Cited by 1,511Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressFree Radicals and Antioxidants

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The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

Pryor, W. A., Squadrito, G. L.·1995·American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI 10.1152/ajplung.1995.268.5.l699

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Abstract

Nitric oxide and superoxide, which are produced by several cell types, rapidly combine to form peroxynitrite. This reaction can result in nitric oxide scavenging, and thus mitigation of the biological effects of superoxide. Also, superoxide can trap and hence modulate the effects of nitric oxide; superoxide dismutase, by controlling superoxide levels, therefore can influence the reaction pathways open to nitric oxide. The production of peroxynitrite, however, causes its own sequelae of events: Although neither .NO nor superoxide is a strong oxidant, peroxynitrite is a potent and versatile oxidant that can attack a wide range of biological targets. The peroxynitrite anion is relatively stable, but its acid, peroxynitrous acid (HOONO), rearranges to form nitrate with a half-life of approximately 1 s at pH 7, 37 degrees C. HOONO exists as a Boltzmann distribution of rotamers; at 5-37 degrees C HOONO has an apparent acidity constant, pKa,app, of 6.8. Oxidation reactions of HOONO can involve two-electron processes (such as an SN2 displacement) or a one-electron transfer (ET) reaction in which the substrate is oxidized by one electron and peroxynitrite is reduced. These oxidation reactions could involve one of two mechanisms. The first mechanism is homolysis of HOONO to give HO. and .NO2, which initially are held together in a solvent cage. This caged pair of radicals (the "geminate" pair) can either diffuse apart, giving free radicals that can perform oxidations, or react together either to form nitrate or to reform HOONO (a process called cage return). A large amount of cage return can explain the small entropy of activation (Arrhenius A-factor) observed for the decomposition of HOONO. A cage mechanism also can explain the residual yield of nitrate that appears to be formed even in the presence of high concentrations of all of the scavengers studied to date, since scavengers capture only free HO. and .NO2 and not caged radicals. If the cage mechanism is correct, the rate of disappearance of peroxynitrite be slower in solvents of higher viscosity, and we do not find this to be the case. The second mechanism is that an activated isomer of peroxynitrous acid, HOONO*, can be formed in a steady state. The HOONO* mechanism can explain the inability of hydroxyl radical scavengers to completely block either nitrate formation or the oxidation of substrates such as methionine, since HOONO* would be less reactive, and therefore more selective, than the hydroxyl radical itself.(ABSTRACT TRUNCATED AT 400 WORDS)

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Superoxide Dismutase
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Critical Review of Rate Constants for Reactions of Hydrated Electrons, Hydrogen Atoms and Hydroxyl Radicals (OH/O−) in Aqueous Solution
Buxton, G. V., Greenstock, C. L., Helman, W. P., & Ross, A. B. (1988) · Journal of Physical and Chemical Reference Data · doi:10.1063/1.555805 · Cited by 12,332
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Tables of bond lengths determined by X-ray and neutron diffraction. Part 1. Bond lengths in organic compounds
Allen, F. H., Kennard, O., Watson, D. G., Brammer, L., Orpen, A. G., & Taylor, R. (1987) · Journal of the Chemical Society Perkin Transactions 2 · doi:10.1039/p298700000s1 · Cited by 8,029
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Advanced Organic Chemistry: Reactions, Mechanisms, and Structure
March, J. (1977) · Andalas University Repository (Andalas University) · Cited by 4,022
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
The reaction of NO with superoxide
Huie, R. E., & Padmaja, S. (1993) · Free Radical Research Communications · doi:10.3109/10715769309145868 · Cited by 2,121
Redox signaling: Nitrosylation and related target interactions of nitric oxide
Stamler, J. S. (1994) · Cell · doi:10.1016/0092-8674(94)90269-0 · Cited by 1,723
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate
Marletta, M. A., Yoon, P. S., Iyengar, R., Leaf, C. D., & Wishnok, J. S. (1988) · Biochemistry · doi:10.1021/bi00424a003 · Cited by 1,601
Handbook of Chemistry
LANGE, N. A. (1944) · Soil Science · doi:10.1097/00010694-194407000-00013 · Cited by 1,585
The foundations of chemical kinetics
Benson, S. W. (1960) · Journal of the Franklin Institute · doi:10.1016/0016-0032(60)90305-7 · Cited by 1,462
Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives
Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
Koppenol, W. H., Moreno, J. J., Pryor, W. A., Ischiropoulos, H., & Beckman, J. S. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00030a017 · Cited by 1,338
Self-citation
Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry
Beckman, J. S., Ye, Y. Z., Anderson, P. G., Chen, J., Accavitti, M. A., Tarpey, M. M., & White, C. R. (1994) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1994.375.2.81 · Cited by 1,122
Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system.
