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Bile Acids as Hormones: The FXR-FGF15/19 Pathway
Open accessAbstract
While it has long been recognized that bile acids are essential for solubilizing lipophilic nutrients in the small intestine, the discovery in 1999 that bile acids serve as ligands for the nuclear receptor farnesoid X receptor (FXR) opened the floodgates in terms of characterizing their actions as selective signaling molecules. Bile acids act on FXR in ileal enterocytes to induce the expression of fibroblast growth factor (FGF)15/19, an atypical FGF that functions as a hormone. FGF15/19 subsequently acts on a cell surface receptor complex in hepatocytes to repress bile acid synthesis and gluconeogenesis, and to stimulate glycogen and protein synthesis. FGF15/19 also stimulates gallbladder filling. Thus, the bile acid-FXR-FGF15/19 signaling pathway regulates diverse aspects of the postprandial enterohepatic response. Pharmacologically, this endocrine pathway provides exciting new opportunities for treating metabolic disease and bile acid-related disorders such as primary biliary cirrhosis and bile acid diarrhea. Both FXR agonists and FGF19 analogs are currently in clinical trials.
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“FGF19 has the potential to regulate several pathways involved in NASH pathogenesis since it can act on CYP7A1, the rate limiting enzyme in BA synthesis from cholesterol, in addition to mimicking the effect of insulin on glycogen synthesis and gluconeogenesis [258].”
From Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH (2020) · cites this paper as [258]
In the citing paper
“FGF19 has the potential to regulate several pathways involved in NASH pathogenesis since it can act on CYP7A1, the rate limiting enzyme in BA synthesis from cholesterol, in addition to mimicking the effect of insulin on glycogen synthesis and gluconeogenesis [258].”
From Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH (2020) · cites this paper as [258]
In the citing paper
“FGF19 is an endocrine hormone that is induced in the gut by activation of FXR.10”
From NGM282 for Treatment of Patients With Primary Biliary Cholangitis: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Trial (2018) · cites this paper as [10]
In the citing paper
“FGF19 expression is induced in response to FXR activation in the ileum.10”
From NGM282 for Treatment of Patients With Primary Biliary Cholangitis: A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Trial (2018) · cites this paper as [10]
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Identification of a nuclear receptor for bile acids
Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714
Self-citationBile Acids: Natural Ligands for an Orphan Nuclear Receptor
Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274
Self-citationA regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940
Self-citationFibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865
Self-citationTargeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636
A G Protein-coupled Receptor Responsive to Bile Acids
Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487
Self-citationBile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
渡辺, 光., Houten, S. M., Wang, L., Moschetta, A., Mangelsdorf, D. J., Heyman, R. A., Moore, D. D., & Auwerx, J. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21025 · Cited by 1,425
Self-citationIdentification of a nuclear receptor that is activated by farnesol metabolites
Forman, B. M., Goode, E., Chen, J., Oro, A. E., Bradley, D. J., Perlmann, T., Noonan, D. J., Burka, L. T., McMorris, T., Lamph, W. W., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90530-8 · Cited by 1,210
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Huang, F., Zheng, X., Ma, X., Jiang, R., Zhou, W., Zhou, S., Zhang, Y., Lei, S., Wang, S., Kuang, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12896-x · Cited by 799
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Samuel, V. T., & Shulman, G. I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.002 · Cited by 745
“However, FXR also regulates the expression of numerous metabolic pathways, including gluconeogenesis and lipogenesis (Kliewer and Mangelsdorf, 2015).”
