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Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier
Open accessAbstract
Lactobacillus plantarum, a commensal bacterium of humans, has been proposed to enhance the intestinal barrier, which is compromised in a number of intestinal disorders. To study the effect of L. plantarum strain WCFS1 on human barrier function, healthy subjects were administered L. plantarum or placebo in the duodenum for 6 h by means of a feeding catheter. The scaffold protein zonula occludens (ZO)-1 and transmembrane protein occludin were found to be significantly increased in the vicinity of the tight-junction (TJ) structures, which form the paracellular seal between cells of the epithelium. In an in vitro model of the human epithelium, L. plantarum induced translocation of ZO-1 to the TJ region; however, the effects on occludin were minor compared with those seen in vivo. L. plantarum was shown to activate Toll-like receptor 2 (TLR2) signaling, and treatment of Caco-2 monolayers with the TLR2 agonist Pam(3)-Cys-SK4(PCSK) significantly increased fluorescent staining of occludin in the TJ. Pretreatment of Caco-2 monolayers with L. plantarum or PCSK significantly attenuated the effects of phorbol ester-induced dislocation of ZO-1 and occludin and the associated increase in epithelial permeability. Our results identifying commensal bacterial stimulation of TLR2 in the gut epithelium as a regulator of epithelial integrity have important implications for understanding probiotic mechanisms and the control of intestinal homeostasis.
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Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Complete genome sequence of Lactobacillus plantarum WCFS1
Kleerebezem, M., Boekhorst, J., van Kranenburg, R., Molenaar, D., Kuipers, O. P., Leer, R., Tarchini, R., Peters, S. A., Sandbrink, H. M., Fiers, M. W. E. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337704100 · Cited by 1,472
The tight junction: a multifunctional complex.
Schneeberger, E., & Lynch, R. D. (2004) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00558.2003 · Cited by 1,450
Epithelial NEMO links innate immunity to chronic intestinal inflammation
Nenci, A., Becker, C., Wullaert, A., Gareus, R., Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C. F., Madison, B., et al. (2007) · Nature · doi:10.1038/nature05698 · Cited by 1,077
Structure and function of claudins
Krause, G., Winkler, L., Mueller, S., Haseloff, R. F., Piontek, J., & Blasig, I. E. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.10.018 · Cited by 824
Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
Cario, E., Gerken, G., & Podolsky, D. K. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.056 · Cited by 697
Resta-Lenert, S., & Barrett, K. E. (2003) · Gut · doi:10.1136/gut.52.7.988 · Cited by 642
Tight junctions and the modulation of barrier function in disease
Förster, C. Y. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0424-9 · Cited by 617
A porous defense: the leaky epithelial barrier in intestinal disease
Clayburgh, D. R., Shen, L., & Turner, J. R. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700050 · Cited by 496
Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
Ukena, S. N., Singh, A., Dringenberg, U., Engelhardt, R., Seidler, U., Hansen, W., Bleich, A., Bruder, D., Franzke, A., Rogler, G., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001308 · Cited by 482
Flagged first, then by citations
Research works printed but not linked: 2
- Dotan I, 2005, Curr Opin Gastroenterol, 21, 426
- Oshitani N, 2005, Int J Mol Med, 15, 407
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Items 201–300 of 674
Salami, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.613120 · Cited by 67
Environmental and Human Microbiome for Health
Panthee, B., Gyawali, S., Panthee, P., & Techato, K. (2022) · Life · doi:10.3390/life12030456 · Cited by 68
Lee, S. Y., Lee, D. Y., Kang, J. H., Kim, J. H., Jeong, J. W., Kim, H. W., Oh, D. H., Yoon, S. H., & Hur, S. J. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111327 · Cited by 69
Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory Pathways
Yoon, S. S., & Sun, J. (2011) · Gastroenterology Research and Practice · doi:10.1155/2011/971938 · Cited by 67
Zhao, L. M., Xie, Q., Evivie, S. E., Liu, D., Dong, J., Ping, L., Liu, F., Li, B., & Huo, G. (2021) · Food & Function · doi:10.1039/d1fo01164b · Cited by 66
Microbiota and body weight control: Weight watchers within?
