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Cited by 411

The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.

Transport of Milk Constituents by the Mammary Gland

Shennan, D. B., Peaker, M.·2000·Physiological Reviews
DOI 10.1152/physrev.2000.80.3.925
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Abstract

This review deals with the cellular mechanisms that transport milk constituents or the precursors of milk constituents into, out of, and across the mammary secretory cell. The various milk constituents are secreted by different intracellular routes, and these are outlined, including the paracellular pathway between interstitial fluid and milk that is present in some physiological states and in some species throughout lactation. Also considered are the in vivo and in vitro methods used to study mammary transport and secretory mechanisms. The main part of the review addresses the mechanisms responsible for uptake across the basolateral cell membrane and, in some cases, for transport into the Golgi apparatus and for movement across the apical membrane of sodium, potassium, chloride, water, phosphate, calcium, citrate, iodide, choline, carnitine, glucose, amino acids and peptides, and fatty acids. Recent work on the control of these processes, by volume-sensitive mechanisms for example, is emphasized. The review points out where future work is needed to gain an overall view of milk secretion, for example, in marsupials where milk composition changes markedly during development of the young, and particularly on the intracellular coordination of the transport processes that result in the production of milk of relatively constant composition at a particular stage of lactation in both placental and marsupial mammals.

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Metadata

Authors
Shennan, D. B., & Peaker, M.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2000-07-01
Volume
80
Issue
3
Pages
925-951
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.2000.80.3.925
OpenAlex
W1828150019
Cited by
411
References
113
FWCI
2.67
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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