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Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes
Abstract
The tissue-specific role of mitochondrial respiratory capacity in the development of insulin resistance and type 2 diabetes is unclear. We determined mitochondrial function in glycolytic and oxidative skeletal muscle and liver from lean (+/?) and obese diabetic (db/db) mice. In lean mice, the mitochondrial respiration pattern differed between tissues. Tissue-specific mitochondrial profiles were then compared between lean and db/db mice. In liver, mitochondrial respiratory capacity and protein expression, including peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), was decreased in db/db mice, consistent with increased mitochondrial fission. In glycolytic muscle, mitochondrial respiration, as well as protein and mRNA expression of mitochondrial markers, was increased in db/db mice, suggesting increased mitochondrial content and fatty acid oxidation capacity. In oxidative muscle, mitochondrial complex I function and PGC-1α and mitochondrial transcription factor A (TFAM) protein levels were decreased in db/db mice, along with increased level of proteins related to mitochondrial dynamics. In conclusion, mitochondrial respiratory performance is under the control of tissue-specific mechanisms and is not uniformly altered in response to obesity. Furthermore, insulin resistance in glycolytic skeletal muscle can be maintained by a mechanism independent of mitochondrial dysfunction. Conversely, insulin resistance in liver and oxidative skeletal muscle from db/db mice is coincident with mitochondrial dysfunction.
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“and with insulin resistance in the same mice model (Holmstrom et al., 2012).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Holmstrom et al., 2012
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Cites
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321
Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952
CORRELATED MORPHOMETRIC AND BIOCHEMICAL STUDIES ON THE LIVER CELL
Weibel, E. R., Stäubli, W., Gnägi, H. R., & Hess, F. A. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.42.1.68 · Cited by 1,142
Wang, Y., Rimm, E. B., Stampfer, M. J., Willett, W. C., & Hu, F. B. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.3.555 · Cited by 1,130
Kelley, D. E., Goodpaster, B., Wing, R. R., & Simoneau, J.-A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1130 · Cited by 1,096
Mootha, V. K., Bunkenborg, J., Olsen, J. V., Hjerrild, M., Wisniewski, J. R., Stahl, E., Bolouri, M. S., Ray, H. N., Sihag, S., Kamal, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00926-7 · Cited by 889
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
Hancock, C. R., Han, D.-H., Chen, M., Terada, S., Yasuda, T., Wright, D. C., & Holloszy, J. O. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802057105 · Cited by 538 · cited 1×
“Several lines of evidence suggest that mitochondrial function in liver or skeletal muscle is associated with insulin sensitivity and T2DM in animal models (2, 10, 12, 20, 40, 48) and humans (25, 27, 36–39).”
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“, 2012) and with insulin resistance in the same mice model (Holmstrom et al., 2012).”
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Enos, R. T., Velázquez, K. T., & Murphy, E. A. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.01.011 · Cited by 48
Takahashi, T., Yamamoto, M., Amikura, K., Kato, K., Serizawa, T., Serizawa, K., Akazawa, D., Aoki, T., Kawai, K., Ogasawara, E., et al. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.220673 · Cited by 44
Leduc‐Gaudet, J., Reynaud, O., Chabot, F., Mercier, J., Andrich, D. E., St-Pierre, D. H., & Gouspillou, G. (2018) · Physiological Reports · doi:10.14814/phy2.13548 · Cited by 45
Chen, S., Qian, G., Ghanem, B., Wang, Y., Shu, Z., Zhao, X., Yang, L., Liao, X., & Zheng, Y. (2022) · Advanced Science · doi:10.1002/advs.202203460 · Cited by 42
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Müller, M. J., Heymsfield, S. B., & Bosy‐Westphal, A. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab184 · Cited by 42
Jheng, H., Huang, S., Kuo, H.-M., Hughes, M. W., & Tsai, Y.-S. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12863 · Cited by 38
Papilloud, A., Guillot de Suduiraut, I., Zanoletti, O., Grosse, J., & Sandi, C. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0215-6 · Cited by 38
