Cited by 302Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Mechanisms of Dopamine Activation of Fast-Spiking Interneurons That Exert Inhibition in Rat Prefrontal Cortex

Gorelova, Natalia, Seamans, Jeremy K., Yang, Charles R.·2002·Journal of Neurophysiology

DOI 10.1152/jn.00335.2002

Open this paper in CoChat — free account

Abstract

Prefrontal cortical dopamine (DA) modulates pyramidal cell excitability directly and indirectly by way of its actions on local circuit GABAergic interneurons. DA modulation of interneuronal functions is implicated in the computational properties of prefrontal networks during cognitive processes and in schizophrenia. Morphologically and electrophysiologically distinct classes of putative GABAergic interneurons are found in layers II-V of rat prefrontal cortex. Our whole cell patch-clamp study shows that DA induced a direct, TTX-insensitive, reversible membrane depolarization, and increased the excitability of fast-spiking (FS) interneurons. The DA-induced membrane depolarization was reduced significantly by D1/D5 receptor antagonist SCH 23390, but not by the D2 receptor antagonist (−)sulpiride, D4 receptor antagonists U101958 or L-745870, α1-adrenoreceptor antagonist prazosin, or serotoninergic receptor antagonist mianserin. The D1/5 agonists SKF81297 or dihydrexidine, but not D2 agonist quinpirole, also induced a prolonged membrane depolarization. Voltage-clamp analyses of the voltage-dependence of DA-sensitive currents, and the effects of changing [K+]O on reversal potentials of DA responses, revealed that DA suppressed a Cs+-sensitive inward rectifier K+current and a resting leak K+current. D1/D5, but not D2 agonists mimicked the suppressive effects of DA on the leak current, but the DA effects on the inward rectifier K+current were not mimicked by either agonist. In a subgroup of FS interneurons, the slowly inactivating membrane outward rectification evoked by depolarizing voltage steps was also attenuated by DA. Collectively, these data showed that DA depolarizes FS interneurons by suppressing a voltage-independent ‘leak’ K+current (via D1/D5 receptor mechanism) and an inwardly rectifying K+current (via unknown DA mechanisms). Additional suppression of a slowly inactivating K+current led to increase in repetitive firing in response to depolarizing inputs. This D1-induced increase in interneuron excitability enhances GABAergic transmission to PFC pyramidal neurons and could represent a mechanism via which DA suppresses persistent firing of pyramidal neurons in vivo.

