5‐HT1Areceptors are involved in the cannabidiol‐induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats
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BACKGROUND AND PURPOSE: Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa which induces anxiolytic- and antipsychotic-like effects in rodents. These effects could be mediated by facilitation of the endocannabinoid system or by the activation of 5-HT(1A) receptors. As either of these mechanisms could promote adaptation to inescapable stress, the aim of the present work was to test the hypothesis that CBD would attenuate the autonomic and behavioural consequences of restraint stress (RS). We also investigated if the responses to CBD depended on activation of 5-HT(1A) receptors. EXPERIMENTAL APPROACH: Male Wistar rats received i.p. injections of vehicle or CBD (1, 10 or 20 mg kg(-1)) and 30 min later were submitted to 60 min of restraint where their cardiovascular responses were recorded. The protocol of the second experiment was similar to the first one except that animals received i.p. injections of the 5-HT(1A) receptor antagonist WAY100635 (0.1 mg kg(-1)) before CBD treatment and exposure to restraint. 24 h later they were also tested in the elevated plus-maze (EPM), an animal model of anxiety. KEY RESULTS: Exposure to RS increased blood pressure and heart rate and induced an anxiogenic response in the EPM 24 h later. These effects were attenuated by CBD. WAY100635 by itself did not change the cardiovascular and anxiogenic response to RS, but blocked the effects of CBD. CONCLUSION AND IMPLICATIONS: The results suggest that CBD can attenuate acute autonomic responses to stress and its delayed emotional consequences by facilitating 5-HT(1A) receptor-mediated neurotransmission.
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The acute effects of CBD clearly depend on facilitation of serotonin 5HT1A receptor-mediated neurotransmission in defense-related areas.
“The acute effects of CBD clearly depend on facilitation of serotonin 5HT1A receptor-mediated neurotransmission in defense-related areas (28, 31, 39, 40, 42, 43, 46, 47).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [31]
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Cites
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822 · see citing works
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092 · see citing works
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011 · see citing works
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · see citing works
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957 · see citing works
Guide to receptors and channels (GRAC), 5th edition
Alexander, S., Mathie, A., & Peters, J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01649_1.x · Cited by 1,947 · see citing works
Bisogno, T., Hanuš, L., PETROCELLIS, L. D., Tchilibon, S., Ponde, D. E., Brandi, I., Moriello, A. S., Davis, J. B., Mechoulam, R., & Marzo, V. D. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704327 · Cited by 1,315 · see citing works
Current advances and trends in the treatment of depression
Blier, P., & de Montigny, C. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90315-8 · Cited by 1,113 · see citing works
Ethological and temporal analyses of anxiety-like behavior: The elevated plus-maze model 20 years on
Carobrez, A. P., & Bertoglio, L. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.017 · Cited by 993 · see citing works
Role of 5-HT in stress, anxiety, and depression
Graeff, F. G., Guimarães, F. S., De Andrade, T. G. C. S., & Deakin, J. F. W. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02135-3 · Cited by 984 · see citing works
Self-citationThe neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 963 · see citing works
Stressor specificity of central neuroendocrine responses: implications for stress-related disorders
Pacák, K., & Palkovits, M. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0436 · Cited by 926 · see citing works
Agonistic properties of cannabidiol at 5-HT1a receptors
Russo, E. B., Burnett, A., Hall, B., & Parker, K. K. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6978-1 · Cited by 878 · see citing works
Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action
Marzo, V. D., Melck, D. J., Bisogno, T., & PETROCELLIS, L. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01283-1 · Cited by 704 · see citing works
Action of cannabidiol on the anxiety and other effects produced by ?9-THC in normal subjects
Zuardi, A. W., Shirakawa, I., Finkelfarb, E., & Karniol, I. G. (1982) · Psychopharmacology · doi:10.1007/bf00432554 · Cited by 608 · see citing works
Pharmacological Actions of Cannabinoids
Pertwee, R. G. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_1 · Cited by 600 · see citing works
Is there a role for 5-HT1A agonists in the treatment of depression?
