Cited by 123Exercise and Physiological ResponsesPhysical Activity and HealthCardiovascular and exercise physiology

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Time course of changes in inflammatory markers during a 6-mo exercise intervention in sedentary middle-aged men: a randomized-controlled trial

Thompson, Dylan, Markovitch, Daniella, Betts, James A., Mazzatti, Dawn, Turner, James, Tyrrell, Rex M.·2010·Journal of Applied Physiology

DOI 10.1152/japplphysiol.00822.2009

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Abstract

Regular exercise may improve systemic markers of chronic inflammation, but direct evidence and dose-response information is lacking. The objective of this study was to examine the effect and time course of changes in markers of chronic inflammation in response to progressive exercise training (and subsequent detraining). Forty-one sedentary men 45–64 yr of age completed either a progressive 24-wk exercise intervention or control followed by short-term removal of the intervention (2-wk detraining). Serum IL-6 fell by −0.4 pg/ml (SD 0.6) after 12 wk and responded to moderate-intensity exercise. Serum alanine aminotransferase (ALT) activity fell −7 U/l (SD 11) at 24 wk although there was no evidence of any change by week 12 (and therefore ALT required more vigorous-intensity activity and/or a more prolonged intervention). The effect on IL-6 was lost after 2-wk detraining whereas the change in ALT was retained. The temporal fall and rise in IL-6 with training and subsequent detraining in men with high IL-6 at baseline provided a retrospective opportunity to examine parallel genomic changes in peripheral mononuclear cells. A subset of 53 probes was differentially regulated by at least twofold after training with 31 of these changes being lost after detraining ( n = 6). IL-6 responded quickly to the carefully monitored exercise intervention (within weeks) and required only moderate-intensity exercise, whereas ALT took longer to change and/or required more vigorous-intensity exercise. Further work is required to determine whether any of the genes that temporally changed in parallel with changes in IL-6 are a cause or consequence of this response.

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Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,032
Designing Experiments and Analysing Data: A Model Comparison Perspective.
Freeman, G. H., Maxwell, S. E., & Delaney, H. D. (1991) · Biometrics · doi:10.2307/2532173 · Cited by 1,229
Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms
Mora, S., Cook, N., Buring, J. E., Ridker, P. M., & Lee, I.-M. (2007) · Circulation · doi:10.1161/circulationaha.107.729939 · Cited by 1,000
Designing Experiments and Analyzing Data: A Model Comparison Perspective, Third Edition
Maxwell, S. E., & Delaney, H. D. (1999) · Medical Entomology and Zoology · Cited by 975
Long-Term Interleukin-6 Levels and Subsequent Risk of Coronary Heart Disease: Two New Prospective Studies and a Systematic Review
Danesh, J., Kaptoge, S., Mann, A. G., Sarwar, N., Wood, A., Angleman, S. B., Wensley, F., Higgins, J. P. T., Lennon, L., Eiriksdottir, G., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050078 · Cited by 676

Show all 52 references

Research works printed but not linked: 2

Mohamed-Ali V, 1997, J Clin Endocrinol Metab, 82, 4196
Mori N, 1993, Cancer Res, 53, 4643

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Koehler, K., & Drenowatz, C. J. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-212-5 · Cited by 3
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Pauer, J., Fék, A., Buday, B., Literáti-Nagy, B., Pach, F. P., Vitai, M., Péterfai, É., & Koranyi, L. I. (2013) · Orvosi Hetilap · doi:10.1556/oh.2013.29538 · Cited by 3
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Bril, F., Ntim, K., Lomonaco, R., & Cusi, K. J. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch20 · Cited by 3
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Ferreira, S. V., Gardy, S., Churchward‐Venne, T. A., Josse, A. R., & Gibbs, J. C. (2025) · Bone Reports · doi:10.1016/j.bonr.2025.101850 · Cited by 2
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Johnston, C. A. (2011) · American Journal of Lifestyle Medicine · doi:10.1177/1559827611425023 · Cited by 2
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Elias, R. G. M., Farias, J. P., de Faria, W. F., Neto, A. S., da Silva, C. C., & Rinaldi, W. (2015) · journal of physical education · doi:10.4025/reveducfis.v26i4.26416 · Cited by 2
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Graby, J., Khavandi, A., Gillison, F., Smith, T. R., Murphy, D., Peacock, O., McLeod, H., Dastidar, A. G., Antoniades, C. A., Thompson, D., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-080735 · Cited by 1
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Murphy, D., Graby, J., Smith, T. R., Peacock, O. J., Abramik, J., Antoniades, C. A., Rodrigues, J. C. L., Thompson, D., & Khavandi, A. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-103090 · Cited by 1
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Wang, Y., & Zhuo, W. (2023) · journal of nutritional oncology · doi:10.1097/jn9.0000000000000012 · Cited by 1

Authors: Thompson, D., Markovitch, D., Betts, J. A., Mazzatti, D., Turner, J., & Tyrrell, R. M.
Affiliations: University of Bath (GB)
School for Health and
Unilever (United Kingdom) (GB)
Corresponding author: Thompson, Dylan
ORCID: Thompson, Dylan
Betts, James A.
Tyrrell, Rex M.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2010-04
Volume: 108
Issue: 4
Pages: 769-779
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.00822.2009
OpenAlex: W2064048817
Cited by: 123
References: 52
Citations by year: 2026: 5 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 8 · 2017: 12 · 2016: 10 · 2015: 9 · 2014: 6 · 2013: 10 · 2012: 9
FWCI: 9.84
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: British Heart Foundation (PG/04/124/17944)
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: chronic inflammation, exercise training, detraining, interleukin-6, alanine aminotransferase, peripheral blood mononuclear cells, gene expression, moderate-intensity exercise, high-intensity exercise, dose-response relationship
MeSH terms: Alanine Transaminase, Cell Count, Chronic Disease, Exercise Therapy, Hematologic Tests, Humans, Inflammation, Leukocytes, Mononuclear, Male, Middle Aged, Biomarkers, Exercise, Interleukin-6, Gene Expression, Oligonucleotide Array Sequence Analysis, Sedentary Behavior

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Time course of changes in inflammatory markers during a 6-mo exercise intervention in sedentary middle-aged men: a randomized-controlled trial

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