Cited by 676Probiotics and Fermented FoodsGastrointestinal motility and disordersBarrier Structure and Function Studies

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Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier

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Karczewski, Jurgen, Troost, Freddy J., Konings, Irene, Dekker, Jan, Kleerebezem, Michiel, Brummer, Robert-Jan M., Wells, Jerry M.·2010·American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI 10.1152/ajpgi.00327.2009

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Abstract

Lactobacillus plantarum, a commensal bacterium of humans, has been proposed to enhance the intestinal barrier, which is compromised in a number of intestinal disorders. To study the effect of L. plantarum strain WCFS1 on human barrier function, healthy subjects were administered L. plantarum or placebo in the duodenum for 6 h by means of a feeding catheter. The scaffold protein zonula occludens (ZO)-1 and transmembrane protein occludin were found to be significantly increased in the vicinity of the tight-junction (TJ) structures, which form the paracellular seal between cells of the epithelium. In an in vitro model of the human epithelium, L. plantarum induced translocation of ZO-1 to the TJ region; however, the effects on occludin were minor compared with those seen in vivo. L. plantarum was shown to activate Toll-like receptor 2 (TLR2) signaling, and treatment of Caco-2 monolayers with the TLR2 agonist Pam(3)-Cys-SK4(PCSK) significantly increased fluorescent staining of occludin in the TJ. Pretreatment of Caco-2 monolayers with L. plantarum or PCSK significantly attenuated the effects of phorbol ester-induced dislocation of ZO-1 and occludin and the associated increase in epithelial permeability. Our results identifying commensal bacterial stimulation of TLR2 in the gut epithelium as a regulator of epithelial integrity have important implications for understanding probiotic mechanisms and the control of intestinal homeostasis.

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Authors: Karczewski, J., Troost, F. J., Konings, I., Dekker, J., Kleerebezem, M., Brummer, R.-J. M., & Wells, J. M.
Affiliations: TiFN (NL)
Maastricht University (NL)
Örebro University (SE)
Corresponding author: Wells, Jerry M.
ORCID: Troost, Freddy J.
Dekker, Jan
Kleerebezem, Michiel
Brummer, Robert-Jan M.
Wells, Jerry M.
Venue: American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher: American Physiological Society
Published: 2010-06
Volume: 298
Issue: 6
Pages: G851-G859
ISSN: 0193-1857 (ISSN-L)
1522-1547
DOI: 10.1152/ajpgi.00327.2009
OpenAlex: W2101272036
Cited by: 676
References: 49
Citations by year: 2026: 36 · 2025: 43 · 2024: 50 · 2023: 43 · 2022: 62 · 2021: 67 · 2020: 56 · 2019: 45 · 2018: 35 · 2017: 41 · 2016: 33 · 2015: 30 · 2014: 39 · 2013: 32 · 2012: 28
FWCI: 47.11
Type: journal article
Language: en
Open access: green
research.wur.nl
Locations: American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Research Publications (Maastricht University) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: Lactobacillus plantarum, tight junction proteins, intestinal barrier function, zonula occludens-1, occludin, TLR2, probiotics, commensal bacteria, epithelial permeability, phorbol ester, Caco-2 cells, intestinal homeostasis
MeSH terms: Adult, Duodenum, Epithelial Cells, Humans, Intestinal Mucosa, Membrane Proteins, Phosphoproteins, Signal Transduction, Cross-Over Studies, Microscopy, Confocal, Caco-2 Cells, Tight Junctions, Cytoprotection, Lactobacillus plantarum, Lactiplantibacillus plantarum, Toll-Like Receptor 2, Occludin, Zonula Occludens-1 Protein

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Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier

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