Cited by 127Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionHemoglobin structure and function

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Nitrite is an alternative source of NO in vivo

Tsuchiya, Koichiro, Kanematsu, Yasuhisa, Yoshizumi, Masanori, Ohnishi, Hideki, Kirima, Kazuyoshi, Izawa, Yuki, Shikishima, Michiyo, Ishida, Tatsuhiro, Kondo, Shuji, Kagami, Shoji, Takiguchi, Yoshiharu, Tamaki, Toshiaki·2005·American Journal of Physiology-Heart and Circulatory Physiology

DOI 10.1152/ajpheart.00525.2004

Open this paper in CoChat — free account

Abstract

In this study, we investigated whether orally administered nitrite is changed to NO and whether nitrite attenuates hypertension in a dose-dependent manner. We utilized a stable isotope of [15N]nitrite (15NO2-) as a source of nitrite to distinguish between endogenous nitrite and that exogenously administered and measured hemoglobin (Hb)-NO as an index of circulating NO in whole blood using electron paramagnetic resonance (EPR) spectroscopy. When 1 mg/kg Na15NO2 was orally administered to rats, an apparent EPR signal derived from Hb15NO (A(Z) = 23.4 gauss) appeared in the blood. The peak blood HbNO concentration occurred at the first measurement after intake (5 min) for treatment with 1 and 3 mg/kg (HbNO: 4.93 +/- 0.52 and 10.58 +/- 0.40 microM, respectively) and at 15 min with 10 mg/kg (HbNO: 38.27 +/- 9.23 microM). In addition, coadministration of nitrite (100 mg/l drinking water) with N(omega)-nitro-L-arginine methyl ester (L-NAME; 1 g/l) for 3 wk significantly attenuated the L-NAME-induced hypertension (149 +/- 10 mmHg) compared with L-NAME alone (170 +/- 13 mmHg). Furthermore, this phenomenon was associated with an increase in circulating HbNO. Our findings clearly indicate that orally ingested nitrite can be an alternative to L-arginine as a source of NO in vivo and may explain, at least in part, the mechanism of the nitrite/nitrate-rich Dietary Approaches to Stop Hypertension diet-induced hypotensive effects.