Integrity signals

Registry

Crossref · 10.1152/jn.00335.2002

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663
The cognitive neuropsychology of schizophrenia
(1993) · Choice Reviews Online · doi:10.5860/choice.31-0601 · Cited by 1,901
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation
Whittington, M. A., Traub, R. D., & Jefferys, J. G. R. (1995) · Nature · doi:10.1038/373612a0 · Cited by 1,613
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498
GABAergic cell subtypes and their synaptic connections in rat frontal cortex
Kawaguchi, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.476 · Cited by 1,416
D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Sawaguchi, T., & Goldman-Rakic, P. S. (1991) · Science · doi:10.1126/science.1825731 · Cited by 1,364
Neuropsychological Function in Schizophrenia
Saykin, A. J. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310036007 · Cited by 1,160
GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder
Benes, F. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00225-1 · Cited by 1,082
Working memory dysfunction in schizophrenia
(1994) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.6.4.348 · Cited by 1,068
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002
Differences between somatic and dendritic inhibition in the hippocampus
Miles, R., Tóth, K., Gulyás, A. I., Hájos, N., & Freund, T. F. (1996) · Neuron · doi:10.1016/s0896-6273(00)80101-4 · Cited by 942
Salient features of synaptic organisation in the cerebral cortex1Published on the World Wide Web on 3 March 1998.1
Somogyi, P., Tamás, G., Luján, R., & Buhl, E. H. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00061-1 · Cited by 876
Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA
Bouthenet, M.-L., Souil, E., Martres, M., Sokoloff, P., Bruno Giros, A., & Schwartz, J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91456-b · Cited by 868
Dynamics of neuronal interactions in monkey cortex in relation to behavioural events
Vaadia, E., Haalman, I., Abeles, M., Bergman, H., Prut, Y., Slovin, H., & Aertsen, A. (1995) · Nature · doi:10.1038/373515a0 · Cited by 802
INWARD RECTIFIER POTASSIUM CHANNELS
Nichols, C. G., & Lopatin, A. N. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.171 · Cited by 792
Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
Rudy, B., & McBain, C. J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01892-0 · Cited by 781
Neurocomputational models of working memory
Durstewitz, D., Seamans, J. K., & B, T. J. S. A. (2000) · Nature Neuroscience · doi:10.1038/81460 · Cited by 729
Self-citation
Prefrontal Dopamine D1Receptors and Working Memory in Schizophrenia
Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Huang, Y., Hwang, D.-R., Keilp, J., Kochan, L., Van Heertum, R., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03708.2002 · Cited by 724
Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET
Okubo, Y., Suhara, T., Suzuki, K., Kobayashi, K., Inoue, O., Terasaki, O., Someya, Y., Sassa, T., Sudo, Y., Matsushima, E., et al. (1997) · Nature · doi:10.1038/385634a0 · Cited by 710
The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task
Sawaguchi, T., & Goldman‐Rakic, P. S. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.2.515 · Cited by 649
Dopamine-Mediated Stabilization of Delay-Period Activity in a Network Model of Prefrontal Cortex
Durstewitz, D., Seamans, J. K., & B, T. J. S. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.3.1733 · Cited by 626
Self-citation
Spatiotemporal firing patterns in the frontal cortex of behaving monkeys
Abeles, M., Bergman, H., Margalit, E., & Vaadia, E. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.4.1629 · Cited by 600
Interneurons unbound
McBain, C. J., & Fisahn, A. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049047 · Cited by 581
Primary cortical representation of sounds by the coordination of action-potential timing
deCharms, R. C., & Merzenich, M. M. (1996) · Nature · doi:10.1038/381610a0 · Cited by 541
Physiological subgroups of nonpyramidal cells with specific morphological characteristics in layer II/III of rat frontal cortex
Kawaguchi, Y. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02638.1995 · Cited by 533
Two classes of cortical GABA neurons defined by differential calcium binding protein immunoreactivities
Hendry, S. H. C., Jones, E. G., Emson, P. C., Lawson, D. E. M., Heizmann, C. W., & Streit, P. (1989) · Experimental Brain Research · doi:10.1007/bf00247904 · Cited by 512
Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons
Seamans, J. K., Gorelova, N., Durstewitz, D., & Yang, C. R. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03628.2001 · Cited by 507
Self-citation
Local circuit neurons immunoreactive for calretinin, calbindin D‐28k or parvalbumin in monkey prefronatal cortex: Distribution and morphology
Condé, F., Lund, J. S., Jacobowitz, D. M., Baimbridge, K. G., & Lewis, D. A. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903410109 · Cited by 500
Localization of dopamine D4 receptors in GABAergic neurons of the primate brain
