The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting
Open accessAbstract
Liposomes are delivery systems that have been used to formulate a vast variety of therapeutic and imaging agents for the past several decades. They have significant advantages over their free forms in terms of pharmacokinetics, sensitivity for cancer diagnosis and therapeutic efficacy. The multifactorial nature of cancer and the complex physiology of the tumor microenvironment require the development of multifunctional nanocarriers. Multifunctional liposomal nanocarriers should combine long blood circulation to improve pharmacokinetics of the loaded agent and selective distribution to the tumor lesion relative to healthy tissues, remote-controlled or tumor stimuli-sensitive extravasation from blood at the tumor’s vicinity, internalization motifs to move from tumor bounds and/or tumor intercellular space to the cytoplasm of cancer cells for effective tumor cell killing. This review will focus on current strategies used for cancer detection and therapy using liposomes with special attention to combination therapies.
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Cited by
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“The delivery of these liposomes to cancer cells often relies on passive targeting and is based on the enhanced permeability and retention (EPR) effect, for which a leaky tumor vasculature is necessary [1].”
BackgroundMethodCurrent Trends in The Use of Liposomes for Tumor Targeting
Deshpande, P. P., Biswas, S., & Torchilin, V. P. (2013) · Nanomedicine · doi:10.2217/nnm.13.118 · Cited by 657
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Metadata
- Authors
- Perche, F., & Torchilin, V. P.
- Venue
- Journal of Drug Delivery
- Publisher
- Wiley
- Published
- 2013-03-07
- Volume
- 2013
- Pages
- 1-32
- ISSN
- 2090-3014 (ISSN-L)
- 2090-3022
- OpenAlex
- W2022058170
- Cited by
- 230
- References
- 15
- FWCI
- 11.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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