Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention
Open accessAbstract
The beneficial effects of physical activity on the cardiovascular system nowadays have achieved the relevance of clinical evidence. In fact, several studies have documented the benefits of exercise training in the prevention of the cardiovascular risk. Abnormalities of insulin signaling transduction account for the impairment of insulin sensitivity and development of insulin resistance, which, in turn, is responsible for the enhancement of cardiovascular risk. Insulin sensitivity is related to the degree of physical activity, and physical training has been shown to ameliorate insulin action in insulin-resistant subjects. This effect is mediated by the improvement of the molecular abnormalities that are responsible of the insulin resistance, contributing in this way to restore the physiological insulin sensitivity. However, it should be underlined that mechanisms that account for this phenomenon are extremely complex and still unclear. Further studies are required to better clarify the molecular basis of the exercise-evoked improvement of insulin signal. Graphical abstract.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In subjects with diabetes or obesity, exercise increases insulin sensitivity independently of changes in body fat with nutritional interventions.
“In subjects with diabetes or obesity, exercise is the cornerstone of therapeutic interventions. It increases insulin sensitivity independently of changes in body fat with nutritional interventions”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [240]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,548 · see citing works
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · cited 2× · see citing works
“Interestingly, two longitudinal studies achieved similar results: The Finnish Diabetes Prevention [26] and the Diabetes Prevention Program [27] showed, in non-diabetic persons at elevate risk for diabetes, that a lifestylemodification program associated with a regular physical activity is able to reduce the incidence…”
ResultEuropean Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490 · see citing works
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M.-T., Corrà, U., Cosyns, B., Deaton, C., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw106 · Cited by 6,457 · see citing works
Arnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., Himmelfarb, C. D., Khera, A., Lloyd-Jones, D., McEvoy, J. W., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000678 · Cited by 4,536 · see citing works
(2019) · doi:10.1161/cir.0000000000000677 · Cited by 4,501 · see citing works
Pan, X.-R., Li, G.-W., Hu, Y.-H., Wang, J.-X., Yang, W.-Y., An, Z.-X., Hu, Z.-X., Juan-Lin, Xiao, J.-Z., Cao, H.-B., et al. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.537 · Cited by 4,320 · see citing works
2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
Jensen, M. D., Ryan, D. H., Apovian, C. M., Ard, J. D., Comuzzie, A. G., Donato, K. A., Hu, F. B., Hubbard, V. S., Jakicic, J. M., Kushner, R. F., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.004 · Cited by 4,058 · see citing works
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100 · cited 3× · see citing works
“Studies performed in animal models of insulin resistance have documented that exercise training is capable to blunt the enhancement of proinflammatory cytokines such as IL-6 and TNF-α and, at the same time, ameliorates the anti-inflammatory response by increasing the circulatory levels of IL-4 and IL-10 [104, 105], re…”
BackgroundObesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093 · see citing works
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes
The Look AHEAD Research Group (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1212914 · Cited by 2,908 · see citing works
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001940 · Cited by 2,885 · see citing works
DONNELLY, J. E., BLAIR, S. N., JAKICIC, J. M., MANORE, M. M., RANKIN, J. W., & SMITH, B. K. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181949333 · Cited by 2,658 · see citing works
Executive Summary: Heart Disease and Stroke Statistics—2016 Update
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S. D., Després, J., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000366 · Cited by 2,467 · see citing works
Pescatello, L. S., Franklin, B. A., Fagard, R. H., Farquhar, W. B., Kelley, G. A., & Ray, C. A. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000115224.88514.3a · Cited by 1,918 · see citing works
Wen, C. P., Wai, J. P. M., Tsai, M. K., Yang, Y. C., Cheng, T. Y. D., Lee, M.-C., Chan, H. T., Tsao, C. K., Tsai, S. P., & Wu, X. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60749-6 · Cited by 1,908 · see citing works
Boulé, N. G., Haddad, E., Kenny, G. P., Wells, G. A., & Sigal, R. J. (2001) · JAMA · doi:10.1001/jama.286.10.1218 · Cited by 1,889 · see citing works
Exercise Training for Blood Pressure: A Systematic Review and Meta‐analysis
Cornelissen, V. A., & Smart, N. A. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.112.004473 · Cited by 1,683 · see citing works
Effects of the amount and intensity of exercise on plasma lipoproteins
Kraus, W. E., Houmard, J. A., Duscha, B. D., Knetzger, K. J., Wharton, M. B., McCartney, J. S., Bales, C. W., Henes, S., Samsa, G. P., Otvos, J. D., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020194 · Cited by 1,554 · see citing works
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes
The Look AHEAD Research Group (2007) · Diabetes Care · doi:10.2337/dc07-0048 · Cited by 1,522 · see citing works
Andersen, L. B., Schnohr, P., Schroll, M., & Hein, H. O. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.11.1621 · Cited by 1,035 · see citing works
Exercise for overweight or obesity
Shaw, K. A., Gennat, H. C., O'Rourke, P., & Del Mar, C. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003817.pub3 · Cited by 950 · see citing works
Hu, F. B., Sigal, R. J., Rich-Edwards, J. W., Colditz, G. A., Solomon, C. G., Willett, W. C., Speizer, F. E., & Manson, J. E. (1999) · JAMA · doi:10.1001/jama.282.15.1433 · Cited by 914 · see citing works
Exercise and the Cardiovascular System: Clinical Science and Cardiovascular Outcomes
Lavie, C. J., Arena, R., Swift, D. L., Johannsen, N. M., Sui, X., Lee, D.-C., Earnest, C. P., Church, T. S., O’Keefe, J. H., Milani, R. V., et al. (2015) · Circulation Research · doi:10.1161/circresaha.117.305205 · Cited by 782 · see citing works