Kellogg, E. W., & Fridovich, I. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40745-x · Cited by 966
Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite
Beckman, J. S., Ischiropoulos, H., Zhu, L., van der Woerd, M., Smith, C. D. L., Chen, J., Harrison, J. G., Martin, J. C., & Tsai, M. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90432-v · Cited by 768
Generation of superoxide by purified brain nitric oxide synthase
Pou, S., Pou, W. S., Bredt, D. S., Snyder, S. H., & Rosen, G. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35745-4 · Cited by 750
Peroxynitrite-mediated oxidation of dihydrorhodamine 123
Kooy, N. W., Royall, J. A., Ischiropoulos, H., & Beckman, J. S. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90138-4 · Cited by 720
Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.
Clancy, R. M., Leszczynska-Piziak, J., & Abramson, S. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115929 · Cited by 686
Superoxide and peroxynitrite inatherosclerosis.
White, C. R., Brock, T. A., Chang, L. Y., Crapo, J. D., BRISCOE, P. M., Ku, D. D., Bradley, W. A., Gianturco, S. H., Gore, J. Z., & Freeman, B. Α. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.1044 · Cited by 684
Endothelium-derived relaxing factor
Moncada, S., Radomski, M. W., & Palmer, R. M. J. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90236-5 · Cited by 676
Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.
Castro, L., Rodriguez, M., & Radi, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43894-x · Cited by 589
The physiological role of nitric oxide
Butler, A. R., & Williams, D. L. H. (1993) · Chemical Society Reviews · doi:10.1039/cs9932200233 · Cited by 555
Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide/oxygen reaction
Wink, D. A., Darbyshire, J. F., Nims, R. W., Saavedra, J. E., & Ford, P. C. (1993) · Chemical Research in Toxicology · doi:10.1021/tx00031a003 · Cited by 480
Detection of superoxide generated by endothelial cells.
Rosen, G. M., & Freeman, B. Α. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.23.7269 · Cited by 402
Inhibition of low‐density lipoprotein oxidation by nitric oxide Potential role in atherogenesis
Hogg, N., Kalyanaraman, B., Joseph, J., Struck, A. T., & Parthasarathy, S. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81706-6 · Cited by 400
The Utility of Superoxide Dismutase in Studying Free Radical Reactions
McCord, J. M., & Fridovich, I. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63246-6 · Cited by 387
Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite
van der Vliet, A., O’neill, C. A., Halliwell, B. B., Cross, C. E., & Kaur, H. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80391-9 · Cited by 381
Reaction Kinetics for Nitrosation of Cysteine and Glutathione in Aerobic Nitric Oxide Solutions at Neutral pH. Insights into the Fate and Physiological Effects of Intermediates Generated in the NO/O2 Reaction
Wink, D. A., Nims, R. W., Darbyshire, J. F., Christodoulou, D., Hanbauer, I., Cox, G. W., Laval, F., Laval, J., & Cook, J. A. (1994) · Chemical Research in Toxicology · doi:10.1021/tx00040a007 · Cited by 378
Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle
Rubanyi, G. M., & Vanhoutte, P. M. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.5.h815 · Cited by 376
Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils
Carreras, M. C., Pargament, G. A., Catz, S. D., Poderoso, J. J., & Boveris, A. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80241-6 · Cited by 364
Paradoxical fate and biological action of peroxynitrite on human platelets.