Mrzljak, L., Bergson, C., Pappy, M., Huff, R., Levenson, R., & Goldman-Rakic, P. S. (1996) · Nature · doi:10.1038/381245a0 · Cited by 494
D1Receptor Modulation of Hippocampal–Prefrontal Cortical Circuits Integrating Spatial Memory with Executive Functions in the Rat
Seamans, J. K., Floresco, S., & Phillips, A. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01613.1998 · Cited by 480
Self-citation
Neuronal networks for induced ‘40 Hz’ rhythms
Jefferys, J. G. R., Traub, R. D., & Whittington, M. A. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10023-0 · Cited by 467
Function of Specific K + Channels in Sustained High-Frequency Firing of Fast-Spiking Neocortical Interneurons
Erisir, A., Lau, D., Rudy, B., & Leonard, C. S. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.5.2476 · Cited by 458
Electrical synapses between Gaba-Releasing interneurons
Galarreta, M., & Hestrin, S. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077566 · Cited by 434
Dopamine synaptic complex with pyramidal neurons in primate cerebral cortex.
Goldman-Rakic, P. S., Leranth, C., Williams, S. M., Mons, N. E., & Geffard, M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.9015 · Cited by 429
Ion channel regulation by G proteins
Wickman, K., & Clapham, D. E. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.4.865 · Cited by 427
Destruction and Creation of Spatial Tuning by Disinhibition: GABAABlockade of Prefrontal Cortical Neurons Engaged by Working Memory
Rao, S. G., Williams, G. V., & Goldman-Rakic, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00485.2000 · Cited by 407
Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons
Seamans, J. K., Durstewitz, D., Christie, B. R., Stevens, C. F., & B, T. J. S. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.301 · Cited by 399
Self-citation
Asymmetries in hemispheric control of attention in schizophrenia.
Posner, M., Early, T., Reiman, E., Pardo, P., & Dhawan, M. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800330038004 · Cited by 396
Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects
Akil, M., Pierri, J. N., Whitehead, R. E., Edgar, C. L., Mohila, C., Sampson, A. R., & Lewis, D. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.10.1580 · Cited by 396
Groupings of nonpyramidal and pyramidal cells with specific physiological and morphological characteristics in rat frontal cortex
Kawaguchi, Y. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.2.416 · Cited by 390
D1 dopamine receptor immunoreactivity in human and monkey cerebral cortex: predominant and extrasynaptic localization in dendritic spines.
Smiley, J. F., Levey, A. I., Ciliax, B. J., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5720 · Cited by 383
Dopamine D1 receptor actions in layers V-VI rat prefrontal cortex neurons in vitro: modulation of dendritic-somatic signal integration
Yang, C., & Seamans, J. K. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01922.1996 · Cited by 369
Self-citation
D1 and D2 Receptor Gene Expression in the Rat Frontal Cortex: Cellular Localization in Different Classes of Efferent Neurons
Gaspar, P., Bloch, B., & Le Moine, C. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01092.x · Cited by 323
Single axon IPSPs elicited in pyramidal cells by three classes of interneurones in slices of rat neocortex.
Thomson, A. M., West, D. C., Hahn, J. D., & Deuchars, J. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021667 · Cited by 276
Altered GABA neurotransmission and prefrontal cortical dysfunction in schizophrenia
Lewis, D. A., Pierri, J. N., Volk, D. W., Melchitzky, D. S., & Woo, T.-U. W. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00061-x · Cited by 258
Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques
Bunney, B. S., & Aghajanian, G. K. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90087-4 · Cited by 250
Inwardly rectifying potassium channels.
Reimann, F., & Ashcroft, F. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80073-8 · Cited by 246
IPSPs modulate spike backpropagation and associated [Ca2+]i changes in the dendrites of hippocampal CA1 pyramidal neurons
Tsubokawa, H., & Ross, W. N. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.5.2896 · Cited by 246
Differentially Interconnected Networks of GABAergic Interneurons in the Visual Cortex of the Cat
Tamás, G., Somogyi, P., & Buhl, E. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-11-04255.1998 · Cited by 242
K+Channel Expression Distinguishes Subpopulations of Parvalbumin- and Somatostatin-Containing Neocortical Interneurons
Chow, A., Erişir, A., Farb, C. R., Nadal, M. S., Ozaita, A., Lau, D., Welker, E., & Rudy, B. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09332.1999 · Cited by 238
Inhibitory effects of ventral tegmental area stimulation on the activity of prefrontal cortical neurons: Evidence for the involvement of both dopaminergic and GABAergic components
Pirot, S., Godbout, R., Mantz, J., Tassin, J., Glowinski, J., & Thierry, A. M. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90362-6 · Cited by 237