Lin, X., Zhang, X., Guo, J., Roberts, C. K., McKenzie, S., Wu, W., Liu, S., & Song, Y. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002014 · Cited by 758 · see citing works
Exercise for type 2 diabetes mellitus
Thomas, D., Elliott, E. J., & Naughton, G. A. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002968.pub2 · Cited by 728 · see citing works
Wei, M., Gibbons, L. W., Kampert, J. B., Nichaman, M. Z., & Blair, S. N. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-8-200004180-00002 · Cited by 709 · see citing works
Perseghin, G., Price, T. B., Petersen, K. F., Roden, M., Cline, G. W., Gerow, K., Rothman, D. L., & Shulman, G. I. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351804 · Cited by 699 · see citing works
Long-term weight loss after diet and exercise: a systematic review
Curioni, C. C., & Lourenço, P. M. C. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803015 · Cited by 694 · see citing works
Miller, W., Koceja, D., & Hamilton, E. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800499 · Cited by 686 · see citing works
Prevention of type 2 diabetes by lifestyle intervention: a Japanese trial in IGT males
Kosaka, K., Noda, M., & Kuzuya, T. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.06.010 · Cited by 656 · see citing works
Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome
MYERS, J. N., Kokkinos, P. F., & Nyelin, E. (2019) · Nutrients · doi:10.3390/nu11071652 · Cited by 633 · see citing works
Physical Activity in the Prevention of Type 2 Diabetes
Laaksonen, D. E., Lindström, J., Lakka, T. A., Eriksson, J. G., Niskanen, L., Wikström, K., Aunola, S., Keinänen-Kiukaanniemi, S., Laakso, M., Valle, T. T., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.1.158 · Cited by 614 · see citing works
McTigue, K. M., Harris, R., Hemphill, B., Lux, L. J., Sutton, S. F., Bunton, A. J., & Lohr, K. N. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-11-200312020-00013 · Cited by 601 · see citing works
Effect of the volume and intensity of exercise training on insulin sensitivity
Houmard, J. A., Tanner, C. J., Slentz, C. A., Duscha, B. D., McCartney, J. S., & Kraus, W. E. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00707.2003 · Cited by 568 · see citing works
Obesity: Overview of an Epidemic
Mitchell, N. S., Catenacci, V. A., Wyatt, H. R., & Hill, J. O. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.08.005 · Cited by 526 · see citing works
King, A. C., Haskell, W. L., Young, D. R., Oka, R. K., & Stefanick, M. L. (1995) · Circulation · doi:10.1161/01.cir.91.10.2596 · Cited by 517 · see citing works
Promoting Physical Activity and Exercise
Fletcher, G. F., Landolfo, C. K., Niebauer, J., Ozemek, C., Arena, R. A., & Lavie, C. J. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2141 · Cited by 512 · see citing works
Lund, S., Holman, G. D., Schmitz, O., & Pedersen, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5817 · Cited by 492 · see citing works
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M. T., Corrà, U., Cosyns, B., Deaton, C., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.05.037 · Cited by 488 · see citing works
Douen, A. G., Ramlal, T., Rastogi, S., Bilan, P. J., Cartee, G. D., Vranić, M., Holloszy, J. O., & Klip, A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77362-6 · Cited by 473 · see citing works
Exercise capacity and body composition as predictors of mortality among men with diabetes
Church, T. S., Cheng, Y. J., Earnest, C. P., Barlow, C. E., Gibbons, L. W., Priest, E. L., & Blair, S. N. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.83 · Cited by 469 · see citing works
Dose of Jogging and Long-Term Mortality
Schnohr, P., O’Keefe, J. H., Marott, J. L., Lange, P., & Jensen, G. B. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.11.023 · Cited by 416 · see citing works
Ren, J., Semenkovich, C. F., Gulve, E. A., Gao, J. H., & Holloszy, J. O. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36636-x · Cited by 416 · see citing works
Lobelo, F., Rohm Young, D., Sallis, R., Garber, M. D., Billinger, S. A., Duperly, J., Hutber, A., Pate, R. R., Thomas, R. J., Widlansky, M. E., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000559 · Cited by 402 · see citing works
The sympathetic nervous system and the metabolic syndrome
Mancia, G., Bousquet, P., Elghozi, J. L., Esler, M., Grassi, G., Julius, S., Reid, J., & Van Zwieten, P. A. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e328048d004 · Cited by 385 · see citing works
Insulin signaling and insulin sensitivity after exercise in human skeletal muscle
Wojtaszewski, J. F., Hansen, B. F., Gade, Kiens, B., Markuns, J. F., Goodyear, L. J., & Richter, E. A. (2000) · Diabetes · doi:10.2337/diabetes.49.3.325 · Cited by 382 · see citing works
Weight-loss maintenance for 10 years in the National Weight Control Registry
Thomas, J. G., Bond, D. S., Phelan, S., Hill, J. O., & Wing, R. R. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2013.08.019 · Cited by 358 · see citing works
Effect of exercise on insulin action in human skeletal muscle
Richter, E. A., Mikines, K. J., Galbo, H., & Kiens, B. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.2.876 · Cited by 357 · see citing works
Enhanced Peripheral and Splanchnic Insulin Sensitivity in NIDDM Men After Single Bout of Exercise
Devlin, J. T., Hirshman, M., Horton, E. D., & Horton, E. S. (1987) · Diabetes · doi:10.2337/diab.36.4.434 · Cited by 342 · see citing works
The Writing Group for the Activity Counseling Trial Research Group, T. W. G. F. T. A. C. T. R. G. (2001) · JAMA · doi:10.1001/jama.286.6.677 · Cited by 340 · see citing works
Hemmingsen, B., Gimenez-Perez, G., Mauricio, D., Roqué i Figuls, M., Metzendorf, M.-I., & Richter, B. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003054.pub4 · Cited by 316 · see citing works
The effect of physical activity on mediators of inflammation
Nimmo, M. A., Leggate, M., Viana, J. L., & King, J. A. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12156 · Cited by 301 · see citing works
Savikj, M., Gabriel, B. M., Alm, P. S., Smith, J., Caidahl, K., Björnholm, M., Fritz, T., Krook, A., Zierath, J. R., & Wallberg-Henriksson, H. (2019) · Diabetologia · doi:10.1007/s00125-018-4767-z · Cited by 277 · see citing works
Effects of Exercise on Adiponectin: A Systematic Review
Simpson, K. A., & Singh, M. A. F. (2008) · Obesity · doi:10.1038/oby.2007.53 · Cited by 260 · see citing works
Exercise and risk factors associated with metabolic syndrome in older adults
Stewart, K. J., Bacher, A. C., Turner, K., Lim, J. G., Hees, P. S., Shapiro, E. P., Tayback, M., & Ouyang, P. (2004) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2004.09.006 · Cited by 252 · see citing works
