Cognitive-behavioral therapy for somatization and symptom syndromes: a critical review of controlled clinical trials
Abstract
OBJECTIVE: Few treatments for somatization have been proven effective. In the past decade, however, clinical trials of cognitive-behavioral therapy (CBT) have been promising. Our aim was to critically review and synthesize the evidence from these trials. METHODS: A search of the Medline database from 1966 through July 1999 was conducted to identify controlled trials designed to evaluate the efficacy of CBT in patients with somatization or symptom syndromes. RESULTS: A total of 31 controlled trials (29 randomized and 2 nonrandomized) were identified. Twenty-five studies targeted a specific syndrome (e.g. chronic fatigue, irritable bowel, pain) while 6 focused on more general somatization or hypochondriasis. Primary outcome assessment included physical symptoms, psychological distress and functional status in 28, 26 and 19 studies, respectively. Physical symptoms appeared the most responsive: CBT-treated patients improved more than control subjects in 71% of the studies and showed possibly greater improvement (i.e., a trend) in another 11% of the studies. A definite or possible advantage of CBT for reducing psychological distress was demonstrated in only 38 and 8% of studies, and for improving functional status in 47 and 26%. Group therapy and interventions as brief as 5 sessions proved efficacious. Benefits were sustained for up to 12 months. CONCLUSION: CBT can be an effective treatment for patients with somatization or symptom syndromes. Benefits can occur whether or not psychological distress is ameliorated. Since chronic symptoms are exceptionally common and most studies were conducted in referral populations, the optimal sequencing of CBT in treating primary care patients and the identification of those most likely to accept and respond to therapy should be further evaluated.
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Historically, treatments within the cognitive behavioral therapy domain have shown the strongest empirical support for a wide range of psychiatric and medical conditions.
“Historically, treatments within the cognitive behavioral therapy domain have shown the strongest empirical support for a wide range of psychiatric and medical conditions [3].”
From Acceptance and Commitment Therapy: A Transdiagnostic Behavioral Intervention for Mental Health and Medical Conditions. (2017) · cites this paper as [3]
Cites
Collaborative management to achieve treatment guidelines. Impact on depression in primary care
Katon, W. J. (1995) · JAMA · doi:10.1001/jama.273.13.1026 · Cited by 1,464 · see citing works
Behavioral and Pharmacological Therapies for Late-Life Insomnia: A Randomized Controlled Trial
Morin, C. M., Colecchi, C., Stone, J., Sood, R., & Brink, D. (1999) · JAMA · doi:10.1001/jama.281.11.991 · Cited by 1,095 · see citing works
Physical symptoms in primary care. Predictors of psychiatric disorders and functional impairment
Kroenke, K. (1994) · Archives of Family Medicine · doi:10.1001/archfami.3.9.774 · Cited by 741 · see citing works
Self-citationCognitive behaviour therapy for the chronic fatigue syndrome: a randomised controlled trial.
Sharpe, M., Hawton, K., Simkin, S., Surawy, C., Hackmann, A., Klimes, I., Peto, T., Warrell, D., & Seagroatt, V. (1996) · BMJ · doi:10.1136/bmj.312.7022.22 · Cited by 528 · see citing works
Cognitive behavior therapy for chronic fatigue syndrome: a randomized controlled trial.
