CoChat
Sign Up
Cited by 314Adrenal and Paraganglionic TumorsRenal cell carcinoma treatmentMedical Imaging Techniques and Applications

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Adrenocortical Carcinomas and Adrenal Pheochromocytomas: Mass and Enhancement Loss Evaluation at Delayed Contrast-enhanced CT

Szolar, Dieter H., Korobkin, Melvyn, Reittner, Pia, Berghold, Andrea, Bauernhofer, Thomas, Trummer, Harald, Schoellnast, Helmut, Preidler, Klaus W., Samonigg, Hellmuth·2005·Radiology
DOI 10.1148/radiol.2342031876
Open this paper in CoChat — free account

Abstract

PURPOSE: To retrospectively measure the adrenal gland attenuation and the percentage loss of adrenal gland enhancement at delayed contrast medium-enhanced computed tomography (CT) in patients with adrenocortical carcinomas and pheochromocytomas and to compare these data with those in patients with adenomas and metastases. MATERIALS AND METHODS: The study protocol was approved by the ethics committee, which waived informed consent. Eleven patients with proved adrenocortical carcinoma, 17 with proved pheochromocytoma, 23 with adrenal adenoma, and 16 with metastasis to the adrenal gland underwent helical CT. Nonenhanced CT was followed by contrast-enhanced CT 1 minute and 10 minutes later. Attenuation and enhancement loss values were calculated. RESULTS: The mean attenuation of adenomas (8 HU +/- 18 [standard deviation]) was significantly lower than those of adrenocortical carcinomas (39 HU +/- 14), pheochromocytomas (44 HU +/- 11), and metastases (34 HU +/- 11) on nonenhanced CT scans (P < .001). Although the mean attenuation values for nonadenomas (ie, adrenocortical carcinomas, pheochromocytomas, and metastases) were significantly higher than the value for adenomas on the 1-minute contrast-enhanced CT scans (P < .001), there was more overlap in attenuation between adenomas and nonadenomas on contrast-enhanced scans than on nonenhanced scans. On the 10-minute delayed contrast-enhanced scans, the mean attenuation of adenomas (32 HU +/- 17) was significantly lower than the mean attenuations of carcinomas (72 HU +/- 15), pheochromocytomas (83 HU +/- 14), and metastases (66 HU +/- 13) (P < .001). At optimal threshold values of 50% for absolute percentage of enhancement loss and 40% for relative percentage of enhancement loss at 10 minutes, both the sensitivity and the specificity for the diagnosis of adenoma were 100% when adenomas were compared with carcinomas, pheochromocytomas, and metastases. CONCLUSION: The enhancement loss in adrenocortical carcinomas and pheochromocytomas is similar to that in adrenal metastases but significantly less than that in adrenal adenomas. The percentage change in contrast material washout is a useful adjunct to absolute CT attenuation values in differentiating adrenal adenomas from adrenocortical carcinomas and pheochromocytomas.

Overview

Integrity signals

Registry

Crossref · 10.1148/radiol.2342031876

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 26 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Szolar, D. H., Korobkin, M., Reittner, P., Berghold, A., Bauernhofer, T., Trummer, H., Schoellnast, H., Preidler, K. W., & Samonigg, H.
Affiliations
University of Graz (AT)
ORCID
Venue
Radiology
Publisher
Radiological Society of North America (RSNA)
Published
2005-02
Volume
234
Issue
2
Pages
479-485
ISSN
  • 0033-8419 (ISSN-L)
  • 1527-1315
DOI
10.1148/radiol.2342031876
OpenAlex
W2137978892
Cited by
314
References
26
Citations by year
2026: 5 · 2025: 6 · 2024: 9 · 2023: 5 · 2022: 17 · 2021: 13 · 2020: 13 · 2019: 14 · 2018: 18 · 2017: 14 · 2016: 10 · 2015: 18 · 2014: 15 · 2013: 25 · 2012: 22
FWCI
14.42
Type
journal article
Language
en
Open access
closed
Locations
  • Radiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Oncology › Renal cell carcinoma treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords
adrenocortical carcinoma, adrenal pheochromocytoma, adrenal adenoma, adrenal metastasis, differential diagnosis, adrenal imaging, sensitivity and specificity, adrenal mass characterization
MeSH terms
Adenoma, Adolescent, Adrenal Cortex Neoplasms, Adrenal Gland Neoplasms, Adult, Aged, Female, Humans, Male, Middle Aged, Pheochromocytoma, Sensitivity and Specificity, Tomography, X-Ray Computed, Adrenocortical Carcinoma

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review