Rethinking our approach to physical activity
Das, P., & Horton, R. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61024-1 · Cited by 252 · see citing works
Ciolac, E. G., Bocchi, E. A., Bortolotto, L. A., Carvalho, V. O., Greve, J. M. D., & Guimarães, G. V. (2010) · Hypertension Research · doi:10.1038/hr.2010.72 · Cited by 242 · see citing works
Wojtaszewski, J. F. P., Higaki, Y., Hirshman, M. F., Michael, M. D., Dufresne, S. D., Kahn, C. R., & Goodyear, L. J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7961 · Cited by 235 · see citing works
Lee, A. D., Hansen, P. A., & Holloszy, J. O. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00147-2 · Cited by 234 · see citing works
NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases
Fiordelisi, A., Iaccarino, G., Morisco, C., Coscioni, E., & Sorriento, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071599 · Cited by 217 · see citing works
Polak, J., Klimčáková, E., Moro, C., Viguerie, N., Berlan, M., Hejnová, J., Richterova, B., Kraus, I., Langin, D., & Štich, V. (2006) · Metabolism · doi:10.1016/j.metabol.2006.06.008 · Cited by 213 · see citing works
Christ-Roberts, C. Y., Pratipanawatr, T., Pratipanawatr, W., Berria, R., Belfort, R., Kashyap, S., & Mandarino, L. J. (2004) · Metabolism · doi:10.1016/j.metabol.2004.03.022 · Cited by 210 · see citing works
Wewege, M. A., Thom, J. M., Rye, K.-A., & Parmenter, B. J. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.05.002 · Cited by 210 · see citing works
Cornelissen, V. A., Buys, R., & Smart, N. A. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835ca964 · Cited by 209 · see citing works
Goodyear, L. J., Chang, P.-Y., Sherwood, D. J., Dufresne, S. D., & Moller, D. E. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.2.e403 · Cited by 208 · see citing works
Exercise training improves baroreflex sensitivity in type 2 diabetes
Loimaala, A., Huikuri, H. V., Kööbi, T., Rinne, M., Nenonen, A., & Vuori, I. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1837 · Cited by 207 · see citing works
Rossi, A., Dikareva, A., Bacon, S. L., & Daskalopoulou, S. S. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283544669 · Cited by 203 · see citing works
Lin, J. S., O’Connor, E., Evans, C. V., Senger, C. A., Rowland, M. G., & Groom, H. C. (2014) · Annals of Internal Medicine · doi:10.7326/m14-0130 · Cited by 191 · see citing works
Hansen, D., Niebauer, J., Cornelissen, V., Barna, O., Neunhäuserer, D., Stettler, C., Tonoli, C., Greco, E., Fagard, R., Coninx, K., et al. (2018) · Sports Medicine · doi:10.1007/s40279-018-0930-4 · Cited by 191 · see citing works
Exercise training lowers resting renal but not cardiac sympathetic activity in humans.
Meredith, I. T., Friberg, P., Jennings, G. L., Dewar, E. M., Fazio, V. A., Lambert, G. W., & Esler, M. D. (1991) · Hypertension · doi:10.1161/01.hyp.18.5.575 · Cited by 189 · see citing works
Physical training and baroreceptor control of sympathetic nerve activity in humans.
Grassi, G., Seravalle, G., Calhoun, D. A., & Mancia, G. (1994) · Hypertension · doi:10.1161/01.hyp.23.3.294 · Cited by 187 · see citing works
Ropelle, E. R., Pauli, J. R., Prada, P. O., de Souza, C. T., Picardi, P. K., Faria, M. C., Cintra, D. E., Fernandes, M. F. D. A., Flores, M. B. S., Velloso, L. A., et al. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120006 · Cited by 187 · see citing works
Exercise in Obesity, Metabolic Syndrome, and Diabetes
Church, T. (2011) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2011.03.013 · Cited by 186 · see citing works
Epidemiology of Physical Activity and Exercise Training in the United States
Katzmarzyk, P. T., Lee, I.-M., Martin, C. K., & Blair, S. N. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.01.004 · Cited by 178 · see citing works
Mons, U., Hahmann, H., & Brenner, H. (2014) · Heart · doi:10.1136/heartjnl-2013-305242 · Cited by 171 · see citing works
Ashen, M. D., & Blumenthal, R. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmcp044370 · Cited by 168 · see citing works
Friedman, J. E., Sherman, W. M., Reed, M. J., Eiton, C. W., & Dohm, G. L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80960-q · Cited by 166 · see citing works
Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle
Kirwan, J. P., Aguila, L. F. D., Hernandez, J. M., Williamson, D. L., O’Gorman, D. J., Lewis, R. R., & Krishnan, R. K. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.2.797 · Cited by 160 · see citing works
Ryder, J. W., Chibalin, A., & Zierath, J. R. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00827.x · Cited by 155 · see citing works
Primary prevention of ischaemic heart disease: populations, individuals, and health professionals
Gupta, R., & Wood, D. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31893-8 · Cited by 154 · see citing works
Penn, L., White, M. J., Oldroyd, J. C., Walker, M., Alberti, K. G. M. M., & Mathers, J. C. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-342 · Cited by 153 · see citing works
Palatini, P., Graniero, G. R., Mormino, P., Nicolosi, L. N., Mos, L., Visentin, P., & Pessina, A. C. (1994) · Circulation · doi:10.1161/01.cir.90.6.2870 · Cited by 144 · see citing works
Cartee, G. D. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00416.2015 · Cited by 140 · see citing works
Higaki, Y., Mikami, T., Fujii, N., Hirshman, M. F., Koyama, K., Seino, T., Tanaka, K., & Goodyear, L. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00150.2007 · Cited by 138 · see citing works
Kjøbsted, R., Treebak, J. T., Fentz, J., Lantier, L., Viollet, B., Birk, J. B., Schjerling, P., Björnholm, M., Zierath, J. R., & Wojtaszewski, J. F. P. (2014) · Diabetes · doi:10.2337/db14-1402 · Cited by 135 · see citing works
Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity
Muntzel, M. S., Morgan, D. A., Mark, A. L., & Johnson, A. K. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.267.5.r1350 · Cited by 134 · see citing works
Chambers, M. A., Moylan, J. S., Smith, J. D., Goodyear, L. J., & Reid, M. B. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.165639 · Cited by 132 · see citing works
Anti-inflammatory nature of exercise
Das, U. N. (2004) · Nutrition · doi:10.1016/j.nut.2003.11.017 · Cited by 126 · see citing works
Thompson, D., Markovitch, D., Betts, J. A., Mazzatti, D., Turner, J., & Tyrrell, R. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00822.2009 · Cited by 123 · see citing works
Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle
Arias, E. B., Kim, J., Funai, K., & Cartee, G. D. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00602.2006 · Cited by 118 · see citing works
