Cited by 106Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular and exercise physiologyPhysical Activity and Health

Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention

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Iaccarino, Guido, Franco, Danilo, Sorriento, Daniela, Strisciuglio, Teresa, Barbato, Emanuele, Morisco, Carmine·2021·Journal of Cardiovascular Translational Research

Abstract

The beneficial effects of physical activity on the cardiovascular system nowadays have achieved the relevance of clinical evidence. In fact, several studies have documented the benefits of exercise training in the prevention of the cardiovascular risk. Abnormalities of insulin signaling transduction account for the impairment of insulin sensitivity and development of insulin resistance, which, in turn, is responsible for the enhancement of cardiovascular risk. Insulin sensitivity is related to the degree of physical activity, and physical training has been shown to ameliorate insulin action in insulin-resistant subjects. This effect is mediated by the improvement of the molecular abnormalities that are responsible of the insulin resistance, contributing in this way to restore the physiological insulin sensitivity. However, it should be underlined that mechanisms that account for this phenomenon are extremely complex and still unclear. Further studies are required to better clarify the molecular basis of the exercise-evoked improvement of insulin signal. Graphical abstract.

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  1. [2](2010). In Global recommendations on physical activity for health (WHO Guidelines Approved by the Guidelines Review Committee). Geneva.

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Authors
Iaccarino, G., Franco, D., Sorriento, D., Strisciuglio, T., Barbato, E., & Morisco, C.
Affiliations
University of Naples Federico II (IT)
Corresponding author
Morisco, Carmine
Venue
Journal of Cardiovascular Translational Research
Published
2020-07-31
Volume
14
Issue
2
Pages
256-270
ISSN
  • 1937-5387 (ISSN-L)
  • 1937-5395
OpenAlex
W3046313480
Cited by
106
References
129
Citations by year
2026: 17 · 2025: 16 · 2024: 14 · 2023: 22 · 2022: 21 · 2021: 14 · 2020: 2
FWCI
2.26
Type
journal article
Language
en
Open access
Locations
  • Journal of Cardiovascular Translational Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
Funders
Cardiopath PhD program
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
insulin sensitivity, exercise training, insulin resistance, insulin signaling, cardiovascular risk prevention, physical activity
MeSH terms
Healthy Lifestyle, Heart Disease Risk Factors, Animals, Cardiovascular Diseases, Health Status, Humans, Insulin Resistance, Prognosis, Biomarkers, Exercise, Risk Assessment, Risk Reduction Behavior, Protective Factors

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