Moro, M. Á., Darley-Usmar, V. M., Goodwin, D. A., Read, N. G., Zamora-Pino, R., Feelisch, M., Radomski, M. W., & Moncada, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6702 · Cited by 363
Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes
Rubanyi, G. M., Ho, E. H., Cantor, E. H., Lumma, W. C., & Botelho, L. H. P. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)92093-y · Cited by 360
Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells
Kubes, P., Kanwar, S., Niu, X., & Gaboury, J. P. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.13.8405815 · Cited by 318
Activation by nitric oxide of an oxidative-stress response that defends Escherichia coli against activated macrophages.
Nunoshiba, T., deRojas-Walker, T., Wishnok, J. S., Tannenbaum, S. R., & Demple, B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.9993 · Cited by 311
Photosensitized formation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) in DNA by riboflavin: a nonsinglet oxygen-mediated reaction
Kasai, H., Yamaizumi, Z., Berger, M., & Cadet, J. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00050a078 · Cited by 300
Kinetics of the Reaction of Nitric Oxide with Oxygen in Aqueous Solutions
Lewis, R. S., & Deen, W. M. (1994) · Chemical Research in Toxicology · doi:10.1021/tx00040a013 · Cited by 293
Oxidation of thiols by nitric oxide and nitrogen dioxide: synthetic utility and toxicological implications
Pryor, W. A., Church, D. F., Govindan, C. K., & Crank, G. (1982) · The Journal of Organic Chemistry · doi:10.1021/jo00340a038 · Cited by 293
Self-citation
The Chemistry of amino, nitroso, and nitro compounds and their derivatives
Patai, S. (1982) · UMI Books on Demand · Cited by 292
Peroxynitrite modification of low‐density lipoprotein leads to recognition by the macrophage scavenger receptor
Graham, A., Hogg, N., Kalyanaraman, B., O'leary, V. J., Darley-Usmar, V. M., & Moncada, S. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80269-z · Cited by 278
Peroxynitrite-induced rat colitis—A new model of colonic inflammation
Rachmilewitz, D., Stamler, J. S., Karmeli, F., Mullins, M. E., Singel, D. J., Loscalzo, J., Xavier, R. J., & Podolsky, D. K. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)91063-n · Cited by 262
Reaction of nitric oxide with heme proteins and model compounds of hemoglobin
Sharma, V. S., Traylor, T. G., Gardiner, R., & Mizukami, H. (1987) · Biochemistry · doi:10.1021/bi00387a015 · Cited by 245
Formation and decay of peroxynitric acid: a pulse radiolysis study
Loegager, T., & Sehested, K. (1993) · The Journal of Physical Chemistry · doi:10.1021/j100141a025 · Cited by 211
Mechanism of covalent modification of glyceraldehyde‐3‐phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents
Mohr, S., Stamler, J. S., & Brüne, B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00596-6 · Cited by 208
On the pH-dependent yield of hydroxyl radical products from peroxynitrite
Crow, J. P., Spruell, C., Chen, J., Gunn, C., Ischiropoulos, H., Tsai, M. Y., Smith, C. D. L., Radí, R., Koppenol, W. H., & Beckman, J. S. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90034-5 · Cited by 203
The formation of peroxynitrite in vivo from nitric oxide and superoxide
Squadrito, G. L., & Pryor, W. A. (1995) · Chemico-Biological Interactions · doi:10.1016/0009-2797(94)03591-u · Cited by 200
Self-citation
Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries.
