Cited by 127Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionHemoglobin structure and function

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Nitrite is an alternative source of NO in vivo

Tsuchiya, Koichiro, Kanematsu, Yasuhisa, Yoshizumi, Masanori, Ohnishi, Hideki, Kirima, Kazuyoshi, Izawa, Yuki, Shikishima, Michiyo, Ishida, Tatsuhiro, Kondo, Shuji, Kagami, Shoji, Takiguchi, Yoshiharu, Tamaki, Toshiaki·2005·American Journal of Physiology-Heart and Circulatory Physiology

DOI 10.1152/ajpheart.00525.2004

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Abstract

In this study, we investigated whether orally administered nitrite is changed to NO and whether nitrite attenuates hypertension in a dose-dependent manner. We utilized a stable isotope of [15N]nitrite (15NO2-) as a source of nitrite to distinguish between endogenous nitrite and that exogenously administered and measured hemoglobin (Hb)-NO as an index of circulating NO in whole blood using electron paramagnetic resonance (EPR) spectroscopy. When 1 mg/kg Na15NO2 was orally administered to rats, an apparent EPR signal derived from Hb15NO (A(Z) = 23.4 gauss) appeared in the blood. The peak blood HbNO concentration occurred at the first measurement after intake (5 min) for treatment with 1 and 3 mg/kg (HbNO: 4.93 +/- 0.52 and 10.58 +/- 0.40 microM, respectively) and at 15 min with 10 mg/kg (HbNO: 38.27 +/- 9.23 microM). In addition, coadministration of nitrite (100 mg/l drinking water) with N(omega)-nitro-L-arginine methyl ester (L-NAME; 1 g/l) for 3 wk significantly attenuated the L-NAME-induced hypertension (149 +/- 10 mmHg) compared with L-NAME alone (170 +/- 13 mmHg). Furthermore, this phenomenon was associated with an increase in circulating HbNO. Our findings clearly indicate that orally ingested nitrite can be an alternative to L-arginine as a source of NO in vivo and may explain, at least in part, the mechanism of the nitrite/nitrate-rich Dietary Approaches to Stop Hypertension diet-induced hypotensive effects.

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Authors: Tsuchiya, K., Kanematsu, Y., Yoshizumi, M., Ohnishi, H., Kirima, K., Izawa, Y., Shikishima, M., Ishida, T., Kondo, S., Kagami, S., Takiguchi, Y., & Tamaki, T.
Affiliations: Tokushima University (JP)
ORCID: Tsuchiya, Koichiro
Kanematsu, Yasuhisa
Kirima, Kazuyoshi
Ishida, Tatsuhiro
Venue: American Journal of Physiology-Heart and Circulatory Physiology
Publisher: American Physiological Society
Published: 2005-05
Volume: 288
Issue: 5
Pages: H2163-H2170
ISSN: 0363-6135 (ISSN-L)
1522-1539
DOI: 10.1152/ajpheart.00525.2004
OpenAlex: W2125647807
Cited by: 127
References: 99
Citations by year: 2025: 2 · 2024: 4 · 2023: 4 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 9 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 9
FWCI: 5.14
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: nitrite, nitric oxide, L-NAME-induced hypertension, nitric oxide synthase inhibition, dietary nitrate, DASH diet, L-arginine, blood pressure
MeSH terms: Administration, Oral, Animals, Blood Pressure, Electron Spin Resonance Spectroscopy, Enzyme Inhibitors, Glycated Hemoglobin, Hypertension, Male, Nitric Oxide, Nitrites, Nitrogen Isotopes, Rats, Sprague-Dawley, NG-Nitroarginine Methyl Ester, Rats

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Nitrite is an alternative source of NO in vivo

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