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.3.408 · Cited by 491 · see citing works
Comorbidity of fibromyalgia with medical and psychiatric disorders
Hudson, J. I., Goldenberg, D. L., Pope, H. G., Keck, P. E., & Schlesinger, L. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90265-d · Cited by 489 · see citing works
Psychiatric Consultation in Somatization Disorder
Smith, G. R., Monson, R. A., & Ray, D. C. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605293142203 · Cited by 459 · see citing works
Sanders, M. R., Shepherd, R. W., Cleghorn, G. J., & Woolford, H. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.62.2.306 · Cited by 374 · see citing works
Buchwald, D. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.1994.00420180053007 · Cited by 369 · see citing works
Speckens, A. E. M., van Hemert, A. M., Spinhoven, P., Hawton, K. E., Bolk, J. H., & Rooijmans, H. G. M. (1995) · BMJ · doi:10.1136/bmj.311.7016.1328 · Cited by 330 · see citing works
Difficult Patient Encounters in the Ambulatory Clinic
Jackson, J. L., & Kroenke, K. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.10.1069 · Cited by 329 · see citing works
Self-citationSmith, G. R. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950150070012 · Cited by 304 · see citing works
Nicholas, M. K., Wilson, P. H., & Goyen, J. (1992) · Pain · doi:10.1016/0304-3959(92)90082-m · Cited by 271 · see citing works
Two psychological treatments for hypochondriasis: A randomised controlled trial
Clark, D. M., Salkovskis, P. M., Hackmann, A., Wells, A., Fennell, M., Ludgate, J., Ahmad, S., Richards, H. C., & Gelder, M. (1998) · British Journal of Psychiatry · doi:10.1192/bjp.173.3.218 · Cited by 270 · see citing works
Compas, B. E., Haaga, D. A. F., Keefe, F. J., Leitenberg, H., & Williams, D. A. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.66.1.89 · Cited by 262 · see citing works
A controlled trial of cognitive-behavioural treatment of hypochondriasis
Warwick, H. M. C., Clark, D. M., Cobb, A. M., & Salkovskis, P. M. (1996) · British Journal of Psychiatry · doi:10.1192/bjp.169.2.189 · Cited by 240 · see citing works
Simon, G. E., Gater, R. A., Kisely, S. R., & Piccinelli, M. P. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199609000-00010 · Cited by 237 · see citing works
(1996) · PubMed · Cited by 234 · see citing works
Smith, R. C., Lyles, J. S., Mettler, J., Stoffelmayr, B. E., Van Egeren, L. F., Marshall, A. A., Gardiner, J. C., Maduschke, K. M., Stanley, J. M., Osborn, G. G., et al. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00008 · Cited by 228 · see citing works
Lin, E. H. B., Katon, W. J., Korff, M. V., Bush, T. M., Lipscomb, P. A., Russo, J. E., & Wagner, E. H. (1991) · Journal of General Internal Medicine · doi:10.1007/bf02598969 · Cited by 209 · see citing works
Bergdahl, J., Anneroth, G., & Ferris, H. (1995) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.1995.tb01169.x · Cited by 205 · see citing works
Turner, J. A. (1982) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.50.5.757 · Cited by 204 · see citing works
Psychological treatment for atypical non-cardiac chest pain: a controlled evaluation
Klimeš, I., Mayou, R., Pearce, M. J., Coles, L., & Fagg, J. (1990) · Psychological Medicine · doi:10.1017/s0033291700017116 · Cited by 201 · see citing works
Efficacy of cognitive therapy for chronic low back pain
Turner, J. A., & Jensen, M. P. (1993) · Pain · doi:10.1016/0304-3959(93)90128-c · Cited by 196 · see citing works
Keefe, F. J., Dunsmore, J., & Burnett, R. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.60.4.528 · Cited by 195 · see citing works
Comparison of operant behavioral and cognitive-behavioral group treatment for chronic low back pain.
Turner, J. A., & Clancy, S. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.56.2.261 · Cited by 192 · see citing works
Cognitive therapy for irritable bowel syndrome.
Greene, B., & Blanchard, E. B. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.62.3.576 · Cited by 188 · see citing works
Payne, A., & Blanchard, E. B. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.63.5.779 · Cited by 186 · see citing works
A controlled study of a stress-reduction, cognitive-behavioral treatment program in fibromyalgia.