Integrity signals

Registry

Crossref · 10.1152/ajpheart.00525.2004

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates
Ignarro, L. J., Lippton, H., Edwards, J. C., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Gruetter, C. A. (1981) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32738-2 · Cited by 1,633 · cited 1×
“Nitrite is known as a vasodilator at high concentrations in vitro (29, 32, 33, 47, 58, 68) and ex vivo (15).”
Background
Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
Jia, L., Bonaventura, C., Bonaventura, J., & Stamler, J. S. (1996) · Nature · doi:10.1038/380221a0 · Cited by 1,592
Clinical Physiology of Acid-Base and Electrolyte Disorders
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-2-176_8 · Cited by 1,152
Nitric Oxide: Pathophysiological Mechanisms
Gross, S. S., & Wolin, M. S. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003513 · Cited by 888
Methods in nitric oxide research
Feelisch, M., & Stamler, J. S. (1996) · ePrints Soton (University of Southampton) · Cited by 828
Enzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788
Range-Finding Toxicity Data: List VII
SMYTH, H. F., Carpenter, C. P., Weil, C. S., Pozzani, U. C., Striegel, J. A., & Nycum, J. S. (1969) · American Industrial Hygiene Association Journal · doi:10.1080/00028896909343157 · Cited by 766
Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate
Duncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R., Leifert, C., Smith, L., Golden, M., & Benjamin, N. (1995) · Nature Medicine · doi:10.1038/nm0695-546 · Cited by 734
Stomach NO synthesis
Benjamin, N., O'Driscoll, F., Dougall, H., Duncan, C., Smith, L., Golden, M., & McKenzie, H. (1994) · Nature · doi:10.1038/368502a0 · Cited by 665
Intragastric nitric oxide production in humans: measurements in expelled air.
Lundberg, J. O., Weitzberg, E., Lundberg, J. M., & Alving, K. (1994) · Gut · doi:10.1136/gut.35.11.1543 · Cited by 661
Influence of dietary nitrate on nitrite content of human saliva: Possible relevance to in vivo formation of N-nitroso compounds
Spiegelhalder, B., Eisenbrand, G., & Preussmann, R. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80005-3 · Cited by 596
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., Scheeren, T., Gödecke, A., Schrader, J., Schulz, R., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00406-4 · Cited by 586
Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381098 · Cited by 585
Export by red blood cells of nitric oxide bioactivity
Pawloski, J. R., Hess, D. T., & Stamler, J. S. (2001) · Nature · doi:10.1038/35054560 · Cited by 579
Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.
Gruetter, C. A., Gruetter, D. Y., Lyon, J., Kadowitz, P. J., & Ignarro, L. J. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32778-3 · Cited by 533
Diffusion-limited reaction of free nitric oxide with erythrocytes
Liu, X., Miller, M. J. S., Joshi, M. S., Sadowska-Krowicka, H., Clark, D. A., & Lancaster, J. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.30.18709 · Cited by 512
Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions
Millar, T. M., Stevens, C. R., Benjamin, N., Eisenthal, R., Harrison, R., & Blake, D. R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00430-x · Cited by 491
Rationale and design of the Dietary Approaches to Stop Hypertension trial (DASH)
Sacks, F. M., Obarzanek, E., WINDHAUSER, M. M., Svetkey, L. P., Vollmer, W. M., McCullough, M. L., KARANJA, N. M., Lin, P., Steele, P., Proschan, M. A., et al. (1995) · Annals of Epidemiology · doi:10.1016/1047-2797(94)00055-x · Cited by 490
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation
Gladwin, M. T., Crawford, J. H., & Patel, R. P. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.11.032 · Cited by 383
Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans
McKnight, G. M., Smith, L. M., Drummond, R. S., Duncan, C. W., Golden, M., & Benjamin, N. (1997) · Gut · doi:10.1136/gut.40.2.211 · Cited by 375
Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., & Pater, D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43285-1 · Cited by 334
Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats.
Takemoto, M., Egashira, K., Usui, M., Numaguchi, K., Tomita, H., Tsutsui, H., Shimokawa, H., Sueishi, K., & Takeshita, A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119156 · Cited by 322
Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols
Ignarro, L. J., & Gruetter, C. S. (1980) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(80)90297-4 · Cited by 317
Intravascular flow decreases erythrocyte consumption of nitric oxide
Liao, J. C., Hein, T. W., Vaughn, M. W., Huang, K., & Kuo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8757 · Cited by 301
Nonenzymatic Nitric Oxide Production in Humans
Weitzberg, E., & Lundberg, J. O. N. (1998) · Nitric Oxide · doi:10.1006/niox.1997.0162 · Cited by 296
Nitric oxide's reactions with hemoglobin: a view through the SNO-storm
Gladwin, M. T., Lancaster, J. R., Freeman, B. Α., & Schechter, A. N. (2003) · Nature Medicine · doi:10.1038/nm0503-496 · Cited by 290
Relative role of heme nitrosylation and β-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation
Gladwin, M. T., Ognibene, F. P., Pannell, L. K., Nichols, J. S., Pease‐Fye, M. E., Shelhamer, J. H., & Schechter, A. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180155397 · Cited by 269
Relative significance of dietary sources of nitrate and nitrite
White, J. W. (1975) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf60201a034 · Cited by 267
Effective diffusion distance of nitric oxide in the microcirculation
Vaughn, M. W., Kuo, L., & Liao, J. C. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.5.h1705 · Cited by 248
Physiology of the Salivary Glands
(1962) · Postgraduate Medical Journal · doi:10.1136/pgmj.38.436.126 · Cited by 222
Erythrocytes Possess an Intrinsic Barrier to Nitric Oxide Consumption
Vaughn, M. W., Huang, K., Kuo, L., & Liao, J. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2342 · Cited by 220
Ascorbic acid in the human stomach
Sobala, G. M., Schorah, C. J., Sanderson, M. J., Dixon, M. F., Tompkins, D., Godwin, P. G. R., & Axon, A. T. R. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90071-1 · Cited by 216
Chemical nature of nitric oxide storage forms in rat vascular tissue
Rodriguez, J., Maloney, R. E., Rassaf, T., Bryan, N. S., & Feelisch, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0234600100 · Cited by 210
BLOOD PRESSURE IN VEGETARIANS12
SACKS, F. M., ROSNER, B., & KASS, E. H. (1974) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112050 · Cited by 207
Routes to S -nitroso-hemoglobin formation with heme redox and preferential reactivity in the β subunits
Luchsinger, B. P., Rich, E. N., Gow, A. J., Williams, E. M., Stamler, J. S., & Singel, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0233287100 · Cited by 202
The rate of oxygen uptake by human red blood cells.
Coin, J. T., & Olson, J. S. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34185-6 · Cited by 201
Diffusion of nitric oxide and scavenging by blood in the vasculature
Butler, A. R., Megson, I. L., & Wright, P. G. R. (1998) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00065-8 · Cited by 199
A Rapid and Simple Method for the Measurement of Nitrite and Nitrate in Plasma by High Performance Capillary Electrophoresis
Leone, A. M., Francis, P. L., Rhodes, P., & Moncada, S. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1542 · Cited by 197
DASH (Dietary Approaches to Stop Hypertension) Diet Is Effective Treatment for Stage 1 Isolated Systolic Hypertension
Moore, T. J., Conlin, P. R., Ard, J. D., & Svetkey, L. P. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.155 · Cited by 189
The pharmacology of dietary nitrate and the origin of urinary nitrate
Bartholomew, B., & Hill, M. J. (1984) · Food and Chemical Toxicology · doi:10.1016/0278-6915(84)90116-9 · Cited by 175
Evaluation of the Magnitude and Rate of Nitric Oxide Production from Nitrite in Biological Systems
Samouilov, A., Kuppusamy, P., & Zweier, J. L. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0785 · Cited by 170
S -Nitrosothiols in the Blood: Roles, Amounts, and Methods of Analysis
Stamler, J. S. (2004) · Circulation Research · doi:10.1161/01.res.0000122071.55721.bc · Cited by 170 · cited 2×
“(55) and Stamler (82) proposed that HbNO transfers NO to cysteine 93 to form S-nitrosohemoglobin, which in turn interacts with physiologically relevant millimolar concentrations of GSH to transfer the NO from erythrocytes (23) or with cysteine thiols in the cytoplasmic domain of membrane-associated band 3 protein (AE1…”
Background
Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation
Li, H., Samouilov, A., Liu, X., & Zweier, J. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314336200 · Cited by 146
Stoichiometry of the reaction of oxyhemoglobin with nitrite
Kosaka, H., Imaizumi, K., Imai, K., & Tyuma, I. (1979) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(79)90235-6 · Cited by 139
Electron Paramagnetic Resonance and Oxygen Binding Studies of α-Nitrosyl Hemoglobin
Yonetani, T., Tsuneshige, A., Zhou, Y., & Chen, X. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20323 · Cited by 138
Use of ascorbic acid to inhibit nitrosation: kinetic and mass transfer considerations for an in vitro system
Licht, W. R., Tannenbaum, S. R., & Deen, W. M. (1988) · Carcinogenesis · doi:10.1093/carcin/9.3.365 · Cited by 129
BLOCKING THE FORMATION OF N‐NITROSO COMPOUNDS WITH ASCORBIC ACID IN VITRO AND IN VIVO*
Mirvish, S. S. (1975) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1975.tb29277.x · Cited by 126
Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice
Mowat, C., Carswell, A., Wirz, A. A., & McColl, K. E. L. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70064-8 · Cited by 125
Nitric Oxide Uptake by Erythrocytes Is Primarily Limited by Extracellular Diffusion Not Membrane Resistance
Liu, X., Samouilov, A., Lancaster, J. R., & Zweier, J. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201939200 · Cited by 123
Cardiac Angiotensin II Receptors Are Upregulated by Long-Term Inhibition of Nitric Oxide Synthesis in Rats
Katoh, M., Egashira, K., Usui, M., Ichiki, T., Tomita, H., Shimokawa, H., Rakugi, H., & Takeshita, A. (1998) · Circulation Research · doi:10.1161/01.res.83.7.743 · Cited by 118
Interactions of light and sodium nitrite in producing relaxation of rabbit aorta.