Yao, S. K., Ober, J. C., Krishnaswami, A., Ferguson, J. J., Anderson, H. V., Golino, P., Buja, L. M., & Willerson, J. T. (1992) · Circulation · doi:10.1161/01.cir.86.4.1302 · Cited by 198
A practical method for preparing peroxynitrite solutions of low ionic strength and free of hydrogen peroxide
Pryor, W. A., Cueto, R., Jin, X., Koppenol, W. H., Ngu-Schwemlein, M., Squadrito, G. L., Uppu, P. L., & Uppu, R. M. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00105-s · Cited by 197
Self-citation
Detection of nitric oxide production from a perfused organ by a luminol-hydrogen peroxide system
Kikuchi, K., Nagano, T., Hayakawa, H., Hirata, Y., & Hirobe, M. (1993) · Analytical Chemistry · doi:10.1021/ac00061a025 · Cited by 193
Mechanisms of sulfur reactions
Pryor, W. A. (1962) · McGraw-Hill eBooks · Cited by 192
Self-citation
The kinetics of the oxidation of l-ascorbic acid by peroxynitrite
Bartlett, D., Church, D. F., Bounds, P. L., & Koppenol, W. H. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)e0133-4 · Cited by 192
Nitric oxide, superoxide and peroxynitrite: Putative mediators of NMDA-induced cell death in cerebellar granule cells
Lafon‐Cazal, M., Culcasi, M., Gaven, F., Pietri, S., & Bockaert, J. (1993) · Neuropharmacology · doi:10.1016/0028-3908(93)90020-4 · Cited by 189
Biosynthesis and regulation of superoxide dismutases
Hassan, H. M. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90111-6 · Cited by 182
Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite
Wu, M., Pritchard, K. A., Kaminski, P. M., Fayngersh, R. P., Hintze, T. H., & Wolin, M. S. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.5.h2108 · Cited by 180
Spin-Trapping Studies of Peroxynitrite Decomposition and of 3-Morpholinosydnonimine N-Ethylcarbamide Autooxidation: Direct Evidence for Metal-Independent Formation of Free-Radical Intermediates
Augusto, O., Gatti, R. M., & Radí, R. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1147 · Cited by 170
Free Radical Chemistry of Nitric Oxide
Freeman, B. Α. (1994) · CHEST Journal · doi:10.1378/chest.105.3_supplement.79s · Cited by 167
Regulation of macrophage physiology by L-arginine: role of the oxidative L-arginine deiminase pathway.
Albina, J. E., Mills, C. D., Henry, W. L., & Caldwell, M. D. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.11.3641 · Cited by 127
Biomimetic Synthesis of the Putative Cytotoxin Peroxynitrite, ONOO-, and Its Characterization as a Tetramethylammonium Salt
Bohle, D. S., Hansert, B., Paulson, S. C., & Smith, B. D. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00095a062 · Cited by 125
Nitric Oxide in Cells
Lancaster, J. R. (1992) · Cited by 116
Captopril: a free radical scavenger.
Chopra, M., Scott, N., McMurray, J. J. V., McLay, J., Bridges, A., Smith, W. E., & Belch, J. J. F. (1989) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1989.tb05384.x · Cited by 109
The metal-mediated formation of hydroxyl radical by aqueous extracts of cigarette tar
Cosgrove, J. P., Borish, E. T., Church, D. F., & Pryor, W. A. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)91034-4 · Cited by 108
Self-citation
168. Pernitrous acid. The reaction between hydrogen peroxide and nitrous acid, and the properties of an intermediate product
Halfpenny, E., & Robinson, P. L. (1952) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9520000928 · Cited by 106
Kinetics of decomposition of peroxynitrous acid
Keith, W. G., & Powell, R. E. (1969) · Journal of the Chemical Society A Inorganic Physical Theoretical · doi:10.1039/j19690000090 · Cited by 103
Endothelium-derived relaxing factors. A perspective from in vivo data.
Marshall, J. J., & Kontos, H. A. (1990) · Hypertension · doi:10.1161/01.hyp.16.4.371 · Cited by 102
Photochemical Production of Ethylene from Methionine and Its Analogues in the Presence of Flavin Mononucleotide
Yang, S. F., Ku, H. S., & Pratt, H. K. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99422-6 · Cited by 101
Unraveling the biological significance of nitric oxide.