Goldenberg, D. L., Kaplan, K. H., Nadeau, M. G., Brodeur, C., Smith, S., & Schmid, C. H. (1994) · Journal of Musculoskeletal Pain · doi:10.1300/j094v02n02_05 · Cited by 183 · see citing works
COGNITIVE BEHAVIOUR THERAPY FOR PSYCHIATRIC PROBLEMS: A practical guide
Higgins, P. M. (1990) · Europe PMC (PubMed Central) · Cited by 182 · see citing works
Treatment of Functional Somatic Symptoms
Mai, F. M. (1995) · doi:10.1093/oso/9780192624994.001.0001 · Cited by 181 · see citing works
A controlled trial of cognitive behavioural therapy for non-cardiac chest pain
MAYOU, R. A., BRYANT, B. M., SANDERS, D., BASS, C., KLIMES, I., & FORFAR, C. (1997) · Psychological Medicine · doi:10.1017/s0033291797005254 · Cited by 179 · see citing works
Lloyd, A. R., Hickie, I. B., Brockman, A., Hickie, C., Wilson, A., Dwyer, J., & Wakefield, D. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90183-p · Cited by 174 · see citing works
Payne, A., & Blanchard, E. B. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.63.5.779 · Cited by 166 · see citing works
Operant-behavioural and cognitive-behavioural treatment for chronic low back pain
Nicholas, M. K., Wilson, P. H., & Goyen, J. (1991) · Behaviour Research and Therapy · doi:10.1016/0005-7967(91)90112-g · Cited by 159 · see citing works
Hellman, C. J. C., Budd, M., Borysenko, J., McClelland, D. C., & Benson, H. (1990) · Behavioral Medicine · doi:10.1080/08964289.1990.9934605 · Cited by 155 · see citing works
Yunus, M. B., Masi, A. T., & Aldag, J. C. (1989) · PubMed · Cited by 147 · see citing works
Brief group cognitive-behavioral intervention for temporomandibular disorders
Dworkin, S. F., Turner, J. A., Wilson, L., Massoth, D. L., Whitney, C. W., Huggins, K. H., Burgess, J. A., Sommers, E. E., & Truelove, E. L. (1994) · Pain · doi:10.1016/0304-3959(94)90070-1 · Cited by 145 · see citing works
The Course of Somatization and Its Effects on Utilization of Health Care Resources
Smith, G. R. (1994) · Psychosomatics · doi:10.1016/s0033-3182(94)71774-6 · Cited by 134 · see citing works
Kerns, R. D., Turk, D. C., Holzman, A. D., & Rudy, T. E. (1985) · Clinical Journal of Pain · doi:10.1097/00002508-198501040-00003 · Cited by 125 · see citing works
Psychosomatic Syndromes and Somatic Symptoms
(1992) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550046 · Cited by 123 · see citing works
Cognitive-Behavioral Group Therapy for Irritable Bowel Syndrome
van Dulmen, S., Fennis, J. F. M., & Bleijenberg, G. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199609000-00013 · Cited by 122 · see citing works
Intervention for minor depression in primary care patients.
de Miranda, J. V. M., & Muñoz, R. F. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199403000-00009 · Cited by 121 · see citing works
Lidbeck, J. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb09899.x · Cited by 116 · see citing works
The management of chronic tinnitus—Comparison of a cognitive-behavioural group training with yoga.
Kröner-Herwig, B., Hebing, G., Van Rijn-Kalkmann, U., Frenzel, A., Schilkowsky, G., & Esser, G. (1995) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)00098-p · Cited by 101 · see citing works
Cognitive-behavioral therapy for noncardiac chest pain: a randomized trial
Peski-Oosterbaan, A. S. V., Spinhoven, P., van Rood, Y. R., van der Does, W. A. J., Bruschke, A. V. G., & Rooijmans, H. G. M. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00049-2 · Cited by 101 · see citing works
Blanchard, E. B., Appelbaum, K. A., Radnitz, C. L., Michultka, D. M., Morrill, B., Kirsch, C. A., Hillhouse, J., Evans, D. D., Guarnieri, P., Attanasio, V., et al. (1990) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.58.2.210 · Cited by 78 · see citing works
Cognitive and Behavioural Treatment of Hypochondriasis
Bouman, T. K., & Visser, S. (1998) · Psychotherapy and Psychosomatics · doi:10.1159/000012283 · Cited by 75 · see citing works
Group cognitive therapy for medical patients: An application to tinnitus
Jakes, S. C., Hallam, R., McKenna, L., & HINCHCLIFFE, R. (1992) · Cognitive Therapy and Research · doi:10.1007/bf01172957 · Cited by 67 · see citing works
Fortnightly review: Cognitive behaviour therapy–clinical applications
Enright, S. J. (1997) · BMJ · doi:10.1136/bmj.314.7097.1811 · Cited by 66 · see citing works
Wilkinson, P., & Mynors‐Wallis, L. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90056-6 · Cited by 52 · see citing works
Sequential Treatment: A New Way of Integrating Pharmacotherapy and Psychotherapy
Fava, G. A. (1999) · Psychotherapy and Psychosomatics · doi:10.1159/000012338 · Cited by 45 · see citing works
Hillert, L., Kolmodin‐Hedman, B., Dölling, B. F., & Arnetz, B. B. (1998) · Psychotherapy and Psychosomatics · doi:10.1159/000012295 · Cited by 37 · see citing works
Meeting the expectations of chronic tinnitus patients
Wise, K., Rief, W., & Goebel, G. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00310-3 · Cited by 27 · see citing works
Kroenke, K. (1997) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1997.00092.x · Cited by 26 · see citing works
Self-citationIs a Paradigm Shift Occurring in Brief Psychological Treatments?
