ROS-induced ROS release in vascular biology: redox-redox signaling
Open accessAbstract
The involvement of reactive oxygen species (ROS) in regulating vascular function both in normal vessels and as part of an adaptive response during disease has been intensively studied. From the recognition that ROS serve as important signaling molecules has emerged multiple lines of evidence that there is a functional connectivity between intracellular sites of ROS production. This cross talk has been termed ROS-induced ROS release (RIRR) and is supported by a variety of observations showing that RIRR is a common mechanism for ROS amplification and regional ROS generation. The compartmentalization of ROS production within a cell is critical to its signaling function and is facilitated by microlocalization of specific scavengers. This review will provide descriptions and examples of important mechanisms of RIRR.
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Circulating lipids increase NOX2 production in ECs in vitro.
“Circulating lipids also increase NOX2 production in ECs in vitro (159, 208, 856, 1063).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [1063]
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- Authors
- Zinkevich, N. S., & Gutterman, D. D.
- Affiliations
- Medical College of Wisconsin (US)
- Corresponding author
- Gutterman, David D.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2011-09
- Volume
- 301
- Issue
- 3
- Pages
- H647-H653
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC3191081
- OpenAlex
- W2133517541
- Cited by
- 163
- References
- 73
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 12 · 2021: 12 · 2020: 16 · 2019: 13 · 2018: 5 · 2017: 10 · 2016: 10 · 2015: 6 · 2014: 25 · 2013: 13 · 2012: 13
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL094971, HL080704, R01HL094971, R01HL080704)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- reactive oxygen species, redox signaling, vascular function, vascular biology
- MeSH terms
- Animals, Antioxidants, Blood Vessels, Humans, Mitochondria, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases
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