Marletta, M. A., Tayeh, M. A., & Hevel, J. M. (1990) · PubMed · Cited by 100
Scatchard analysis of methane sulfinic acid production from dimethyl sulfoxide: A method to quantify hydroxyl radical formation in physiologic systems
Babbs, C. F., & Griffin, D. W. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90042-7 · Cited by 93
Flash Photolysis of Nitrate Ions in Aqueous Solution
Wagner, I., Strehlow, H., & Busse, G. (1980) · Zeitschrift für Physikalische Chemie · doi:10.1524/zpch.1980.123.1.001 · Cited by 91
Evidence for the formation of hydroxyl radicals in the isomerization of pernitrous acid to nitric acid in aqueous solution
Mahoney, L. R. (1970) · Journal of the American Chemical Society · doi:10.1021/ja00720a068 · Cited by 89
Inhibition by sulfhydryl compounds of vascular relaxation induced by nitric oxide and endothelium-derived relaxing factor.
Jia, L., & Furchgott, R. F. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39469-3 · Cited by 85
Free radical yields from the homolysis of peroxynitrous acid
Yang, G. Z., Candy, T. E. G., Boaro, M., Wilkin, H. E., Jones, P., Nazhat, N. B., Saadalla-Nazhat, R. A., & Blake, D. R. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90120-6 · Cited by 85
The Chemistry of Peroxonitrites
Edwards, J. O., & Plumb, R. C. (1994) · Progress in inorganic chemistry · doi:10.1002/9780470166420.ch8 · Cited by 82
Determination of the barriers to internal rotation in ONOOX (X = H, Cl) and characterization of the minimum energy conformers
McGrath, M. P., & Rowland, F. S. (1994) · The Journal of Physical Chemistry · doi:10.1021/j100055a004 · Cited by 81
Cigarette smoke chemistry: conversion of nitric oxide to nitrogen dioxide and reactions of nitrogen oxides with other smoke components as studied by Fourier transform infrared spectroscopy
Cueto, R., & Pryor, W. A. (1994) · Vibrational Spectroscopy · doi:10.1016/0924-2031(94)85045-3 · Cited by 81
Self-citation
Nitrosation by stimulated macrophages. Inhibitors, enhancers and substrates
Kosaka, H., Wishnok, J. S., Miwa, M., Leaf, C. D., & Tannenbaum, S. R. (1989) · Carcinogenesis · doi:10.1093/carcin/10.3.563 · Cited by 79
Nitric oxide donor GEA 3162 inhibits endothelial cell‐mediated oxidation of low density lipoprotein
Malo‐Ranta, U., Ylä‐Herttuala, S., Metsä‐Ketelä, T., Jaakkola, O., Moilanen, E., Vuorinen, P., & Nikkari, T. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80269-6 · Cited by 79
Product analysis of the hydroxyl + nitrogen dioxide + M reaction
Burkholder, J. B., Hammer, P. D., & Howard, C. J. (1987) · The Journal of Physical Chemistry · doi:10.1021/j100292a032 · Cited by 76
Inhibition of nitric oxide formation in vivo enhances superoxide release by the perfused liver
Bautista, A. P., Jr., & Spitzer, J. J. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.266.5.g783 · Cited by 73
The influence of delivery rate on the chemistry and biological effects of nitric oxide
Tamir, S., Lewis, R. S., deRojas-Walker, T., Deen, W. M., Wishnok, J. S., & Tannenbaum, S. R. (1993) · Chemical Research in Toxicology · doi:10.1021/tx00036a021 · Cited by 72
Reaction of nitric oxide with heme proteins: studies on metmyoglobin, opossum methemoglobin, and microperoxidase
Sharma, V. S., Isaacson, R. A., John, M. E., Waterman, M. R., & Chevion, M. (1983) · Biochemistry · doi:10.1021/bi00285a026 · Cited by 71
Pharmacological evidence that captopril possesses an endothelium-mediated component of vasodilation: effect of sulfhydryl groups on endothelium-derived relaxing factor.