Marks, I. M. (1999) · Psychotherapy and Psychosomatics · doi:10.1159/000012328 · Cited by 21 · see citing works
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Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection
Kroenke, K., Spitzer, R. L., Williams, J. B. W., Monahan, P. O., & Löwe, B. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-5-200703060-00004 · Cited by 4,741 · see citing works
Self-citationNo health without mental health
Prince, M. J., Patel, V., Saxena, S., Maj, M., Maselko, J., Phillips, M. R., & Rahman, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61238-0 · Cited by 3,835 · see citing works
Depression and Pain Comorbidity: A Literature Review
Bair, M. J., Robinson, R. L., Katon, W., & Kroenke, K. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.20.2433 · Cited by 3,463 · see citing works
Self-citationThe PHQ-15: Validity of a New Measure for Evaluating the Severity of Somatic Symptoms
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200203000-00008 · Cited by 3,305 · see citing works
Self-citationSpitzer, R. L., Williams, J. B. W., Kroenke, K., Hornyak, R., & McMurray, J. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.106580 · Cited by 847 · see citing works
Self-citationMedically Unexplained Physical Symptoms, Anxiety, and Depression: A Meta-Analytic Review
Henningsen, P., Zimmermann, T., & Sattel, H. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000075977.90337.e7 · Cited by 829 · see citing works
Depression, anxiety and somatization in primary care: Syndrome overlap and functional impairment
Löwe, B., Spitzer, R. L., Williams, J. B. W., Mussell, M., Schellberg, D., & Kroenke, K. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2008.01.001 · Cited by 706 · see citing works
Self-citationPatients presenting with somatic complaints: epidemiology, psychiatric co‐morbidity and management
Kroenke, K. (2003) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.140 · Cited by 624 · see citing works
Self-citationAre there two qualitatively distinct forms of dissociation? A review and some clinical implications
Holmes, E. A., Brown, R. J., Mansell, W., Fearon, R. P., Hunter, E. C. M., Frasquilho, F., & Oakley, D. A. (2005) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.08.006 · Cited by 619 · see citing works
Bair, M. J., Wu, J., Damush, T. M., Sutherland, J. M., & Kroenke, K. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318185c510 · Cited by 572 · see citing works
Self-citationSomatoform disorders in general practice
de Waal, M. W. M., Arnold, I. A., Eekhof, J. A., & van Hemert, A. M. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.184.6.470 · Cited by 528 · see citing works
Psychological Mechanisms of Medically Unexplained Symptoms: An Integrative Conceptual Model.
Brown, R. J. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.5.793 · Cited by 498 · see citing works
Cognitive-behavioral therapy for psychogenic nonepileptic seizures
Goldstein, L. H., Chalder, T., Chigwedere, C., Khondoker, M. R., Moriarty, J., Toone, B., & Mellers, J. D. C. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e39658 · Cited by 482 · see citing works
Deary, V., Chalder, T., & Sharpe, M. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2007.07.002 · Cited by 480 · see citing works
Somatoform Disorders: Time for a New Approach in DSM-V
Mayou, R., Kirmayer, L. J., Simon, G., Kroenke, K., & Sharpe, M. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.5.847 · Cited by 477 · see citing works
Self-citationEfficacy of treatment for somatoform disorders: a review of randomized controlled trials
Kroenke, K. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31815b00c4 · Cited by 450 · see citing works
Self-citationKroenke, K., Bair, M. J., Damush, T. M., Wu, J., Hoke, S., Sutherland, J., & Tu, W. (2009) · JAMA · doi:10.1001/jama.2009.723 · Cited by 447 · see citing works
Self-citationA systematic review of the epidemiology of somatisation disorder and hypochondriasis
Creed, F., & Barsky, A. (2004) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(03)00622-6 · Cited by 421 · see citing works
Katon, W. J., Sullivan, M. D., & Walker, E. A. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-9_part_2-200105011-00017 · Cited by 416 · see citing works
Psychogenic nonepileptic seizures: review and update
Reuber, M., & Elger, C. E. (2003) · Epilepsy & Behavior · doi:10.1016/s1525-5050(03)00104-5 · Cited by 404 · see citing works
Dindo, L., Van Liew, J. R., & Arch, J. J. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0521-3 · Cited by 371 · see citing works
Outcome in psychogenic nonepileptic seizures: 1 to 10‐year follow‐up in 164 patients
Reuber, M., Pukrop, R., Bauer, J. M., Helmstaedter, C., Tessendorf, N., & Elger, C. E. (2003) · Annals of Neurology · doi:10.1002/ana.3000 · Cited by 371 · see citing works
Should an obsessive-compulsive spectrum grouping of disorders be included in DSM-V?