Boscaini, S., Leigh, S., Lavelle, A., García‐Cabrerizo, R., Lipuma, T., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101427 · Cited by 67
Kawano, M., Miyoshi, M., Ogawa, A., Sakai, F., & Kadooka, Y. (2016) · Journal of Nutritional Science · doi:10.1017/jns.2016.12 · Cited by 64
Orlando, A., Linsalata, M., Bianco, G., Notarnicola, M., D’Attoma, B., Scavo, M. P., Tafaro, A., & Russo, F. (2018) · Nutrients · doi:10.3390/nu10111698 · Cited by 64
Toohey, J. C., Townsend, J. R., Johnson, S. B., Toy, A. M., Vantrease, W. C., Bender, D., Crimi, C. C., Stowers, K. L., Ruiz, M. D., VanDusseldorp, T. A., et al. (2020) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002675 · Cited by 62
Karimi, S., Jonsson, H., Lundh, T., & Roos, S. (2018) · Physiological Reports · doi:10.14814/phy2.13514 · Cited by 63
Aluthge, N. D., van Sambeek, D. M., Hinkle, E., Li, Y. S., Fernando, S. C., & Burkey, T. E. (2019) · Journal of Animal Science · doi:10.1093/jas/skz208 · Cited by 61
Ma, Y., Hu, C., Yan, W., Jiang, H., & Liu, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.591408 · Cited by 62
Hudcovic, T., Kolinska, J., Klepetar, J., Stepankova, R., Řezanka, T., Šrůtková, D., Schwarzer, M., Erban, V., Du, Z., Wells, J. M., et al. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04498.x · Cited by 60
Probiotics and the intestinal tight junction barrier function
Ferris, M. M., Antonio, L. S., & Al–Sadi, R. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1671152 · Cited by 61
Prebiotics for prevention of gut infections
Licht, T. R., Ebersbach, T., & Frøkiær, H. (2011) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2011.08.011 · Cited by 60
van Beek, A. A., Sovran, B., Hugenholtz, F., Meijer, B., Hoogerland, J. A., Mihailova, V., van der Ploeg, C., Belzer, C., Boekschoten, M. V., Hoeijmakers, J. H. J., et al. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00408 · Cited by 61
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Upadhaya, S. D., & Kim, I. H. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00790-4 · Cited by 66
Probiotics and their Beneficial Health Effects
Zaib, S., Hayat, A., & Khan, I. A. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230608163823 · Cited by 60
Pászti-Gere, E., Szekér, K., Csibrik-Nemeth, E., Csizinszky, R., Marosi, A., Palócz, O., Farkas, O., & Gálfi, P. (2012) · Inflammation · doi:10.1007/s10753-012-9462-5 · Cited by 58
Chen, X., Oshima, T., Tomita, T., Fukui, H., Watari, J., Matsumoto, T., & Miwa, H. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00096.2011 · Cited by 58
Meijerink, M., Ferrando, M. L., Lammers, G., Taverne, N., Smith, H. E., & Wells, J. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035849 · Cited by 58
Pre-, pro- and synbiotics in cancer prevention and treatment—a review of basic and clinical research
Scott, A. J., Merrifield, C. A., Younes, J. A., & Pekelharing, E. P. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.869 · Cited by 59
Li, D. K., Chaudhari, S. N., Sojoodi, M., Lee, Y., Adhikari, A. A., Zukerberg, L. R., Shroff, S. G., Barrett, S. C., Tanabe, K. K., Chung, R. T., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo2794 · Cited by 59
Probiotics in Clostridium difficile infection: reviewing the need for a multistrain probiotic
Hell, M., Bernhofer, C., Stalzer, P., Kern, J. M., & Claassen, E. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0049 · Cited by 59
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Knaus, U. G., Hertzberger, R. Y., Pîrcălăbioru, G. G., Yousefi, S. P. M., & dos Santos, F. B. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1279378 · Cited by 58
Carbuhn, A. F., Reynolds, S. M., Campbell, C. W., Bradford, L. A., Deckert, J. A., Kreutzer, A., & Fry, A. C. (2018) · Sports · doi:10.3390/sports6040116 · Cited by 56
