Cited by 219Obstructive Sleep Apnea ResearchSleep and related disordersDiabetes, Cardiovascular Risks, and Lipoproteins

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The Effect of Continuous Positive Airway Pressure Treatment on Insulin Sensitivity in Patients with Obstructive Sleep Apnoea Syndrome and Type 2 Diabetes

Harsch, Igor Alexander, Schahin, Simin Pour, Brückner, Kerstin, Radespiel-Tröger, Martin, Fuchs, Florian S., Hahn, Eckhart Georg, Konturek, Peter Christopher, Lohmann, Tobias, Ficker, Joachim Hans·2004·Respiration

DOI 10.1159/000077423

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Abstract

Background: The obstructive sleep apnoea syndrome (OSA) is a frequent condition, as well as type 2 diabetes mellitus. Both diseases are characterized by insulin resistance. Objectives: The aim of this study was to establish whether OSA is an independent risk factor for increased insulin resistance in diabetics. For this purpose, we tested the hypothesis that the insulin sensitivity in patients with type 2 diabetes and OSA can be improved by 2 days or 3 months of continuous positive airway pressure (CPAP) treatment. Methods: In 9 obese patients with type 2 diabetes and OSA [apnoea/hypopnoea index 43.1 ± 21.3; body mass index (BMI) 37.3 ± 5.6 kg/m 2] and good glycaemic control on oral antidiabetics or on diet alone (HbA1c 6.4 ± 0.7%), the insulin sensitivity index (ISI) was established by euglycaemic hyperinsulinaemic clamp tests at baseline, after 2 days and after 3 months of effective CPAP treatment. Results: ISI was unchanged after 2 days of CPAP treatment, but was significantly improved after 3 months (4.38 ± 2.94 vs. 2.74 ± 2.25 at baseline; p = 0.021), without any significant changes in BMI. Glycaemic control was unaffected after 3 months (HbA1c 6.3 ± 0.6%; not significant). Fasting leptin levels showed no significant changes. Conclusions: These results indicate that OSA itself is an independent risk factor for insulin resistance. This effect may be explained by the elevated sympathetic activity in OSA.

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Authors: Harsch, I. A., Schahin, S. P., Brückner, K., Radespiel-Tröger, M., Fuchs, F. S., Hahn, E. G., Konturek, P. C., Lohmann, T., & Ficker, J. H.
Affiliations: Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
ORCID: Harsch, Igor Alexander
Fuchs, Florian S.
Ficker, Joachim Hans
Venue: Respiration
Publisher: S. Karger AG
Published: 2004
Volume: 71
Issue: 3
Pages: 252-259
ISSN: 0025-7931 (ISSN-L)
1423-0356
DOI: 10.1159/000077423
OpenAlex: W2043246888
Cited by: 219
References: 46
Citations by year: 2025: 4 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 9 · 2017: 8 · 2016: 17 · 2015: 18 · 2014: 15 · 2013: 7 · 2012: 17
FWCI: 7.61
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Respiration (publishedVersion)
PubMed (publishedVersion)
Funders: B. Braun-Stiftung
Karl-Franzens-Universität Graz
Topics: Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: obstructive sleep apnea, type 2 diabetes, insulin resistance, continuous positive airway pressure, CPAP therapy, insulin sensitivity, hyperinsulinemic-euglycemic clamp, leptin, obesity, sympathetic activity, glycemic control
MeSH terms: Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Male, Middle Aged, Risk Factors, Treatment Outcome, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure

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The Effect of Continuous Positive Airway Pressure Treatment on Insulin Sensitivity in Patients with Obstructive Sleep Apnoea Syndrome and Type 2 Diabetes

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