Picklo, M. J., & Thyfault, J. P. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0302 · Cited by 38
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Chen, P. B., Yang, J. S., & Park, Y. (2018) · Lipids · doi:10.1002/lipd.12037 · Cited by 37
Coleman, V., Sa‐nguanmoo, P., Koenig, J., Schulz, T. J., Grune, T., Klaus, S., Kipp, A. P., & Ost, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-20901-4 · Cited by 39
Roseno, S. L., Davis, P. R., Bollinger, L. M., Powell, J. J. S., Witczak, C. A., & Brault, J. J. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0037-y · Cited by 36
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Xu, Z., Zhang, L., Li, X., Jiang, Z., Sun, L., Zhao, G., Zhou, G., Zhang, H., Shang, J., & Wang, T. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv061 · Cited by 34
Low-frequency stimulation regulates metabolic gene expression in paralyzed muscle
Petrie, M. A., Suneja, M., & Shields, R. K. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00628.2014 · Cited by 33
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Alimujiang, M., Xue-ying, Y., Yu, M., Hou, W., Yan, Z., Yang, Y., Bao, Y., & Yin, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15238 · Cited by 33
Nadal-Casellas, A., Bauzá-Thorbrügge, M., Proenza, A. M., Gianotti, M., & Lladó, I. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1481-x · Cited by 31
Romo‐Vaquero, M., Larrosa, M., Yáñez-Gascón, M. J., Issaly, N., Flanagan, J., Roller, M., Tomás-Barberán, F. A., Espı́n, J. C., & García‐Conesa, M. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300524 · Cited by 29
Petrie, M. A., Suneja, M., Faidley, E. A., & Shields, R. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115791 · Cited by 29
Li, H., Liu, J., Wang, Y., Fu, Z., Hüttemann, M., Monks, T. J., Chen, A. F., & Wang, J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00073.2017 · Cited by 27
Li, Y., Lou, N., Liu, X., Zhuang, X., & Chen, S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116755 · Cited by 27
Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice
Holmström, M., Tom, R. Z., Björnholm, M., García-Rovés, P. M., & Zierath, J. R. (2013) · Metabolism · doi:10.1016/j.metabol.2013.04.001 · Cited by 27
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Dunham‐Snary, K. J., & Ballinger, S. W. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.007 · Cited by 27
Koch, R. E., & Hill, G. E. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12400 · Cited by 25
The Na/K‐ATPase α1/Src interaction regulates metabolic reserve and Western diet intolerance
Kutz, L. C., Cui, X., Xie, J. X., Mukherji, S. T., Terrell, K. C., Huang, M., Wang, X., Wang, J., Martin, A. J., Pessoa, M. T., et al. (2021) · Acta Physiologica · doi:10.1111/apha.13652 · Cited by 24
Ennequin, G., Capel, F., Caillaud, K., Chavanelle, V., Etienne, M., Teixeira, A., Li, X., Boisseau, N., & Sirvent, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-02029-z · Cited by 22
Angelino, E., Bodo, L., Sartori, R., Malacarne, V., D’Anna, B., Formaggio, N., Barua, S., Raiteri, T., Lauria, A., Reano, S., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01397-5 · Cited by 22
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Heim, A. B., Chung, D. J., Florant, G. L., & Chicco, A. J. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00427.2016 · Cited by 22
Dasari, S., Newsom, S. A., Ehrlicher, S. E., Stierwalt, H. D., & Robinson, M. M. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00051.2018 · Cited by 21
Mitochondrial DNA content and function, childhood obesity, and insulin resistance
Shoar, Z., Goldenthal, M. J., Luca, F. D., & Suarez, E. A. (2015) · Endocrine Research · doi:10.3109/07435800.2015.1068797 · Cited by 21
Kugler, B. A., Lourie, J., BERGER, N. J. A., Lin, N., Nguyen, P., DosSantos, E., Ali, A. S., Sesay, A., Rosen, H. G., KALEMBA, B. L., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101802 · Cited by 21
Adar, O., Hollander, A., & Ilan, Y. (2023) · Advances in respiratory medicine · doi:10.3390/arm91050028 · Cited by 20
Moreno‐Navarrete, J. M., Ortega, F. J., Gómez‐Serrano, M., García‐Santos, E., Ricart, W., Tinahones, F. J., Mingrone, G., Peral, B., & Fernández‐Real, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070810 · Cited by 21
Grizzanti, J., Lee, H., Camins, A., Pallàs, M., & Casadesús, G. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.11.002 · Cited by 21
Swapna Sasi, U. S., Sindhu, G., & Raghu, K. G. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104952 · Cited by 19
