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Bile Acids as Hormones: The FXR-FGF15/19 Pathway
Open accessAbstract
While it has long been recognized that bile acids are essential for solubilizing lipophilic nutrients in the small intestine, the discovery in 1999 that bile acids serve as ligands for the nuclear receptor farnesoid X receptor (FXR) opened the floodgates in terms of characterizing their actions as selective signaling molecules. Bile acids act on FXR in ileal enterocytes to induce the expression of fibroblast growth factor (FGF)15/19, an atypical FGF that functions as a hormone. FGF15/19 subsequently acts on a cell surface receptor complex in hepatocytes to repress bile acid synthesis and gluconeogenesis, and to stimulate glycogen and protein synthesis. FGF15/19 also stimulates gallbladder filling. Thus, the bile acid-FXR-FGF15/19 signaling pathway regulates diverse aspects of the postprandial enterohepatic response. Pharmacologically, this endocrine pathway provides exciting new opportunities for treating metabolic disease and bile acid-related disorders such as primary biliary cirrhosis and bile acid diarrhea. Both FXR agonists and FGF19 analogs are currently in clinical trials.
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In the citing paper
“FGF19 has the potential to regulate several pathways involved in NASH pathogenesis since it can act on CYP7A1, the rate limiting enzyme in BA synthesis from cholesterol, in addition to mimicking the effect of insulin on glycogen synthesis and gluconeogenesis [258].”
From Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH (2020) · cites this paper as [258]
In the citing paper
“FGF19 has the potential to regulate several pathways involved in NASH pathogenesis since it can act on CYP7A1, the rate limiting enzyme in BA synthesis from cholesterol, in addition to mimicking the effect of insulin on glycogen synthesis and gluconeogenesis [258].”
From Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH (2020) · cites this paper as [258]
In the citing paper
“FGF19 is an endocrine hormone that is induced in the gut by activation of FXR.10”
From NGM282 for Treatment of Patients With Primary Biliary Cholangitis: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Trial (2018) · cites this paper as [10]
In the citing paper
“FGF19 expression is induced in response to FXR activation in the ileum.10”
From NGM282 for Treatment of Patients With Primary Biliary Cholangitis: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Trial (2018) · cites this paper as [10]
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Identification of a nuclear receptor for bile acids
Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714
Self-citationBile Acids: Natural Ligands for an Orphan Nuclear Receptor
Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274
Self-citationA regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940
Self-citationFibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865
Self-citationTargeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636
A G Protein-coupled Receptor Responsive to Bile Acids
Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487
Self-citationBile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
渡辺, 光., Houten, S. M., Wang, L., Moschetta, A., Mangelsdorf, D. J., Heyman, R. A., Moore, D. D., & Auwerx, J. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21025 · Cited by 1,425
Self-citationIdentification of a nuclear receptor that is activated by farnesol metabolites
Forman, B. M., Goode, E., Chen, J., Oro, A. E., Bradley, D. J., Perlmann, T., Noonan, D. J., Burka, L. T., McMorris, T., Lamph, W. W., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90530-8 · Cited by 1,210
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Host response to cholestyramine can be mediated by the gut microbiotaPreprint
Newman, N. K., Monnier, P. M., Rodrigues, R. R., Gurung, M., Vasquez‐Perez, S., Hioki, K. A., Greer, R. L., Brown, K., Morgun, A., & Shulzhenko, N. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.08.416487 · Cited by 7
Zhang, M., Zhong, J., Shen, Y., & Song, Z. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1533141 · Cited by 7
Primary biliary cholangitis. Treatment options in 2025. A narrative review
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Guo, Y., Qiao, R., Xie, G., Yao, Y., Du, C., Shao, Y., Guan, Y., & Zhang, X. (2024) · Kidney Diseases · doi:10.1159/000538107 · Cited by 6
Wang, Y., Bendre, S. V., Krauklis, S. A., Steelman, A. J., & Nelson, E. R. (2025) · Endocrinology · doi:10.1210/endocr/bqaf031 · Cited by 6
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Alonso‐Peña, M., Espinosa-Escudero, R. A., Hermanns, H. M., Briz, Ó., Herranz, J. M., García‐Ruiz, C., Fernández-Checa, J. C., Juampérez, J., Avila, M. A., Argemí, J., et al. (2022) · Cells · doi:10.3390/cells11243983 · Cited by 6
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Xenobiotic and endobiotic handling by the mucosal immune system
Chen, M. L., & Sundrud, M. S. (2018) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000478 · Cited by 6
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Charach, L., Charach, G., Karniel, E., Galin, L., Bar-Ziv, D., Grossman, L., Kaye, I., & Grosskopf, I. (2023) · Bioengineering · doi:10.3390/bioengineering10080935 · Cited by 5
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Zhang, J., Gong, Y., Zhu, Y., Zeng, Q., Zhang, H., Han, R., Guo, Y., Li, D., Tian, Y., Kang, X., et al. (2024) · Poultry Science · doi:10.1016/j.psj.2024.104746 · Cited by 5
Bile Acids and TGR5 (Gpbar1) Signaling
Keitel, V., Gertzen, C. G. W., Schäfer, S., Klindt, C., Wöhler, C., Deutschmann, K., Reich, M., Gohlke, H., & Häussinger, D. (2020) · Springer eBooks · doi:10.1007/978-3-030-39684-8_4 · Cited by 7
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Wolf, S., Nagler, M., & Osto, E. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108320 · Cited by 5
Yang, Y., Jiao, L., Huang, Y., Shang, H., Li, E., Chang, H., Cui, H., & Wan, Y. (2025) · Environmental Health Perspectives · doi:10.1289/ehp15435 · Cited by 4
Zhang, S., Huang, Z., Wang, X., Lu, X., Xie, Q., Su, Z., Xie, J., Chen, J.-N., & Chen, L. (2026) · Food & Function · doi:10.1039/d5fo03052h · Cited by 4
Levy, C., Caldwell, S. H., Mantry, P., Luketic, V. A., Landis, C. S., Huang, J., Mena, E., Maheshwari, R., Rank, K. M., Xu, J., et al. (2024) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000744 · Cited by 5
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Yang, Y., Yu, S., Rong, H., Lei, Z., Yang, C., Wu, H., Zhang, T., Yang, F., Nie, Y., Chen, L., et al. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12650 · Cited by 4
Han, B., Kim, B.-K., Kim, K., & Fang, S. (2016) · Animal Cells and Systems · doi:10.1080/19768354.2016.1211175 · Cited by 4
Teng, T., Sun, G., Song, X., & Shi, B. (2022) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13739 · Cited by 4
He, H., & Wu, J. J. (2023) · Drugs in R&D · doi:10.1007/s40268-023-00444-4 · Cited by 5
Meroni, M., Panera, N., Paolini, E., Longo, M., Tiano, F., Stefanis, C. D., Doria, V., Mosca, A., Badiali, S., Maggioni, M., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101717 · Cited by 3
Ma, Y., Wang, Q., LIU, L., & Jia, J. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152354 · Cited by 3
Ren, X., Yang, P., Sun, L., Jia, Y., Zhong, C., Zhang, J., Zhang, Q., Xu, T., Zheng, X., & Zhang, Y. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.03.013 · Cited by 3
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Nonogaki, K., & Kaji, T. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1080790 · Cited by 3
Kim, D.-H., Lee, K., Park, J., Chi, S., Han, J., Bang, Y., Kim, S.-M., Kang, S. G., Cha, S.-H., & Han, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115587 · Cited by 3
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Sun, Y., Sun, K., Ling, H., & Xia, Q. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5551 · Cited by 4
Tacer, K. F. (2020) · Springer eBooks · doi:10.1007/978-3-030-39684-8_6 · Cited by 3
Jiang, M. (2022) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/3822 · Cited by 3
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Shearn, C. T., Anderson, A. L., Devereaux, M. W., Koch, S. D., Larsen, L. D., Spencer, L. A., Orlicky, D. J., Colgan, S. P., Steiner, C. A., & Sokol, R. J. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000589 · Cited by 2
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Freemark, M., & Collins, S. (2017) · Contemporary Endocrinology · doi:10.1007/978-3-319-68192-4_7 · Cited by 2
Xu, J., Wang, Y., Yin, J., Yin, M., Wang, M., & Liu, J. (2018) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20187312 · Cited by 2
Expression of Halo-hFGF18 and study of its effect on differentiation of ATDC5 cells
Xu, N., Wang, B. H., Zhou, Q., Ouyang, Y., Gong, W., Tian, H., Li, X., & Jiang, C. (2018) · Protein Expression and Purification · doi:10.1016/j.pep.2018.10.010 · Cited by 2
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Kim, B., & Kim, B. K. (2023) · Kosin Medical Journal · doi:10.7180/kmj.23.138 · Cited by 2
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Truong, V. N. Y., Liu, C., Myers, J., Miller, M., Yang, A., Lee, J.-H., Welborn, N. D., & Johnston, A. N. (2024) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.17165 · Cited by 2
Sahu, S., Nath, P., Mallick, B., Praharaj, D., Giri, S., Panigrahi, S., Anand, A., & Sahu, M. (2025) · Cureus · doi:10.7759/cureus.97523 · Cited by 2
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Li, L., Sun, W., Tan, T., Xu, J., Chen, Y., Chen, Y., Gao, G., Ai, X., Zhou, J., Li, Y., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07826-7 · Cited by 1
Site-specific bidirectional regulation of Fgf15 transcription in the mouse ileum
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Reynolds, A., Glenn, E., Lavoie, B. A., Ishaq, S. L., & Li, Y. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1815972 · Cited by 1
Ravikumar, A., & Sabarathinam, S. (2026) · Biochimie · doi:10.1016/j.biochi.2026.06.001 · Cited by 1
Mózes, B., Kiss, G., Fóthi, Á., Ferenczi, S., & Psáder, R. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2026.1829399 · Cited by 1
Verespejova, A. I., Grendár, M., Kertys, M., Hunarova, N., Chien, L. S., Grofik, M., Škorvanová, M., Šofránko, J., Žideková, N., Kurča, E., et al. (2026) · Biomolecules · doi:10.3390/biom16060875 · Cited by 1
Li, J., de Vries, H. D., Ustyantsev, K., Hovingh, M. V., Mulder, N. L., Havinga, R., Huijkman, N., Falcone, S., de Bruyn, K., Weersing, E., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101088 · Cited by 1
Adiga, U., Vasishta, S., Adiga, S., & Augustine, A. A. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11124-5 · Cited by 1
Yoon, S. J., Eom, J. A., & Suk, K. T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1864805 · Cited by 1
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Feng, C. C., Zhang, A. H., Miao, J., Sun, H., Han, Y., Gl, Y. G., Wu, F. F., & Wang, X. (2018) · Open Journal of Proteomics and Genomics · doi:10.17352/ojpg.000007 · Cited by 1
Setchell, K. D. R., & Kohli, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-37591-7.00002-1 · Cited by 1
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Абатуров, А. Е., & Никулина, А. А. (2020) · Педиатрия Восточная Европа · doi:10.34883/pi.2020.8.2.013 · Cited by 1
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Ahadi, S., Gharekhani, A., & Shiva, A. (2019) · Arab Journal of Gastroenterology · doi:10.1016/j.ajg.2019.11.004 · Cited by 1
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Pitchumoni, C. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-30192-7_6 · Cited by 1
Olkkonen, V. M. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.03.023 · Cited by 1
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Sayin, S. I. (2016) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Efecto de los glucocorticoides sobre la vía de señalización enterohepática de FXR/FGF19
Alaqil, F. A. (2017) · Gredos (University of Salamanca) · doi:10.14201/gredos.135701
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Xu, Y., Zhang, Y., & Xu, C. (2020) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v28.i9.341
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Tovar‐Palacio, C., Noriega, L. G., Torre-Villalvazo, I., Díaz‐Villaseñor, A., & Palacios‐González, B. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160608-00094
Quigley, E. M. M. (2016) · CRC Press eBooks · doi:10.1201/b20188-19
Endoplasmic reticulum stress in intestinal inflammation: implications of bile acids
Eugene, S. P., & Trinath, J. (2021) · Proceedings of the Indian National Science Academy · doi:10.1007/s43538-021-00031-8
Jen, P. Y. P., Akhrass, F. A., Ashby, H. E., Helphenstine, N., Gulley, N., Bentley, N., Shepherd, E., Williams, R., Pray, N., Akhrass, C. A., et al. (2022) · European Journal of Anatomy · doi:10.52083/rigu3109
Bayram, M., İrak, K., Çifçi, S., Köksal, A. R., Kazezoğlu, C., Acar, Z., Özarı, H. O., & Alkım, H. (2022) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2022.2028275
Yang, A., Zhu, X., Zhang, L., Zhang, Y., Zhang, D., Niu, J., Zhang, H., Ding, Y., & Lv, G. (2022) · Research Square · doi:10.21203/rs.3.rs-1428925/v1
Nonogaki, K., & Kaji, T. (2022) · Research Square · doi:10.21203/rs.3.rs-1769210/v1
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Cook, J. R., Green, P. H. R., & Haeusler, R. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.30.518512
Lacaze, L., Picot, D., & Thibault, R. (2023) · Springer eBooks · doi:10.1007/978-3-031-22265-8_43
Chen, J., Wang, R., Xiong, F., Sun, H., KEMPER, B. W., Li, W., & Kemper, J. K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.20.567833
Chen, J., Wang, R., Xiong, F., Sun, H., KEMPER, B. W., Li, W., & Kemper, J. K. (2024) · eLife · doi:10.7554/elife.91438.1
Chen, J., Wang, R., Xiong, F., Sun, H., KEMPER, B. W., Li, W., & Kemper, J. K. (2024) · eLife · doi:10.7554/elife.91438.2
Geng, X., Tian, W., Zhuang, M., Wang, R., Ma, W., Lin, R., Shang, H., Yu, Z., Shen, R., & Li, J. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250283
Research Progress on the Effects of FXR on the Development of Colorectal Cancer
钱, 奕. (2024) · Hans Journal of Biomedicine · doi:10.12677/hjbm.2024.144066
Wang, X., Zhao, X., Zhang, M., Han, C., Li, D., Wu, Y.-Z., Guo, P., Feng, L., Ma, X., & Wang, C. (2024) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2024.136789
GPR146 regulates CYP7A1 transcription in cells and in vivo of mice
Liu, X., Han, J., Li, X., Zhang, Z., Li, J., & Yao, Y. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152045
Cholecystectomy effect on the digestive system
Наджафова, К. Н., Gnutov, A. A., Kizimova, O. A., Sousova, Y. V., Fominykh, Y. A., & Майорова, А. М. (2025) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-234-2-234-242
Gut microbiota and mental issues in humans
Singh, J., Mistry, C. R., Sharma, A., Baiju, A., Kumar, B., Maji, A., Sharma, M., Singh, A., Prasad, V., Lalbiaktluangi, C., et al. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29932-2.00013-x
Dong, D., Shen, W., Bittner, S., Chen, J., Xiao, H., Donowitz, M., Kraemer, F. B., & Azhar, S. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00716.2025
Gut Microbiota Composition Correlates to Trunk Fat Percentage in Male Cynomolgus Macaque Monkeys
Lützhøft, D. O., Jakobsen, R. R., Stefanova, D. V., Pedersen, K., Nielsen, D. S., Christoffersen, B. Ø., Bader, L., Kirigiti, M. A., Straarup, E. M., Kievit, P., et al. (2025) · Clinical and Translational Science · doi:10.1111/cts.70393
Shi, L., Zhao, T., Huang, L., Pan, X., Wu, T., Feng, X., Chen, T., Wu, J., & Niu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26622472
Beyond the lungs: what CF sheep reveal about liver disease in cystic fibrosis
Bradbury, N. A. (2026) · Physiological Genomics · doi:10.1152/physiolgenomics.00310.2025
Homéostasie des céramides et hépatopathies métaboliques
Régnier, M. (2018) · theses.fr (ABES) · doi:10.70675/2fb92711z373cz4b27z8082z7aa3f8930e63
Hypercholestérolémie familiale : recherche de nouveaux gènes et étude des formes polygéniques
Ghaleb, Y. (2017) · theses.fr (ABES) · doi:10.70675/ab0b16eez4c40z4cb7zb42fzb7740e0c98ea
Metadata
- Authors
- Kliewer, S. A., & Mangelsdorf, D. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Venue
- Digestive Diseases
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 33
- Issue
- 3
- Pages
- 327-331
- ISSN
- 0257-2753 (ISSN-L)
- 1421-9875
- PMC
- PMC4465534
- OpenAlex
- W1555526329
- Cited by
- 424
- References
- 51
- Citations by year
- 2026: 39 · 2025: 38 · 2024: 51 · 2023: 41 · 2022: 39 · 2021: 58 · 2020: 51 · 2019: 34 · 2018: 29 · 2017: 33 · 2016: 7 · 2015: 4
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Digestive Diseases (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-067158, R01DK067158)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- bile acids, farnesoid X receptor, FGF15/19, bile acid signaling, enterohepatic circulation, postprandial metabolism, bile acid synthesis, gluconeogenesis, gallbladder filling, FXR agonists, primary biliary cirrhosis, bile acid diarrhea, metabolic disorders
- MeSH terms
- Receptor, Farnesoid X-Activated, Animals, Bile Acids and Salts, Cholesterol 7-alpha-Hydroxylase, Fibroblast Growth Factors, Gene Expression Regulation, Gluconeogenesis, Glycogen, Homeostasis, Humans, Insulin Resistance, Signal Transduction, Receptors, Cytoplasmic and Nuclear, Enterocytes, Lipid Metabolism, Mice
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