Prefontal cortex in long-term memory: an “interference” approach using magnetic stimulation
Rossi, S., Cappa, S., Babiloni, C., Pasqualetti, P., Miniussi, C., Carducci, F., Babiloni, F., & Rossini, P. (2001) · Nature Neuroscience · doi:10.1038/nn0901-948 · Cited by 232
Noradrenergic Excitation and Inhibition of GABAergic Cell Types in Rat Frontal Cortex
Kawaguchi, Y., & Shindou, T. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-17-06963.1998 · Cited by 230
Multiple Forms of Short-Term Plasticity at Excitatory Synapses in Rat Medial Prefrontal Cortex
Hempel, C. M., Hartman, K. H., Wang, X.-J., Turrigiano, G. G., & Nelson, S. B. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.3031 · Cited by 229
Cellular distribution of dopamine D1 and D2 receptors in rat medial prefrontal cortex
Vincent, S. L., Khan, Y., & Benes, F. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-06-02551.1993 · Cited by 223
D1Receptor in Interneurons of Macaque Prefrontal Cortex: Distribution and Subcellular Localization
Muly, E. C., Szigeti‐Buck, K., & Goldman‐Rakic, P. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10553.1998 · Cited by 220
Characterization of G-Protein-Gated K+Channels Composed of Kir3.2 Subunits in Dopaminergic Neurons of the Substantia Nigra
Inanobe, A., Yoshimoto, Y., Horio, Y., Morishige, K., Hibino, H., Matsumoto, S., Tokunaga, Y., Maeda, T., Hata, Y., Takai, Y., et al. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-01006.1999 · Cited by 207
Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study.
Sesack, S. R., & Bunney, B. S. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24159-3 · Cited by 200
Dopamine facilitates long-term depression of glutamatergic transmission in rat prefrontal cortex
Otani, S., Blond, O., Desce, J. M., & Crépel, F. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00677-5 · Cited by 196
D5 Dopamine Receptors Enhance Zn2+-Sensitive GABAA Currents in Striatal Cholinergic Interneurons through a PKA/PP1 Cascade
Yan, Z., & Surmeier, D. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80402-x · Cited by 195
Developing a Neuronal Model for the Pathophysiology of Schizophrenia Based on the Nature of Electrophysiological Actions of Dopamine in the Prefrontal Cortex
Yang, C. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00112-2 · Cited by 185
Self-citation
Rapid sampling of extracellular dopamine in the rat prefrontal cortex during food consumption, handling and exposure to novelty
Feenstra, M. G. P., & Botterblom, M. H. A. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00945-6 · Cited by 169
Dopamine Excites Fast-Spiking Interneurons in the Striatum
Bracci, E., Centonze, D., Bernardi, G., & Calabresi, P. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00754.2001 · Cited by 166
Biological Profile of L-745,870, a Selective Antagonist with High Affinity for the Dopamine D4 Receptor
Patel, S. S., Freedman, S., Chapman, K. L., Emms, F., Fletcher, A. E., Knowles, M., Marwood, R., McAllister, G., Myers, J., Patel, S., et al. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37092-2 · Cited by 161
D1Dopamine Receptor Activation Reduces GABAAReceptor Currents in Neostriatal Neurons Through a PKA/DARPP-32/PP1 Signaling Cascade
Flores‐Hernández, J., Hernandez, S., Snyder, G. L., Yan, Z., Fienberg, A. A., Moss, S. J., Greengard, P., & Surmeier, D. J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.2996 · Cited by 150
Dopamine D1-Like Receptor Activation Excites Rat Striatal Large Aspiny NeuronsIn Vitro
Aosaki, T., Kiuchi, K., & Kawaguchi, Y. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05180.1998 · Cited by 149
Dopamine innervation of a subclass of local circuit neurons in monkey prefrontal cortex: ultrastructural analysis of tyrosine hydroxylase and parvalbumin immunoreactive structures
Sesack, S. R. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.7.614 · Cited by 148
Ultrastructural Double‐Labelling Study of Dopamine Terminals and GABA‐Containing Neurons in Rat Anteromedial Cerebral Cortex
Verney, C., Alvarez, C., Geffard, M., & Berger, B. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00008.x · Cited by 147
Dopamine D2 receptor mediated presynaptic inhibition of striatopallidal GABAA IPSCs in vitro
Cooper, A. J., & Stanford, I. M. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00038-7 · Cited by 146
Prefrontal Microcircuits: Membrane Properties and Excitatory Input of Local, Medium, and Wide Arbor Interneurons
Krimer, L. S., & Goldman-Rakic, P. S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03788.2001 · Cited by 141
Dopamine Modulation of Membrane and Synaptic Properties of Interneurons in Rat Cerebral Cortex
Zhou, F.-M., & Hablitz, J. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.3.967 · Cited by 136
Altered ratios of alternatively spliced long and short γ2 subunit mRNAs of the γ-amino butyrate type A receptor in prefrontal cortex of schizophrenics
Huntsman, M. M., Tran, B., Potkin, S. G., Bunney, W. E., & Jones, E. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15066 · Cited by 134
Distinct Firing Patterns of Neuronal Subtypes in Cortical Synchronized Activities
