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Cited by 311

The DOI matches its Crossref record.

Lactate-proton cotransport in skeletal muscle

Juel, C.·1997·Physiological Reviews
DOI 10.1152/physrev.1997.77.2.321
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Abstract

Skeletal muscle and most other tissues possess a membrane transport system mediating a coupled lactate and H+ translocation. Muscle possesses several lactate-proton transporter isoforms of which two have been cloned; however, the main isoform remains to be identified. The isoforms may have different properties and functional roles, but these have not been specifically characterized. The distribution of lactate-proton transport capacity in skeletal muscle is fiber type dependent, with a higher capacity in slow-twitch fibers compared with fast-twitch fibers. During intense muscle activity and in the recovery period, the lactate and H+ effluxes are mainly mediated by the lactate-proton transporter, which reduces the accumulation of lactate in muscle as well as the drop in internal pH suggested to be involved in muscle fatigue. Thus the lactate-proton transporter is of functional importance for pH regulation in association with muscle activity. This carrier is also important for lactate uptake into resting muscle and other tissues; therefore, the carrier distribution is important for the fate of lactate in the body. In addition, the capacity of the lactate-proton transporter can be increased by intense training and is reduced by inactivity; thus the lactate-proton transporter can undergo adaptive changes.

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Metadata

Authors
Juel, C.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
1997-04-01
Volume
77
Issue
2
Pages
321-358
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.1997.77.2.321
OpenAlex
W1849470447
Cited by
311
References
0
FWCI
45.62
Type
journal article
Language
en
Open access
closed

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