Phillips, K. A., Stein, D. J., Rauch, S. L., Hollander, E., Fallon, B. A., BARSKY, A. J., Fineberg, N. A., Mataix‐Cols, D., Ferrão, Y. A., Saxena, S., et al. (2010) · Depression and Anxiety · doi:10.1002/da.20705 · Cited by 349 · see citing works
Irritable bowel syndrome: a little understood organic bowel disease?
Talley, N. J., & Spiller, R. E. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09712-x · Cited by 304 · see citing works
van Dessel, N., den Boeft, M., van der Wouden, J. C., Kleinstäuber, M., Leone, S. S., Terluin, B., Numans, M. E., van der Horst, H. E., & van Marwijk, H. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011142.pub2 · Cited by 302 · see citing works
The long-term health outcomes of childhood abuse: An overview and a call to action
Springer, K. W., Sheridan, J., Kuo, D., & Carnes, M. (2003) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2003.20918.x · Cited by 299 · see citing works
Watson, D., Levin‐Aspenson, H. F., Waszczuk, M. A., Conway, C. C., Dalgleish, T., Dretsch, M. N., Eaton, N. R., Forbes, M. K., Forbush, K. T., Hobbs, K. A., et al. (2022) · World Psychiatry · doi:10.1002/wps.20943 · Cited by 285 · see citing works
Short-Term Psychodynamic Psychotherapy for Somatic Disorders
Abbass, A., Kisely, S., & Kroenke, K. (2009) · Psychotherapy and Psychosomatics · doi:10.1159/000228247 · Cited by 280 · see citing works
Self-citation(2003) · Europe PMC (PubMed Central) · Cited by 255 · see citing works
Assessment and management of medically unexplained symptoms
Hatcher, S., & Arroll, B. (2008) · BMJ · doi:10.1136/bmj.39554.592014.be · Cited by 242 · see citing works
Lakhan, S. E., & Schofield, K. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071834 · Cited by 233 · see citing works
The epidemiology of multiple somatic symptoms
Creed, F. H., Davies, I., Jackson, J., Littlewood, A., Chew-Graham, C. A., Tomenson, B., Macfarlane, G. J., BARSKY, A. J., Katon, W. J., & McBeth, J. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.01.009 · Cited by 224 · see citing works
Cognitive behavioral therapy for psychogenic nonepileptic seizures
LaFrance, W. C., Miller, I. W., Ryan, C. E., Blum, A. S., Solomon, D. A., Kelley, J. E., & Keitner, G. I. (2009) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2009.02.016 · Cited by 215 · see citing works
Guided self-help for functional (psychogenic) symptoms
Sharpe, M., Walker, J., Williams, C. M., Stone, J., Cavanagh, J., Murray, G. D., Butcher, I., Duncan, R., Smith, S., & Carson, A. J. (2011) · Neurology · doi:10.1212/wnl.0b013e318228c0c7 · Cited by 213 · see citing works
Kleinstäuber, M., Witthöft, M., & Hiller, W. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.09.001 · Cited by 212 · see citing works
Cognitive-Behavioral Therapy for Somatization Disorder: A Randomized Controlled Trial
Allen, L. A., Woolfolk, R. L., Escobar, J. I., Gara, M. A., & Hamer, R. M. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.14.1512 · Cited by 209 · see citing works
“Unexplained” Somatic Symptoms, Functional Syndromes, and Somatization: Do We Need a Paradigm Shift?
