Cited by 44Muscle metabolism and nutritionMuscle Physiology and DisordersPI3K/AKT/mTOR signaling in cancer

Lost in translation: regulation of skeletal muscle protein synthesis

Weigl, Lukas G·2012·Current Opinion in Pharmacology

Abstract

Skeletal muscle accounts for about 50% of the body's mass in higher vertebrates. Besides its obvious role in motor activity, it also can serve as a reservoir for amino acids during times of starvation, or even as a metabolic water supply for migratory birds' during long flights. An imbalance between anabolic and catabolic processes can lead to the loss of muscle mass and life-threatening cachexia or sarcopenia. This review summarizes the current state of knowledge about the regulation of protein translation in skeletal muscle; it also discusses the role of the mTOR pathway, as well as new findings about the influence of specific miRNAs on protein expression in skeletal muscle.

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Crossref · 10.1016/j.coph.2012.02.017

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Authors
Weigl, L. G.
Affiliations
Medical University of Vienna (AT)
Corresponding author
Weigl, Lukas G
Venue
Current Opinion in Pharmacology
Publisher
Elsevier BV
Published
2012-06
Volume
12
Issue
3
Pages
377-382
ISSN
1471-4892 (ISSN-L)
OpenAlex
W1990069955
Cited by
44
References
45
Citations by year
2025: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 1
FWCI
0.56
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Verein für Wissenschaft und Forschung in Anästhesiologie und Schmerzmedizin, Vienna, Austria
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
skeletal muscle, protein synthesis, translational regulation, mTOR signaling, microRNA, muscle atrophy, cachexia, sarcopenia, amino acid metabolism, anabolic-catabolic balance
MeSH terms
Animals, Gene Expression Regulation, Humans, Muscle Proteins, RNA, Messenger, Signal Transduction, Muscle, Skeletal, RNA Stability, MicroRNAs, Protein Stability, TOR Serine-Threonine Kinases

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