Cytochrome c oxidase is decreased in Alzheimer’s disease platelets
Abstract
Cytochrome c oxidase (COX) activity reportedly is reduced in Alzheimer's disease (AD) brain and platelets. The reasons for the defect in either tissue are unknown, but its presence in a non-degenerating tissue suggests it is not simply a consequence of neurodegeneration. We now offer confirmation of the AD platelet COX defect. Compared to age-matched controls, in mitochondria isolated from AD platelets there was a 15% decrease in COX activity despite the fact that COX subunits were present at normal levels. Platelet ATP levels were diminished in AD (from 11.33 +/- 0.52 to 9.11 +/- 0.72 nmol/mg), while reactive oxygen species (ROS) were increased (from 97.03 +/- 25.9 to 338.3 +/- 100 K/mg). Platelet membrane fluidity, Vitamin E, and cholesterol content were similar between groups. We conclude that COX catalytic activity is indeed diminished in AD platelet mitochondria, does not result from altered membrane fluidity, and is associated with ROS overproduction and ATP under-production.
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In mitochondria isolated from AD platelets, the activity of complex IV, or cytochrome c oxidase, is significantly decreased.
“however, in mitochondria isolated from AD platelets, the activity of complex IV, or cytochrome c oxidase, is significantly decreased [109,110,111]”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [110]
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- Authors
- Cardoso, S. M., Proença, M. T., Santos, S., Santana, I., & Oliveira, C. R.
- Affiliations
- University of Coimbra (PT)
- Unidade Local de Saúde de Coimbra (PT)
- Corresponding author
- Oliveira, Catarina R
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 25
- Issue
- 1
- Pages
- 105-110
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2072453593
- Cited by
- 281
- References
- 38
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 9 · 2023: 15 · 2022: 13 · 2021: 16 · 2020: 14 · 2019: 16 · 2018: 7 · 2017: 9 · 2016: 14 · 2015: 10 · 2014: 13 · 2013: 22 · 2012: 17
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Keywords
- cytochrome c oxidase, Alzheimer's disease, platelets, mitochondrial dysfunction, ATP production, reactive oxygen species, platelet mitochondria, platelet membrane fluidity, vitamin E, cholesterol
- MeSH terms
- Adenine Nucleotides, Adenosine Triphosphate, Aged, Alzheimer Disease, Blood Platelets, Cholesterol, Chromatography, High Pressure Liquid, Citrate (si)-Synthase, Electron Transport Complex IV, Free Radicals, Humans, Middle Aged, Mitochondria, NADP, Succinate Cytochrome c Oxidoreductase, Vitamin E, Electrophoresis, Gel, Two-Dimensional, Case-Control Studies, Age of Onset, Electron Transport Complex I
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