Cited by 283Cannabis and Cannabinoid ResearchMedicinal Plant Extracts EffectsStress Responses and Cortisol

5‐HT1Areceptors are involved in the cannabidiol‐induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats

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Resstel, Leonardo B.M., Tavares, Rodrigo F., Lisboa, Sabrina F.S., Joca, Sâmia R.L., Corrêa, Fernando M.A., Guimarães, Francisco S.·2009·British Journal of Pharmacology

Abstract

BACKGROUND AND PURPOSE: Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa which induces anxiolytic- and antipsychotic-like effects in rodents. These effects could be mediated by facilitation of the endocannabinoid system or by the activation of 5-HT(1A) receptors. As either of these mechanisms could promote adaptation to inescapable stress, the aim of the present work was to test the hypothesis that CBD would attenuate the autonomic and behavioural consequences of restraint stress (RS). We also investigated if the responses to CBD depended on activation of 5-HT(1A) receptors. EXPERIMENTAL APPROACH: Male Wistar rats received i.p. injections of vehicle or CBD (1, 10 or 20 mg kg(-1)) and 30 min later were submitted to 60 min of restraint where their cardiovascular responses were recorded. The protocol of the second experiment was similar to the first one except that animals received i.p. injections of the 5-HT(1A) receptor antagonist WAY100635 (0.1 mg kg(-1)) before CBD treatment and exposure to restraint. 24 h later they were also tested in the elevated plus-maze (EPM), an animal model of anxiety. KEY RESULTS: Exposure to RS increased blood pressure and heart rate and induced an anxiogenic response in the EPM 24 h later. These effects were attenuated by CBD. WAY100635 by itself did not change the cardiovascular and anxiogenic response to RS, but blocked the effects of CBD. CONCLUSION AND IMPLICATIONS: The results suggest that CBD can attenuate acute autonomic responses to stress and its delayed emotional consequences by facilitating 5-HT(1A) receptor-mediated neurotransmission.

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Crossref · 10.1111/j.1476-5381.2008.00046.x

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Authors
Resstel, L. B. M., Tavares, R. F., Lisboa, S. F. S., Joca, S. R. L., Corrêa, F. M. A., & Guimarães, F. S.
Affiliations
Universidade de São Paulo (BR)
Corresponding author
Resstel, Leonardo B.M.
Venue
British Journal of Pharmacology
Publisher
Wiley
Published
2008-12-24
Volume
156
Issue
1
Pages
181-188
ISSN
  • 0007-1188 (ISSN-L)
  • 1476-5381
OpenAlex
W2084770788
Cited by
283
References
76
Citations by year
2026: 17 · 2025: 20 · 2024: 19 · 2023: 24 · 2022: 14 · 2021: 25 · 2020: 31 · 2019: 14 · 2018: 13 · 2017: 19 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 6 · 2012: 13
FWCI
8.67
Type
journal article
Language
en
Open access
Locations
  • British Journal of Pharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundação de Amparo à Pesquisa do Estado de São Paulo
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
cannabidiol, 5-HT1A receptor, restraint stress, anxiety, cardiovascular response, blood pressure, heart rate, WAY-100635, endocannabinoid system, elevated plus maze, stress adaptation, anxiolytic effects
MeSH terms
Animals, Behavior, Animal, Blood Pressure, Cannabidiol, Dose-Response Relationship, Drug, Heart Rate, Hemodynamics, Injections, Intraperitoneal, Male, Piperazines, Pyridines, Restraint, Physical, Serotonin Antagonists, Stress, Psychological, Anti-Anxiety Agents, Rats, Wistar, Maze Learning, Receptor, Serotonin, 5-HT1A, Rats, Serotonin 5-HT1 Receptor Agonists

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