The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Modulation of LTP at rat hippocampal CA3-CA1 synapses by direct current stimulation
Abstract
Transcranial direct current stimulation (tDCS) can produce a lasting polarity-specific modulation of cortical excitability in the brain, and it is increasingly used in experimental and clinical settings. Recent studies suggest that the after-effects of tDCS are related to molecular mechanisms of activity-dependent synaptic plasticity. Here we investigated the effect of DCS on the induction of one of the most studied N-methyl-d-aspartate receptor-dependent forms of long-term potentiation (LTP) of synaptic activity at CA3-CA1 synapses in the hippocampus. We show that DCS applied to rat brain slices determines a modulation of LTP that is increased by anodal and reduced by cathodal DCS. Immediate early genes, such as c-fos and zif268 ( egr1/NGFI-A/krox24), are rapidly induced following neuronal activation, and a specific role of zif268 in the induction and maintenance of LTP has been demonstrated. We found that both anodal and cathodal DCS produce a marked subregion-specific increase in the expression of zif268 protein in the cornus ammonis (CA) region, whereas the same protocols of stimulation produce a less pronounced increase in c-fos protein expression in the CA and in dentate gyrus regions of the hippocampus. Brain-derived neurotrophic factor expression was also investigated, and it was found to be reduced in cathodal-stimulated slices. The present data demonstrate that it is possible to modulate LTP by using DCS and provide the rationale for the use of DCS in neurological diseases to promote the adaptive and suppress the maladaptive forms of brain plasticity.
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Cites
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Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
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Cited by
Antal, A., Alekseichuk, I., Bikson, M., Brockmöller, J., Brunoni, A. R., Chen, R., Cohen, L. G., Dowthwaite, G., Ellrich, J., Flöel, A., et al. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.06.001 · Cited by 1,301
Variability in Response to Transcranial Direct Current Stimulation of the Motor Cortex
Wiethoff, S., Hamada, M., & Rothwell, J. C. (2014) · Brain Stimulation · doi:10.1016/j.brs.2014.02.003 · Cited by 785
Cellular effects of acute direct current stimulation: somatic and synaptic terminal effects
Rahman, A., Reato, D., Arlotti, M., Gasca, F., Datta, A., Parra, L. C., & Bikson, M. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.247171 · Cited by 560
Neurobiological after-effects of non-invasive brain stimulation
Cirillo, G., Di Pino, G., Capone, F., Ranieri, F., Florio, L., Todisco, V., Tedeschi, G., Funke, K., & Di Lazzaro, V. (2017) · Brain Stimulation · doi:10.1016/j.brs.2016.11.009 · Cited by 446
Self-citationEphaptic coupling to endogenous electric field activity: Why bother?
Anastassiou, C. A., & Koch, C. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.002 · Cited by 171
Metadata
- Authors
- Ranieri, F., Podda, M. V., Riccardi, E., Frisullo, G., Dileone, M., Profice, P., Pilato, F., Di Lazzaro, V., & Grassi, C.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2012-04-01
- Volume
- 107
- Issue
- 7
- Pages
- 1868-1880
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2070310146
- Cited by
- 208
- References
- 10
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ranieri, F., Podda, M. V., Riccardi, E., Frisullo, G., Dileone, M., Profice, P., Pilato, F., Di Lazzaro, V., & Grassi, C. (2012). Modulation of LTP at rat hippocampal CA3-CA1 synapses by direct current stimulation. Journal of Neurophysiology. https://doi.org/10.1152/jn.00319.2011
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