Cited by 87Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

Cardiovascular risk of adipokines: a review

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Dutheil, Frédéric, Gordon, Brett Ashley, Naughton, Geraldine, Crendal, Edward, Courteix, Daniel, Chaplais, Elodie, Thivel, David, Lac, Gérard +1 more·2018·Journal of International Medical Research

Abstract

Over the last two decades, the understanding of adipose tissue has undergone radical change. The perception has evolved from an inert energy storage tissue to that of an active endocrine organ. Adipose tissue releases a cluster of active molecules named adipokines. The severity of obesity-related diseases does not necessarily correlate with the extent of body fat accumulation but is closely related to body fat distribution, particularly to visceral localization. There is a distinction between the metabolic function of central obesity (visceral abdominal) and peripheral obesity (subcutaneous) in the production of adipokines. Visceral fat accumulation, linked with levels of some adipokines, induces chronic inflammation and metabolic disorders, including glucose intolerance, hyperlipidaemia, and arterial hypertension. Together, these conditions contribute to a diagnosis of metabolic syndrome, directly associated with the onset of cardiovascular disease. If it is well known that adipokines contribute to the inflammatory profile and appetite regulation, this review is novel in synthesising the current state of knowledge of the role of visceral adipose tissue and its secretion of adipokines in cardiovascular risk.

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  1. [113]Gonzalez-Gay MA Vazquez-Rodriguez TR Garcia-Unzueta MT et al. Visfatin is not associated with inflammation or metabolic syndrome in patients with severe rheumatoid arthritis undergoing anti-TNF-alpha therapy. Clin. Exp. Rheumatol 2010; 28: 56– 62. 20346239

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Authors
Dutheil, F., Gordon, B. A., Naughton, G., Crendal, E., Courteix, D., Chaplais, E., Thivel, D., Lac, G., & Benson, A. C.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • La Trobe University (AU)
  • Australian Catholic University (AU)
  • Université Clermont Auvergne (FR)
  • RMIT University (AU)
Corresponding author
Dutheil, Frédéric
Venue
Journal of International Medical Research
Published
2017-09-25
Volume
46
Issue
6
Pages
2082-2095
ISSN
  • 0300-0605 (ISSN-L)
  • 1473-2300
OpenAlex
W2757219335
Cited by
87
References
123
Citations by year
2026: 11 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 13 · 2021: 12 · 2020: 14 · 2019: 13 · 2018: 3 · 2017: 1
FWCI
6.64
Type
journal article
Language
en
Open access
Locations
  • Journal of International Medical Research (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • RMIT Research Repository (RMIT University Library) (submittedVersion, cc-by-nc)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by-nc)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion)
  • La Trobe University
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
adipokines, cardiovascular risk, visceral adipose tissue, obesity, body fat distribution, abdominal obesity, subcutaneous adipose tissue, metabolic syndrome, chronic inflammation, impaired glucose tolerance, hyperlipidemia, hypertension, appetite regulation, adipose tissue endocrine function
MeSH terms
Cardiovascular Diseases, Humans, Inflammation, Obesity, Risk Factors, Biomarkers, Metabolic Syndrome, Intra-Abdominal Fat, Adipokines

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