Sharpe, M., & Carson, A. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-9_part_2-200105011-00018 · Cited by 209 · see citing works
Psychological approaches to treatment of postconcussion syndrome: a systematic review
Sayegh, A. A., Sandford, D. M., & Carson, A. J. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.170092 · Cited by 206 · see citing works
Lane, R. D., Weihs, K. L., Herring, A. M., Hishaw, A., & Smith, R. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.007 · Cited by 205 · see citing works
Overview of Peer Support Models to Improve Diabetes Self-Management and Clinical Outcomes
Heisler, M. (2007) · Diabetes Spectrum · doi:10.2337/diaspect.20.4.214 · Cited by 203 · see citing works
A randomized trial of telephonic counseling plus walking for depressed diabetes patients
Piette, J. D., Richardson, C., Himle, J., Duffy, S., Torres, T., Vogel, M., Barber, K., & Valenstein, M. (2011) · Medical Care · doi:10.1097/mlr.0b013e318215d0c9 · Cited by 198 · see citing works
Gastrointestinal symptoms in primary care: Prevalence and association with depression and anxiety
Mussell, M., Kroenke, K., Spitzer, R. L., Williams, J. B. W., Herzog, W., & Löwe, B. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.02.019 · Cited by 194 · see citing works
Self-citationHeisler, M. (2009) · Family Practice · doi:10.1093/fampra/cmp003 · Cited by 187 · see citing works
RetractedFunctional somatic symptoms and syndromes
Mayou, R., & Farmer, A. (2002) · BMJ · doi:10.1136/bmj.325.7358.265 · Cited by 178 · see citing works
Psychological Approaches to Origins and Treatments of Somatoform Disorders
Witthöft, M., & Hiller, W. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.121208.131505 · Cited by 172 · see citing works
Moene, F. C., Spinhoven, P., Hoogduin, K. A. L., & van Dyck, R. (2002) · Psychotherapy and Psychosomatics · doi:10.1159/000049348 · Cited by 162 · see citing works
Psychosomatic Medicine: Emerging Trends and Perspectives
Fava, G. A., & Sonino, N. (2000) · Psychotherapy and Psychosomatics · doi:10.1159/000012393 · Cited by 162 · see citing works
Classification of Somatization and Functional Somatic Symptoms in Primary Care
Fink, P., Rosendal, M., & Olesen, F. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01682.x · Cited by 161 · see citing works
Kisely, S. R., Campbell, L. A., Yelland, M. J., & Paydar, A. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004101.pub5 · Cited by 160 · see citing works
Sattel, H. C., Lahmann, C., Gündel, H., Guthrie, E., Kruse, J., Noll‐Hussong, M., Ohmann, C., Ronel, J., Sack, M., Sauer, N., et al. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.093526 · Cited by 159 · see citing works
van Tilburg, M. A. L., Palsson, O. S., & Whitehead, W. E. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.03.004 · Cited by 151 · see citing works
Sumathipala, A. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31815b5cf6 · Cited by 151 · see citing works
An Evaluation of Cognitive Behavioral Therapy as a Treatment for Dissociative Seizures
Goldstein, L. H., Deale, A. C., O’Malley, S. J. M., Toone, B., & Mellers, J. D. C. (2004) · Cognitive and Behavioral Neurology · doi:10.1097/00146965-200403000-00005 · Cited by 151 · see citing works
Psychosocial Treatments for Multiple Unexplained Physical Symptoms: A Review of the Literature
Allen, L. A., Escobar, J. I., Lehrer, P. M., Gara, M. A., & Woolfolk, R. L. (2002) · Psychosomatic Medicine · doi:10.1097/01.psy.0000024231.11538.8f · Cited by 149 · see citing works
Van Dessel, N., Den Boeft, M., van der Wouden, J. C., Kleinstäuber, M., Leone, S. S., Terluin, B., Numans, M. E., van der Horst, H. E., & van Marwijk, H. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011142 · Cited by 148 · see citing works
Liu, J., Gill, N. S., Teodorczuk, A., Li, Z., & Sun, J. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.10.114 · Cited by 148 · see citing works
Chilcot, J., & Moss-Morris, R. (2013) · Behaviour Research and Therapy · doi:10.1016/j.brat.2013.07.007 · Cited by 146 · see citing works
The outcome of physical symptoms with treatment of depression
Greco, T., Eckert, G., & Kroenke, K. (2004) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2004.30531.x · Cited by 145 · see citing works
Self-citationManagement of medically unexplained symptoms
Rosendal, M., Olesen, F., & Fink, P. (2004) · BMJ · doi:10.1136/bmj.330.7481.4 · Cited by 145 · see citing works
Functional symptoms in neurology: management
Stone, J. (2005) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.061663 · Cited by 141 · see citing works
van der Feltz-Cornelis, C. M., van Oppen, P., Adèr, H. J., & van Dyck, R. (2006) · Psychotherapy and Psychosomatics · doi:10.1159/000093949 · Cited by 138 · see citing works
Distinguishing between excessive daytime sleepiness and fatigue
Pigeon, W. R., Sateia, M. J., & Ferguson, R. J. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00542-1 · Cited by 138 · see citing works
The Association or Otherwise of the Functional Somatic Syndromes
Kanaan, R., Lepine, J. P., & Wessely, S. C. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31815b001a · Cited by 134 · see citing works
Emotion regulation in patients with somatic symptom and related disorders: a systematic review
Okur Güney, Z. E., Sattel, H., Witthöft, M., & Henningsen, P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217277 · Cited by 133 · see citing works
Heisler, M., & Piette, J. D. (2005) · The Diabetes Educator · doi:10.1177/0145721705283247 · Cited by 130 · see citing works
The outcomes among patients presenting in primary care with a physical symptom at 5 years
Jackson, J. L., & Passamonti, M. (2005) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2005.0241.x · Cited by 126 · see citing works
Psychogenic movement disorders
Hinson, V. K., & Haren, W. B. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70523-3 · Cited by 124 · see citing works
Treating patients with medically unexplained symptoms in primary care
Smith, R. C., Lein, C., Collins, C., Lyles, J. S., Given, B., Dwamena, F. C., Coffey, J., Hodges, A., Gardiner, J. C., Goddeeris, J., et al. (2003) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2003.20815.x · Cited by 123 · see citing works
Jackson, J. L., & Kroenke, K. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31816aa0ee · Cited by 123 · see citing works
Self-citationIllness beliefs and locus of control
Stone, J., Binzer, M., & Sharpe, M. (2004) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2004.03.013 · Cited by 118 · see citing works
Voigt, K., Nagel, A., Meyer, B., Langs, G., Braukhaus, C., & Löwe, B. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.01.015 · Cited by 115 · see citing works
Kroenke, K., & Rosmalen, J. G. M. (2006) · Medical Clinics of North America · doi:10.1016/j.mcna.2006.04.003 · Cited by 115 · see citing works
Self-citationThe outcome of neurology outpatients with medically unexplained symptoms: a prospective cohort study
Carson, A. J. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.7.897 · Cited by 114 · see citing works
Labbate, L. A., Croft, H. A., & Oleshansky, M. A. (2003) · PubMed · Cited by 113 · see citing works
(2016) · PubMed · Cited by 113 · see citing works
Somatoform disorders: severe psychiatric illnesses neglected by psychiatrists
Bass, C., Peveler, R., & House, A. O. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.179.1.11 · Cited by 111 · see citing works
Somatization Increases Disability Independent of Comorbidity
Harris, A. M., Orav, E. J., Bates, D. W., & BARSKY, A. J. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0845-0 · Cited by 109 · see citing works
Sharpe, M., Stone, J., Hibberd, C., Warlow, C., Duncan, R., Coleman, R. J., Roberts, R., Cull, R. E., Pelosi, A. J., Cavanagh, J., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291709990717 · Cited by 108 · see citing works
Abuse, Dissociation, and Somatization in Irritable Bowel Syndrome: Towards an Explanatory Model
Salmon, P., Skaife, K., & Rhodes, J. M. (2003) · Journal of Behavioral Medicine · doi:10.1023/a:1021718304633 · Cited by 107 · see citing works
Antidepressants and Cognitive-Behavioral Therapy for Symptom Syndromes
Jackson, J. L., O’Malley, P. G., & Kroenke, K. (2006) · CNS Spectrums · doi:10.1017/s1092852900014383 · Cited by 107 · see citing works
Self-citationFink, P., & Rosendal, M. (2008) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3282f51254 · Cited by 105 · see citing works