The gut–liver axis and gut microbiota in health and liver disease
Hsu, C. L., & Schnabl, B. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00904-3 · Cited by 737
Diversification of host bile acids by members of the gut microbiota
Winston, J. A., & Theriot, C. M. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1674124 · Cited by 597
Bile acid metabolism and signaling, the microbiota, and metabolic disease
Cai, J., Rimal, B., Jiang, C., Chiang, J. Y. L., & Patterson, A. D. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108238 · Cited by 529
Harrison, S. A., Rinella, M. E., Abdelmalek, M. F., Trotter, J. F., Paredes, A. H., Arnold, H. L., Kugelmas, M., Bashir, M. R., Jaros, M. J., Ling, L., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30474-4 · Cited by 425
Bile acids as modulators of gut microbiota composition and function
Larabi, A. B., Masson, H. L. P., & Bäumler, A. J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2172671 · Cited by 443
An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease
Gonzalez, F. J., Jiang, C., & Patterson, A. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.08.057 · Cited by 382
Roth, K., Yang, Z., Agarwal, M., Liu, W. J., Peng, Z., Long, Z., Birbeck, J. A., Westrick, J. A., Liu, W., & Petriello, M. C. (2021) · Environment International · doi:10.1016/j.envint.2021.106843 · Cited by 322
Emerging roles of bile acids in mucosal immunity and inflammation
Chen, M. L., Takeda, K., & Sundrud, M. S. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0162-4 · Cited by 305
Bile acid signaling pathways from the enterohepatic circulation to the central nervous system
Mertens, K. L., Kalsbeek, A., Soeters, M. R., & Eggink, H. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00617 · Cited by 287
A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis
Kowdley, K. V., Luketic, V., Chapman, R., Hirschfield, G. M., Poupon, R., Schramm, C., Vincent, C., Rust, C., Parés, A., Mason, A., et al. (2018) · Hepatology · doi:10.1002/hep.29569 · Cited by 281
Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis
Schneider, E., O’Riordan, K. J., Clarke, G. A., & Cryan, J. F. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01108-6 · Cited by 317
Harrison, S. A., Neff, G., Guy, C. D., Bashir, M. R., Paredes, A. H., Frias, J. P., Younes, Z., Trotter, J. F., Gunn, N. T., Moussa, S. E., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.08.004 · Cited by 280
Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease
Hegyi, P., Maléth, J., Walters, J. R., Hofmann, A. F., & Keely, S. J. (2018) · Physiological Reviews · doi:10.1152/physrev.00054.2017 · Cited by 269
Dietary fat, bile acid metabolism and colorectal cancer
Ocvirk, S., & O’Keefe, S. J. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.10.003 · Cited by 266
Natural history of metabolic dysfunction-associated steatotic liver disease.
Lekakis, V., & Papatheodoridis, G. (2023) · European journal of internal medicine · doi:10.1016/j.ejim.2023.11.005 · Cited by 222
Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance
Preidis, G. A., Kim, K. H., & Moore, D. D. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88893 · Cited by 203
Molecular basis of bile acid-FXR-FGF15/19 signaling axis
Katafuchi, T., & Makishima, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116046 · Cited by 193
FXR agonists in NASH treatment
Adorini, L., & Trauner, M. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.07.034 · Cited by 200
Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders
Rastelli, M., Knauf, C., & Cani, P. D. (2018) · Obesity · doi:10.1002/oby.22175 · Cited by 191
Hirschfield, G. M., Chazouillères, O., Drenth, J. P., Thorburn, D., Harrison, S. A., Landis, C. S., Mayo, M. J., Muir, A. J., Trotter, J. F., Leeming, D. J., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.035 · Cited by 187
Tang, S.-P., Mao, X., Chen, Y., Yan, L., Ye, L., & Li, S.-W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.870239 · Cited by 194
Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform
Kozuka, K., He, Y., Koo-McCoy, S., Kumaraswamy, P., Nie, B., Shaw, K., Chan, P., Leadbetter, M., He, L., Lewis, J. G., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.013 · Cited by 179
Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease
Yan, C., Hu, W., Tu, J., Li, J., Liang, Q., & Han, S. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04166-8 · Cited by 195
Zhou, M., Learned, R. M., Rossi, S. J., DePaoli, A. M., Tian, H., & Ling, L. (2017) · Hepatology Communications · doi:10.1002/hep4.1108 · Cited by 152
Harrison, S. A., Abdelmalek, M. F., Neff, G., Gunn, N., Guy, C. D., Alkhouri, N., Bashir, M. R., Freilich, B., Kohli, A., Khazanchi, A., et al. (2022) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(22)00017-6 · Cited by 148
The intestine as an endocrine organ and the role of gut hormones in metabolic regulation
Bany Bakar, R., Reimann, F., & Gribble, F. M. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00830-y · Cited by 144
Metabolic Targets in Nonalcoholic Fatty Liver Disease
Esler, W. P., & Bence, K. K. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.04.007 · Cited by 145
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de Boer, J. F., Schonewille, M., Boesjes, M., Wolters, H., Bloks, V. W., Bos, T., van Dijk, T. H., Jurdzinski, A., Boverhof, R., Wolters, J. C., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.12.037 · Cited by 142
Bile acid receptors in the biliary tree: TGR5 in physiology and disease
Deutschmann, K., Reich, M., Klindt, C., Dröge, C., Spomer, L., Häussinger, D., & Keitel, V. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.08.021 · Cited by 141
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Sydor, S., Best, J., Messerschmidt, I., Manka, P., Vilchez-Vargas, R., Brodesser, S., Lucas, C., Wegehaupt, A., Wenning, C., Aßmuth, S., et al. (2020) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000131 · Cited by 127
The Gut–Liver Axis in the Control of Energy Metabolism and Food Intake in Animals
Ringseis, R., Geßner, D. K., & Eder, K. (2019) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-021419-083852 · Cited by 129
Mayo, M. J., Wigg, A. J., Leggett, B. A., Arnold, H., Thompson, A. J., Weltman, M., Carey, E. J., Muir, A. J., Ling, L., Rossi, S. J., et al. (2018) · Hepatology Communications · doi:10.1002/hep4.1209 · Cited by 125
Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
Zhou, M., Yang, H., Learned, R. M., Tian, H., & Ling, L. (2017) · Nature Communications · doi:10.1038/ncomms15433 · Cited by 123
Mu, W., Cheng, X., Liu, Y., Lv, Q., Gao-lin, L., Zhang, J.-G., & Li, X. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01566 · Cited by 127
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids
Liu, C., Du, M., Xie, L., Wang, W.-Z., Chen, B., Yun, C., Sun, X., Luo, X., Jiang, Y., Wang, K., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01570-0 · Cited by 129
Bile acids as inflammatory mediators and modulators of intestinal permeability
Calzadilla, N., Comiskey, S., Dudeja, P. K., Saksena, S., Gill, R. K., & Alrefai, W. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1021924 · Cited by 123
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Chen, X., Huang, X., Wang, D., Yu, D., Hou, S., Cui, H., & Song, L. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01053-z · Cited by 128
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Gut-liver axis signaling in portal hypertension
Simbrunner, B., Mandorfer, M., Trauner, M., & Reiberger, T. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i39.5897 · Cited by 113
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Merk, D., Sreeramulu, S., Kudlinzki, D., Saxena, K., Linhard, V. L., Gande, S. L., Hiller, F., Lamers, C., Nilsson, E., Aagaard, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10853-2 · Cited by 111
Dana, J., Debray, D., Bèaufrere, A., Hillaire, S., Fabrè, M., Reinhold, C., Baumert, T. F., Berteloot, L., & Vilgrain, V. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.09.042 · Cited by 109
Koutsos, A., Riccadonna, S., Ulaszewska, M., Franceschi, P., Trôst, K., Galvin, A., Braune, T., Fava, F., Perenzoni, D., Mattivi, F., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz282 · Cited by 117
Lü, H. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.07.003 · Cited by 106
Role of TGR5 (GPBAR1) in Liver Disease
Häussinger, D., & Keitel, V. (2018) · Seminars in Liver Disease · doi:10.1055/s-0038-1669940 · Cited by 106
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Ji, S., Liu, Q., Zhang, S., Chen, Q., Wang, C., Zhang, W., Chen, X., Li, Y., Nian, C., Li, J., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2018.12.021 · Cited by 106
Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling
Qiu, Y., Yu, J., Li, Y., Yang, F., Yu, H., Xue, M., Zhang, F., Jiang, X., Ji, X., & Bao, Z. (2021) · Annals of Medicine · doi:10.1080/07853890.2021.1900593 · Cited by 112
The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice
Sasaki, T., Kuboyama, A., Mita, M., Murata, S., Shimizu, M., Inoue, J., Mori, K., & Sato, R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002733 · Cited by 109
Keitel, V., Dröge, C., & Häussinger, D. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_231 · Cited by 106
Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15
Zhou, M., Luo, J., Chen, M., Yang, H., Learned, R. M., DePaoli, A. M., Tian, H., & Ling, L. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.01.027 · Cited by 102
The hypothalamus for whole-body physiology: from metabolism to aging
Liu, T., Xu, Y., Yi, C., Tong, Q., & Cai, D. (2021) · Protein & Cell · doi:10.1007/s13238-021-00834-x · Cited by 109
Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease
Puengel, T., Liu, H., Guillot, A., Heymann, F., Tacke, F., & Peiseler, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052668 · Cited by 95
Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease
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Henriksson, E., & Andersen, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601349 · Cited by 97
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Loomba, R., Ling, L., Dinh, D. M., DePaoli, A. M., Lieu, H. D., Harrison, S. A., & Sanyal, A. J. (2021) · Hepatology · doi:10.1002/hep.31523 · Cited by 88
Zietek, T., Giesbertz, P., Ewers, M., Reichart, F., Weinmüller, M., Urbauer, E., Haller, D., Demir, İ. E., Ceyhan, G. O., Kessler, H., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.577656 · Cited by 92
Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism
Xu, Y., Li, Y., Jadhav, K. S., Pan, X., Zhu, Y., Hu, S., Chen, S., Chen, L., Tang, Y., Wang, H. H., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-020-00331-1 · Cited by 91
Liu, S., Marcelin, G., Blouet, C., Jeong, J. H., Jo, Y., Schwartz, G. J., & Chua, S. C. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.12.003 · Cited by 89
McIlvride, S., Dixon, P. H., & Williamson, C. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.05.003 · Cited by 90
Song, L., Hou, Y., Xu, D., Dai, X., Luo, J., Liu, Y., Huang, Z., Yang, M., Chen, J., Hu, Y., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.09.008 · Cited by 91
Calderón, G., MCRAE, A. N., Rievaj, J., Davis, J. A., Zandvakili, I., Nord, S. L., Burton, D. B., Roberts, G. P., Reimann, F. M., Gedulin, B. R., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102759 · Cited by 83
The interrelationship between bile acid and vitamin A homeostasis
Saeed, A., Hoekstra, M., Hoeke, M. O., Heegsma, J., & Faber, K. N. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.01.007 · Cited by 85
Kim, Y.-C., Seok, S., Zhang, Y., Ma, J., Kong, B., Guo, G. L., Kemper, B., & Kemper, J. (2020) · Nature Communications · doi:10.1038/s41467-020-19803-9 · Cited by 73
Sanyal, A. J., Ling, L., Beuers, U. H., DePaoli, A. M., Lieu, H. D., Harrison, S. A., & Hirschfield, G. M. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100255 · Cited by 80
Tudela, H., Claus, S. P., & Saleh, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.719072 · Cited by 81