Effects of exercise training on muscle GLUT-4 protein content and translocation in obese Zucker rats
Brozinick, J. T., Etgen, G. J., Yaspelkis, B. B., Kang, H. Y., & Ivy, J. L. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.3.e419 · Cited by 113 · see citing works
O'Leary, V. B., Jorett, A. E., Marchetti, C. M., Gonzalez, F., Phillips, S. A., Ciaraldi, T. P., & Kirwan, J. P. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00123.2007 · Cited by 107 · see citing works
Whelton, P. K., & Williams, B. (2018) · JAMA · doi:10.1001/jama.2018.16755 · Cited by 106 · see citing works
Insulin Resistance and Improvements in Signal Transduction
Musi, N., & Goodyear, L. J. (2006) · Endocrine · doi:10.1385/endo:29:1:73 · Cited by 103 · see citing works
Pehmøller, C. K., Brandt, N., Birk, J. B., Høeg, L. D., Sjøberg, K. A., Goodyear, L. J., Kiens, B., Richter, E. A., & Wojtaszewski, J. F. P. (2012) · Diabetes · doi:10.2337/db11-1572 · Cited by 103 · see citing works
Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats
Teixeira‐Lemos, E., Reis, F., Baptista, S., Pinto, R. M. A., Sepodes, B. M. N., Vala, H., Rocha‐Pereira, P., Correia‐da‐Silva, G., Teixeira, N. A. A., Santos‐Silva, A., et al. (2008) · Nutrition · doi:10.1016/j.nut.2008.08.014 · Cited by 101 · see citing works
High-intensity interval training and hypertension: maximizing the benefits of exercise?
Ciolac, E. G. (2012) · PubMed Central · Cited by 99 · see citing works
Combined Training Reduces Subclinical Inflammation in Obese Middle-Age Men
Brunelli, D. T., Chacon‐Mikahil, M. P. T., Gáspari, A. F., Lopes, W. A., Bonganha, V., Bonfante, I. L. P., Bellotto, M. L., Libardi, C. A., & Cavaglieri, C. R. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000658 · Cited by 90 · see citing works
Prior, S. J., Blumenthal, J. B., Katzel, L. I., Goldberg, A. P., & Ryan, A. S. (2014) · Diabetes Care · doi:10.2337/dc13-2358 · Cited by 89 · see citing works
Muscle glucose transport, GLUT-4 content, and degree of exercise training in obese Zucker rats
Banks, E. A., Brozinick, J. T., Yaspelkis, B. B., Kang, H. Y., & Ivy, J. L. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.5.e1015 · Cited by 88 · see citing works
Castorena, C. M., Arias, E. B., Sharma, N., & Cartee, G. D. (2014) · Diabetes · doi:10.2337/db13-1686 · Cited by 87 · see citing works
Contractile Activity Stimulates the c-Jun NH2-terminal Kinase Pathway in Rat Skeletal Muscle
Aronson, D., Dufresne, S. D., & Goodyear, L. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25636 · Cited by 86 · see citing works
Hamada, T., Arias, E. B., & Cartee, G. D. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00416.2006 · Cited by 84 · see citing works
Insulin Signaling After Exercise in Insulin Receptor Substrate-2-Deficient Mice
Howlett, K. F., Sakamoto, K., Hirshman, M. F., Aschenbach, W. G., Dow, M. A., White, M. F., & Goodyear, L. J. (2002) · Diabetes · doi:10.2337/diabetes.51.2.479 · Cited by 74 · see citing works
Oldroyd, J. C., Unwin, N. C., White, M. J., Imrie, K., Mathers, J. C., & Alberti, K. G. M. M. (2001) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(00)00244-8 · Cited by 73 · see citing works
Insulin Resistance and Cardiovascular Risk: New Insights From Molecular and Cellular Biology
Morisco, C., Lembo, G., & Trimarco, B. (2006) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2006.03.008 · Cited by 63 · see citing works
Kim, J., Solis, R. S., Arias, E. B., & Cartee, G. D. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00909.2003 · Cited by 60 · see citing works
Gray, S. R., Baker, G., Wright, A., Fitzsimons, C. F., Mutrie, N., & Nimmo, M. A. (2008) · Preventive Medicine · doi:10.1016/j.ypmed.2008.10.013 · Cited by 58 · see citing works
Treadmill Running Increases Phosphatidylinostol 3-Kinase Activity in Rat Skeletal Muscle
Zhou, Q., & Dohm, G. L. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7028 · Cited by 57 · see citing works
Goulopoulou, S., Baynard, T., Franklin, R. M., Fernhall, B., Carhart, R. L., Weinstock, R. S., & Kanaley, J. A. (2009) · Metabolism · doi:10.1016/j.metabol.2009.10.011 · Cited by 56 · see citing works
Differential effects of exercise on insulin-signaling gene expression in human skeletal muscle
Wadley, G. D., Tunstall, R. J., Sanigorski, A., Collier, G. R., Hargreaves, M., & Cameron‐Smith, D. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.2.436 · Cited by 53 · see citing works
Exercise-mediated changes in high-density lipoprotein: Impact on form and function
Blazek, A. D., Rutsky, J., Osei, K., Maiseyeu, A., & Rajagopalan, S. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.05.021 · Cited by 52 · see citing works
Effects of Endurance Training of Gene Expression on Insulin Signal Transduction Pathway
Kim, Y. B., Inoue, T., Nakajima, R., Nakae, K., Tamura, T., Tokuyama, K., & Suzuki, M. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1725 · Cited by 48 · see citing works
Eghbalzadeh, K., Brixius, K., Bloch, W., & Brinkmann, C. K. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.12.009 · Cited by 38 · see citing works
Cocks, M. S., & Wagenmakers, A. J. M. (2015) · The Journal of Physiology · doi:10.1113/jp270329 · Cited by 37 · see citing works
Endothelial Function and Physical Exercise
Pagan, L. U., Gomes, M. J., & Okoshi, M. P. (2018) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20180211 · Cited by 37 · see citing works
Buono, F., Crispo, S., Pagano, G., Rengo, G., Petitto, M., Grieco, F., Trimarco, B., & Morisco, C. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328365c87d · Cited by 35 · see citing works
Mazzone, G., Morisco, C., Lembo, V., D’Argenio, G., D'Armiento, M. R., Rossi, A., Giudice, C. D., Trimarco, B., Caporaso, N., & Morisco, F. (2018) · United European Gastroenterology Journal · doi:10.1177/2050640618774140 · Cited by 34 · see citing works
Laughlin, M. H. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00789.2015 · Cited by 33 · see citing works
Volpe, M., Gallo, G., Battistoni, A., & Tocci, G. (2019) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-018-00297-y · Cited by 31 · see citing works
Associations between cardiorespiratory fitness and the metabolic syndrome in British men
Ingle, L., Swainson, M. G., Brodie, D. A., & SANDERCOCK, G. R. H. (2016) · Heart · doi:10.1136/heartjnl-2016-310142 · Cited by 26 · see citing works
Martín-Cordero, L., García, J. J., Hinchado, M. D., Bote, E., Manso, R., & Ortega, E. (2010) · NeuroImmunoModulation · doi:10.1159/000322053 · Cited by 19 · see citing works
PGC-1α activation: a therapeutic target for type 2 diabetes?