Goldschmidt, J., & Tallarida, R. J. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24682-1 · Cited by 63
Reaction of nucleophiles with electron acceptors by SN2 or electron transfer (ET) mechanisms: tert-butyl peroxybenzoate/dimethyl sulfide and benzoyl peroxide/N,N-dimethylaniline systems
Pryor, W. A., & HENDRICKSON, W. H. J. (1983) · Journal of the American Chemical Society · doi:10.1021/ja00362a016 · Cited by 63
Self-citation
Autoinhibition of murine macrophage-mediated oxidation of low-density lipoprotein by nitric oxide synthesis
Jessup, W., & Dean, R. T. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90111-7 · Cited by 57
FREE RADICALS AS INTERMEDIATE STEPS OF OXIDATION-REDUCTIONPreprint
Michaelis, L. (1939) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1939.007.01.003 · Cited by 47
The effect of nitric oxide generators on ischemia reperfusion injury and histamine release in isolated perfused guinea-pig heart
Masini, E., Bianchi, S., Mugnai, L., Gambassi, F., Lupini, M., Pistelli, A., & Mannaioni, P. F. (1991) · Inflammation Research · doi:10.1007/bf01993125 · Cited by 45
The chemistry of peroxonitrites. Part II. Copper(II)-catalysed reaction between hydroxylamine and peroxonitrite in alkali
Hughes, M., & Nicklin, H. G. (1970) · Journal of the Chemical Society A Inorganic Physical Theoretical · doi:10.1039/j19700000925 · Cited by 38
Radical production from the interaction of closed shell molecules. II. Reaction of organic sulfides with tert-butyl peroxybenzoates
Pryor, W. A., & HENDRICKSON, W. H. J. (1975) · Journal of the American Chemical Society · doi:10.1021/ja00839a054 · Cited by 36
Self-citation
Structure activity relationships of peroxynitrite scavengers an approach to nitric oxide neurotoxicity.
Js, A., Oien, T. T., Gj, F., Scherch, H. M., Sethy, V. H., & Pf, V. (1994) · PubMed · Cited by 32
Flash photolysis of the nitrate ion in aqueous solution: excitation at 200 nm
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The mechanism of radical production from the reaction of N,N-dimethylaniline with benzoyl peroxide.
Pryor, W. A., & HENDRICKSON, W. H. J. (1983) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)81681-0 · Cited by 25
Self-citation
Reactions of radicals. XXVI. On the use of activation parameters as a test for concerted decomposition of initiators
Pryor, W. A., & Smith, K. (1971) · International Journal of Chemical Kinetics · doi:10.1002/kin.550030502 · Cited by 14
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“Indeed, nitration of tyrosine residues appears to be a "marker" of ONOO − -dependent damage in vivo (42, (54) (55) (56) (57) (58) (59) (60) (61) (62) (63) .”
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“Another antioxidant mechanism of proteins could result from their ability to reduce lipid hydroperoxides to relatively nonreactive lipid hydroxides by non-radical reactions (Garner et al., 1998a; Garner et al., 1998b; Pryor et al., 1994; Pryor and Squadrito, 1995).”
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Authors: Pryor, W. A., & Squadrito, G. L.
Affiliations: Louisiana State University (US)
Venue: American Journal of Physiology-Lung Cellular and Molecular Physiology
Publisher: American Physiological Society
Published: 1995-05-01
Volume: 268
Issue: 5
Pages: L699-L722
ISSN: 1040-0605 (ISSN-L)
1522-1504
DOI: 10.1152/ajplung.1995.268.5.l699
OpenAlex: W2209831038
Cited by: 1,511
References: 94
Citations by year: 2026: 11 · 2025: 13 · 2024: 19 · 2023: 21 · 2022: 21 · 2021: 19 · 2020: 24 · 2019: 28 · 2018: 29 · 2017: 30 · 2016: 30 · 2015: 35 · 2014: 42 · 2013: 55 · 2012: 47
FWCI: 52.08
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Lung Cellular and Molecular Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords: peroxynitrite, nitric oxide, superoxide, peroxynitrous acid, nitrate formation, superoxide dismutase, nitric oxide scavenging, single electron transfer, two-electron oxidation, peroxynitrite decomposition, hydroxyl radical scavengers, nitric oxide synthase, nitric oxide signaling
MeSH terms: Animals, Humans, Hydrogen-Ion Concentration, Hydroxylation, Methionine, Nitrates, Nitric Oxide, Nitroso Compounds, Oxidation-Reduction, Sulfhydryl Compounds, Superoxides, Viscosity

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The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

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