Kawaguchi, Y. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07261.2001 · Cited by 123
Influence of dopamine on GABA release in striatum: evidence for D1–D2 interactions and non-synaptic influences
Hársing, L. G., & Zigmond, M. J. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00475-7 · Cited by 117
Human Dopamine D3 and D2L Receptors Couple to Inward Rectifier Potassium Channels in Mammalian Cell Lines
Kuzhikandathil, E. V., Yu, W., & Oxford, G. S. (1998) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1998.0722 · Cited by 109
Dopamnine‐Immunoreactive axon varicosities form nonrandom contacts with GABA‐immunoreactive neurons of rat medial prefrontal cortex
Benes, F. M., Vincent, S. L., & Molloy, R. P. (1993) · Synapse · doi:10.1002/syn.890150405 · Cited by 98
Inhibitory influence of the mesocortical dopaminergic neurons on their target cells: electrophysiological and pharmacological characterization.
Godbout, R., Mantz, J., Pirot, S., Glowinski, J., & Thierry, A. M. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20466-9 · Cited by 97
Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist.
Merchant, K., Gill, G. S., Harris, D. W., Huff, R. M., Eaton, M. J., Lookingland, K. J., Lutzke, B. S., McCall, R. B., Piercey, M. F., Schreur, P. J. K. D., et al. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21300-3 · Cited by 90
Cocaine and Amphetamine Depress Striatal GABAergic Synaptic Transmission through D2 Dopamine Receptors
Centonze, D. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00299-8 · Cited by 90
Interneurons, Spike Timing, and Perception
Fricker, D., & Miles, R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00528-1 · Cited by 88
Associative long-term potentiation in piriform cortex slices requires GABAA blockade
Kanter, E., & Haberly, L. B. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-06-02477.1993 · Cited by 83
Phasic and tonic attenuation of EPSPs by inward rectifier K+ channels in rat hippocampal pyramidal cells
Takigawa, T., & Alzheimer, C. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.012883 · Cited by 79
Voltage-gated potassium currents in acutely dissociated rat cortical neurons
Foehring, R. C., & Surmeier, D. J. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.1.51 · Cited by 78
Inhibitory control of the GABAergic transmission in the rat neostriatum by D2 dopamine receptors
Delgado, A., Sierra, A., Querejeta, E., Valdiosera, R., & Aceves, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00495-9 · Cited by 76
Dopamine Inhibition of Evoked IPSCs in Rat Prefrontal Cortex
Gonzalez-Islas, C. E., & Hablitz, J. J. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.6.2911 · Cited by 74
Ultrastructural associations between dopamine terminals and local circuit neurons in the monkey prefrontal cortex: a study of calretinin-immunoreactive cells
Sesack, S. R., Bressler, C. N., & Lewis, D. A. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12076-g · Cited by 71
A dendritic GABAA-mediated IPSP regulates facilitation of NMDA-mediated responses to burst stimulation of afferent fibers in piriform cortex
Kanter, E., Kapur, A., & Haberly, L. B. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00307.1996 · Cited by 68
Dopaminergic modulation of cholinergic responses in rat medial prefrontal cortex: an electrophysiological study
Yang, C. R., & Mogenson, G. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90701-c · Cited by 62
Self-citation
Long-term potentiation in rat prefrontal slices facilitated by phased application of dopamine
Blond, O., Crépel, F., & Otani, S. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01291-8 · Cited by 52
Chapter VI Dopamine systems in the primate brain
Lewis, D. A., & Sesack, S. R. (1997) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(97)80008-5 · Cited by 50
Dopamine: Biphasic Dose Responses
Calabrese, E. J. (2001) · Critical Reviews in Toxicology · doi:10.1080/20014091111839 · Cited by 46
Evidence for a Slowly Inactivating K+ Current in Prefrontal Cortical Cells
Hammond, C., & Crépel, F. (1992) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1992.tb00135.x · Cited by 41
Direct Block of Inward Rectifier Potassium Channels by Nicotine
Wang, H., Yang, B., Zhang, L., Xu, D., & Wang, Z. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2000.8896 · Cited by 35
Direct block of native and cloned (Kir2.1) inward rectifier K+ channels by chloroethylclonidine
Barrett‐Jolley, R., Dart, C., & Standen, N. B. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702819 · Cited by 32
Autoradiographic localization of dopamine D1 and D2 receptors in rat cerebral cortex following unilateral neurotoxic lesions
Al‐Tikriti, M. S., Roth, R. H., KESSLER, R. M., & Innis, R. B. (1992) · Brain Research · doi:10.1016/0006-8993(92)90420-e · Cited by 26
Potassium-channel closure taken to TASK
North, R. A. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01592-7 · Cited by 24
Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways.
Lavenex (2000) · Pure Amsterdam UMC · doi:10.1002/1098-1063(2000)10:4 · Cited by 1