Yuan, D., Xiao, D., Gao, Q., & Zeng, L. (2018) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-018-0622-y · Cited by 18 · see citing works
Vanzella, L. M., Linares, S. N., Miranda, R. A. T., da Silva, A. K. F., Christófaro, D. G. D., Netto, J., & Vanderlei, L. C. M. (2019) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000111 · Cited by 9 · see citing works
Kodama, S. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.10.999 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [2](2010). In Global recommendations on physical activity for health (WHO Guidelines Approved by the Guidelines Review Committee). Geneva.
Cited by
Sorted by citations
Kruk, J., Aboul-Enein, B. H., Duchnik, E., & Marchlewicz, M. (2022) · The Journal of Physiological Sciences · doi:10.1186/s12576-022-00845-1 · Cited by 247 · see citing works
Insulin Resistance the Hinge Between Hypertension and Type 2 Diabetes
Mancusi, C., Izzo, R., Gioia, G. D., Losi, M. A., Barbato, E., & Morisco, C. (2020) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-020-00408-8 · Cited by 232 · see citing works
Jankauskas, S. S., Kansakar, U., Varzideh, F., Wilson, S. M., Mone, P., Lombardi, A., Gambardella, J., & Santulli, G. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154910 · Cited by 221 · see citing works
Papakonstantinou, E., Oikonomou, C., Nychas, G., & Dimitriadis, G. D. (2022) · Nutrients · doi:10.3390/nu14040823 · Cited by 199 · see citing works
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021) · Journal of Diabetes Research · doi:10.1155/2021/7796727 · Cited by 91 · see citing works
Khalyfa, A., Ericsson, A. C., Qiao, Z., Almendros, I., Farré, R., & Gozal, D. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103208 · Cited by 83 · see citing works
The interface of depression and diabetes: treatment considerations
Fanelli, G., Raschi, E., Hafez, G., Matura, S., Schiweck, C., Poluzzi, E., & Lunghi, C. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03234-5 · Cited by 99 · see citing works
Metabolic syndrome: epidemiology, mechanisms, and current therapeutic approaches
Hamooya, B. M., Siame, L., Muchaili, L., Masenga, S. K., & Kirabo, A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1661603 · Cited by 88 · see citing works
Santulli, G., Visco, V., Varzideh, F., Guerra, G., Kansakar, U., Gasperi, M., Marro, A., Wilson, S. M., Ferrante, M. N. V., Pansini, A., et al. (2024) · Hypertension · doi:10.1161/hypertensionaha.124.23087 · Cited by 67 · see citing works
Astillo, P. V., Duguma, D. G., Park, H., Kim, J., Kim, B., & You, I. (2021) · Future Generation Computer Systems · doi:10.1016/j.future.2021.10.023 · Cited by 63 · see citing works
Decoding the Liver-Heart Axis in Cardiometabolic Diseases
Capone, F., Vacca, A., Bidault, G., Sarver, D. C., Kamińska, D., Strocchi, S., Vidal‐Puig, A., Greco, C. M., Lusis, A. J., & Schiattarella, G. G. (2025) · Circulation Research · doi:10.1161/circresaha.125.325492 · Cited by 72 · see citing works
The Impact of Exercise on Immunity, Metabolism, and Atherosclerosis
Meyer-Lindemann, U., Moggio, A., Dutsch, A., Kessler, T., & Sager, H. B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043394 · Cited by 58 · see citing works
Physical Exercise in the Context of Air Pollution: An Emerging Research Topic
You, Y., Wang, D., Liu, J., Chen, Y., Ma, X., & Li, W. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.784705 · Cited by 51 · see citing works
Obesity: The Perfect Storm for Heart Failure
Lembo, M., Strisciuglio, T., Fonderico, C., Mancusi, C., Izzo, R., Trimarco, V., Bellis, A., Barbato, E., Esposito, G., Morisco, C., et al. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14641 · Cited by 46 · see citing works
Li, J., Li, J., & Lu, Y. (2021) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2021.08.002 · Cited by 41 · see citing works
Glycemic variability: Importance, relationship with physical activity, and the influence of exercise
Sparks, J. R., Kishman, E. E., Sarzynski, M. A., Davis, J. M., Grandjean, P. W., Durstine, J. L., & Wang, X. (2021) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2021.09.004 · Cited by 43 · see citing works
Exercise Training: The Holistic Approach in Cardiovascular Prevention
Giallauria, F., Strisciuglio, T., Cuomo, G., Lorenzo, A. D., D’Angelo, A., Volpicelli, M., Izzo, R., Manzi, M. V., Barbato, E., & Morisco, C. (2021) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-021-00482-6 · Cited by 35 · see citing works
Muskiet, F. A. J., Carrera‐Bastos, P., Pruimboom, L., Lucía, A., & Furman, D. (2022) · Nutrients · doi:10.3390/nu14071388 · Cited by 34 · see citing works
Roxburgh, B. H., Cotter, J. D., Campbell, H. A., Reymann, U., Wilson, L. C., Gwynne‐Jones, D., van Rij, A. M., & Thomas, K. N. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.10.039 · Cited by 33 · see citing works
Insulin Resistance and Vitamin D Deficiency: A Link Beyond the Appearances
Trimarco, V., Manzi, M. V., Mancusi, C., Strisciuglio, T., Fucile, I., Fiordelisi, A., Pilato, E., Izzo, R., Barbato, E., Lembo, M., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.859793 · Cited by 33 · see citing works
Recent Advances in the Emerging Therapeutic Strategies for Diabetic Kidney Diseases
Huang, W., Chen, Y., Li, Z., He, F., & Zhang, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810882 · Cited by 32 · see citing works
Miro, C., Nappi, A., Sagliocchi, S., Cicco, E. D., Murolo, M., Torabinejad, S., Acampora, L., Pastore, A., Luciano, P., Civita, E. L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512074 · Cited by 32 · see citing works
Aging-related modifications to G protein-coupled receptor signaling diversity
van Gastel, J., Leysen, H., Boddaert, J., Vangenechten, L., Luttrell, L. M., Martin, B., & Maudsley, S. R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107793 · Cited by 31 · see citing works
Rajabi, A., Khajehlandi, M., Siahkuhian, M., Akbarnejad, A., Khoramipour, K., & Suzuki, K. (2022) · Sports · doi:10.3390/sports10110167 · Cited by 28 · see citing works