Ma, L., Zheng, A., Ni, L., Wu, L., Hu, L., Zhao, Y., Fu, Z., & Ni, Y. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100639 · Cited by 56
Diet alters probiotic L actobacillus persistence and function in the intestine
Tachon, S., Lee, B., & Marco, M. L. (2013) · Environmental Microbiology · doi:10.1111/1462-2920.12297 · Cited by 59
Yoshikawa, K., Kurihara, C., Furuhashi, H., Takajo, T., Maruta, K., Yasutake, Y., Sato, H., Narimatsu, K., Okada, Y., Higashiyama, M., et al. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1205-1 · Cited by 60
Cousin, F., Foligné, B., Deutsch, S., Massart, S., Parayre, S., Loir, Y. L., Boudry, G., & Jan, G. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302245m · Cited by 55
Zhao, H., Ye, H., Zhou, J., Tang, G., Hou, Z., & Bai, H. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c15494 · Cited by 54
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Ma, L., & Morel, L. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.919792 · Cited by 55
Yin, Y., Liao, Y., Li, J., Pei, Z., Wang, L., Shi, Y., Peng, H., Tan, Y., Li, C., Bai, H., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1195382 · Cited by 60
Remote Sensing Between Liver and Intestine: Importance of Microbial Metabolites
Fu, Z. D., & Cui, J. Y. (2017) · Current Pharmacology Reports · doi:10.1007/s40495-017-0087-0 · Cited by 54
Nath, A., Molnár, M. A., Csighy, A., Kőszegi, K., Galambos, I., Pásztor‐Huszár, K., Koris, A. K., & Vatai, G. N. (2018) · Medicina · doi:10.3390/medicina54060098 · Cited by 56
Yin, X., Heeney, D. D., Srisengfa, Y. T., Golomb, B. L., Griffey, S. M., & Marco, M. L. (2017) · Beneficial Microbes · doi:10.3920/bm2017.0096 · Cited by 56
Mohebali, N., Ekat, K., Kreikemeyer, B., & Breitrück, A. (2020) · Nutrients · doi:10.3390/nu12082251 · Cited by 54
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Guo, W., Zhou, X., Li, X., Zhu, Q., Peng, J., Zhu, B., Zheng, X., Lu, Y., Yang, D., Wang, B., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.636803 · Cited by 55
Zhang, F., Zhai, M., Wu, Q., Jia, X., Wang, Y., & Wang, N. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00847 · Cited by 53
Impact of dietary fibers in infant formulas on gut microbiota and the intestinal immune barrier
Kong, C., Faas, M. M., de Vos, P., & Akkerman, R. (2020) · Food & Function · doi:10.1039/d0fo01700k · Cited by 51
Bhat, M. I., Sowmya, K., Kapila, S., & Kapila, R. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09608-8 · Cited by 52
Takashima, S., Tanaka, F., Kawaguchi, Y., Usui, Y., Fujimoto, K., Nadatani, Y., Otani, K., Hosomi, S., Nagami, Y., Kamata, N., et al. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13841 · Cited by 51
Adesulu-Dahunsi, A. T., Dahunsi, S. O., & Ajayeoba, T. A. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.684730 · Cited by 54
Charoensappakit, A., Sae‐khow, K., & Leelahavanichkul, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158223 · Cited by 52
Farsi, D. N., Lara, J., Koutsidis, G., Nelson, A., Finnigan, T. J. A., Cheung, W., Muñoz-Muñoz, J., & Commane, D. M. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03088-x · Cited by 62
Wheeler, R., Bastos, P. A. D., Disson, O., Rifflet, A., Gabanyi, I., Spielbauer, J., Berard, M., Lecuit, M., & Boneca, I. G. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209936120 · Cited by 50
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Rossi, O., van Baarlen, P., & Wells, J. M. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_191 · Cited by 50
Protective role of gut commensal microbes against intestinal infections
Yoon, M. Y., Lee, K., & Yoon, S. S. (2014) · The Journal of Microbiology · doi:10.1007/s12275-014-4655-2 · Cited by 56
Paveljšek, D., Ivičak‐Kocjan, K., Treven, P., Benčina, M., Jerala, R., & Rogelj, I. (2020) · Cellular Microbiology · doi:10.1111/cmi.13264 · Cited by 54
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Fortea, M., Albert-Bayo, M., Abril-Gil, M., Mall, J. G., Serra-Ruiz, X., Henao-Paez, A., Expósito, E., González-Castro, A. M., Guagnozzi, D., Lobo, B., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718093 · Cited by 49
Cataldi, S., Poli, L., Şahin, F. N., Patti, A., Santacroce, L., Bianco, A., Greco, G., Ghinassi, B., Baldassarre, A. D., & Fischetti, F. (2022) · Nutrients · doi:10.3390/nu14163293 · Cited by 58
Veltman, K., Hummel, S., Cichon, C., Sonnenborn, U., & Schmidt, M. A. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.11.006 · Cited by 50
Ye, J., Ma, D., Qin, W., & Liu, Y. (2018) · Molecules · doi:10.3390/molecules23102645 · Cited by 49
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Rashidi, A., Kaiser, T., Graiziger, C. T., Holtan, S. G., Rehman, T. U., Weisdorf, D. J., Dunny, G. M., Khoruts, A., & Staley, C. M. (2019) · Cancer · doi:10.1002/cncr.32641 · Cited by 47
Sudheer, S. M., Gangwar, P., Usmani, Z., Sharma, M., Sharma, V. K., Sana, S. S., Almeida, F. B. D. R., Dubey, N. K., Singh, D. P., Dilbaghi, N., et al. (2021) · Biochimie · doi:10.1016/j.biochi.2021.10.010 · Cited by 50
Yeung, C.-Y., Chiang Chiau, J.-S., Chan, W.-T., Jiang, C.-B., Cheng, M.-L., Liu, H.-L., & Lee, H.-C. (2013) · Gastroenterology Research and Practice · doi:10.1155/2013/973209 · Cited by 49
Kathiriya, M. R., Vekariya, Y. V., & Hati, S. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10104-3 · Cited by 50
Zhang, B., Zuo, F., Yu, R., Zeng, Z., Ma, H., & Chen, S. (2015) · Scientific Reports · doi:10.1038/srep14109 · Cited by 47
Yu, L., Zhai, Q., Tian, F., Liu, X., Wang, G., Zhao, J., Zhang, H., Narbad, A., & Chen, W. (2016) · Nutrients · doi:10.3390/nu8120783 · Cited by 47
Barnett, A. M., Roy, N. C., Cookson, A. L., & McNabb, W. C. (2018) · Nutrients · doi:10.3390/nu10070949 · Cited by 47
Taverniti, V., Cesari, V., Gargari, G., Rossi, U. G., Biddau, C., Lecchi, C., Fiore, W., Arioli, S., Toschi, I., & Guglielmetti, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.706135 · Cited by 48
Christoffersen, T. E., Hult, L. T. O., Kuczkowska, K., Moe, K. M., Skeie, S. B., Lea, T., & Kleiveland, C. R. (2013) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-013-9152-0 · Cited by 46
Wilms, E., Gerritsen, J., Smidt, H., der Vaart, I. B.-V., Rijkers, G. T., Garcia-Fuentes, A., Masclee, A., & Troost, F. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167775 · Cited by 48
The characteristics of patulin detoxification by Lactobacillus plantarum 13M5
Wei, C., Yu, L., Qiao, N., Wang, S., Tian, F., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111787 · Cited by 46
Segui-Perez, C., Huang, L. Z. X., Paganelli, F. L., Lievens, E., & Strijbis, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-92125-2 · Cited by 45
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Remus, D. M., Kleerebezem, M., & Bron, P. A. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.012 · Cited by 49
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Vanhaecke, T., Aubert, P., Grohard, P. ‐., Durand, T., Hulin, P., Paul‐Gilloteaux, P., Fournier, A. P., Docagne, F., Ligneul, A., Fressange-Mazda, C., et al. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13069 · Cited by 45
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Faghfoori, Z., Gargari, B. P., Gharamaleki, A. S., Bagherpour, H., & Khosroushahi, A. Y. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.08.013 · Cited by 46
Tüzün, F., Kumral, A., Duman, N., & Özkan, H. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31827a964b · Cited by 44
The gut as a regulator of early inflammation in type 1 diabetes
Vaarala, O. (2011) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283488218 · Cited by 44
Translating Recent Microbiome Insights in Otitis Media into Probiotic Strategies
