Cited by 207Physical Activity and HealthCardiovascular and exercise physiologyExercise and Physiological Responses

Lifetime sedentary living accelerates some aspects of secondary aging

Booth, Frank W., Laye, Matthew J., Roberts, Michael D.·2011·Journal of Applied Physiology

Abstract

Lifetime physical inactivity interacts with secondary aging (i.e., aging caused by diseases and environmental factors) in three patterns of response. First, lifetime physical inactivity confers no apparent effects on a given set of physiological functions. Second, lifetime physical inactivity accelerates secondary aging (e.g., speeding the reduction in bone mineral density, maximal oxygen consumption, and skeletal muscle strength and power), but does not alter the primary aging of these systems. Third, a lifetime of physical activity to the age of ∼60–70 yr old totally prevents decrements in some age-associated risk factors for major chronic diseases, such as endothelial dysfunction and insulin resistance. The present review provides ample and compelling evidence that physical inactivity has a large impact in shortening average life expectancy. In summary, physical inactivity plays a major role in the secondary aging of many essential physiological functions, and this aging can be prevented through a lifetime of physical activity.

Integrity signals

Registry

Crossref · 10.1152/japplphysiol.00420.2011

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Enhanced metabolic dysfunction within the SM can also be influenced by T2D itself, other chronic diseases, and even a sedentary lifestyle, mediated through a process termed 'secondary aging'.

    “In addition to ‘normal aging’, enhanced metabolic dysfunction within the SM can also be influenced by T2D itself, other chronic diseases, and even a sedentary lifestyle, mediated through a process termed ‘secondary aging’ [17,34].”

Cites

Flagged first, then by citations

1 of the 57 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Booth, F. W., Laye, M. J., & Roberts, M. D.
Affiliations
  • University of Missouri (US)
  • University of Copenhagen (DK)
  • Departments of 1Biomedical Sciences,
Corresponding author
Booth, Frank W.
Venue
Journal of Applied Physiology
Published
2011-11
Volume
111
Issue
5
Pages
1497-1504
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
OpenAlex
W2067103577
Cited by
207
References
57
Citations by year
2026: 7 · 2025: 15 · 2024: 4 · 2023: 15 · 2022: 5 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 7 · 2016: 17 · 2015: 18 · 2014: 18 · 2013: 44 · 2012: 13
FWCI
2.61
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
physical inactivity, sedentary behavior, secondary aging, primary aging, bone mineral density, VO2max, skeletal muscle strength, endothelial dysfunction, insulin resistance, chronic disease risk, life expectancy, physical activity
MeSH terms
Aging, Chronic Disease, Humans, Life Expectancy, Motor Activity, Risk Factors, Exercise, Sedentary Behavior

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review