Neurotransmitter Release

Janz, R., Goda, Y., Geppert, M., Missler, M., & Südhof, T. C. (1999) · Neuron · doi:10.1016/s0896-6273(00)81046-6 · Cited by 372

Ca2+ Regulates the Interaction between Synaptotagmin and Syntaxin 1 (*)

Chapman, E., Hanson, P., An, S. J., & Jahn, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23667 · Cited by 363

Glutamate uptake by brain synaptic vesicles. Energy dependence of transport and functional reconstitution in proteoliposomes.

Maycox, P. R., Deckwerth, T. L., Hell, J. W., & Jahn, R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37605-7 · Cited by 361

Vesicle pools and short-term synaptic depression: lessons from a large synapse

Schneggenburger, R., Sakaba, T., & Neher, E. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02139-2 · Cited by 361

Three-Dimensional Reconstruction of a Calyx of Held and Its Postsynaptic Principal Neuron in the Medial Nucleus of the Trapezoid Body

Sätzler, K., Söhl, L. F., Bollmann, J. H., Borst, J. G., Frotscher, M., Sakmann, B., & Lübke, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10567.2002 · Cited by 358

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

Castillo, P. E., Janz, R., Sdhof, T. C., Tzounopoulos, T., Malenka, R. C., & Nicoll, R. A. (1997) · Nature · doi:10.1038/41574 · Cited by 356

Identification of Synaptophysin as a Hexameric Channel Protein of the Synaptic Vesicle Membrane

Thomas, L., Hartung, K., Langosch, D., Rehm, H., Bamberg, E., Franke, W. W., & Betz, H. (1988) · Science · doi:10.1126/science.2461586 · Cited by 354

The kinetics of transmitter release at the frog neuromuscular junction

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Two Endocytic Recycling Routes Selectively Fill Two Vesicle Pools in Frog Motor Nerve Terminals

Richards, D. A., Guatimosim, C., & Betz, W. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00065-9 · Cited by 353

Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice.

Li, L., Chin, L., Shupliakov, O., Brodin, L., Sihra, T., Hvalby, O., Jensen, V., Zheng, D., McNamara, J. O., & Greengard, P. (1995) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.92.20.9235 · Cited by 351

Rapid Reuse of Readily Releasable Pool Vesicles at Hippocampal Synapses

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Domain structure of synaptotagmin (p65)

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Short-term synaptic plasticity is altered in mice lacking synapsin I

Rosahl, T. (1993) · Cell · doi:10.1016/0092-8674(93)90487-b · Cited by 328

Three-Dimensional Comparison of Ultrastructural Characteristics at Depressing and Facilitating Synapses onto Cerebellar Purkinje Cells

Xu‐Friedman, M. A., Harris, K. M., & Regehr, W. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06666.2001 · Cited by 320

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2‐domain?

Ubach, J., Zhang, X., Shao, X., Südhof, T. C., & Rizo, J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.14.3921 · Cited by 316

Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases

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Calcium dynamics associated with a single action potential in a CNS presynaptic terminal

Helmchen, F., Borst, J. G. G., & Sakmann, B. J. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78792-7 · Cited by 306

Direct Interaction of the Rat unc-13 Homologue Munc13-1 with the N Terminus of Syntaxin

Betz, A., Okamoto, M., Benseler, F., & Brose, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.4.2520 · Cited by 304

Actin-Dependent Regulation of Neurotransmitter Release at Central Synapses

Morales, M., Colicos, M. A., & Goda, Y. (2000) · Neuron · doi:10.1016/s0896-6273(00)00064-7 · Cited by 300

Cast

Ohtsuka, T., Takao‐Rikitsu, E., Inoue, E., Inoue, M., Takeuchi, M., Matsubara, K., Deguchi‐Tawarada, M., Satoh, K., Morimoto, K., Nakanishi, H., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202083 · Cited by 298

Liprins, a Family of LAR Transmembrane Protein-tyrosine Phosphatase-interacting Proteins

Serra‐Pages, C., Medley, Q. G., Tang, M., Hart, A. C., & Streuli, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15611 · Cited by 292

Synaptotagmin Modulation of Fusion Pore Kinetics in Regulated Exocytosis of Dense-Core Vesicles

Wang, C., Grishanin, R. N., Earles, C. A., Chang, P. Y., Martin, T. F. J., Chapman, E. R., & Jackson, M. B. (2001) · Science · doi:10.1126/science.1064002 · Cited by 291

Tomosyn: a Syntaxin-1–Binding Protein that Forms a Novel Complex in the Neurotransmitter Release Process

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Calcium Secretion Coupling at Calyx of Held Governed by Nonuniform Channel–Vesicle Topography

Meinrenken, C., Borst, J. G., & Sakmann, B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01648.2002 · Cited by 290

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