Tang, Z., Ming, Y., Wu, M., Jing, J., Xu, S., Li, H., & Zhu, Y. (2021) · Nutrients · doi:10.3390/nu13093222 · Cited by 27 · see citing works
Zaki, S., Sharma, S. R., & Vats, H. (2023) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2023.2225717 · Cited by 25 · see citing works
Cipryan, L., Litschmannová, M., Maffetone, P. B., Plews, D. J., Dostal, T., Hofmann, P., & Laursen, P. B. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.867690 · Cited by 20 · see citing works
Effects of hypoxia in cardiac metabolic remodeling and heart failure
Jiang, M., Fan, X., Wang, Y., & Sun, X. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113763 · Cited by 20 · see citing works
Fan, R., Kong, J., Zhang, J., & Zhu, L. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1471642 · Cited by 22 · see citing works
The weight-loss paradox in older adults: balancing fat loss with muscle preservation
Arslan, S., & Aydın, A. (2025) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-025-01374-8 · Cited by 19 · see citing works
Richards, C. T., Meah, V. L., James, P. E., Rees, A., & Lord, R. N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.715881 · Cited by 18 · see citing works
Adelowo, O. E., Akindele, B. M., Adegbola, C. A., Oyedokun, P. A., Akhigbe, T. M., & Akhigbe, R. E. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1492771 · Cited by 18 · see citing works
Molecular Regulators of Exercise-mediated Insulin Sensitivity in Non-obese Individuals
Almuraikhy, S., Doudin, A., Domling, A., Althani, A. A. J. F., & Elrayess, M. A. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18015 · Cited by 16 · see citing works
Valente, V., Izzo, R., Manzi, M. V., Luca, M. D., Barbato, E., & Morisco, C. (2021) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2021.1602 · Cited by 16 · see citing works
Nauha, L., Farrahi, V., Jurvelin, H., Jämsä, T. J., Niemelä, M., Ala‐Mursula, L., Kangas, M., & Korpelainen, R. (2024) · Journal of Activity Sedentary and Sleep Behaviors · doi:10.1186/s44167-023-00040-6 · Cited by 12 · see citing works
Teixeira, J. E., Bragada, J. A. A., Bragada, J. P., Coelho, J. P., Pinto, I. G., Reis, L. P., Fernandes, P. O., Morais, J. E., & Magalhães, P. M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063384 · Cited by 14 · see citing works
Ryan, A. S., Li, G., McMillin, S. L., Prior, S. J., Blumenthal, J. B., & Mastella, L. (2021) · Cells · doi:10.3390/cells10123490 · Cited by 13 · see citing works
Li, Y., Peng, C., Zhang, M., Xie, L., Gao, J., Ying-ji, W., Gao, Y., & Hou, L. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4291477 · Cited by 14 · see citing works
RETRACTED: Cardiovascular Disease and Exercise: From Molecular Mechanisms to Clinical Applications
Wang, B., Gan, L., Deng, Y., Zhu, S., Li, G., Nasser, M. I., Liu, N., & Zhu, P. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247511 · Cited by 13 · see citing works
RetractedMontazeri, M., Zarkesh, M., Zadeh-Vakili, A., Khalili, D., Movahedi, M., & Khalaj, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-36365-0 · Cited by 12 · see citing works
Hoseini, Z., Behpour, N., & Hoseini, R. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01158-y · Cited by 12 · see citing works
Sellami, M., Almuraikhy, S., Naja, K., Anwardeen, N. R., Al-Amri, H. S., Prince, M. S., Aden, A. A., Doemling, A., & Elrayess, M. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-86306-2 · Cited by 12 · see citing works
Enríquez-Schmidt, J., Mautner-Molina, C., Kalazich-Rosales, M., Muñoz, M., Ruíz-Uribe, M., Fuentes-Leal, F., Uarac, M. A. M., Cárcamo-Ibaceta, C., Fazakerley, D. J., Larance, M., et al. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2024.03.001 · Cited by 10 · see citing works
Fraser, B. J., Blizzard, C. L., Tomkinson, G. R., Dwyer, T., Venn, A., & Magnussen, C. G. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf102 · Cited by 10 · see citing works
Pînzaru, A. D., Mihai, C. M., Chisnoiu, T., Pantazi, A. C., Lupu, V. V., Kassim, M. A. K., Lupu, A., Grosan, E., Jumaili, A. Z. N. A., Ion, I., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11102671 · Cited by 9 · see citing works
Exercise modifies fatty acid perception and metabolism
Shanmugamprema, D., Muthuswamy, K., Ponnusamy, V., Subramanian, G., Vasanthakumar, K., Vasanth, K., & Selvakumar, S. (2023) · Acta Physiologica · doi:10.1111/apha.13968 · Cited by 9 · see citing works
Abelhad, N. I., Kachur, S. M., Sanchez, A. M., Lavie, C. J., & Milani, R. V. (2023) · Heart and Mind · doi:10.4103/hm.hm_58_22 · Cited by 8 · see citing works
Peng, S., Khairani, A. Z., Zhou, Z., Yuan, F., & Liang, J. (2024) · International Journal of Sport and Exercise Psychology · doi:10.1080/1612197x.2024.2436066 · Cited by 4 · see citing works
A step in the right direction: exploring the effects of aerobic exercise on HbA1c reduction
Singh, B. P., Koneru, Y. C., Zimmerman, H., Kanagala, S. G., Milne, I. G., Sethi, A., & Jain, R. (2023) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-023-00247-8 · Cited by 7 · see citing works
Exercise benefits cardiovascular health: from molecular mechanisms to clinical implications
Zhang, X., Li, J., & Gao, F. (2021) · Scientia Sinica Vitae · doi:10.1360/ssv-2020-0359 · Cited by 7 · see citing works
Igarashi, Y. (2022) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000004236 · Cited by 7 · see citing works
Amaravadi, S. K., Ferreira, A. D. S., & Vigário, P. D. S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0336898 · Cited by 5 · see citing works
Syed, M. I., Deek, F., & Shaikh, A. (2022) · Endocrinology, diabetes and metabolism journal · doi:10.31038/edmj.2022621 · Cited by 3 · see citing works
Rao, C. R., Chandrasekaran, B., Ravishankar, N., Rutebemberwa, E., & Okello, D. (2022) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2022.102663 · Cited by 5 · see citing works
Wei, T., & Jin, Q. (2024) · Medicine · doi:10.1097/md.0000000000038831 · Cited by 5 · see citing works
Physical exercise protects cardiovascular fitness in long-term spaceflight: what have we learned?
