The Catabolic Effects of Prolonged Inactivity and Acute Hypercortisolemia Are Offset by Dietary Supplementation
Abstract
We compared the anabolic stimulus provided by an essential amino acid and carbohydrate (AA/CHO) supplement to a mixed clinical meal during bed rest (BR) and episodic hypercortisolemia ( approximately 24 microg.dl(-1)). In the experimental (EXP; n = 7) and control (CON; n = 6) groups, femoral arteriovenous blood samples and vastus lateralis biopsy samples were obtained during a primed constant infusion of l-[ring-(2)H(5)]phenylalanine and a 14-h infusion of hydrocortisone sodium succinate (60 microg.kg.h(-1)) before (pre-BR) and after (post-BR) 28 d of BR. Muscle protein kinetics were calculated during the postabsorptive state, for 2.5 h after ingestion of a meal and for 2.5 h after ingestion of an AA/CHO supplement (EXP) or placebo (CON). Postabsorptive net phenylalanine balance values were as follows: EXP, -35.14 +/- 2.93, and CON, -32.60 +/- 6.65 (pre-BR); and EXP, -32.91 +/- 5.67, and CON, -30.43 +/- 6.28 nmol phe.ml(-1).100 ml leg volume(-1) (post-BR). After AA/CHO supplementation, net phenylalanine balance improved to 33.51 +/- 8.06 (pre-BR) and 24.15 +/- 11.4 nmol phe.ml(-1).100 ml leg volume(-1) (post-BR), but remained negative after the meal. Cumulative 5.5-h mixed muscle fractional synthetic rate was greater in the EXP group pre-BR (EXP, 0.108 +/- 0.01, and CON, 0.073 +/- 0.04%.h(-1)) and post-BR (EXP, 0.111 +/- 0.015, and CON, 0.05 +/- 0.002%.h(-1)). Unlike a typical clinical meal, AA/CHO supplementation stimulated net muscle protein synthesis despite acute hypercortisolemia and prolonged inactivity.
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The loss of muscle mass and strength associated with bed rest per se can be partly offset by protein or amino acid supplementation.
“The loss of muscle mass and strength associated with bed rest per se can be partly offset by protein or amino acid supplementation.158,167”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [167]
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Self-citationAmino Acid Supplementation and Skeletal Muscle Metabolism in Ageing Populations
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Araraquara, C. D., & Nutricionais, C. (2008)
- Authors
- Paddon-Jones, D., Sheffield-Moore, M., Urban, R. J., Aarsland, A., Wolfe, R. R., & Ferrando, A. A.
- Affiliations
- Shriners Hospitals for Children - Galveston (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2005-03
- Volume
- 90
- Issue
- 3
- Pages
- 1453-1459
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2083626903
- Cited by
- 52
- References
- 49
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration (NAG91155)
- University of Texas Medical Branch
- National Space Biomedical Research Institute (NPFR00205)
- Shriners Hospitals for Children
- National Institutes of Health
- National Institute on Aging (P30AG024832)
- National Institute of General Medical Sciences (R01-GM57295, R01GM057295)
- National Center for Research Resources (M01 RR-00073, M01RR000073)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- muscle protein synthesis, muscle protein degradation, essential amino acid supplementation, carbohydrate supplementation, hypercortisolism, cortisol, bed rest, prolonged inactivity, catabolism
- MeSH terms
- Adult, Amino Acids, Essential, Blood Glucose, Dietary Carbohydrates, Humans, Hydrocortisone, Immobilization, Insulin, Male, Middle Aged, Muscle Proteins, Phenylalanine, Body Mass Index, Muscle, Skeletal
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