Flagged first, then by citations

Research works printed but not linked: 6

Ahn S, 2000, Soc Neurosci Abst, 366, 6
Björklund A, 1984, Handbook of Chemical Neuroanatomy: Classical Transmitter In The Rat, 2, 55
Godbout R, 1991, J Pharmacol Exp Ther, 258, 728
Gorelova N, 1998, Soc Neurosci Abstr, 24, 350
Merchant KM, 1996, J Pharmacol Exp Ther, 279, 1392
Sesack SR, 1989, J Pharmacol Exp Ther, 248, 1323

Sorted by citations

Decision making, the P3, and the locus coeruleus–norepinephrine system
Nieuwenhuis, S., Aston-Jones, G., & Cohen, J. D. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.4.510 · Cited by 1,678
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592
Self-citation
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V., & Arnsten, A. F. T. (2007) · Nature Neuroscience · doi:10.1038/nn1846 · Cited by 1,013
Dopamine Receptor Signaling
Neve, K. A., Seamans, J. K., & Trantham‐Davidson, H. (2004) · Journal of Receptors and Signal Transduction · doi:10.1081/rrs-200029981 · Cited by 836
Self-citation
The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes
Bilder, R. M., Volavka, J., Lachman, H. M., & Grace, A. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300542 · Cited by 769

See all 302

Authors: Gorelova, N., Seamans, J. K., & Yang, C. R.
Affiliations: University of British Columbia (CA)
Medical University of South Carolina (US)
Eli Lilly (United States) (US)
ORCID: Seamans, Jeremy K.
Venue: Journal of Neurophysiology
Publisher: American Physiological Society
Published: 2002-12-01
Volume: 88
Issue: 6
Pages: 3150-3166
ISSN: 0022-3077 (ISSN-L)
1522-1598
DOI: 10.1152/jn.00335.2002
OpenAlex: W2033043582
Cited by: 302
References: 99
Citations by year: 2026: 7 · 2025: 5 · 2024: 9 · 2023: 6 · 2022: 15 · 2021: 8 · 2020: 4 · 2019: 6 · 2018: 14 · 2017: 13 · 2016: 15 · 2015: 12 · 2014: 8 · 2013: 14 · 2012: 10
FWCI: 4.30
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neurophysiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: dopamine, fast-spiking interneurons, prefrontal cortex, GABAergic interneurons, dopamine D1/D5 receptors, interneuron excitability, membrane depolarization, inward rectifier potassium current, dopamine D2 receptor, repetitive firing, schizophrenia
MeSH terms: Action Potentials, Animals, Dopamine, Electrophysiology, Interneurons, Male, Neural Inhibition, Reaction Time, Potassium Channels, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, Dopamine D1, Patch-Clamp Techniques, Potassium Channels, Inwardly Rectifying, Receptors, Dopamine D5, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mechanisms of Dopamine Activation of Fast-Spiking Interneurons That Exert Inhibition in Rat Prefrontal Cortex

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks