Cited by 163Redox biology and oxidative stressNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

ROS-induced ROS release in vascular biology: redox-redox signaling

Open access
Zinkevich, Natalya S., Gutterman, David D.·2011·American Journal of Physiology-Heart and Circulatory Physiology

Abstract

The involvement of reactive oxygen species (ROS) in regulating vascular function both in normal vessels and as part of an adaptive response during disease has been intensively studied. From the recognition that ROS serve as important signaling molecules has emerged multiple lines of evidence that there is a functional connectivity between intracellular sites of ROS production. This cross talk has been termed ROS-induced ROS release (RIRR) and is supported by a variety of observations showing that RIRR is a common mechanism for ROS amplification and regional ROS generation. The compartmentalization of ROS production within a cell is critical to its signaling function and is facilitated by microlocalization of specific scavengers. This review will provide descriptions and examples of important mechanisms of RIRR.

Integrity signals

Registry

Crossref · 10.1152/ajpheart.01271.2010

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Zinkevich, N. S., & Gutterman, D. D.
Affiliations
Medical College of Wisconsin (US)
Corresponding author
Gutterman, David D.
Venue
American Journal of Physiology-Heart and Circulatory Physiology
Published
2011-09
Volume
301
Issue
3
Pages
H647-H653
ISSN
  • 0363-6135 (ISSN-L)
  • 1522-1539
OpenAlex
W2133517541
Cited by
163
References
73
Citations by year
2026: 7 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 12 · 2021: 12 · 2020: 16 · 2019: 13 · 2018: 5 · 2017: 10 · 2016: 10 · 2015: 6 · 2014: 25 · 2013: 13 · 2012: 13
FWCI
1.54
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL094971, HL080704, R01HL094971, R01HL080704)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
reactive oxygen species, redox signaling, vascular function, vascular biology
MeSH terms
Animals, Antioxidants, Blood Vessels, Humans, Mitochondria, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review