Antiaggressive activity of central oxytocin in male rats

Calcagnoli, Federica; de Boer, Sietse F.; Althaus, Monika; den Boer, Johan A.; Koolhaas, Jaap M.

doi:10.1007/s00213-013-3124-7

Cited by 90Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Antiaggressive activity of central oxytocin in male rats

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Calcagnoli, Federica, de Boer, Sietse F., Althaus, Monika, den Boer, Johan A., Koolhaas, Jaap M.·2013·Psychopharmacology

DOI 10.1007/s00213-013-3124-7

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Abstract

Rationale A substantial body of research suggests that the neuropeptide oxytocin promotes social affiliative behaviors in a wide range of animals including humans. However, its antiaggressive action has not been unequivocally demonstrated in male laboratory rodents.Objective Our primary goal was to examine the putative serenic effect of oxytocin in a feral strain (wild type Groningen, WTG) of rats that generally show a much broader variation and higher levels of intermale aggression than commonly used laboratory strains of rats.Methods Resident animals were intracerebroventricularly (icv) administered with different doses of synthetic oxytocin and oxytocin receptor antagonist, alone and in combination, in order to manipulate brain oxytocin functioning and to assess their behavioral response to an intruder.Results Our data clearly demonstrate that acute icv administered oxytocin produces dose-dependent and receptor-selective changes in social behavior, reducing aggression and potentiating social exploration. These antiaggressive effects are stronger in the more offensive rats. On the other hand, administration of an oxytocin receptor antagonist tends to increase (nonsignificantly) aggression only in low-medium aggressive animals.Conclusions These results suggest that transiently enhancing brain oxytocin function has potent antiaggressive effects, whereas its attenuation tends to enhance aggressiveness. In addition, a possible inverse relationship between trait aggression and endogenous oxytocinergic signaling is revealed. Overall, this study emphasizes the importance of brain oxytocinergic signaling for regulating intermale offensive aggression. This study supports the suggestion that oxytocin receptor agonists could clinically be useful for curbing heightened aggression seen in a range of neuropsychiatric disorders like antisocial personality disorder, autism, and addiction.

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Several studies have demonstrated a reduction in aggressive behaviors upon treatment with exogenous OT or an increase in such behaviors in animals genetically lacking OT or OTR.
“Several studies have employed the RI paradigm to demonstrate a reduction in aggressive behaviors upon treatment with exogenous OT (Calcagnoli et al., 2013, Calcagnoli et al., 2014, Calcagnoli et al., 2015, Jong et al., 2014, Karpova et al., 2016) or an increase in such behaviors in animals genetically lacking OT or OTR (Dhakar et al., 2012, Pagani et al., 2015, Ragnauth et al., 2005, Takayanagi et”
From Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors (2020) · cites this paper as Calcagnoli et al., 2013

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Authors: Calcagnoli, F., de Boer, S. F., Althaus, M., den Boer, J. A., & Koolhaas, J. M.
Affiliations: University Medical Center Groningen (NL)
University of Groningen (NL)
Corresponding author: Calcagnoli, Federica
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2013-04-28
Volume: 229
Issue: 4
Pages: 639-651
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-013-3124-7
OpenAlex: W2069557491
Semantic Scholar: 33f36f259200a44fec3edeee2a1d8d797a0e77f8
Cited by: 90
References: 116
Citations by year: 2025: 2 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 12 · 2014: 13 · 2013: 1
FWCI: 16.97
Type: journal article
Language: en
Open access: green
research.rug.nl
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, antiaggressive effects, male-male aggression, oxytocin receptor antagonist, intracerebroventricular administration, social exploration, social affiliation, aggressive personality, antisocial behavior
MeSH terms: Aggression, Animals, Behavior, Animal, Brain, Dose-Response Relationship, Drug, Injections, Intraventricular, Male, Oxytocin, Social Behavior, Signal Transduction, Receptors, Oxytocin, Rats

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Antiaggressive activity of central oxytocin in male rats

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