Matsunaga, K., & Furchgott, R. F. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23756-9 · Cited by 117
Gastric juice ascorbic acid: effects of disease and implications for gastric carcinogenesis
Schorah, C., Sobala, G. M., Sanderson, M. J., Collis, N., & Primrose, J. M. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.287s · Cited by 114
Inhibition of NO Synthesis Induces Inflammatory Changes and Monocyte Chemoattractant Protein-1 Expression in Rat Hearts and Vessels
Tomita, H., Egashira, K., Kubo-Inoue, M., Usui, M., Koyanagi, M., Shimokawa, H., Takeya, M., Yoshimura, T., & Takeshita, A. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.9.1456 · Cited by 114
Urinary nitrite: more than a marker of infection
Lundberg, J. O. N., Carlsson, S., Engstrand, L., Morcos, E., Wiklund, N. P., & Weitzberg, E. (1997) · Urology · doi:10.1016/s0090-4295(97)00257-4 · Cited by 108
Reaction of Nitrite With Ascorbate and Its Relation to Nitrosamine Formation2
Archer, M. C., Tannenbaum, S. R., Fan, T.-Y., & Weisman, M. (1975) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/54.5.1203 · Cited by 105
Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat
Kohn, M. C., Melnick, R. L., Ye, F., & Portier, C. J. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.6.676 · Cited by 98
ESR spectral transition by arteriovenous cycle in nitric oxide hemoglobin of cytokine-treated rats
Kosaka, H., Sawai, Y., Sakaguchi, H., Kumura, E., Harada, N., Watanabe, M., & Shiga, T. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.5.c1400 · Cited by 95
Conditions for acid catalysed luminal nitrosation are maximal at the gastric cardia
Suzuki, H., Iijima, K., Moriya, A., McElroy, K., Scobie, G., Fyfe, V., & McColl, K. E. L. (2003) · Gut · doi:10.1136/gut.52.8.1095 · Cited by 94
Nitric oxide binding to oxygenated hemoglobin under physiological conditions
Huang, Z., Louderback, J. G., Goyal, M., Azizi, F., King, S. B., & Kim‐Shapiro, D. B. (2001) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(01)00227-6 · Cited by 91
Effect of thiocyanate on nitrosation of amines
Boyland, E. J., & WALKER, S. A. (1974) · Nature · doi:10.1038/248601a0 · Cited by 87
Nitric Oxide-forming Reaction between the Iron-N-Methyl-d-glucamine Dithiocarbamate Complex and Nitrite
Tsuchiya, K., Yoshizumi, M., Houchi, H., & Mason, R. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1551 · Cited by 77
The Exposure of Humans to Nitrite
Walters, C. L. (2009) · Oncology · doi:10.1159/000225455 · Cited by 76
Oxidation of quercetin by salivary components. Quercetin-dependent reduction of salivary nitrite under acidic conditions producing nitric oxide
Takahama, U., Oniki, T., & Hirota, S. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf011697q · Cited by 74
Dietary nitrate inhibits stress-induced gastric mucosal injury in the rat
Miyoshi, M., Kasahara, E., Park, A.-M., Hiramoto, K., Minamiyama, Y., Takemura, S., Sato, E. F., & Inoue, M. (2003) · Free Radical Research · doi:10.1080/1071576021000086632 · Cited by 74
Analysis of nitrate in biological fluids by capillary electrophoresis
Friedberg, M. A., Hinsdale, M. E., & Shihabi, Z. K. (1997) · Journal of Chromatography A · doi:10.1016/s0021-9673(97)00583-9 · Cited by 72
Hypothesis: the effect of oral nitrite on blood pressure in the spontaneously hypertensive rat. Does dietary nitrate mitigate hypertension after conversion to nitrite?
Classen, H. G., Stein-Hammer, C., & Thöni, H. (1990) · Journal of the American College of Nutrition · doi:10.1080/07315724.1990.10720407 · Cited by 59 · cited 1×
“Thöni and colleagues (4, 11) suggested that a nitrate-derived NO formation pathway is a possible mechanism for the hypotensive effect of vegetable- and fruit-rich diets.”
Background
Inhibition by vitamins C and E of in vivo nitrosation and vitamin C occurrence in the stomach
Mirvish, S. S. (1996) · European Journal of Cancer Prevention · doi:10.1097/00008469-199609000-00027 · Cited by 59
Oxidation reaction of human oxyhemoglobin with nitrite: a reexamination
Spagnuolo, C. C., Rinelli, P., Coletta, M., Chiancone, E., & Ascoli, F. (1987) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(87)90270-6 · Cited by 55
Circulating nitrite anions are a directly acting vasodilator and are donors for nitric oxide
DEMONCHEAUX, E. A. G., HIGENBOTTAM, T. W., FOSTER, P. J., BORLAND, C. D. R., SMITH, A. P. L., MARRIOTT, H. M., BEE, D., AKAMINE, S., & DAVIES, M. B. (2002) · Clinical Science · doi:10.1042/cs1020077 · Cited by 48
The presence of 4‐hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach
Takahama, U., Oniki, T., & Murata, H. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02659-5 · Cited by 47
Negative NO3− difference in human coronary circulation with severe atherosclerotic stenosis
Ishibashi, T., Matsubara, T., Ida, T., Hori, T., Yamazoe, M., Aizawa, Y., Yoshida, J., & Nishio, M. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00575-5 · Cited by 46
Quercetin-Dependent Reduction of Salivary Nitrite to Nitric Oxide under Acidic Conditions and Interaction between Quercetin and Ascorbic Acid during the Reduction
Takahama, U., Yamamoto, A., Hirota, S., & Oniki, T. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf021253+ · Cited by 46
