Prohedonic effect of cannabidiol in a rat model of depression
Abstract
BACKGROUND: Accumulating evidence suggests that cannabidiol (CBD) may be an effective and safe anxiolytic agent and potentially also an antidepressant. AIM: The objective of this study was to further examine these properties of CBD using the 'depressive-like' Wistar-Kyoto (WKY) rat, focusing on the drug's effect on anhedonia-like behaviors. METHODS: Forty-eight WKY and 48 control Wistar adult male rats were pretreated orally with CBD (15, 30 and 45 mg/kg) or vehicle. The saccharin preference test (SPT), the elevated plus maze (EPM) test and the novel object exploration (NOE) test were used. RESULTS: CBD showed a prohedonic effect on the WKY rats at 30 mg/kg in the SPT. In the NOE, CBD increased exploration of the novel object and locomotion at 45 mg/kg and increased locomotion at 15 mg/kg, indicating an improvement in the characteristically low motivation of WKY rats to explore. There was no similar effect at any dose in the EPM or in open-field behavior in the habituation to the NOE. CONCLUSIONS: These findings extend the limited knowledge on the antidepressant effect of CBD, now shown for the first time in a genetic animal model of depression. These results suggest that CBD may be beneficial for the treatment of clinical depression and other states with prominent anhedonia.
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CBD has antidepressant-like effects observed in the forced swimming stress, Wistar-Kyoto and bulbectomy models.
“These effects could be associated with the antidepressant-like effects of CBD observed in the forced swimming stress, (33, 34), Wistar-Kyoto (35) and bulbectomy models (36).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [35]
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- Authors
- Shoval, G., Shbiro, L., Hershkovitz, L., Hazut, N., Zalsman, G., Mechoulam, R., & Weller, A.
- Affiliations
- Geha Mental Health Center (IL)
- Columbia University (US)
- Hebrew University of Jerusalem (IL)
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 73
- Issue
- 2
- Pages
- 123-129
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W2314142999
- Cited by
- 110
- References
- 28
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 16 · 2023: 16 · 2022: 11 · 2021: 12 · 2020: 14 · 2019: 15 · 2018: 11 · 2017: 2 · 2016: 1
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kessler Foundation
- Bar-Ilan University
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- cannabidiol, depression, anhedonia, antidepressant effects, novel object exploration, elevated plus maze, locomotor activity, Wistar-Kyoto rats
- MeSH terms
- Analysis of Variance, Animals, Antidepressive Agents, Anxiety, Cannabidiol, Depressive Disorder, Disease Models, Animal, Dose-Response Relationship, Drug, Exploratory Behavior, Food Preferences, Male, Motor Activity, Rats, Inbred WKY, Saccharin, Rats, Wistar, Anhedonia
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