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Cited by 288Neurotransmitter Receptor Influence on BehaviorMitochondrial Function and PathologyNeuroendocrine regulation and behavior

Mitochondrial function in the brain links anxiety with social subordination

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Hollis, Fiona, van der Kooij, Michael A., Zanoletti, Olivia, Lozano, Laura, Cantó, Carles, Sandi, Carmen·2015·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1512653112PMC PMC4687564
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Abstract

Significance: Within a dominance hierarchy, low social status strongly reduces individual well-being. In socially living species, rank in a hierarchy is determined through competitive encounters. Despite the numerous health consequences, the ability of personality traits to predispose individuals to a particular social rank remains largely unclear. Our work identifies trait anxiety as a predisposing factor to a subordinate rank. We demonstrate that mitochondrial function in the nucleus accumbens, a brain region relevant for motivation and depression, is a critical mediating factor in the subordinate status displayed by high-anxious rats. These findings highlight a role for cerebral energy metabolism in social behavior and point to mitochondrial function in the nucleus accumbens as a potential marker and avenue of treatment for mood disorders.

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Cited by

Sorted by citations

Authors
Hollis, F., van der Kooij, M. A., Zanoletti, O., Lozano, L., Cantó, C., & Sandi, C.
Affiliations
  • École Polytechnique Fédérale de Lausanne (CH)
  • Brain Mind Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland;
  • Nestlé Institute of Health Sciences SA, CH-1015 Lausanne, Switzerland
Corresponding author
Sandi, Carmen
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2015-11-30
Volume
112
Issue
50
Pages
15486-15491
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1512653112
PMC
PMC4687564
OpenAlex
W2182045965
Cited by
288
References
14
Citations by year
2026: 23 · 2025: 38 · 2024: 32 · 2023: 32 · 2022: 31 · 2021: 21 · 2020: 25 · 2019: 33 · 2018: 31 · 2017: 13 · 2016: 9
FWCI
8.24
Type
journal article
Language
en
Open access
Licence
www.pnas.org/site/misc/userlicense.xhtml (vor)
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders
Swiss National Science Foundation (31003A-152614)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
trait anxiety, social dominance, dominance hierarchy, mitochondrial function, nucleus accumbens, mitochondrial complex I, succinate dehydrogenase, brain energy metabolism, reactive oxygen species, nicotinamide, social subordination, social behavior, rats
MeSH terms
Animals, Anxiety, Brain, Dominance-Subordination, Male, Mitochondria, Niacinamide, Nucleus Accumbens, Social Behavior, Rats, Wistar, Electron Transport Chain Complex Proteins

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