Lost in translation: regulation of skeletal muscle protein synthesis
Abstract
Skeletal muscle accounts for about 50% of the body's mass in higher vertebrates. Besides its obvious role in motor activity, it also can serve as a reservoir for amino acids during times of starvation, or even as a metabolic water supply for migratory birds' during long flights. An imbalance between anabolic and catabolic processes can lead to the loss of muscle mass and life-threatening cachexia or sarcopenia. This review summarizes the current state of knowledge about the regulation of protein translation in skeletal muscle; it also discusses the role of the mTOR pathway, as well as new findings about the influence of specific miRNAs on protein expression in skeletal muscle.
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The molecular pathways activated by exercise are shared with a number of nutrient sensing mechanisms.
“These same pathways are shared with a number of the nutrient sensing mechanisms [3,4].”
From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [3]
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- Authors
- Weigl, L. G.
- Affiliations
- Medical University of Vienna (AT)
- Corresponding author
- Weigl, Lukas G
- ORCID
- Weigl, Lukas G
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 12
- Issue
- 3
- Pages
- 377-382
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W1990069955
- Cited by
- 44
- References
- 45
- Citations by year
- 2025: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Verein für Wissenschaft und Forschung in Anästhesiologie und Schmerzmedizin, Vienna, Austria
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- skeletal muscle, protein synthesis, translational regulation, mTOR signaling, microRNA, muscle atrophy, cachexia, sarcopenia, amino acid metabolism, anabolic-catabolic balance
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Muscle Proteins, RNA, Messenger, Signal Transduction, Muscle, Skeletal, RNA Stability, MicroRNAs, Protein Stability, TOR Serine-Threonine Kinases
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