Rinella, M. E., Trotter, J. F., Abdelmalek, M. F., Paredes, A. H., Connelly, M. A., Jaros, M. J., Ling, L., Rossi, S. J., DePaoli, A. M., & Harrison, S. A. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.11.032 · Cited by 83
β-Klotho gene variation is associated with liver damage in children with NAFLD
Dongiovanni, P., Crudele, A., Panera, N., Romito, I., Meroni, M., Stefanis, C. D., Palma, A., Comparcola, D., Fracanzani, A. L., Miele, L., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.10.011 · Cited by 78
Wu, L., Zhou, J., Zhou, A., Lei, Y., Tang, L., Hu, S., Wang, S., Xu, X., Chen, Q., Tu, D., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2390176 · Cited by 83
Byun, S., Kim, D.-H., Ryerson, D., Kim, Y., Sun, H., Kong, B., Yau, P. M., Guo, G. L., Xu, H. E., KEMPER, B. W., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04697-5 · Cited by 76
Kundi, Z. M., Lee, J. C., Pihlajamäki, J., Chan, C. B., Leung, K. S., So, S. S. Y., Nordlund, E., Kolehmainen, M., & El-Nezami, H. S. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900580 · Cited by 77
A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling
Shulpekova, Y. O., Shirokova, E. N., Жаркова, М. С., Tkachenko, P. E., Тихонов, И. Н., Stepanov, A. A., Sinitsyna, A. A., Izotov, A., Butkova, T. V., Shulpekova, N. V., et al. (2022) · Molecules · doi:10.3390/molecules27061983 · Cited by 77
Role of the microbiota–gut–heart axis between bile acids and cardiovascular disease
Zhang, Z., Lv, T., Wang, X., Wu, M., Zhang, R., Yang, X., Fu, Y., & Liu, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116567 · Cited by 79
Novel and emerging therapies for cholestatic liver diseases
Goldstein, J., & Levy, C. (2018) · Liver International · doi:10.1111/liv.13880 · Cited by 74
Regulation of bile acid receptor activity
Wan, Y. Y., & Sheng, L. (2018) · Liver Research · doi:10.1016/j.livres.2018.09.008 · Cited by 75
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Bile acids and cardiovascular function in cirrhosis
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DePaoli, A. M., Zhou, M., Kaplan, D. D., Hunt, S. C., Adams, T. D., Learned, R. M., Tian, H., & Ling, L. (2019) · Diabetes · doi:10.2337/db18-1305 · Cited by 65
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Struik, D., Dommerholt, M. B., & Jonker, J. W. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000599 · Cited by 61
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Lemons, J. M. S., Conrad, M. A., Tanes, C., Chen, J., Friedman, E. S., Roggiani, M., Curry, D., Chau, L., Hecht, A. L., Harling, L. C., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.09.005 · Cited by 60
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Metadata
- Authors
- Kliewer, S. A., & Mangelsdorf, D. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Venue
- Digestive Diseases
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 33
- Issue
- 3
- Pages
- 327-331
- ISSN
- 0257-2753 (ISSN-L)
- 1421-9875
- PMC
- PMC4465534
- OpenAlex
- W1555526329
- Cited by
- 424
- References
- 51
- Citations by year
- 2026: 39 · 2025: 38 · 2024: 51 · 2023: 41 · 2022: 39 · 2021: 58 · 2020: 51 · 2019: 34 · 2018: 29 · 2017: 33 · 2016: 7 · 2015: 4
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Digestive Diseases (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-067158, R01DK067158)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- bile acids, farnesoid X receptor, FGF15/19, bile acid signaling, enterohepatic circulation, postprandial metabolism, bile acid synthesis, gluconeogenesis, gallbladder filling, FXR agonists, primary biliary cirrhosis, bile acid diarrhea, metabolic disorders
- MeSH terms
- Receptor, Farnesoid X-Activated, Animals, Bile Acids and Salts, Cholesterol 7-alpha-Hydroxylase, Fibroblast Growth Factors, Gene Expression Regulation, Gluconeogenesis, Glycogen, Homeostasis, Humans, Insulin Resistance, Signal Transduction, Receptors, Cytoplasmic and Nuclear, Enterocytes, Lipid Metabolism, Mice
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