Reflex suppression in the anti-saccade task is dependent on prestimulus neural processes
Abstract
Reflexive responses often must be suppressed to correctly execute a voluntary behavior. It is largely unknown why this control sometimes fails. To examine the neural processes responsible for these failures, we recorded single-neuron activity in the superior colliculus (SC) in behaving monkeys during an anti-saccade task in which they had to suppress a saccade to a visual stimulus that suddenly appeared in the periphery and generate a saccade to the opposite side. We found that the level and distribution of prestimulus activity of buildup neurons in the SC was highly predictive of whether a correct response or an error occurred. A high level of prestimulus activity in buildup neurons at the location in the SC where the visual stimulus was represented was associated with the generation of a reflexive saccade to the stimulus. These findings suggest that the successful suppression of reflexive saccades is dependent on prestimulus neural processes in the SC.
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FEF is one of the core regions supporting correct AS performance.
“FEF is one of the core regions supporting correct AS performance (Everling et al., 1998).”
From Effects of incentives, age, and behavior on brain activation during inhibitory control: a longitudinal fMRI study (2015) · cites this paper as Everling et al., 1998
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- Authors
- Everling, S., Dorris, M. C., & Munoz, D. P.
- Affiliations
- Queen's University (CA)
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1998-09-01
- Volume
- 80
- Issue
- 3
- Pages
- 1584-1589
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2286065405
- Cited by
- 195
- References
- 28
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 8 · 2012: 9
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- antisaccade task, reflex suppression, superior colliculus, pre-stimulus activity, saccade generation, single-unit activity, error prediction
- MeSH terms
- Animals, Conditioning, Psychological, Electrophysiology, Macaca mulatta, Male, Motor Neurons, Neurons, Afferent, Photic Stimulation, Psychomotor Performance, Reflex, Saccades
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