Perelló-Amorós, M., Fernández‐Borràs, J., Sánchez-Moya, A., Vélez, E. J., García-Pérez, I., Gutiérrez, J., & Blasco, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.678985 · Cited by 18
Sun, S., Castro, L. F. C., Monroig, Ó., Cao, X., & Gao, J. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10774-x · Cited by 19
Leonetti, D., Soleti, R., Clere, N., Vergori, L., Jacques, C., Duluc, L., Dourguia, C., Martínez, M. C., & Andriantsitohaina, R. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00529 · Cited by 17
Effect of nutrition and atherogenic index on the occurrence and intensity of insulin resistance
Ostrowska, L., Witczak-Sawczuk, K., & Adamska-Patruno, E. (2013) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.1774 · Cited by 16
Ebrahimnezhad, N., Nayebifar, S., Soltani, Z., & Khoramipour, K. (2023) · PubMed Central · doi:10.22038/ijbms.2023.70833.15387 · Cited by 16
Hofstadter, W. A., Cook, K. C., Tsopurashvili, E., Gebauer, R., Pražák, V., Machala, E. A., Park, J. W., Grünewald, K., Quemin, E. R. J., & Cristea, I. M. (2024) · Nature Communications · doi:10.1038/s41467-024-51680-4 · Cited by 14
Minta, W., Palee, S., Mantor, D., Sutham, W., Jaiwongkam, T., Kerdphoo, S., Pratchayasakul, W., Kumfu, S., Chattipakorn, S. C., & Chattipakorn, N. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.006 · Cited by 16
Gesing, A., Masternak, M. M., Lewiñski, A., Karbownik‐Lewińska, M., Kopchick, J. J., & Bartke, A. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls231 · Cited by 14
Kodde, A., van der Beek, E. M., Phielix, E., Engels, E., Schipper, L., & Oosting, A. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0191-5 · Cited by 15
Adaptation of Mitochondrial Substrate Flux in a Mouse Model of Nonalcoholic Fatty Liver Disease
Staňková, P., Kučera, O., Peterová, E., Lotková, H., Maseko, T. E., Nozickova, K., & Červinková, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031101 · Cited by 16
Kim, J. S., Han, Y. K., Kong, M. J., & Park, K. M. (2022) · Physiological Reports · doi:10.14814/phy2.15348 · Cited by 13
Effects of Lifestyle Intervention in Tissue-Specific Lipidomic Profile of Formerly Obese Mice
Dahdah, N., González-Franquesa, A., Samino, S., Gama-Pérez, P., Herrero, L., Perales, J. C., Yanes, Ó., Malagón, M. M., & García-Rovés, P. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073694 · Cited by 13
Kumar, V., Chang, H. L., Reiter, D. A., Bradley, D. P., Belury, M. A., McCormack, S. E., & Raman, S. V. (2017) · Journal of Visualized Experiments · doi:10.3791/54977 · Cited by 9
Kladnická, I., Čedíková, M., Jedlička, J., Kohoutová, M., Müller, L., Plavinová, I., Kripnerová, M., Bludovská, M., Kuncová, J., & Müllerová, D. (2021) · Biomolecules · doi:10.3390/biom11081068 · Cited by 9
Lee, J.-H., Zhang, D., Kwak, S. E., Shin, H.-E., & Song, W. J. (2021) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes20043 · Cited by 8
Metadata
- Authors
- Holmström, M. H., Iglesias-Gutierrez, E., Zierath, J. R., & Garcia-Roves, P. M.
- Affiliations
- Departments of 1Molecular Medicine and Surgery and
- Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
- Karolinska Institutet (SE)
- Corresponding author
- Zierath, Juleen R.
- ORCID
- Zierath, Juleen R.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2012-03-15
- Volume
- 302
- Issue
- 6
- Pages
- E731-E739
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2112563343
- Cited by
- 137
- References
- 53
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 10 · 2023: 7 · 2022: 6 · 2021: 10 · 2020: 11 · 2019: 7 · 2018: 13 · 2017: 13 · 2016: 7 · 2015: 11 · 2014: 15 · 2013: 15 · 2012: 6
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mitochondrial respiration, insulin resistance, type 2 diabetes, obesity, db/db mice, skeletal muscle, liver, PGC-1α, TFAM, mitochondrial dynamics, mitochondrial fission, mitochondrial biogenesis, fatty acid oxidation, mitochondrial complex I
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Animal Nutritional Physiological Phenomena, Blood Glucose, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, DNA-Binding Proteins, Glycogen, Glycolysis, High Mobility Group Proteins, Insulin Resistance, Mice, Inbred C57BL, Mice, Obese, Mitochondria, Mitochondria, Liver, Mitochondria, Muscle, Obesity, Oxygen Consumption, Transcription Factors, Triglycerides, Blotting, Western, Trans-Activators, Mice, Inbred NOD, Cell Lineage, Mice, Real-Time Polymerase Chain Reaction
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