Zhang, Z., Xing, W., Wu, G., Zhang, X., Li, J., YingXian, L. I., & Gao, F. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3139-9 · Cited by 4 · see citing works
Antioxidative Stress Metabolic Pathways in Moderately Active Individuals
Almuraikhy, S., Anwardeen, N. R., Doudin, A., Sellami, M., Dömling, A. S. S., Agouni, A., Thani, A. A. A., & Elrayess, M. A. (2023) · Metabolites · doi:10.3390/metabo13090973 · Cited by 4 · see citing works
Cui, G., Li, S., Qin, Y., Zhang, Y., Hui, K., Feng, M., Li, W., & Zhang, X. (2025) · Journal of Diabetes · doi:10.1111/1753-0407.70142 · Cited by 4 · see citing works
AMP kinase: A promising therapeutic drug target for post-COVID-19 complications
Ashraf, M. S., Tuli, K., Moiz, S., Sharma, S. K., Sharma, D., & Adnan, M. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123202 · Cited by 4 · see citing works
Antioxidants Prevent the Effects of Physical Exercise on Visual Cortical Plasticity
Sansevero, G., Consorti, A., Marco, I. D., Tozzini, E. T., Cellerino, A., & Sale, A. (2022) · Cells · doi:10.3390/cells12010048 · Cited by 4 · see citing works
Pacak, C. A., Suzuki‐Hatano, S., Khadir, F., Daugherty, A. L., Sriramvenugopal, M., Gosiker, B. J., Kang, P. B., & Cade, W. T. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04626-1 · Cited by 4 · see citing works
Zhao, R., Ding, J., Ji, Y., Cheng, Z., & Wang, Y. (2025) · Journal of Sports Sciences · doi:10.1080/02640414.2025.2515757 · Cited by 3 · see citing works
Stogianni, A., Melin, E. O., Dereke, J., Rööst, M., Hillman, M., Landin‐Olsson, M., Wanby, P., & Thunander, M. (2023) · Acta Diabetologica · doi:10.1007/s00592-023-02096-x · Cited by 3 · see citing works
Effects of Running on the Development of Diabetes and Diabetes-Induced Complications
Podvigina, T. T., Yarushkina, N. I., & Filaretova, L. P. (2022) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093022010161 · Cited by 3 · see citing works
Palabıyık, A. A., & Palabıyık, E. (2025) · Nutrire · doi:10.1186/s41110-025-00381-z · Cited by 4 · see citing works
Amare, F., Kiflu, A., & Taddese, A. (2026) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-026-01528-9 · Cited by 2 · see citing works
Shojah-anzabi, B., Farzizadeh, R., Seifi-Asgshahr, F., & Nejati-afkham, A. (2026) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2026.200360 · Cited by 4 · see citing works
Yang, M., Zhou, Y., Wu, Q., Zhang, W., Zhang, R., Yang, Z., Yu, T., Wang, R., Fu, H., Fu, Q., et al. (2026) · Life Metabolism · doi:10.1093/lifemeta/loag014 · Cited by 2 · see citing works
Fisiopatología y mecanismos de acción del ejercicio en el manejo de la diabetes mellitus tipo 2
León-Ariza, H. H., Guardela, M. J. R., & Barrera, A. F. C. (2023) · Revista Colombiana de Endocrinología Diabetes & Metabolismo · doi:10.53853/encr.10.2.790 · Cited by 2 · see citing works
Peng, S., Khairani, A. Z., Yuan, F., Uba, A. R., & Yang, X.-M. (2024) · Behavioral Science · doi:10.3390/bs14121143 · Cited by 4 · see citing works
Insulin Resistance and Cardiometabolic Syndrome
Kim, J. (2021) · CardioMetabolic Syndrome Journal · doi:10.51789/cmsj.2021.1.e9 · Cited by 3 · see citing works
Fakhrealali, M., Hejazi, K., & Marafeti, H. (2024) · Jentashapir Journal of Cellular and Molecular Biology · doi:10.5812/jjcmb-157664 · Cited by 1 · see citing works
Kharazi, U., Salmani, N., Oghbaei, F., Hamidian, G., Ghaderpour, S., Ghiasi, R., & Keyhanmanesh, . (2025) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2025-0026 · Cited by 1 · see citing works
Whaikid, P., & Piaseu, N. (2025) · Healthcare · doi:10.3390/healthcare13182357 · Cited by 1 · see citing works
Glucose Homeostasis Remains Normal in a Physically Active Military Population
Potter, A. W., Jacques, J. I., Chapman, C. L., Tharion, W. J., Looney, D. P., & Friedl, K. E. (2025) · Military Medicine · doi:10.1093/milmed/usaf512 · Cited by 1 · see citing works
Curiel-Cervantes, V. (2026) · Physiologia · doi:10.3390/physiologia6010005 · Cited by 1 · see citing works
Kabeto, M. U., Sharma, M. K., Ford, D., & Faul, J. D. (2026) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2026.107779 · Cited by 1 · see citing works
A review of the impact of energy balance on triple-negative breast cancer
Akingbesote, N. D., Owusu, D., Liu, R., Cartmel, B., Ferrucci, L. M., Zupa, M., Lustberg, M. B., Sanft, T. B., Blenman, K., Irwin, M. L., et al. (2023) · JNCI Monographs · doi:10.1093/jncimonographs/lgad011 · Cited by 1 · see citing works
Rahimpour, P., Sheikholeslami‐Vatani, D., Moloudi, M. R., & Ghaeeni, S. (2023) · PubMed Central · doi:10.22074/cellj.2023.1971874.1158 · Cited by 1 · see citing works