van den Broek, M. F. L., Boeck, I. D., Kiekens, F., Boudewyns, A. N., Vanderveken, O. M., & Lebeer, S. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00010-18 · Cited by 46
Semin, I. K., Ninnemann, J., Bondareva, M. A., Gimaev, I., & Kruglov, A. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.644333 · Cited by 50
König, J., & Brummer, R. J. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0033 · Cited by 43
Yoshifuji, A., Wakino, S., Irie, J., Matsui, A., Hasegawa, K., Tokuyama, H., Hayashi, K., & Itoh, H. (2018) · Clinical and Experimental Nephrology · doi:10.1007/s10157-018-1577-z · Cited by 42
Stefano, M. D., Santonocito, S., Polizzi, A., Mauceri, R., Troiano, G., Giudice, A. L., Romano, A., Mascitti, M., & Isola, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021084 · Cited by 45
Ren, C., Zhang, Q., de Haan, B. J., Faas, M. M., Zhang, H., & de Vos, P. (2020) · Food & Function · doi:10.1039/c9fo02933h · Cited by 41
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Denny, J. E., Powell, W. L., & Schmidt, N. W. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00041 · Cited by 41
Stadlbauer, V., Horvath, A., Komarova, I., Schmerboeck, B., Feldbacher, N., Klymiuk, I., Durdević, M., Rainer, F., Blesl, A., Stiegler, P., et al. (2019) · Beneficial Microbes · doi:10.3920/bm2018.0067 · Cited by 41
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Witkowski, M., Witkowski, M., Gagliani, N., & Huber, S. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0658-5 · Cited by 39
Martinic, A., Barouei, J., Bendiks, Z., Mishchuk, D. O., Heeney, D. D., Martin, R. J., Marco, M. L., & Slupsky, C. M. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00282 · Cited by 42
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Sidira, M., Kourkoutas, Y., Kanellaki, M., & Charalampopoulos, D. (2015) · Food Research International · doi:10.1016/j.foodres.2015.07.036 · Cited by 40
Taguer, M., & Maurice, C. F. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.366 · Cited by 38
Ho, S. W., El-Nezami, H. S., & Shah, N. P. (2020) · Scientific Reports · doi:10.1038/s41598-020-57478-w · Cited by 40
Yue, B., Yu, Z., Lv, C., Geng, X., Wang, Z., & Dou, W. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i30.4378 · Cited by 38
Sanders, M. E., & Hill, C. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.04.017 · Cited by 42
Li, Z., Yu, E., Wang, G., Yu, D., Zhang, K., Gong, W., & Xie, J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01913 · Cited by 36
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Metadata
- Authors
- Karczewski, J., Troost, F. J., Konings, I., Dekker, J., Kleerebezem, M., Brummer, R.-J. M., & Wells, J. M.
- Affiliations
- TiFN (NL)
- Maastricht University (NL)
- Örebro University (SE)
- Corresponding author
- Wells, Jerry M.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2010-06
- Volume
- 298
- Issue
- 6
- Pages
- G851-G859
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2101272036
- Cited by
- 676
- References
- 49
- Citations by year
- 2026: 36 · 2025: 43 · 2024: 50 · 2023: 43 · 2022: 62 · 2021: 67 · 2020: 56 · 2019: 45 · 2018: 35 · 2017: 41 · 2016: 33 · 2015: 30 · 2014: 39 · 2013: 32 · 2012: 28
- FWCI
- 47.11
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- Lactobacillus plantarum, tight junction proteins, intestinal barrier function, zonula occludens-1, occludin, TLR2, probiotics, commensal bacteria, epithelial permeability, phorbol ester, Caco-2 cells, intestinal homeostasis
- MeSH terms
- Adult, Duodenum, Epithelial Cells, Humans, Intestinal Mucosa, Membrane Proteins, Phosphoproteins, Signal Transduction, Cross-Over Studies, Microscopy, Confocal, Caco-2 Cells, Tight Junctions, Cytoprotection, Lactobacillus plantarum, Lactiplantibacillus plantarum, Toll-Like Receptor 2, Occludin, Zonula Occludens-1 Protein
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