Edwards, T. M., Stern, A., Clarke, D. D., Ivbijaro, G. O., & Kasney, L. M. (2010) · PubMed Central · Cited by 104 · see citing works
Landa, A., Peterson, B. S., & Fallon, B. A. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182688e8b · Cited by 104 · see citing works
Functional symptoms in neurology: questions and answers
Reuber, M. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.048280 · Cited by 104 · see citing works
Brown, R. J. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2007.07.003 · Cited by 102 · see citing works
Somatization Disorder: A Practical Review
Mai, F. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404901002 · Cited by 100 · see citing works
Aiarzagüena, J. M., Gonzalo Grandes, O., Gaminde, I., Salazar, A., Sánchez, Á., & Ariño, J. (2006) · Psychological Medicine · doi:10.1017/s0033291706009536 · Cited by 98 · see citing works
Psychosocial interventions for somatizing patients by the general practitioner
Larisch, A., Schweickhardt, A., Wirsching, M., & Fritzsche, K. (2004) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2004.04.372 · Cited by 97 · see citing works
Assessment of Psychological Distress in the Setting of Medical Disease
Fava, G. A., Mangelli, L., & Ruini, C. (2001) · Psychotherapy and Psychosomatics · doi:10.1159/000056249 · Cited by 94 · see citing works
Direct to consumer advertising
Mansfield, P. R., Mintzes, B. J., Richards, D. A., & Toop, L. J. (2004) · BMJ · doi:10.1136/bmj.330.7481.5 · Cited by 94 · see citing works
Tailored psychotherapy for patients with functional neurological symptoms: A pilot study
Reuber, M., Burness, C. E., Howlett, S., Brazier, J. E., & Grünewald, R. A. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.06.013 · Cited by 93 · see citing works
Screening for Psychological Illness in Military Personnel
Rona, R. J. (2005) · JAMA · doi:10.1001/jama.293.10.1257 · Cited by 93 · see citing works
Abrahamsen, R., Baad-Hansen, L., & Svensson, P. (2008) · Pain · doi:10.1016/j.pain.2007.06.013 · Cited by 93 · see citing works
Multidisciplinary and Interdisciplinary Management of Chronic Pain
Stanos, S. P., & Houle, T. T. (2006) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2005.12.004 · Cited by 92 · see citing works
Clarke, D. M., Piterman, L., Byrne, C. J., & Austin, D. (2008) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2008.tb02180.x · Cited by 92 · see citing works
The Effects of Repeated Thermal Therapy for Patients with Chronic Pain
Masuda, A., Koga, Y., Hattanmaru, M., Minagoe, S., & Tei, C. (2005) · Psychotherapy and Psychosomatics · doi:10.1159/000086319 · Cited by 91 · see citing works
Dickinson, W. P. (2003) · The Annals of Family Medicine · doi:10.1370/afm.5 · Cited by 90 · see citing works
Dijk, J., & Tijssen, M. (2010) · Lancet Neurology · doi:10.1016/s1474-4422(10)70193-9 · Cited by 82 · see citing works
Psychogenic Movement Disorders
Thomas, M., & Jankovic, J. J. (2004) · CNS Drugs · doi:10.2165/00023210-200418070-00003 · Cited by 86 · see citing works
Bleichhardt, G. M., Timmer, B., & Rief, W. (2004) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(03)00630-5 · Cited by 85 · see citing works
- Authors
- Kroenke, K., & Swindle, R.
- Affiliations
- Regenstrief Institute (US)
- Venue
- Psychotherapy and Psychosomatics
- Publisher
- S. Karger AG
- Published
- 2000
- Volume
- 69
- Issue
- 4
- Pages
- 205-215
- ISSN
- 0033-3190 (ISSN-L)
- 1423-0348
- OpenAlex
- W1977249692
- Cited by
- 478
- References
- 55
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 3 · 2020: 3 · 2019: 12 · 2018: 16 · 2017: 18 · 2016: 9 · 2015: 16 · 2014: 14 · 2013: 20 · 2012: 25
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychotherapy and Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- cognitive behavioral therapy, somatization, health anxiety, chronic fatigue, irritable bowel syndrome, chronic pain, somatic symptoms, psychological distress, functional status, group therapy, treatment efficacy
- MeSH terms
- Humans, Psychophysiology, Somatoform Disorders, Syndrome, Cognitive Behavioral Therapy, Controlled Clinical Trials as Topic
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