The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
MR Imaging of Human Brain at 3.0 T: Preliminary Report on Transverse Relaxation Rates and Relation to Estimated Iron Content
Abstract
PURPOSE: To determine the transverse relaxation rates R2 and R2' from several gray matter regions and from frontal cortical white matter in healthy human brains in vivo and to determine the relationship between relaxation rates and iron concentration [Fe]. MATERIALS AND METHODS: Six healthy adults aged 19-42 years underwent thin-section gradient-echo sampling of free induction decay and echo magnetic resonance (MR) imaging at 3.0 T. Imaging covered the mesencephalon and basal ganglia. RESULTS: Relaxation rates (mean +/- SD) were highest in globus pallidus (R2 = 25.8 seconds-1 +/- 1.1, R2' = 12.0 seconds-1 +/- 2.1) and lowest in prefrontal cortex (R2 = 14.4 seconds-1 +/- 1.8, R2' = 3.4 seconds-1 +/- 1.1). Frontal white matter measurements were as follows: R2 = 18.0 seconds-1 +/- 1.2 and R2' = 3.9 seconds-1 +/- 1.2. For gray matter, both R2 and R2' showed a strong correlation (r = 0.92, P < .001 and r = 0.90, P < .001, respectively) with [Fe]. Although the slopes of the regression lines for R2' versus [Fe] and for R2 versus [Fe] were similar, the iron-independent component of R2' (2.2 seconds-1 +/- 0.6), the value when [Fe] = 0, was much less than that of R2 (12.7 seconds-1 +/- 0.7). CONCLUSION: The small iron-independent component R2', as compared with that of R2, is consistent with the hypothesis that R2' has higher iron-related specificity.
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Cites
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Self-citationAssessment of relative brain iron concentrations using T2‐weighted and T2*‐weighted MRI at 3 Tesla
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Self-citationTheory and application of static field inhomogeneity effects in gradient‐echo imaging
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The relation between brain iron and NMR relaxation times: An in vitro study
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Cited by
T1, T2 relaxation and magnetization transfer in tissue at 3T
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Imaging iron stores in the brain using magnetic resonance imaging
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Periaqueductal Gray Matter Dysfunction in Migraine: Cause or the Burden of Illness?
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Self-citationBiophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals
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MRI measurement of brain iron in patients with restless legs syndrome
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Metadata
- Authors
- Gelman, N., Gorell, J. M., Barker, P. B., Savage, R. M., Spickler, E. M., Windham, J. P., & Knight, R. A.
- Venue
- Radiology
- Published
- 1999-03
- Volume
- 210
- Issue
- 3
- Pages
- 759-767
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2160027020
- Cited by
- 373
- References
- 30
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: MR Imaging of Human Brain at 3.0 T: Preliminary Report on Transverse Relaxation Rates and Relation to Estimated Iron Content. https://app.cochat.ai/papers/10.1148/radiology.210.3.r99fe41759
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- Gelman, N., Gorell, J. M., Barker, P. B., Savage, R. M., Spickler, E. M., Windham, J. P., & Knight, R. A. (1999). MR Imaging of Human Brain at 3.0 T: Preliminary Report on Transverse Relaxation Rates and Relation to Estimated Iron Content. Radiology. https://doi.org/10.1148/radiology.210.3.r99fe41759
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