Blier, P., & Ward, N. M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01643-8 · Cited by 529 · see citing works
Vergé, D., Daval, G., Marcinkiewicz, M. M., Patey, A., Mestikawy, S. E., GOZLAN, H., & Hamon, M. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-12-03474.1986 · Cited by 518 · see citing works
Cannabidiol: An Overview of Some Pharmacological Aspects
Mechoulam, R., Parker, L. A., & Gallily, R. (2002) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.2002.tb05998.x · Cited by 511 · see citing works
Guide to Receptors and Channels (GRAC), 3rd edition
Alexander, S. P. H., Mathie, A. A., & Peters, J. A. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707746 · Cited by 510 · see citing works
Mechoulam, R. (1970) · Science · doi:10.1126/science.168.3936.1159 · Cited by 494 · see citing works
Huestis, M. A., Gorelick, D. A., Heishman, S. J., Preston, K. L., Nelson, R. A., Moolchan, E. T., & Frank, R. A. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.322 · Cited by 479 · see citing works
Psychiatric effects of cannabis
Johns, A. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.2.116 · Cited by 472 · see citing works
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs
Martin, B. R., Compton, D. M., Thomas, B. F., Prescott, W. R., Little, P., Razdan, R. K., Johnson, M. R., Melvin, L. S., Mechoulam, R., & Ward Susan, J. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90349-7 · Cited by 410 · see citing works
Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug
Zuardi, A. W., Crippa, J. A. S., Hallak, J. E. C., Moreira, F. A., & Guimarães, F. S. (2006) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2006000400001 · Cited by 402 · see citing works
Self-citationChalmers, D. T., & Watson, S. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90748-k · Cited by 388 · see citing works
Vergé, D., Daval, G., Patey, A., GOZLAN, H., Mestikawy, S. E., & Hamon, M. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90099-8 · Cited by 385 · see citing works
Antianxiety effect of cannabidiol in the elevated plus-maze
Guimarães, F. S., Chiaretti, T. M., Graeff, F. G., & Zuardi, A. W. (1990) · Psychopharmacology · doi:10.1007/bf02244012 · Cited by 379 · see citing works
Campos, A. C., & Guimarães, F. S. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1168-x · Cited by 364 · see citing works
Self-citationChemical Basis of Hashish Activity
Mechoulam, R., Shani, A., Edery, H., & Grunfeld, Y. (1970) · Science · doi:10.1126/science.169.3945.611 · Cited by 331 · see citing works
Pharmacological characterization of cannabinoids in the elevated plus maze.
Onaivi, E. S., Green, M. R., & Martin, B. R. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13195-9 · Cited by 312 · see citing works
Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats
Lichtman, A. H., Dimen, K. R., & Martin, B. R. (1995) · Psychopharmacology · doi:10.1007/bf02246292 · Cited by 311 · see citing works
Cannabidiol interferes with the effects of Δ9-tetrahydrocannabinol in man
Karniol, I. G., Shirakawa, I., Kasinski, N., Pfeferman, A., & Carlini, E. A. (1974) · European Journal of Pharmacology · doi:10.1016/0014-2999(74)90129-0 · Cited by 303 · see citing works
A robust animal model of state anxiety: fear-potentiated behaviour in the elevated plus-maze
Korte, S. M., & de Boer, S. F. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01279-2 · Cited by 293 · see citing works
Altered Emotional States in Knockout Mice Lacking 5-HT1A or 5-HT1B Receptors
Zhuang, X. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00047-0 · Cited by 276 · see citing works
Enhancement of some 5-HT-dependent behavioural responses following repeated immobilization in rats
Kennett, G. A., Dickinson, S. L., & Curzon, G. (1985) · Brain Research · doi:10.1016/0006-8993(85)90684-5 · Cited by 254 · see citing works
Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects
Mechoulam, R., & Hanuš, L. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00144-5 · Cited by 250 · see citing works
Comparative Receptor Binding Analyses of Cannabinoid Agonists and Antagonists
Thomas, B. F., Gilliam, A. F., Burch, D. F., Roche, M. J., & Seltzman, H. H. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37365-3 · Cited by 242 · see citing works
File, S. E., Gonzalez, L. E., & Andrews, N. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-15-04810.1996 · Cited by 230 · see citing works
Kennett, G. A., Dourish, C. T., & Curzon, G. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90357-8 · Cited by 229 · see citing works
Mishima, K., Hayakawa, K., Abe, K., Ikeda, T., Egashira, N., Iwasaki, K., & Fujiwara, M. (2005) · Stroke · doi:10.1161/01.str.0000163083.59201.34 · Cited by 225 · see citing works
Compton, D. M., Johnson, M. R., Melvin, L. S., & Martin, B. R. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11216-0 · Cited by 216 · see citing works
Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test
Moreira, F. A., Aguiar, D. C., & Guimarães, F. S. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.004 · Cited by 207 · see citing works
Self-citationEffects of cannabidiol in animal models predictive of antipsychotic activity
Zuardi, A. W., Antunes Rodrigues, J., & Cunha, J. M. (1991) · Psychopharmacology · doi:10.1007/bf02244189 · Cited by 191 · see citing works
Resstel, L. B. M., Joca, S. R. L., Moreira, F. A., Corrêa, F. M. A., & Guimarães, F. S. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.016 · Cited by 182 · see citing works
Self-citationPetitet, F., Jeantaud, B., Reibaud, M., Impérato, A., & Dubroeucq, M. C. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00238-0 · Cited by 180 · see citing works
Kennett, G. A., Dickinson, S. L., & Curzon, G. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90290-0 · Cited by 175 · see citing works
Kim‐Mitsuyama, S., Yamamoto, E., Tanaka, T., Zhan, Y., Izumi, Y., Izumiya, Y., Ioroi, T., Wanibuchi, H., & Iwao, H. (2005) · Stroke · doi:10.1161/01.str.0000163084.16505.e3 · Cited by 173 · see citing works
Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids
Ilan, A. B., Gevins, A., Coleman, M., Elsohly, M., & de Wit, H. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00023 · Cited by 169 · see citing works
Pertwee, R. G., Ross, R. A., Craib, S. J., & Thomas, A. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02624-9 · Cited by 156 · see citing works
Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus
Tsetsenis, T., Ma, X.-H., Iacono, L. L., Beck, S. G., & Gross, C. T. (2007) · Nature Neuroscience · doi:10.1038/nn1919 · Cited by 147 · see citing works
Joca, S. R. L., Ferreira, F. R., & Guimarães, F. S. (2007) · Stress · doi:10.1080/10253890701223130 · Cited by 137 · see citing works
Self-citationRestraint-induced hypoactivity in an elevated plus-maze
Padovan, C. M., & Guimarães, F. S. (2000) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2000000100011 · Cited by 133 · see citing works
Self-citationAn Assessment of Anxiolytic Drug Screening Tests: Hormetic Dose Responses Predominate
Calabrese, E. J. (2008) · Critical Reviews in Toxicology · doi:10.1080/10408440802014238 · Cited by 132 · see citing works
Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats.
Fadda, P., Robinson, L., Fratta, W., Pertwee, R., & Riedel, G. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.08.009 · Cited by 122 · see citing works
Reduced anxiety-related behaviour in transgenic mice overexpressing serotonin1A receptors
Kusserow, H., Davies, B., Hörtnagl, H., Voigt, I., Stroh, T., Bert, B., Deng, D. R., Fink, H., Veh, R. W., & Theuring, F. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.06.028 · Cited by 120 · see citing works
Hippocampal 5-HT receptors and consolidation of stressful memories
Guimarães, F. S., Bel, E. A. D., Padovan, C. M., Netto, S. M., & Titze‐de‐Almeida, R. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90098-b · Cited by 112 · see citing works
Self-citationJoca, S. R. L., Padovan, C. M., & Guimarães, F. S. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02943-3 · Cited by 108 · see citing works
Self-citationSerotonergic regulation of inhibitory avoidance and one-way escape in the rat elevated T-maze
Zangrossi, H., Viana, M. D. B., Zanoveli, J. M., Bueno, C. H., Nogueira, R. L., & Graeff, F. G. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00047-1 · Cited by 103 · see citing works
L-NAME prevents anxiety-like and depression-like behaviour in rats exposed to restraint stress
Sevgi, S., Özek, M., & Eroǧlu, L. (2006) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2006.28.2.977840 · Cited by 93 · see citing works
Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Irie, K., Fujioka, M., Orito, K., Abe, K., Hasebe, N., Egashira, N., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04565.x · Cited by 84 · see citing works
Role of the medial prefrontal cortex in cardiovascular responses to acute restraint in rats
Tavares, R. F., & Corrêa, F. M. D. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.030 · Cited by 83 · see citing works
Self-citationMarzo, V. D., PETROCELLIS, L. D., Bisogno, T., & Melck, D. J. (1999) · Lipids · doi:10.1007/bf02562332 · Cited by 81 · see citing works
Altered Emotional States in Knockout Mice Lacking 5-HT1A or 5-HT1B Receptors
Zhuang, X., Gross, C. T., Santarelli, L., Compan, V., Trillat, A., & Hen, R. (1999) · Neuropsychopharmacology · doi:10.1038/sj.npp.1395371 · Cited by 81 · see citing works
Kaster, M. P., Santos, A. R. S., & Rodrigues, A. L. S. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.05.025 · Cited by 75 · see citing works
Tsuji, M., Takeda, H., & Matsumiya, T. (2000) · Psychopharmacology · doi:10.1007/s002130000514 · Cited by 65 · see citing works
Dekeyne, A., Brocco, M., Adhumeau-Auclair, A., Gobert, A., & Millan, M. J. (2000) · Psychopharmacology · doi:10.1007/s002130000449 · Cited by 62 · see citing works
5‐Hydroxytryptamine1AReceptor Agonists in Animal Models of Depression and Anxiety
Kostowski, W., Dyr, W., Krząścik, P., Järbe, T. U. C., & Archer, T. (1992) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1992.tb00515.x · Cited by 55 · see citing works
Distribution and characterization of anandamide amidohydrolase in mouse brain and liver
Watanabe, K., Ogi, H., Nakamura, S., Kayano, Y., Matsunaga, T., Yoshimura, H., & Yamamoto, I. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00052-6 · Cited by 53 · see citing works
Hsu, H., Chen, T.-Y., Chan, M., & Chen, H. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.03.040 · Cited by 51 · see citing works
Kagamiishi, Y., Yamamoto, T., & Watanabe, S. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.021 · Cited by 47 · see citing works
Fadda, P., Robinson, L., Fratta, W., et al. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.11.022 · Cited by 37 · see citing works
Pre- or postsynaptic activity of 5-HT1A compounds in mice depends on the anxiety paradigm
López‐Rubalcava, C. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(96)00018-4 · Cited by 28 · see citing works
McQueen, D. S., Bond, S. M., Smith, P., Balali-Mood, K., & Smart, D. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.03.045 · Cited by 26 · see citing works
5‐HT1A Receptor Activation before Acute Stress Counteracted the Induced Long‐Term Behavioral Effects
Rioja, J., Santín, L. J., Garcia‐Fernandez, M. I., et al. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.041 · Cited by 10 · see citing works
Serotonin-1A receptor responsiveness in stress and following adaptation to stress.
Samad, N., & Haleem, D. J. (2007) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
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Sorted by citations
Safety and side effects of cannabidiol, a Cannabis sativa constituent
Machado Bergamaschi, M., Helena Costa Queiroz, R., Waldo Zuardi, A., & Alexandre S. Crippa, J. (2011) · Current Drug Safety · doi:10.2174/157488611798280924 · Cited by 558 · see citing works
Crippa, J. A. S., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., Simões, M. V., Bhattacharyya, S., Fusar-Poli, P., Atakan, Z., et al. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110379283 · Cited by 535 · see citing works
Campos, A. C., Moreira, F. A., Gomes, F. V., Del Bel, E. A., & Guimarães, F. S. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2011.0389 · Cited by 475 · see citing works
Self-citationZanelati, T., Biojone, C., Moreira, F., Guimarães, F., & Joca, S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00521.x · Cited by 366 · see citing works
Self-citationCannabis and adolescent brain development.
Lubman, D. I., Cheetham, A., & Yücel, M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.11.009 · Cited by 360 · see citing works
Jin, D., Dai, K., Xie, Z., & Chen, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-60172-6 · Cited by 348 · see citing works
Phytocannabinoids as novel therapeutic agents in {CNS} disorders.
Hill, A. J., Williams, C. M., Whalley, B. J., & Stephens, G. J. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.09.002 · Cited by 312 · see citing works
Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age
Crippa, J. A., Guimarães, F. S., Campos, A. C., & Zuardi, A. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02009 · Cited by 308 · see citing works
Self-citationGarcía-Gutiérrez, M. S., Navarrete, F., Gasparyan, A., Austrich-Olivares, A., Sala, F., & Manzanares, J. (2020) · Biomolecules · doi:10.3390/biom10111575 · Cited by 306 · see citing works
The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABA A receptors
Bakas, T., van Nieuwenhuijzen, P. S., Devenish, S. O., McGregor, I. S., Arnold, J. C., & Chebib, M. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.02.022 · Cited by 246 · see citing works
Waldo Zuardi, A., Alexandre S. Crippa, J., E.C. Hallak, J., Bhattacharyya, S., Atakan, Z., Martin-Santos, R., K. McGuire, P., & Silveira Guimaraes, F. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802884681 · Cited by 222 · see citing works
Campos, A. C., Fogaça, M. V., Scarante, F. F., Joca, S. R. L., Sales, A. J., Gomes, F. V., Sonego, A. B., Rodrigues, N. S., Galve-Roperh, I., & Guimarães, F. S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00269 · Cited by 175 · see citing works
Self-citationOn disruption of fear memory by reconsolidation blockade: evidence from cannabidiol treatment
Stern, C. A. J., Gazarini, L., Takahashi, R. N., Guimarães, F. S., & Bertoglio, L. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.63 · Cited by 156 · see citing works
Self-citationSartim, A. G., Guimarães, F. S., & Joca, S. R. L. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.01.033 · Cited by 156 · see citing works
Self-citationLemos, J. I., Resstel, L. B., & Guimarães, F. S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.045 · Cited by 146 · see citing works
Self-citationCannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors
Casarotto, P. C., Gomes, F. V., Resstel, L. B. M., & Guimarães, F. S. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833b33c5 · Cited by 141 · see citing works
Self-citationCampos, A. C., Ferreira, F. R., & Guimarães, F. S. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.08.012 · Cited by 139 · see citing works
Self-citationSchiavon, A. P., Bonato, J. M., Milani, H., Guimarães, F. S., & Weffort de Oliveira, R. M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.017 · Cited by 135 · see citing works
Self-citationSoares, V. D. P., Campos, A. C., Bortoli, V. C. D., Zangrossi, H., Guimarães, F. S., & Zuardi, A. W. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.004 · Cited by 112 · see citing works
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Gomes, F. V., Reis, D. G., Alves, F. H., Corrêa, F. M., Guimarães, F. S., & Resstel, L. B. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881110389095 · Cited by 97 · see citing works
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The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics
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- Authors
- Resstel, L. B. M., Tavares, R. F., Lisboa, S. F. S., Joca, S. R. L., Corrêa, F. M. A., & Guimarães, F. S.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Resstel, Leonardo B.M.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2008-12-24
- Volume
- 156
- Issue
- 1
- Pages
- 181-188
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC2697769
- OpenAlex
- W2084770788
- Cited by
- 283
- References
- 76
- Citations by year
- 2026: 17 · 2025: 20 · 2024: 19 · 2023: 24 · 2022: 14 · 2021: 25 · 2020: 31 · 2019: 14 · 2018: 13 · 2017: 19 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 6 · 2012: 13
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- cannabidiol, 5-HT1A receptor, restraint stress, anxiety, cardiovascular response, blood pressure, heart rate, WAY-100635, endocannabinoid system, elevated plus maze, stress adaptation, anxiolytic effects
- MeSH terms
- Animals, Behavior, Animal, Blood Pressure, Cannabidiol, Dose-Response Relationship, Drug, Heart Rate, Hemodynamics, Injections, Intraperitoneal, Male, Piperazines, Pyridines, Restraint, Physical, Serotonin Antagonists, Stress, Psychological, Anti-Anxiety Agents, Rats, Wistar, Maze Learning, Receptor, Serotonin, 5-HT1A, Rats, Serotonin 5-HT1 Receptor Agonists
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