Nitric oxide hemoglobin in patients receiving nitroglycerin as detected by electron paramagnetic resonance spectroscopy.
Cantilena, L. R., Rp, S., Frasur, S., Kruszyna, H. G., Kruszyna, R., & Wilcox, D. E. (1992) · PubMed · Cited by 46
Effect of nitrite on blood pressure in anaesthetized and free-moving rats
Vleeming, W., van de Kuil, A., Biesebeek, J. D. T., Meulenbelt, J., & Boink, A. B. T. J. (1997) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(97)00015-x · Cited by 44
Evaluation of systemic blood NO dynamics by EPR spectroscopy: HbNO as an endogenous index of NO
Kirima, K., Tsuchiya, K., Séi, H., Hasegawa, T., Shikishima, M., Motobayashi, Y., Morita, K., Yoshizumi, M., & Tamaki, T. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01010.2002 · Cited by 41
Blood pressure differences in older black and white long-term vegetarians and nonvegetarians.
Melby, C. L., Goldflies, D. G., & Toohey, M. L. (1993) · Journal of the American College of Nutrition · doi:10.1080/07315724.1993.10718308 · Cited by 40
Antihypertensive effect of oral nitrite uptake in the spontaneously hypertensive rat.
Beier, S., Hg, C., Loeffler, K., Schumacher, E., & Thöni, H. (1995) · PubMed · Cited by 40
EPR spectroscopy studies on the structural transition of nitrosyl hemoglobin in the arterial-venous cycle of DEANO-treated rats as it relates to the proposed nitrosyl hemoglobin/nitrosothiol hemoglobin exchange
Jaszewski, A. R., Fann, Y. C., Chen, Y., Sato, K., Corbett, J. T., & Mason, R. P. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00324-1 · Cited by 36
Exogenous GTP Enhances the Effects of Sodium Nitrite on Cyclic GMP Accumulation, Vascular Smooth Muscle Relaxation and Platelet Aggregation
Laustiola, K., Vuorinen, P., Pörsti, I. H., Metsä‐Ketelä, T., Manninen, V., & Vapaatalo, H. (1991) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1991.tb01209.x · Cited by 36
Electron paramagnetic resonance characterization of rat neuronal nitric oxide production ex vivo
Kozlov, A. V., Bini, A., Iannone, A., Zini, I., & Tomasi, A. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68025-2 · Cited by 33
ESR demonstration of nitric oxide production from nitroglycerin and sodium nitrite in the blood of rats
Kohno, M., Masumizu, T., & Mori, A. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00165-g · Cited by 32
Alterations in intragastric nitrite and vitamin C levels during acid inhibitory therapy
Mowat, C., & McColl, K. E. L. (2001) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2000.0196 · Cited by 31
Chronic toxicity of sodium nitrite in the male F344 rat
Grant, D., & Butler, W. H. (1989) · Food and Chemical Toxicology · doi:10.1016/0278-6915(89)90015-x · Cited by 30
Persistent Antihypertensive Effect of Oral Nitrite Supplied up to One Year via the Drinking Water in Spontaneously Hypertensive Rats
Haas, M., Classen, H. G., Thöni, H., Classen, U. G., & Drescher, B. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1300421 · Cited by 30
Metabolites of the L-arginine-NO pathway in patients with left-to-right shunt.
Gorenflo, M., Zheng, C., Pöge, A. W., Bettendorf, M., Werle, E., Fiehn, W., & Ulmer, H. E. (2001) · PubMed · Cited by 28
Direct Proof of Nitric Oxide Formation from a Nitrovasodilator Metabolized by Erythrocytes
Kosaka, H., Tanaka, S., Yoshii, T., Kumura, E., Seiyama, A., & Shiga, T. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2569 · Cited by 26
Inhibition by vitamins C and E of in vivo nitrosation and vitamin C occurrence in the stomach
Mirvish, S. S. (1996) · European Journal of Cancer Prevention · doi:10.1097/00008469-199609001-00027 · Cited by 25
Nitrite-induced adrenal effects in rats and the consequences for the no-observed-effect level
Til, H. P., Kuper, C. F., & Falke, H. E. (1997) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(97)00122-1 · Cited by 23
THE RELATION OF PROTEIN FOODS TO HYPERTENSION.
Donaldson, A. N. (1926) · PubMed · Cited by 21
A Possible Role of Iron Deficiency in Gastric Cancer in Colombia
Broitman, S. A., Vélez, H., & Vitale, J. J. (1981) · Springer eBooks · doi:10.1007/978-1-4615-9200-6_9 · Cited by 20
A comparison of the effects of hydrallazine, diazoxide, sodium nitrite and sodium nitroprusside on human isolated arteries and veins.
Moulds, R., Jauernig, R. A., & Shaw, J. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01102.x · Cited by 20
The Role of Dietary Electrolytes in Hypertension
Moore, T. J. (1989) · Journal of the American College of Nutrition · doi:10.1080/07315724.1989.10737972 · Cited by 13
Mechanisms for nitrite loss from the stomach
Licht, W. R., Schultz, D. S., Fox, J. G., Tannenbaum, S. R., & Deen, W. M. (1986) · Carcinogenesis · doi:10.1093/carcin/7.10.1681 · Cited by 12 · cited 1×
“It had been believed that ingested nitrite is absorbed by the gastrointestinal tract (51) or reacts in the stomach with secondary or tertiary amines and amides present in foods such as cheese or meat to form N-nitroso compounds (7).”
Background
Does Potassium and Magnesium Supplementation Lower the Blood Pressure of Spontaneously Hypertensive Rats?
Summanen, J., Vuorela, H. J., & Hiltunen, R. (1994) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600830227 · Cited by 4