Lipid metabolism and insulin sensitivity
Wu, X. (2024) · Theoretical and Natural Science · doi:10.54254/2753-8818/46/20240400 · Cited by 1 · see citing works
Richards, C. T., Meah, V. L., James, D., Rees, A., & Lord, R. N. (2021) · Endocrine Abstracts · doi:10.1530/endoabs.77.p108
Neurodegeneration and microvascular dysfunction
van der Heide, F. C. T. (2022) · doi:10.26481/dis.20220126fh
The Effect of Exercise Training on Circulating microRNAs Related to Lipid Metabolism
Kaya, K., Yerlikaya, F., Kurklu, G. B., & Onmaz, D. E. (2022) · Turkish Society of Clinical Biochemistry · doi:10.56615/tkbd.2022.16
Youzbashi, L., Abdollahi, P., Rahmani, A., & Karimiasl, A. (2023) · Journal of Sport and Exercise Physiology · doi:10.52547/joeppa.16.1.104
Yousefzadeh, H., Fathi, R., Gorkani, E. T., & Hosseini, A. (2022) · مجله علمی پزشکی جندی شاپور · doi:10.32598/jsmj.21.2.2507
Iba, Y., Sugimoto, R., Itoh, K., Yamasaki, M., En, S., Ozaki, K., & Matsuura, T. (2023) · BPB Reports · doi:10.1248/bpbreports.6.3_115
Insulin resistance and cardiovascular diseases: focus on common in pathogenesis and treatment.
Zhuravlyova, L., Rogachova, T., Sokolnikova, N. V., & Yankevich, O. O. (2023) · Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini · doi:10.15407/internalmed2023.02.046
Aluko, E. O. (2023) · International Journal of Research Publications · doi:10.47119/ijrp10013411020235536
Gholami, M. H., Malayeri, S. R., ziloubaf, A., & Hassanpour, H. (2022) · Journal of Sports Physiology and Athletic Conditioning · doi:10.61186/jspac.33236.2.3.17
Khajehlandi, M., & Bolboli, L. (2024) · Research Square · doi:10.21203/rs.3.rs-3858207/v1
Type 2 Diabetes Mellitus Reversibility in African American Adults
Gambhir, K. K. (2023) · Endocrinology and Disorders · doi:10.31579/2640-1045/129
Polycystic ovary syndrome: pathogenic mechanisms and nutritional therapeutic strategies
Zhao, Y., Liu, B., Zhao, J., Liu, Y., Pan, H., Yuan, Y., Tian, X., Qiao, W., Zhang, Z., & Chen, L. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250269
Biochemical perspectives of environmental factors impacting metabolic dysregulation
Akash, M. S. H., & Rehman, K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36312-2.00014-0
Insulin resistance, depression, and type 2 diabetes
Serhiyenko, A. A., Чемерис, О. М., Pankiv, V. І., & Serhiyenko, V. A. (2025) · INTERNATIONAL NEUROLOGICAL JOURNAL · doi:10.22141/2224-0713.21.6.2025.1209
Padilla-López, J., Torres-Duque, L., Muñoz, S., Prado-Aguilar, C. A., Astudillo‐García, C. I., Moran, S., Martínez-Andrade, G. O., Vilchis‐Gil, J., & Duque, X. (2026) · BMC Family Practice · doi:10.1186/s12875-026-03199-4
Nazari, A., Cheraghi, M., & Souri, F. (2025) · Epidemiology and Health System Journal · doi:10.34172/ehsj.26451
Li, L. H., Xu, Y., Liu, J., Dong, J., He, S., Dai, F., & Liu, H. (2026) · Neuroepidemiology · doi:10.1159/000551939
Saki, H., Nazem, F., Matin, H., Fariba, F., Alizadehkhaiyat, O., & Siavoshy, H. (2026) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188261433153
Scalise, F., Toscano, E., Sorropago, A., Amman, C., & Grassi, G. M. (2026) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-032-29564-4_4
Yang, M. J., Lyu, T., & Zhang, C. (2026) · The Journal of Precision Medicine Health and Disease · doi:10.1016/j.premed.2026.100052
- Authors
- Iaccarino, G., Franco, D., Sorriento, D., Strisciuglio, T., Barbato, E., & Morisco, C.
- Affiliations
- University of Naples Federico II (IT)
- Corresponding author
- Morisco, Carmine
- ORCID
- Venue
- Journal of Cardiovascular Translational Research
- Published
- 2020-07-31
- Volume
- 14
- Issue
- 2
- Pages
- 256-270
- ISSN
- 1937-5387 (ISSN-L)
- 1937-5395
- PMC
- PMC8043859
- OpenAlex
- W3046313480
- Cited by
- 106
- References
- 129
- Citations by year
- 2026: 17 · 2025: 16 · 2024: 14 · 2023: 22 · 2022: 21 · 2021: 14 · 2020: 2
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Cardiovascular Translational Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- Funders
- Cardiopath PhD program
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- insulin sensitivity, exercise training, insulin resistance, insulin signaling, cardiovascular risk prevention, physical activity
- MeSH terms
- Healthy Lifestyle, Heart Disease Risk Factors, Animals, Cardiovascular Diseases, Health Status, Humans, Insulin Resistance, Prognosis, Biomarkers, Exercise, Risk Assessment, Risk Reduction Behavior, Protective Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review