The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women
Open accessAbstract
The α-actinin 3 (ACTN3) gene encodes a protein of the Z disk of myofibers, and a polymorphism of ACTN3 results in complete loss of the protein. The ACTN3 genotype (R577X) has been found to be associated with performance in Australian elite athletes (Yang N, MacArthur DG, Gulbin JP, Hahn AG, Beggs AH, Easteal S, and North K. Am J Hum Genet 73: 627–631, 2003). We studied associations between ACTN3 genotype and muscle size [cross-sectional area of the biceps brachii via magnetic resonance imaging (MRI)] and elbow flexor isometric (MVC) and dynamic [1-repetition maximum (1-RM)] strength in a large group of men ( N = 247) and women ( N = 355) enrolled in a 12-wk standardized elbow flexor/extensor resistance training program of the nondominant arm at one of eight study centers. We found no association between ACTN3 R577X genotype and muscle phenotype in men. However, women homozygous for the ACTN3 577X allele (XX) had lower baseline MVC compared with heterozygotes ( P < 0.05) when adjusted for body mass and age. Women homozygous for the mutant allele (577X) demonstrated greater absolute and relative 1-RM gains compared with the homozygous wild type (RR) after resistance training when adjusted for body mass and age ( P < 0.05). There was a trend for a dose-response with genotype such that gains were greatest for XX and least for RR. Significant associations were validated in at least one ethnic subpopulation (Caucasians, Asians) and were independent of training volume. About 2% of baseline MVC and of 1-RM strength gain after training were attributable to ACTN3 genotype (likelihood-ratio test P value, P = 0.01), suggesting that ACTN3 is one of many genes contributing to genetic variation in muscle performance and adaptation to exercise.
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Cites
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The Acute Satellite Cell Response and Skeletal Muscle Hypertrophy following Resistance Training
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Zempo, H., Miyamoto‐Mikami, E., Kikuchi, N., Fuku, N., Miyachi, M., & Murakami, H. (2017) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12804 · Cited by 117
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Genetic and epigenetic sex-specific adaptations to endurance exercise
Landen, S., Voisin, S., Craig, J. M., McGee, S. L., Lamon, S., & Eynon, N. (2019) · Epigenetics · doi:10.1080/15592294.2019.1603961 · Cited by 76
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Pescatello, L. S., Kelsey, B. K., Price, T. B., Seip, R. L., Angelopoulos, T. J., Clarkson, P. M., Gordon, P. M., Moyna, N. M., Visich, P. S., Zoeller, R. F., et al. (2007) · The Journal of Strength and Conditioning Research · doi:10.1519/r-22236.1 · Cited by 44
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Responses to Maximal Strength Training in Different Age and Gender Groups
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Metadata
- Authors
- Clarkson, P. M., Devaney, J. M., Gordish-Dressman, H., Thompson, P. D., Hubal, M. J., Urso, M., Price, T. B., Angelopoulos, T. J., Gordon, P. M., Moyna, N. M., Pescatello, L. S., Visich, P. S., Zoeller, R. F., Seip, R. L., & Hoffman, E. P.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2005-07
- Volume
- 99
- Issue
- 1
- Pages
- 154-163
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2140875001
- Cited by
- 308
- References
- 3
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- green
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