Research works printed but not linked: 1

Council NC.Diet and Health: Implications for Reducing Chronic Disease Risk. Washington, DC: National Academy Press, 1989.

Sorted by citations

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739
Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435
Roles of dietary inorganic nitrate in cardiovascular health and disease
Lundberg, J. O., Carlström, M., Larsen, F. J., & Weitzberg, E. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq325 · Cited by 355
Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
Bryan, N. S., Calvert, J. W., Elrod, J. W., Gundewar, S., Ji, S. Y., & Lefer, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706579104 · Cited by 347
NO Generation From Nitrite and Its Role in Vascular Control
Lundberg, J. O., & Weitzberg, E. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000161048.72004.c2 · Cited by 341

See all 127

Authors: Tsuchiya, K., Kanematsu, Y., Yoshizumi, M., Ohnishi, H., Kirima, K., Izawa, Y., Shikishima, M., Ishida, T., Kondo, S., Kagami, S., Takiguchi, Y., & Tamaki, T.
Affiliations: Tokushima University (JP)
ORCID: Tsuchiya, Koichiro
Kanematsu, Yasuhisa
Kirima, Kazuyoshi
Ishida, Tatsuhiro
Venue: American Journal of Physiology-Heart and Circulatory Physiology
Publisher: American Physiological Society
Published: 2005-05
Volume: 288
Issue: 5
Pages: H2163-H2170
ISSN: 0363-6135 (ISSN-L)
1522-1539
DOI: 10.1152/ajpheart.00525.2004
OpenAlex: W2125647807
Cited by: 127
References: 99
Citations by year: 2025: 2 · 2024: 4 · 2023: 4 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 9 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 9
FWCI: 5.14
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: nitrite, nitric oxide, L-NAME-induced hypertension, nitric oxide synthase inhibition, dietary nitrate, DASH diet, L-arginine, blood pressure
MeSH terms: Administration, Oral, Animals, Blood Pressure, Electron Spin Resonance Spectroscopy, Enzyme Inhibitors, Glycated Hemoglobin, Hypertension, Male, Nitric Oxide, Nitrites, Nitrogen Isotopes, Rats, Sprague-Dawley, NG-Nitroarginine Methyl Ester, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nitrite is an alternative source of NO in vivo

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks